Niche cells hematopoietic stem cells. Medical search. Frequent questions

Is the Subject Area "Hematopoietic stem cell transplantation" applicable to this article? (plos.org)
The first-ever online and open-access education e-course, brought to you by The EBMT Trainee Committee, designed to cover all aspects surrounding hematopoietic cell transplantation and cellular therapy with a focus on trainee-relevant knowledge and skills. (ebmt.org)
Identifying and understanding acute complications after allogeneic haematopoietic cell transplantation (alloHCT). (ebmt.org)
Hematopoietic stem cell (HSC) transplantation provides an effective platform for the treatment of hematological disorders. (rsc.org)
HSCs specifically are defined by their ability for self-renewal and to reconstitute the entire hematopoietic system following transplantation. (stemcell.com)
It is used both by hematopoietic researchers and clinical labs to assess the potency of transplantation units of cord blood (CB) and hematopoietic cellular therapy products. (stemcell.com)
Other uses of the CFU assay include studying the effects of stimulatory and inhibitory growth factors, screening novel compounds to predict potential toxicity to the hematopoietic system, and testing the effects of various in vitro manipulations (e.g. cell processing, cryopreservation, gene transduction, and transmission) on cellular products used in hematopoietic cell transplantation. (stemcell.com)
I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
Dimeo FC, Tilmann MH, Bertz H, Kanz L, Mertelsmann R, Keul J: Aerobic exercise in the rehabilitation of cancer patients after high dose chemotherapy and autologous peripheral stem cell transplantation. (karger.com)
Current treatment options for PMF are limited, and the only potential cure, stem cell transplantation, is often prohibitively toxic for most patients. (lls.org)
The only curative therapy is hematopoietic stem cell transplantation. (frontiersin.org)
Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
The goal of this work is to elucidate novel molecular mechanisms that can be therapeutically targeted to regulate cell migration in a tissue-specific fashion - to inhibit it in certain contexts (e.g., inflammatory diseases and cancer metastasis) and promote it in others (e.g., stem cell transplantation and cell-based therapies). (bu.edu)
It is because of these stem cells and their capacity to regenerate and rebuild the entire hematopoietic (blood) system that makes transplantation a promising therapy. (lu.se)
The growing need for haematopoietic stem cell transplantation (HSCT) is reflected in the increasing number of transplants performed globally each year. (bvsalud.org)

Dexter observed that mesenchymal stromal cells could maintain early HSCs ex vivo, and both Lord and Gong showed that these cells localized to the endosteal margins in long bones. (wikipedia.org)
Steady-state hematopoietic stem cells' (HSCs) self-renewal and differentiation toward their mature progeny in the adult bone marrow is tightly regulated by cues from the microenvironment. (elsevierpure.com)
Here, we review emerging evidence showing how HSCs and their progeny are regulated by an interdependent network of mesenchymal stromal cells, nerve fibers, the vasculature, and also other hematopoietic cells. (elsevierpure.com)
Abstract Hematopoiesis is the process leading to the sustained production of blood cells by hematopoietic stem cells (HSCs). (ox.ac.uk)
Growth, survival, and differentiation of HSCs occur in specialized microenvironments called "hematopoietic niches," through molecular cues that are only partially understood. (ox.ac.uk)
Here we show that agrin, a proteoglycan involved in the neuromuscular junction, is a critical niche-derived signal that controls survival and proliferation of HSCs. (ox.ac.uk)
Explore the heterogeneity of HSCs and how niche signals influence their fate decisions, including myeloid and lymphoid lineage commitment. (ebmt.org)
HSCs make up a very small population of the hematopoietic system, however, these cells are invaluable as they have the potential to give rise to all mature blood and immune cell types and sustain life-long blood production. (stemcell.com)
CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)
Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an animal's lifespan. (biorxiv.org)
Here, we show that young and aged LT-HSCs respond differently to inflammatory stress, such that aged LT-HSCs produce a cell-intrinsic, myeloid-biased expression program. (biorxiv.org)
Using single-cell RNA-seq, we identify a myeloid-biased subset within the LT-HSC population (mLT-HSCs) that is much more common amongst aged LT-HSCs and is uniquely primed to respond to acute inflammatory challenge. (biorxiv.org)
Aged LT-HSCs demonstrate a cell-intrinsic myeloid bias during inflammatory challenge. (biorxiv.org)
We hypothesize that the abnormal bone marrow niche in PMF provides protection to disease-causing LSCs at the cost of the normal blood-forming HSCs. (lls.org)
We further hypothesize that targeting the abnormal niche may help eliminate LSCs, preserve normal HSCs, and provide a potential cure to PMF. (lls.org)
We are elucidating the cellular and molecular mechanisms of how LSCs interact with the fibrotic niche in mouse models and how this negatively impacts normal HSCs. (lls.org)
It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
The project will investigate the age-related functional decline of hematopoiesis and dissect the role of Cdc42 in the rejuvenation of Human Hematopoietic Stem Cells (HSCs). (uni-ulm.de)
It will additionally focus on, using single-cell sequencing and deep learning approaches, the transcriptional and mutational heterogeneity of HSCs upon aging. (uni-ulm.de)
The rapid advancement in understanding the biology of hematopoietic stem cells (HSCs) and cancer stem cells (CSCs) in recent years has renewed interest in investigating the role of stem cells in benzene -induced malignancy and bone marrow depression. (cdc.gov)

This event requires a special environment, termed the hematopoietic stem cell niche, which provides the protection and signals necessary to carry out the differentiation of cells from HSC progenitors. (wikipedia.org)
Hematopoiesis involves a series of differentiation steps from one progenitor cell to a more committed cell type, forming the recognizable tree seen in the adjacent diagram. (wikipedia.org)
In hematopoietic tissues, a group of ECs are highly specialized and constitute the vascular HSPC niche to support HSPC maturation, expansion, and differentiation. (go.jp)
The team visualized endothelial differentiation step-by-step from the endoderm to the HSPC niche-constituting ECs via islet1+ endothelial progenitors by live imaging-based lineage tracing. (go.jp)
The adult bone marrow provides essential niches for hematopoietic stem cell (HSC) maintenance and differentiation, which are not fully understood. (elsevierpure.com)
Familiarise with the molecular mechanisms underlying HSC self-renewal and the differentiation within the HSC niche. (ebmt.org)
The colony-forming unit (CFU) assay is a clonal, in vitro culture assay that measures the growth and frequency of functionally viable HSPCs by assessing the proliferation and differentiation of individual progenitor cells, resulting in the formation of discrete colonies in a semi-solid methylcellulose medium (such as MethoCult™ ) when supplemented with appropriate cytokines. (stemcell.com)
Cell markers, or surface antigens, are molecules located on a cell's membrane used to identify specific cell types, their lineage, and their stage in the differentiation process according to the presence or absence of the expression of defined markers. (stemcell.com)
Aged hematopoietic stem cells (HSC) exhibit compromised reconstitution capacity and differentiation-bias towards myeloid lineage, however, the molecular mechanism behind it remains not fully understood. (haematologica.org)
Our results now suggest that 4-MU treatment of MSC not only affects the formation of SG via increased levels of O-linked glycosylation of cellular proteins but also that MSC cultivated under osteogenic stimulation develop SG, which in turn support MSC differentiation into osteogenic precursor cells. (europa.eu)
Thus, conserved endocytic functions may control blood cell progenitor quiescence and differentiation. (nih.gov)
The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
There is clonal proliferation of malignant hematopoietic stem cells, dysregulated cellular differentiation, and compromised tissue function. (standardofcare.com)
Despite significant advances in understanding nephron segment patterning, many questions remain about the underlying genes and signaling pathways that orchestrate renal progenitor cell fate choices and regulate differentiation. (mdpi.com)
The anti-SARS-CoV-2 BNT162b2 vaccine suppresses mithramycin-induced erythroid differentiation and expression of embryo-foetal globin genes in human erythroleukemia K562 cells, bioRvix. (davidicke.com)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)
The proliferation and differentiation of pluripotent stem cells give rise to progeny that can populate the entire immunologic and hematopoietic systems through committed progenitors of both the lymphoid and myeloid lineages. (medscape.com)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

Many human blood cells, such as red blood cells (RBCs), immune cells, and even platelets all originate from the same progenitor cell, the hematopoietic stem cell (HSC). (wikipedia.org)
The CMP can then further differentiate into the megakaryocyte-erythroid progenitor cell (MEP), which goes on to make RBCs and platelets, or the granulocyte/macrophage progenitor (GMP), which gives rise to the granulocytes of the innate immune response. (wikipedia.org)
The hemangioblast theory, which posits that the RBCs and ECs derive from a common progenitor cell, was developed as researchers observed that receptor knockout mice, such as Flk1-/-, exhibited defective RBC formation and vessel growth. (wikipedia.org)
Sites of loosely packed extracellular matrix (ECM) also offer stem and progenitor cell optimal space to proliferate and differentiate. (europa.eu)
The terms "progenitor cell" and "stem cell" are sometimes equated. (phys.org)
Mesenchymal stromal cells are essential components of hematopoietic stem and progenitor cell (HSPC) niches, regulating HSPC proliferation and fates. (gene-tools.com)

These studies and others supported the idea that bone cells create the HSC niche, and all the research that elucidated this specialized hematopoietic microenvironment stemmed from these landmark studies. (wikipedia.org)
CD4 + T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. (nature.com)
The possible underlying mechanisms are proposed to come mainly from bone marrow, including stimulated erythropoiesis with hyperplasia of the hematopoietic bone marrow, improvement of the hematopoietic microenvironment induced by exercise training, and hormone- and cytokine-accelerated erythropoiesis. (karger.com)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
The microenvironment, consisting of lymphocytes, macrophages, fibroblasts, endothelial elements, and stroma in which hematopoietic cells reside, creates a regulatory niche that determines the local area network. (medscape.com)
These steps are supported by functions of the cancer cells themselves or of the tumor microenvironment. (medscape.com)

They found that islet1 -expressing cells are the progenitors of the venous ECs that constitute the majority of the HSPC niche (Figure 1A). (go.jp)
The present results clearly demonstrate that ECs originating from the endoderm via islet1 + endothelial progenitors play a specialized role in forming a functional vascular HSPC niche (Figure 1C). (go.jp)
We have now found that this ventral domain is the sclerotome, and that two markers of mammalian mesenchymal stem/stromal cells, Alcam and Pdgfr-α, are distinctively expressed there and instrumental for the emergence and migration of stromal cell progenitors, which in turn conditions the proper assembly of the vascular component of the CHT niche. (gene-tools.com)

When these islet1 -lineage ECs were specifically ablated, most of the HSPCs were lost from the caudal hematopoietic tissue (CHT), a transient vascular niche for HSPCs in zebrafish (Figure 1B). (go.jp)
islet1 + -derived ECs (green) are mainly located in the caudal hematopoietic tissue (CHT), a transient vascular niche for HSPCs. (go.jp)
In zebrafish, we previously found that the stromal cells of the caudal hematopoietic tissue (CHT), a niche functionally homologous to the mammalian fetal liver, arise from the ventral part of caudal somites. (gene-tools.com)

2018 . DOI : 10.1016/j.cell.2018.01.028. (epfl.ch)
2011 - 2018, ARC Stem Cells Australia program - blood theme. (edu.au)

Many pathological states can arise from disturbances in this niche environment, highlighting its importance in maintaining hematopoiesis. (wikipedia.org)
There are 2 types of hematopoiesis that occur in humans: Primitive hematopoiesis - blood stem cells differentiate into only a few specialized blood lineages (typically isolated to early fetal development). (wikipedia.org)
The pioneering work of Till and McCulloch in 1961 experimentally confirmed the development of blood cells from a single precursor hematopoietic stem cell (HSC), creating the framework for the field of hematopoiesis to be studied over the following decades. (wikipedia.org)
Agrin-deficient mice displayed in vivo apoptosis of CD34+CD135− LSK cells and impaired hematopoiesis, both of which were reverted by an agrin-sufficient stroma. (ox.ac.uk)
Dr. Elliott J. Hagedorn is a cell and developmental biologist with expertise in hematopoiesis, stem cell biology and vascular heterogeneity. (bu.edu)
Clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis and peripheral cytopenias. (standardofcare.com)
Thus the sclerotome contributes essential stromal cells for each of the key steps of developmental hematopoiesis. (gene-tools.com)
We portrayed the Notch system in embryonic stem cell (ESC)-derived embryoid bodies (EBs) differentiating under the standard protocols used to assess yolk sac (YS) hematopoiesis in vitro. (karger.com)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)

HSPCs are multipotent cells that can self-renew and differentiate to give rise to all blood cell lineages. (go.jp)
These may be classified into those that result in pancytopenia and those limited to failure of 1 or 2 hematopoietic lineages. (medscape.com)

Understand the processes involved in stem cell transplant. (ebmt.org)
Familiarize trainees with important clinical aspects of stem cell transplant and cellular therapy, including pharmacology, patient monitoring, and recognition and basic management of complications. (ebmt.org)
At 4 years of age and 29 months post-transplant, the patient demonstrated normal T-lymphocyte and natural killer cell numbers. (frontiersin.org)
Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
If it weren't for the hematopoietic stem cells, this transplant would only be a transient therapy meaning its effects would only last a short time. (lu.se)
4 It also occurs in neutropenic cancer patients and hematopoietic stem cell transplant or solid organ transplant recipients. (cdc.gov)
We report the first outbreak of invasive infection caused by A. ustus among hematopoietic stem cell transplant (HSCT) recipients. (cdc.gov)
Recognition of invasive infections that occurred in 2 clusters of hematopoietic stem cell transplant (HSCT) recipients in our institution prompted us to perform a more thorough clinical investigation and environmental sampling to identify potential sources of acquisition. (cdc.gov)

As the embryo requires rapid oxygenation due to its high mitotic activity, these islands are the main source of red blood cell (RBC) production via fusing endothelial cells (ECs) with the developing embryonic circulation. (wikipedia.org)
Researchers identify the origin of endothelial cells that constitute the vascular niche for hematopoietic stem and progenitor cells in zebrafish. (go.jp)
Endothelial cells (ECs) line blood vessels and can serve as specialized vascular niches for hematopoietic stem and progenitor cells (HSPCs), a special environment where HSPCs reside and self-renew. (go.jp)
Static culture conditions are often unsuitable, especially for endothelial models, since they completely neglect the physiological surface shear stress and corresponding reactions of endothelial cells (ECs) such as alignment in the direction of flow. (bvsalud.org)

In vitro, agrin-deficient MSCs were less efficient in supporting proliferation of mouse Lin−c-Kit+ cells, suggesting that agrin plays a role in the hematopoietic cell development. (ox.ac.uk)
The relevance of cellular in vitro models highly depends on their ability to mimic the physiological environment of the respective tissue or cell niche. (bvsalud.org)

They also serve as specialized vascular niches that provide instructive signals to tissue-specific stem cells or parenchymal cells for tissue formation and repair. (go.jp)
CD34 is a transmembrane phosphoglycoprotein that was first identified on HSPCs, but its expression is also present on other cell types, such as vascular tissue. (stemcell.com)
Stem cells are essential for regeneration and repair of worn-out or injured tissue. (europa.eu)
PMF is a stem cell-derived blood malignancy with the characteristics of too many cells in the blood and a large amount of scar tissue formation (fibrosis) in the bone marrow. (lls.org)
In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)
The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
In skin cells we plan to study the contribution of the protein synthesis apparatus to cellular and tissue aging. (uni-ulm.de)
Neutrophils are the first immune cells that infiltrate the damaged tissue as early as 24 h after injury. (springer.com)
Niches are special microenvironments in tissue where stem cells are located. (bvsalud.org)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)

Learn about the impact of aging on the HSC niche and its implications for haematopoietic disorders and regenerative medicine. (ebmt.org)

Specialized ECs, besides those lining lumenized vessels, constitute an instructive niche for HSPCs. (go.jp)
Collectively, these are referred to as hematopoietic stem and progenitor cells (HSPCs). (stemcell.com)
Additional markers can be used to distinguish HSPC subsets within the CD34+ population and isolate HSPCs with different engraftment abilities and capacities to expand or generate mature blood cells in culture. (stemcell.com)
Throughout our lives, a small pool of hematopoietic stem/progenitor cells (HSPCs) ensures the stable production of a wide range of blood and immune cells in our bodies. (phys.org)
Cells in the blood such as immune cells, red blood cells and other vital cell types are constantly renewed from stem cells, the so-called hematopoietic stem and progenitor cells (HSPCs). (phys.org)

Understanding the interaction mechanisms in these intricate niches will provide great opportunities for HSC-related therapies and immune modulation. (elsevierpure.com)
Despite increased focus on the clinical relevance of dormant metastatic disease, our understanding of dormant niches, mechanisms underlying emergence from dormancy, and the immune system's role in this phenomenon, remains in its infancy. (nature.com)
Project A05 addresses the hypothesis that brain inflammaging is critically regulated by Notch/NF-kB crosstalk signaling which can promote synapse aging via cell-intrinsic and paracrine mechanisms finally resulting in motoric and cognitive decline. (uni-ulm.de)
In this prospect, benzene metabolites formed through metabolism in the liver and bone marrow cause damage in hematopoietic cells via multiple mechanisms that, in addition to traditionally recognized chromosomal aberration and covalent binding, incorporate oxidative stress, alteration of gene expression, apoptosis, error-prone DNA repair, epigenetic regulation, and disruption of tumor surveillance. (cdc.gov)

Under the direction of Melissa Kacena, PhD , the Kacena Lab is exploring the interaction of the bone and hematopoietic systems, thereby potentially improving the treatment of metabolic bone disease, hematopoietic disorders and fracture healing. (iu.edu)
As an outlook, we aim to develop personalized anti-aging clinical interventions that will attenuate aging-driven immune remodeling and hematopoietic disorders. (uni-ulm.de)
Aging of the hematopoietic system promotes various blood, immune, and systemic disorders and is largely driven by hematopoietic stem cell (HSC) dysfunction. (fightaging.org)
A heterogenous group of myeloid disorders characterized by somatically mutated hematopoietic stem cells,the presence of variable peripheral cytopenias, and a broad risk of progression to acute myeloid leukemia (AML). (standardofcare.com)
The precise pathophysiology of inherited single cell and multilineage cytopenias has not been elucidated despite the identification of many of the genes mutated in these disorders. (medscape.com)

Understand the general concepts about stem cell biology, emerging concepts in the field of HSC biology, niche components, and regulation. (ebmt.org)
Funding encompasses a broad spectrum of hematologic inquiry, ranging from stem cell biology to medical management of blood diseases and to assuring the adequacy and safety of the nation's blood supply. (hhs.gov)
Frontiers in Cell and Developmental Biology. (kcl.ac.uk)
However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)

Transcription factor induction of vascular blood stem cell niches in vivo. (bu.edu)
In vivo hematopoietic stem cell modification by mRNA delivery. (davidicke.com)

thus, a successful metastatic colony depends on the ability of cancer cells to appropriate distinct microenvironments at each step in the metastatic cascade: the primary tumor, systemic circulation, and the final metastatic destination. (medscape.com)

The CLP then goes on to differentiate into more committed lymphoid precursor cells. (wikipedia.org)
These factors may regulate myeloid versus lymphoid balance with age, and can potentially mitigate the long-term deleterious effects of inflammation that lead to hematopoietic pathologies. (biorxiv.org)

This new marker can be used to specifically identify functionally potent hematopoietic stem cells during the regenerative process. (lu.se)

However, little is known about EC heterogeneity in hematopoietic tissues. (go.jp)
Therefore, this study provides evidence that the origin of ECs, at least in part, determines their specialization and heterogeneity in the HSPC niche in zebrafish. (go.jp)
Here we review the currently known cellular and molecular components of the niche for hematopoietic stem cells and their progeny, highlight their heterogeneity and interdependency, and discuss some open questions in the field. (elsevierpure.com)
Single-cell omics provide insight into cellular heterogeneity and function. (nature.com)
One sentence summary Murine hematopoietic stem cells display transcriptional heterogeneity that is quantitatively altered with age and leads to the age-dependent myeloid bias evident after inflammatory challenge. (biorxiv.org)

The MDS cell of origin is a hematopoetic stem cell that proliferates and escapes apoptosis. (standardofcare.com)
Accelerated hematopoietic cell apoptosis has been demonstrated in virtually all IBMFS. (medscape.com)
Cancer is a complex disease in which many basic processes, such as cell division, apoptosis, and cell migration are dysregulated. (medscape.com)

Agrin is expressed by multipotent nonhematopoietic mesenchymal stem cells (MSCs) and by differentiated osteoblasts lining the endosteal bone surface, whereas Lin−Sca1+c-Kit+ (LSK) cells express the α-dystroglycan receptor for agrin. (ox.ac.uk)

A year later, Choi showed that blast cells derived from embryonic stem (ES) cells displayed common gene expression of both hematopoietic and endothelial precursors. (wikipedia.org)
The paradox is that the mutation provides advantage at the stem cell level and progenitor cells, with a disadvantage at the level of hematopoietic precursors. (standardofcare.com)

Programs also support the development of novel cell-based therapies to bring the expertise of transfusion medicine and stem cell technology to the repair and regeneration of human tissues and organs. (hhs.gov)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
Gene and cell therapies present novel alternatives to disease management, offering the promise of a single treatment and a lifelong cure. (bvsalud.org)

During embryonic development, the programmed death of certain cells plays an essential role in shaping organs and allowing proper growth. (phys.org)
Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. (bu.edu)
We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)

Relationship between hematogenous tumor cell dissemination and cellular immunity in DCIS patients. (nature.com)
Direct invasion by carcinoma cells of the stromal compartment involves active proteolysis effected principally by matrix metalloproteinases (MMPs), while degrading the BM and other ECM that lie in the path of invading tumor cells, MMP-expressing cells also liberate growth factors that are sequestered there, thereby fostering cancer cell proliferation. (medscape.com)
Although tumor-associated angiogenesis has traditionally been defined as the sprouting of new vessels from preexisting vessels, it is becoming clear that the blood vessels that support tumor growth can also originate from cells recruited from the bone marrow or can even differentiate from tumor stem cells (vascular mimicry). (medscape.com)

The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)

In 1978, after observing that the prototypical colony-forming stem cells were less capable at replacing differentiated cells than bone marrow cells injected into irradiated animals, Schofield proposed that a specialized environment in the bone marrow allows these precursor cells to maintain their cellular reconstitution potential. (wikipedia.org)
A major component outside of the cells, which notably is distinctly involved in controlling and guiding many cellular processes, is the polysaccharide hyaluronan (HA). (europa.eu)
If we could develop technologies that could control cellular activity in bone marrow and the hematopoietic stem cell niche, it could be transformative for disease applications," said Michael Mitchell, one of the study's lead authors. (davidicke.com)

Natural Killer (NK) Cells (2022) pp 31-45. (imperial.ac.uk)

Dormant cancer cells: programmed quiescence, senescence, or both? (nature.com)
Cancer Cell 18 , 485-498 (2010). (nature.com)
Engineering the NK cell cancer immune response using biofunctionalised nanographene oxide . (imperial.ac.uk)
Research in the Hagedorn Lab utilizes a combination of genetics, genomics and advanced live cell imaging in zebrafish to understand how blood and cancer cells migrate into and out of distinct tissues and organs. (bu.edu)
These new studies of benzene leukemogenesis and hematotoxicity are expected to provide insights into how environmental and occupational chemicals affect stem cells to cause cancer and toxicity, which impact the risk assessment, permissible level, and therapy of benzene exposure. (cdc.gov)
Wide Next-Generation Sequencing Characterization of Young Adults Non-Small-Cell Lung Cancer Patients. (cdc.gov)
Molecular profiling of non-small-cell lung cancer patients with or without brain metastases included in the randomized SAFIR02-LUNG trial and association with intracranial outcome. (cdc.gov)
Clinicopathologic and Genomic Landscape of Non-Small Cell Lung Cancer Brain Metastases. (cdc.gov)
Association of CD274 (PD-L1) Copy Number Changes with Immune Checkpoint Inhibitor Clinical Benefit in Non-Squamous Non-Small Cell Lung Cancer. (cdc.gov)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
Metastases represent the end products of a multistep cell-biological process termed the invasion metastasis cascade, which involves dissemination of cancer cells to anatomically distant organ sites. (medscape.com)
Circulating cancer cells that survive, settle in the microvasculature of the target organ and extravasate through the vessel wall. (medscape.com)
This process is marked by a complex and coordinated set of molecular changes leading to the motile behavior of the invading cancer cells, which involves dynamic cytoskeletal changes, cell-matrix interactions, localized proteolysis, actin-myosin contractions, and focal contact disassembly. (medscape.com)

Furthermore, we find that trunk somites are similarly dependent on Alcam and Pdgfr-α to produce mesenchymal cells that foster HSPC emergence from the aorta. (gene-tools.com)

Physiologic aging in both humans and mice leads to permanent changes in LT-HSC function, such as myeloid-biased hematopoietic output ( Akunuru and Geiger, 2016 ). (biorxiv.org)
There was 93% donor T-lymphocytes, 20% donor B-lymphocytes, and 5% donor myeloid cells, indicative of some donor stem cell engraftment. (frontiersin.org)

The clonal outgrowth of mutant stem cells favors and abnormal hematopoietic stem cell niche. (standardofcare.com)

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality. (bu.edu)

The cell- ations in these signals (see Table 1 for a glossary of terms). (lu.se)
Hypoxia leads to the up-regulation of hypoxia-induced transcription factors (HIF)-a and HIF-2a, which are the master regulators of proangiogenic signals, mainly the vascular endothelial cell growth factors (VEGFs). (medscape.com)

Several signaling pathways control blood cell (hemocyte) development in the Drosophila lymph gland. (nih.gov)
In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)

Then, the researchers introduced hematopoietic stem cells isolated from cord blood into this artificial bone marrow. (disabled-world.com)
In a 2020 Nature Biomedical Engineering study, researchers used a type of genetic therapy, known as RNA interference, and nanoparticles modified in such a way that they would accumulate in the cells found in the bone marrow, rather than in the liver. (davidicke.com)
Using this gene therapy technique with specialised nanoparticles, researchers from Penn Engineering and the Massachusetts Institute of Technology ("MIT") developed a way to turn off specific genes in cells of bone marrow. (davidicke.com)
In a paper published last week, Italian researchers treated lymphoblast cells isolated from the bone marrow of a 53-year-old chronic myelogenous leukaemia patient with Pfizer's mRNA covid injection, at increasing concentrations. (davidicke.com)

Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)

These particles could be tailored to help treat heart disease or to boost the yield of stem cells in patients who need stem cell transplants, Penn Engineering Today wrote. (davidicke.com)

A particular stem cell type in the adult human-being is the 'Mesenchymal stem cell' (MSC). (europa.eu)
At present the research community is progressing towards this goal one stem cell population at a time, but it seems plausible that some discoveries will be broadly applicable to all stem cells in the adult body. (fightaging.org)
haematopoietic) is the medical term used to describe the process by which our blood cells are formed, develop and mature into their final "adult" types. (davidicke.com)
Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)

This three-dimensional environment does not only accommodate bone cells and hematopoietic stem cells but also various other cell types with which signal substances are exchanged. (disabled-world.com)

Also making up a part of the hematopoietic system are short-term repopulating progenitor cells, which give rise to lineage-specific cell types. (stemcell.com)
Criteria for diagnosis of MDS consist of anemia, thrombocytopenia, or neutropenia that persist for six months or longer, dysplasia greater than 10% in at least one bone marrow cell lineage, and MDS associated clonal cytogenetic abnormalities or molecular markers. (standardofcare.com)
The nature of the stem cell substates and their relationship to commitment to differ- entiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors. (lu.se)
This requirement strongly limits the number of solutions or entiation and lineage-specification, programmed cell death, and ``states'' for the system. (lu.se)
2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)

Defining the ultrastructure of the hematopoietic stem cell niche by correlative light and electron microscopy. (neurotree.org)

As long as we are healthy, our body keeps the number of blood and immune cells largely constant. (phys.org)
Blood cells, such as erythrocytes or immune cells, are continuously replaced by new ones supplied by hematopoietic stem cells located in a specialized niche of the bone marrow. (disabled-world.com)
Hematopoietic stem cells in the bone marrow give rise to red blood cells and immune cells . (fightaging.org)
Lymphoblast cells are immature white blood cells that develop into healthy immune cells called lymphocytes. (davidicke.com)
Mitchell was already working on new nanotechnologies that target bone marrow and immune cells for treating other diseases, especially blood cancers such as multiple myeloma. (davidicke.com)

In addition, it is still unclear when and how the fate of HSPC niche-constituting ECs is determined. (go.jp)

The interplay between benzene and stem cells is complex involving the stem cell, progenitor, and HSC niche compartments of the bone marrow. (cdc.gov)

As the dosage of Pfizer's injection increased, the growth of stem cells was inhibited. (davidicke.com)
The etiology of bone marrow failure (BMF) includes defective stem/progenitor cells and/or stroma/accessory cells/growth factors, as well as deficient nonspecific nutrients or, as in the case of acquired aplastic anemia, immune-mediated abnormalities. (medscape.com)

Cell-specific transcriptional control of mitochondrial metabolism by TIF1? (bu.edu)

2016 . DOI : 10.1016/j.stem.2015.09.019. (epfl.ch)

DOI : 10.1016/j.cell.2018.03.034. (epfl.ch)
2017 . DOI : 10.1016/j.stem.2017.07.004. (epfl.ch)

Like all stem cell populations, they become increasingly dysfunctional with age , however. (fightaging.org)

Anna's scientific curiosity has led her to explore the regenerative dynamics of hematopoietic stem cells, also known as blood stem cells. (lu.se)

Notch receptors and Notch ligands were detected in virtually all cells throughout EB development. (karger.com)
Notch1 and Notch 2, but not Notch4, were visualized in the nucleus of EB cells, and all these receptors were also observed as patent cytoplasmic foci. (karger.com)

Like stem cells, progenitor cells have a capacity to differentiate into a specific type of cell. (phys.org)
In contrast to stem cells, however, they are already far more specific: they are pushed to differentiate into their "target" cell. (phys.org)
Dental pulp stem cells have been isolated from deciduous and permanent teeth and have the potential to self-renew and differentiate. (bvsalud.org)

RNA interference is a gene therapy that could potentially be used to "treat a variety of diseases" by delivering short strands of RNA that block specific genes from being turned on in a cell. (davidicke.com)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
Although challenges remain, investment in the field has started to bear fruit, with a number of gene and cell therapeutics reaching the market in the past decade. (bvsalud.org)

Therefore, we exposed human umbilical vein ECs (HUVECs) and human induced pluripotent stem cell-derived ECs (iPSC-ECs) as two relevant EC models in a side-by-side comparison to static and physiological dynamic (6.6 dyn cm-2) culture conditions. (bvsalud.org)

Anatomy50

Organisms15

Diseases28

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment56

Psychiatry and Psychology1

Phenomena and Processes48

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science3

Named Groups3

Health Care6

Transplantation15

HSCs20

Differentiation22

Progenitor cell6

Microenvironment7

Progenitors3

Caudal hematopoietic tissue3

20182

Hematopoiesis9

Lineages2

Transplant9

Endothelial cells4

Vitro2

Tissue11

Regenerative medicine1

HSPCs5

Mechanisms4

Disorders5

Biology5

Vivo2

Microenvironments1

Lymphoid2

Functionally1

Heterogeneity5

Apoptosis3

Osteoblasts1

Precursors2

Therapies3

Embryonic3

Tumor3

HSCT1

Cellular3

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Cancer13

Emergence1

Myeloid2

Abnormal1

Macrophages1

Signals2

Pathways2

Researchers4

Clinical2

Patients1

Adult4

Bone cells1

Lineage5

Correlative1

Immune cells5

Fate1

Compartments1

Growth2

Transcriptional1

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10.10162

Populations1

Blood stem cells1

Receptors2

Differentiate3

Gene3

Pluripotent1