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  • pathways
  • Our research explores the molecular and cellular changes that accompany HPV-mediated transformation and in vitroprogression of human epithelial cells, with an emphasis on HPV-induced alterations in signal transduction pathways associated with cell proliferation (epidermal growth factor pathway) as well as inhibition of cell growth (transforming growth factor-beta pathway). (sc.edu)
  • Though several signaling pathways and transcription factors have been implicated in the regulation of molar crown development, relatively little is known about the regulatory mechanisms of root development. (biologists.org)
  • mRNA
  • Moreover, NFI-A mRNA is expressed in adult mouse brain [ 24 ], which suggests that the respective protein participates in the control of gene expression in the mature central nervous system. (biomedcentral.com)
  • In this study intended to elucidate the mechanism for the transition from crown morphogenesis to the initiation of root formation, we focus on the differential gene expression patterns of fibroblast growth factor (Fgf) 10 mRNA between continuously growing teeth and limited-growth teeth ( Fig. 1A ). (biologists.org)
  • CGNs
  • Consistent with this, the cell adhesion molecules ephrin B1 and N-cadherin were identified as NFI gene targets in CGNs using inhibitor and Nfi mutant analysis as well as chromatin immunoprecipitation. (umassmed.edu)
  • Conversely, inhibition of the CaN/NFATc pathway in CGNs maturing under physiological nondepolarizing conditions upregulated the NFI switch program, NFI temporal occupancy, and dendrite formation. (umassmed.edu)
  • These findings define a novel NFI switch and temporal occupancy program that forms a critical link between membrane potential/CaN and dendritic maturation in CGNs. (umassmed.edu)
  • As maturing CGNs become more hyperpolarized, NFATc4 binding declines leading to onset of NFI temporal binding and the NFI switch program. (umassmed.edu)
  • microarrays
  • In particular, gene expression profiling techniques (microarrays) are used to define molecular signatures associated with early and late stages of HPV-mediated transformation and alterations in growth factor responses. (sc.edu)
  • mice
  • Further, NFI temporal binding and switch gene expression were upregulated in the developing cerebellum of Nfatc4 (-/-) mice. (umassmed.edu)
  • histone
  • This ability of NFI-C to contact histone H3 has been proposed to alter the interaction of nucleosomal particles and DNA. (biomedcentral.com)
  • define
  • These studies define NFI as a key regulator of postmitotic CGN development, in particular of axon formation, dendritogenesis, and migratory behavior. (umassmed.edu)
  • Kinase
  • Fms-like tyrosin kinase-3 (flt3) and IL-7 receptor (IL-7R)-mediated signaling are required for the production of pro-B cells ( 7 - 11 ), whereas the transcription factor E2A, early B cell factor (EBF), Myb, Foxp1, and Pax5 all have critical effects on the early stages of B lymphopoiesis ( 12 - 15 ). (pnas.org)