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  • bone marrow niche
  • These dormant HSCs are thought to exist in a microenvironment termed the bone marrow niche. (u-tokyo.ac.jp)
  • Professor Hiromitsu Nakauchi and his research group at the Institute of Medical Science have demonstrated for the first time that the bone marrow niche includes nonmyelinating Schwann cells, a type of glial nerve cell, and have described the mechanism by which hibernation is maintained. (u-tokyo.ac.jp)
  • The research group determined that glial cells suppress HSC division by activating the protein TGF-β, and that HSCs in the bone marrow niche are affected by TGF-β through contact with glial cells. (u-tokyo.ac.jp)
  • In recent years, it has been pointed out that even leukemia stem cells exist in a state of hibernation in the bone marrow niche. (u-tokyo.ac.jp)
  • 1983
  • Garbutt K, Zangerl AR (1983) Application of genotype-environment interaction analysis to niche quantification. (springer.com)
  • nicchio
  • The Italian nicchio for a sea-shell may also be involved, as the traditional decoration for the top of a niche is a scallop shell, as in the illustration, hence also the alternative term of "conch" for a semi-dome, usually reserved for larger exedra. (wikipedia.org)
  • perhaps from Italian nicchia "niche, nook," from nicchio "seashell," said by Klein and Barnhart to be probably from Latin mitulus "mussel," but the change of -m- to -n- is not explained. (dictionary.com)
  • microenvironment
  • Increasing evidence suggests that cancer cells adapt by engaging and manipulating the microenvironment, generating a metastatic niche that promotes cancer cell fitness. (dkfz.de)
  • colonize
  • The ECM components of the metastatic niche support essential functions in cancer progression and effectively help cancer cells to colonize distant organs. (dkfz.de)
  • 2011). Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. (dkfz.de)
  • evident
  • It is increasingly evident that stem cell properties play an important role in metastasis development and that the niche may support and maintain these features. (dkfz.de)
  • Forestry
  • Eleutherodactylus frogs show frequency but no temporal partitioning: implications for the acoustic niche hypothesis," Forestry and Natural Resources, Purdue University, West Lafayette, IN, USA. (wikipedia.org)
  • reproductive
  • The first paradigm stresses the paramount importance of interspecific competition, whereas the second paradigm tries to explain many cases which are thought to be due to competition in the first paradigm, by reinforcement of reproductive barriers and/or random selection of niches. (wikipedia.org)
  • audiences
  • There is a new drive for niche audiences because audiences are now in much greater control of what they watch. (wikipedia.org)
  • LAS VEGAS - Those ever-fragmenting audiences with increasing niche interests that have been causing havoc for the industry are no accident, futurists Alvin and Heidi Toffler told a crowd at the National Assn. of Broadcasters confab on Wednesday. (variety.com)
  • roles
  • Moreover, we are analyzing the signaling and functional roles of other metastatic niche components in cancer progression, with a focus on the ECM. (dkfz.de)
  • reflects
  • The menu at Niche reflects its innovative concept and is divided into snacks such as Norland potato beignets served with miso aioli or the special cheese bread served with charcuterie and pickles. (opentable.com)
  • expands
  • This process uses the individual as the main focus of study and expands on the development of the niche. (wikipedia.org)
  • Module 1 - Lesson 2: Niche Selection Lesson 2 Overview Lesson 2 expands on the quick potential niche selection carried out in lesson 1. (slideshare.net)
  • help
  • Often, approaching others with similar circumstances in internet forums, associations or competitors in the same trade can help track down these niche products. (wikipedia.org)
  • Specialized microenvironments called niches help maintain stem cells in an undifferentiated and self-renewing state. (biomedcentral.com)
  • The Source was initially created to help serve that niche , covering the industry with commentary, reviews, and reported features. (dictionary.com)
  • remarkable
  • Striving to convert humble ingredients into remarkable dishes, Niche in Saint Louis, MO is dedicated to the use of locally grown ingredients to create a unique spin on snacks and dinner options. (opentable.com)
  • uses
  • One of the earliest buildings which uses external niches containing statues is the Church of Orsanmichele in Florence, built between 1380 and 1404. (wikipedia.org)