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  • inactivation
  • However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. (nih.gov)
  • stimuli
  • NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. (lsbio.com)
  • Signaling
  • The Quantitative real-time polymerase chain reaction, electrophoretic mobility shift assay, enzyme-linked immunosorbent assay, immunofluorescence staining, and western blotting were performed to explore the potential interactive mechanism between Pannexin-1 channels and TLR2/TLR4/NF-κB-mediated signaling pathway. (frontiersin.org)
  • Pannexin-1 channels may contribute to inflammatory response and neurobehavioral dysfunction through the TLR2/TLR4/NF-κB-mediated pathway signaling after SAH, suggesting a potential role of Pannexin-1 channels could be a potential therapeutic target for the treatment of SAH. (frontiersin.org)
  • Current mathematical modeling frameworks for NF-$\kappa $B signal transduction, though limited to a small signaling module located in a downstream of IKK, heavily rely on the parameterizations and the numerical studies of ODE models and doubtless lack intuitive explanations about underlying mechanisms of the dynamic patterns of the NF-$\kappa $B signaling. (aps.org)
  • Here we present a systematic way to derive a minimal model from an up-to-dated and detailed NF-$\kappa $B signaling network by means of sensitivity analysis. (aps.org)
  • Using analysis of the minimal model, we predict a dose-response curve shape, existence of Hopf-bifurcation, and underlying mechanisms of all possible dynamic patterns of NF-$\kappa $B signaling. (aps.org)
  • Simulating the detailed ODE model for NF-$\kappa $B signaling network with large sets of the parameter values that are sampled from the biologically feasible parameter space, we present an ensemble of all possible dynamic patterns of NF-$\kappa $B signaling and verify the predictions from the minimal model. (aps.org)
  • B. Kaltschmidt, D. Widera, and C. Kaltschmidt, "Signaling via NF-kappa B in the nervous system", BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH , vol. 1745, 2005, pp. 287-299. (uni-bielefeld.de)
  • A New Paradigm to Mitigate Osteosarcoma by Regulation of MicroRNAs and Suppression of the NF-κB Signaling Cascade. (uni-bielefeld.de)
  • enhancer
  • 000114841 001__ 114841 000114841 005__ 20181203021031.0 000114841 037__ $$aARTICLE 000114841 245__ $$aCharacterization of a new tissue-specific transcription factor binding to the simian virus 40 enhancer TC-II (NF-kappa B) element 000114841 269__ $$a1992 000114841 260__ $$c1992 000114841 336__ $$aJournal Articles 000114841 500__ $$aSwiss Institute for Experimental Cancer Research, Epalinges. (epfl.ch)
  • regulator
  • We provided evidence that inflammaging may involve a novel link between the effects of ICA on SIRT6 (a regulator of aging) and NF- κ B (a regulator of inflammation). (hindawi.com)
  • TL1A and DR3 activate NF-κB in vascular endothelial cells, and can be an important regulator of renal interstitial vascular injury. (biomedcentral.com)
  • potently
  • ET-1 administration slightly downregulated gene expression of p65 of NF- κ B but potently and in a dose-dependent way downregulated p21-cip gene expression in the liver. (hindawi.com)
  • cytokine
  • These data suggest that NF-kappa B, AP-1, and GR interact in a complex regulatory network to modulate gene expression and that cross-coupling of NF-kappa B and GR plays an important role in glucocorticoid-mediated repression of cytokine transcription. (asm.org)
  • inflammatory
  • Zhan Q, Song R, Li F, Ao L, Zeng Q, Xu D, Fullerton DA, Meng X. Double-stranded RNA upregulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-noncanonical NF-?B pathway. (ucdenver.edu)
  • activate
  • Several viruses have developed strategies to activate the NF-kappa-B pathway in order to promote viral replication and prevent virus-induced apoptosis. (uniprot.org)
  • vitro
  • Finally, an increase in the ratio of oxidized to reduced glutathione was shown to inhibit NF kappa B-DNA binding in vitro. (tcd.ie)
  • NFKB1
  • NF-Kappa-B antibody LS-C9278 is an unconjugated rabbit polyclonal antibody to human NF-Kappa-B (NFKB1). (lsbio.com)
  • Human NF B p50 (NFKB1) peptide corresponding to a region near the N-terminus of the human protein conjugated to KLH. (lsbio.com)
  • mechanisms
  • Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. (asm.org)
  • levels
  • Administration with LV-ShRNA-Panx1 markedly decreased the expression levels of TLR2/4/NF-κB pathway-related agents in the brain cortex and significantly ameliorated neurological cognitive and memory deficits in this SAH model. (frontiersin.org)
  • enzyme
  • The aim of the study was to investigate the effect of icariin (ICA) on cardiac aging through its effects on the SIRT6 enzyme and on the NF- κ B pathway. (hindawi.com)