Cytogenetic studies performed on bone marrow provide important prognostic information and can guide treatment by confirming a diagnosis of acute promyelocytic leukemia (APL). (medscape.com)
Acute promyelocytic leukemia (APL), also known as M3, is the most common subtype of AML associated with DIC. (medscape.com)
Prompt Initiation of Conventional Chemotherapy to Avoid Early Death in Patients with Newly Diagnosed Acute Promyelocytic Leukemia. (u-tokyo-hemat.com)
Erythroid4
No myeloid or erythroid precursors are seen. (medscape.com)
OBJECTIVES: At the 2013 Society for Hematopathology/European Association for Hematopathology Workshop, 36 cases were submitted to the session that covered acute erythroid leukemia (AEL), acute megakaryoblastic leukemia (AMKL), and reactive mimics. (bvsalud.org)
RESULTS: For acute erythroleukemia, erythroid/myeloid type, discussion acknowledged overlapping features between AEL and myelodysplastic syndromes. (bvsalud.org)
Cases submitted as pure erythroid leukemia had distinctive morphology and immunophenotype, complex karyotypes, and aggressive clinical behavior, illustrating certain diagnostic features not currently captured by the current World Health Organization (WHO) definition. (bvsalud.org)
Lymphoid3
The natural process of blood cell formation, hematopoietic stem cell differentiation, and generation of myeloid and lymphoid cell lineages. (oncomine.com)
CCDC88C-FLT3 gene fusion in CD34-positive haematopoietic stem and multilineage cells in myeloid/lymphoid neoplasm with eosinophilia. (u-tokyo-hemat.com)
We report four pediatric acute leukemia (AL) cases (prevalence: 0.18%) with megakaryoblasts co-expressing the T-specific antigen CD3 (cytoplasmic), together with a very homogeneous antigen profile of immature cells and other lymphoid traits. (bvsalud.org)
Differentiation1
Panobinostat triggered terminal myeloid differentiation via proteasomal degradation of A/E9a. (ashpublications.org)
Myelodysplastic1
5 Hematopoietic disruptions in the myeloid lineage can lead to 3 major disease categories: acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), and myelodysplastic syndrome (MDS). (oncomine.com)
Stem2
Myeloid malignancies arise from mutations in hematopoietic stem or progenitor cells. (oncomine.com)
Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
Chemotherapy1
Although the incidence of acute nonlymphocytic leukemia is increased in PV, the incidence of acute leukemia in patients not exposed to chemotherapy or radiation therapy is low. (basicmedicalkey.com)
Diagnosis1
Also, see the Childhood Acute Lymphoblastic Leukemia: Diagnosis, Management, and Complications slideshow to help recognize and treat this disease and its associated complications. (medscape.com)
Patients3
Patients with acute monocytic leukemia also have a high incidence of clinically significant DIC. (medscape.com)
3 Results can be available within hours or days, depending on the platform.3 With its demonstrated clinical utility in myeloid malignancies, NGS is transforming the testing paradigm and enabling better outcomes for patients. (oncomine.com)
To define the mutation spectrum in non-Down syndrome acute megakaryoblastic leukemia (non-DS-AMKL), we performed transcriptome sequencing on diagnostic blasts from 14 pediatric patients and validated our findings in a recurrency/validation cohort consisting of 34 pediatric and 28 adult AMKL samples. (bvsalud.org)
Mutation1
Characterized by excessive, abnormal white blood cell (granulocyte) production and the presence of the Philadelphia chromosome/BCR-ABL mutation, chronic myeloid leukemia (CML) is a slow-growing cancer of the blood-forming tissue (bone marrow). (oncomine.com)
Chronic2
See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)
1,2 The 4 primary disorders of MPNs are chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). (oncomine.com)
Pathways1
1,2 This shift is due in part to advances in NGS technology, which have propelled the discovery of somatic mutations that play a pivotal role in hematological disorders and the associated development of targeted therapies.2 These newly identified genetic alterations and molecular pathways provide valuable clinical insights across the continuum of care. (oncomine.com)
Clinical2
1,2 Consequently, the clinical value of next-generation sequencing (NGS) is most apparent today in myeloid molecular testing. (oncomine.com)
Most cases of AMKL in adults would be classified as acute myeloid leukemia with myelodysplasia-related changes according to the WHO classification, but this approach deemphasizes their unique clinical, morphologic, and immunophenotypic features. (bvsalud.org)
Aggressive1
An aggressive disease (rapid onset and progression) that occurs primarily in adulthood and is marked by an abnormal increase and accumulation of myeloblasts (immature myeloid cells) in the bone marrow and blood, which leads to impaired hematopoiesis and bone marrow failure. (oncomine.com)
Children with acute lymphoblastic leukemia (ALL) often present with signs and symptoms that reflect bone marrow infiltration and/or extramedullary disease. (medscape.com)
Immunophenotyping by flow cytometry of bone marrow or peripheral blood samples can be used to help distinguish AML from acute lymphocytic leukemia (ALL) and further classify the subtype of AML. (medscape.com)
Molecular1
Epigenetic modifying enzymes such as histone deacetylases (HDACs), p300, and PRMT1 are recruited by AML1/ETO, the pathogenic protein for t(8;21) acute myeloid leukemia (AML), providing a strong molecular rationale for targeting these enzymes to treat this disease. (ashpublications.org)
Occurs2
However, leukemia that occurs as a result of myelodysplasia is notoriously resistant to treatment. (wikipedia.org)
While acute megakaryoblastic leukaemia (AMKL) occurs in children with (DS-AMKL) and without (paediatric non-DS-AMKL) Down syndrome, it can also affect adults without DS (adult non-DS-AMKL). (bvsalud.org)
Common1
Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children, representing more than a quarter of all pediatric cancers. (medscape.com)
Risk1
With an ever-growing list of biomarkers, inherent genetic complexity, and the risk of rapid progression, myeloid malignancies challenge the current iterative testing paradigm and call for a streamlined testing approach that yields rapid results. (oncomine.com)
High1
12,13 They also have a high propensity to progress to acute myeloid leukemia (AML). (oncomine.com)
Present1
Myeloproliferative neoplasms present with the clonal proliferation of 1 or more myeloid cell lineages.10 The role of genetic and genomic aberrations in pathogenesis has been well documented for these disorders. (oncomine.com)
Myelogenous leukemia1
The problem is most commonly observed in acute myelogenous leukemia with high WBC counts. (medscape.com)
Precursor2
INTRODUCTION: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common neoplasm in children. (bvsalud.org)
The peripheral leukocyte count is determined by several mechanisms, including (1) the size of precursor and storage pool of myeloid and lymphoid cells, (2) the rate of release of the cells from the storage pool in the bone marrow, (3) the rate of marginating cells out of blood vessels into the tissues, and (4) the rate of consumption of the cells in the tissues (ie, cell loss). (medscape.com)
Immature cells1
Leukemia Basophilic A rare acute myeloid leukemia in which the immature cells differentiate towards basophils. (nih.gov)
Pediatric3
14. Associations between pretherapeutic body mass index, outcome, and cytogenetic abnormalities in pediatric acute myeloid leukemia . (nih.gov)
treatment of newly-diagnosed CD33-positive acute myeloid leukemia (AML) in adults and pediatric patients 1 month and older ( 1.1 ). (nih.gov)
MYLOTARG is indicated for the treatment of newly-diagnosed CD33-positive acute myeloid leukemia in adults and pediatric patients 1 month and older. (nih.gov)
Differentiate1
Bone marrow aspiration and biopsy may be necessary to differentiate leukemia from a benign condition (leukemoid reaction), if the patient has persistent leukocytosis. (medscape.com)
Patients4
3. The impact of remission duration on the long-term economic burden of acute myeloid leukemia among patients without hematopoietic stem cell transplant in the United States. (nih.gov)
6. The Prognostic Ability of RAS Pathway-Related Gene Mutations in Patients with Myeloid Neoplasms Treated with Hypomethylating Agents. (nih.gov)
18. Healthcare resource utilization and costs in patients with newly diagnosed acute myeloid leukemia . (nih.gov)
Patients with acute monocytic leukemia also have a high incidence of clinically significant DIC. (medscape.com)
Rare1
Mixed-phenotype acute leukemia (MPAL), a rare and heterogeneous category of acute leukemia, is characterized by cross-lineage antigen expression. (bvsalud.org)
Individuals1
Nearly 30,000 individuals ages over 21 years are diagnosedwith leukemia each year in the United States. (aacrjournals.org)
Types2
15. Automatic recognition of different types of acute leukaemia in peripheral blood by image analysis. (nih.gov)