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  • myeloproliferative
  • Furthermore, ROS have a major role in carcinogenesis and disease progression in the myeloproliferative neoplasms (MPNs), where the malignant clone itself produces excess of ROS thereby creating a vicious self-perpetuating circle in which ROS activate proinflammatory pathways (NF- κ B) which in turn create more ROS. (hindawi.com)
  • Regulation
  • Despite effecting significant up-regulation of the PI3k/Akt pathway with insulin and insulin-like growth factor-1 (IGF-1), I did not demonstrate any change in the HSF1 trimerisation state, DNA-binding ability or nuclear localisation in renal adenocarcinoma cells (ACHN). (bl.uk)
  • mice
  • NF-E2 can alter histone modifications, and NF-E2 transgenic mice show hypoacetylation of histone H3. (rupress.org)
  • the recent demonstration that factor V-deficient mice, which cannot generate thrombin, die in utero of vascular defects in the absence of hemorrhage shows how closely these two systems are interrelated. (ahajournals.org)
  • activity
  • Such passive repression is often mediated by transcription factors that lack an intrinsic repressor activity. (pubmedcentralcanada.ca)
  • Whereas sumoylation-deficient MafG activated p45-dependent transcription normally and did not affect heterodimer activity, repression by the sumoylation-deficient MafG mutant was severely compromised in vivo. (pubmedcentralcanada.ca)
  • Because thrombin plays such a vital role in hemostasis, it comes as no surprise that its activity can be regulated by a variety of endogenous and exogenous factors and that thrombin is a prime target for pharmacologic intervention, as described in detail later in this review. (ahajournals.org)