• At neonatal age, Akt1‐deficient mice exhibited reduced survival with reduced endothelial cell density in the myocardium and attenuated cardiac expression of vascular endothelial growth factor A and collagen I α 1. (physiology.org)
  • The main function of the Rel similarity domain is DNA binding and protein-protein interactions with the AP-1 family of transcription factors. (jimmunol.org)
  • There are ill-defined signals from myocardium that induce EMT of endothelium, but one strongly implicated factor is bone morphogenic protein-2 (BMP-2) ( 10 - 13 ). (pubmedcentralcanada.ca)
  • The specificity and efficiency of this process are determined by the binding of two core multi-protein complexes (CPSF and CSTF, for "cleavage and polyadenylation specificity factor" and "cleavage stimulation factor") to sequences surrounding the poly(A) site as soon as the nascent pre-mRNA transcript emerges from the elongating RNA polymerase II (POL2). (springer.com)
  • Background p38 MAPK activity performs a significant role in a number of steps from the osteoblast lineage development through activation of osteoblast-specific transcription factors which is also needed for the acquisition of the osteoblast phenotype in early development. (techieindex.net)
  • 2004 ). Significant progress has been made over the past decade in elucidating genetic and environmental factors causing these malformations in animal models and clinical studies (Andelfinger 2008 ). (physiology.org)
  • 2010 ). Of the three Akt isoforms, Akt1 plays an essential role in the induction of angiogenesis as a downstream effector of vascular endothelial growth factor (VEGF‐A) through the phosphoinositide 3‐kinase ‐Akt signaling pathway (Chen et al. (physiology.org)
  • Extensive studies of this region lead to discovery of NFIL-5CLEO and NFIL-5C, and GATA-3 or related transcription factor was indicated to involved in Th2-specific IL-5 gene induction via IL-5C-driven transactivation. (nii.ac.jp)
  • However, ample epidemiological evidences suggest a significant contribution of environmental factors to the induction of CHD. (ahajournals.org)
  • However it impaired osteoblastogenesis and osteoblast maturation and activity through reduced appearance of osteoblast-specific transcription elements and their goals. (techieindex.net)