MacrophagesHuman neutrophilsInflammationExtracellularGranulocytes have an averageElastaseActivity of neutrophilsLymphocyteImmuneMonocyteLymphocytesIncreased apoptosisPhagocyticPathogenesisMonocytesChemoattractantInfectionMouse neutrophilsAttract neutrophilsAntimicrobialImmatureNeutropeniaSystemicModulatesActivationEndothelialLungGranulesRheumatoid arthritisInflammatory mediatorsCongenitalPhenotypeMigrationAcuteGranuleSubpopulationsChemotaxisChemotacticEngulf bacteriaPeripheral bloodDefenseMarkersCellsRecruitmentPopulationsS100A8PhagocytesStaphylococcus
Macrophages8
- Here the authors produce and characterize an intranasal liposomal vaccine against a peptide antigen from Streptococcus pyogenes and show that it induces a strong mucosal IgA response lasting for over one year, and that protection is dependent on cellular immunity mediated through IL-17, macrophages and neutrophils. (nature.com)
- Neutrophils are much more numerous than the longer-lived monocyte /macrophages. (bionity.com)
- Being highly motile, neutrophils quickly congregate at a focus of infection , attracted by cytokines expressed by activated endothelium , mast cells and macrophages . (bionity.com)
- In this disease, her team, together with the Department of Internal Medicine at Cochin Hospital headed by Luc Mouthon, showed that the PR3 located not inside the neutrophils but on the surface of their membrane, misleads the macrophages that mistakenly activate the immune system. (inserm.fr)
- Our preliminary results show thatincreased susceptibility of vitamin A-deficient mice to disseminated S. Typhimurium infection is dependent onsynthesis of SLC11A1 by neutrophils, which challenges conventional wisdom that SLC11A1-dependent hostdefenses are associated exclusively with macrophages. (usda.gov)
- In particular, the inflammatory response leads to injury of epithelial/endothelial cells and enhances the release of inflammatory mediators, including chemokines, cytokines and inflammatory cells (mainly neutrophils and macrophages , but also eosinophils , basophils, mast cells). (omicsonline.org)
- Sivelestat significantly inhibited the increase in lung collagen content, fibrotic changes, the numbers of total cells (including macrophages, neutrophils and lymphocytes), the levels of the active form of TGF-β1 and phospho-Smad2 in bleomycin-induced early-stage pulmonary fibrosis. (ersjournals.com)
- CONCLUSIONS Monocyte and neutrophil CD44 expression is reduced in SLE, and this may contribute to the impaired recognition and clearance of apoptotic neutrophils by monocyte derived macrophages. (bmj.com)
Human neutrophils8
- In suspension, human neutrophils have an average diameter of 8.85 µm. (wikipedia.org)
- The average lifespan of inactivated human neutrophils in the circulation has been reported by different approaches to be between 5 and 135 hours(5 days and 15 hours). (wikipedia.org)
- hence, we wanted to test the hypothesis that A. actinomycetemcomitans exploits human neutrophils as a source for catecholamines. (doaj.org)
- In the present study, we showed that human neutrophils synthesize, store, and release epinephrine, one of the three main types of catecholamines. (doaj.org)
- Finally, epinephrine-containing supernatants collected from human neutrophils promoted A. actinomycetemcomitans growth and induced the expression of the qseBC operon under anaerobic conditions. (doaj.org)
- Theobjective of this application is to investigate the role of SLC11A1 in neutrophil control of S. Typhimurium infection.To test our hypothesis, we will use a triangulated approach assessing neutrophil function and response toinfection by utilizing human neutrophils in cell culture, mouse neutrophils ex vivo and a systemic S. Typhimuriuminfection in vivo mouse model. (usda.gov)
- Through NHE1 inhibition in primary human neutrophils, we show that cell swelling is both necessary and sufficient for rapid migration following chemoattractant stimulation. (elifesciences.org)
- a single cell volume measurement technique, to primary human neutrophils. (elifesciences.org)
Inflammation20
- During the beginning (acute) phase of inflammation, particularly as a result of bacterial infection, environmental exposure, and some cancers, neutrophils are one of the first responders of inflammatory cells to migrate toward the site of inflammation. (wikipedia.org)
- The mechanistic functions of neutrophils in skin inflammation are not fully understood. (nature.com)
- Here the authors use human psoriasis samples and a mouse model of skin inflammation to study neutrophils and find a CXCR4 hi population of NET-forming, phagocytic neutrophils whose induction depends on the transcription factor CREB1. (nature.com)
- New findings suggest that neutrophil extracellular traps and their components have a functional role as triggers of IL-17-mediated inflammation and associated bone destruction in periodontitis. (nature.com)
- In addition, we present more recent evidence that interactions between neutrophils and adaptive immune cells establish a feed-forward mechanism that amplifies pathologic inflammation. (nih.gov)
- To demonstrate the relation between optic neuritis (ON) and systemic inflammation markers as neutrophil lymphocyte ratio (N/L ratio), platelet count, mean platelet volume (MPV), and red cell distribution width (RDW) and furthermore to evaluate the utilization of these markers to predict the frequency of the ON episodes. (hindawi.com)
- Neutrophil lymphocyte ratio (N/L ratio) is an effective, easy, and inexpensive method to determine systemic inflammation in various diseases such as cancer, hypertension, diabetes mellitus, and coronary artery disorders [ 10 , 11 ]. (hindawi.com)
- This review discusses aspects of neutrophil activity associated with active TB, including the resulting inflammation and pulmonary impairment. (frontiersin.org)
- However, during the acute phase of inflammation , particularly as a result of bacterial infection , neutrophils leave the vasculature and migrate toward the site of inflammation in a process called chemotaxis . (bionity.com)
- Neutrophils react within an hour of tissue injury and are the hallmark of acute inflammation. (bionity.com)
- However, because neutrophil antimicrobial products can also damage host tissues , other authorities feel that their short life is an adaptation to limit damage to the host during inflammation . (bionity.com)
- Neutrophils undergo a process called chemotaxis that allows them to migrate toward sites of infection or inflammation. (bionity.com)
- As key inflammation regulators, neutrophils are up there with all the other immune cells. (inserm.fr)
- After receiving the International Association of Inflammation Societies' Woman in Science prize, Véronique Witko-Sarsat, leader of the Neutrophils and vasculitis team at Cochin Institute in Paris, is understandably delighted. (inserm.fr)
- And of course this award also marks the recognition of the crucial role played by neutrophils in inflammation! (inserm.fr)
- And in cystic fibrosis, neutrophils have abnormalities that make them supply oxidants, which maintain harmful inflammation in patients. (inserm.fr)
- The team had therefore put its finger on a mechanism that could enable the development of anti-inflammatories that are more targeted than corticosteroids, because they directly attack the neutrophil - the orchestral conductor of inflammation. (inserm.fr)
- In a recent study [ 9 ] it was indicated for the first time that among various mediators involved in the inflammation-driven differentiation of fibroblast to an activated myofibroblast, a main architect is the neutrophil, a cell whose role in fibrosis was obscure up to now. (omicsonline.org)
- Increased inflammation can be observed in the closed eye tears of subjects with dry eye disease, and neutrophils may be a potential source of pathogenic species in dry eye disease. (physiciansweekly.com)
- At day 1 there was a significant influx in neutrophils, a marker for lung inflammation, as well as an increase in LDH activity in particle-exposed groups. (cdc.gov)
Extracellular5
- These include the production of reactive oxygen species, the release of antimicrobial peptides, and the recently discovered expulsion of their nuclear contents to form neutrophil extracellular traps. (nih.gov)
- Neutrophils have the ability to release their own DNA through DNA traps called Neutrophil Extracellular Traps or NETs. (eurekalert.org)
- In a recent Nature Reviews Immunology journal study, researchers assess the role of neutrophil extracellular traps (NETs) in systemic autoimmune and autoinflammatory disorders. (news-medical.net)
- Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases. (news-medical.net)
- Extracellular matrix metalloproteinase 9 (MMP9) and neutrophil elastase (NE) was quantified by an enzyme-linked immunosorbent assay. (physiciansweekly.com)
Granulocytes have an average2
- When adhered to a surface, neutrophil granulocytes have an average diameter of 12-15 micrometers (µm) in peripheral blood smears. (wikipedia.org)
- Neutrophil granulocytes have an average volume of 330 femtoliters (fl) and a diameter of 12-15 micrometers (µm) in peripheral blood smears . (bionity.com)
Elastase3
- Neutrophil elastase plays pivotal roles in the pathogenesis of pulmonary fibrosis. (ersjournals.com)
- In the bleomycin-induced early-stage pulmonary fibrosis model, the neutrophil elastase level was increased in the lungs. (ersjournals.com)
- Neutrophil Elastase (ELA2), also known as polymorphonuclear leukocyte elastase, is a serine protease belonging to the chymotrypsin family. (novusbio.com)
Activity of neutrophils4
- Although neutrophils play an important role in fighting intruding invaders, the impact of increased Na + on the antimicrobial activity of neutrophils remains elusive. (frontiersin.org)
- Stimulation of neutrophils with phorbol-12-myristate-13-acetate (PMA) overcame high salt-induced impairment in ROS production and restored antimicrobial activity of neutrophils. (frontiersin.org)
- Our central hypothesis is that SLC11A1 function promotes the bactericidal activity of neutrophils. (usda.gov)
- To that end, Ivan Zanoni, PhD , a Cancer Research Institute Lloyd J. Old STAR at Boston Children's Hospital and Harvard Medical School, is working to characterize several factors that influence the activity of neutrophils and determine whether they will act in a way that helps or hinders tumors. (cancerresearch.org)
Lymphocyte6
- Neutrophil lymphocyte (N/L) ratio was assessed before second line chemotherapy. (scirp.org)
- Wang, X. (2014) Neutrophil to Lymphocyte Ratio in Relation to Risk of All-Cause Mortality and Cardiovascular Events among Patients Undergoing Angiography or Cardiac Revascularization: A Meta-Analysis of Observational Studies. (scirp.org)
- Wang, J. (2014) The Clinical Significance of Tumor-Infiltrating Neutrophils and Neutrophil-to-CD8+ Lymphocyte Ratio in Patients with Resectable Esophageal Squamous Cell Carcinoma. (scirp.org)
- Xue, P. (2014) Neutrophil-to-Lymphocyte Ratio for Predicting Palliative Chemotherapy Outcomes in Advanced Pancreatic Cancer Patients. (scirp.org)
- What could it mean that my mother has high WBC(11600) & lymphocyte countis very low(22), and slightly low neutrophil count. (healthtap.com)
- The Neutrophil to Lymphocyte Ratio (NLR) calculator is created by QxMD. (qxmd.com)
Immune18
- Neutrophils are a type of innate immune cell that contains distinctive cytoplasmic granules and a nucleus that is divided into three segments. (nature.com)
- Neutrophils and neutrophil-like cells are the major pathogen-fighting immune cells in organisms ranging from slime molds to mammals. (nih.gov)
- Neutrophils are innate immune cells that act as the immune system's first line of defence. (eurekalert.org)
- It highlights the significance of neutrophil function on TB disease outcome and underlines the necessity of monitoring neutrophil function for better assessment of the immune response and severity of lung pathology associated with TB. (frontiersin.org)
- Such parameters can be realistically linked to neutrophil function and/or interaction with other immune cell populations in the view of their specific activities described in subsequent sections below. (frontiersin.org)
- Autoantigens can be altered and presented to the adaptive immune system due to dysregulated neutrophil cell death. (news-medical.net)
- Many of the autoantigens generated by neutrophils in NETs, including double-stranded deoxyribonucleic acid (DNA), citrullinated peptides, histones, myeloperoxidase (MPO), and proteinase 3 (PRTN3), are known to be attacked by the adaptive immune system observed in systemic autoimmunity. (news-medical.net)
- Inflammatory responses primarily involve innate immune cells, such as neutrophils, which are the leading cause of autoinflammatory disorders. (news-medical.net)
- Neutrophil granulocytes , generally referred to as neutrophils , are the most abundant type of white blood cells in humans and form an integral part of the immune system . (bionity.com)
- Neutrophils are the first immune cells to arrive in infected or injured tissues, where they engulf microbes and clean up cell debris. (avhandlingar.se)
- Neutrophils are themost abundant innate immune cells of the body and play a key role in septic pathogenesis. (avhandlingar.se)
- Neutrophils are highly motile phagocytic cells that constitute the first line of defense of the innate immune system. (benthamscience.com)
- Unlike the other innate immune cells, mature neutrophils fully equipped with an armory of granules are short lived cells which are differentiated and programmed from hematopoietic stem cells in the bone marrow. (benthamscience.com)
- Neutrophils are important immunological actors in the gut environment, but unlike T cells and other immune cells, their precise roles have yet to be fully clarified. (cancerresearch.org)
- Your CRI STAR work focuses on a group of immune cells known as neutrophils. (cancerresearch.org)
- What are neutrophils, and what do we know about the roles that they play in immune responses, especially in the context of cancer? (cancerresearch.org)
- Neutrophils are the most abundant cell type in our blood, and they are basically involved in every immune response, and during every inflammatory process they play very important roles. (cancerresearch.org)
- Neutrophils, the most common type of white blood cell in the bloodstream, are among the first immune cells to defend against infection. (msdmanuals.com)
Monocyte7
- Neutrophil/Monocyte Respiratory Burst Assay Kit - 1 kit is backordered and will ship as soon as it is back in stock. (dnamethsoc.com)
- The MSDS of Neutrophil/Monocyte for Respiratory is available from Karlan upon request. (dnamethsoc.com)
- BACKGROUND Increased numbers of apoptotic neutrophils, and impaired monocyte/macrophage clearance of apoptotic cells, have been demonstrated in systemic lupus erythematosus (SLE). (bmj.com)
- Monocyte and neutrophil density of surface CD44 expression was determined by immunofluorescence labelling and flow cytometry, and results expressed as mean channel fluorescence (MCF) values. (bmj.com)
- Monocyte, but not neutrophil, CD44 expression correlated negatively with the percentage of apoptotic neutrophils. (bmj.com)
- There was no significant correlation of monocyte or neutrophil CD44 expression in SLE with disease activity or damage. (bmj.com)
- In conclusion, AAV patients exhibit a skewing of different neutrophil and monocyte subpopulations that are associated with disease subtypes, disease activity, rituximab treatment, and propensity to relapse. (lu.se)
Lymphocytes2
- What causes high neutrophils, low lymphocytes & WBC? (healthtap.com)
- What dose it mean when your WBC high at 12.6 my segmented neutrophils is high 88.5 my lymphocytes is low 6.9? (healthtap.com)
Increased apoptosis1
- In addition, neutrophils from people with SLE have aberrant oxidative metabolism, increased apoptosis, and decreased phagocytic clearance. (news-medical.net)
Phagocytic1
- Fasting, on the other hand, strengthened the neutrophils' phagocytic capacity to engulf bacteria. (wikipedia.org)
Pathogenesis2
- Numerous studies have linked neutrophils to the pathogenesis of systemic autoimmunity. (news-medical.net)
- These results indicate a possible contribution of the spleen in the pathogenesis of this neutrophil dysfunction. (karger.com)
Monocytes3
- OBJECTIVE To determine the expression of CD44 on peripheral blood monocytes and neutrophils in SLE, and examine the relations with disease activity and numbers of circulating apoptotic neutrophils. (bmj.com)
- AAV patients displayed increased frequencies of intermediate monocytes, mature and newly released neutrophils, and an expanded population of CD177 + neutrophils compared to HC. (lu.se)
- Paired data from 23 patients demonstrated that active disease was associated with an increased frequency of mature neutrophils and a decreased frequency of monocytes, in particular intermediate monocytes. (lu.se)
Chemoattractant4
- Chemoattractant exposure increases cell volume and potentiates neutrophil migration, but the causal link between these processes is not known. (elifesciences.org)
- Using a genome-wide CRISPR screen, we identify the regulators of the chemoattractant-induced neutrophil swelling, including NHE1, AE2, PI3K-gamma, and CA2. (elifesciences.org)
- Neutrophils are a powerful system to study the biophysical demands of cell motility, as they acutely initiate rapid migration following stimulation with chemoattractant. (elifesciences.org)
- Soluble factor (s) from hypoxia/reoxygenated endothelial cells also had a powerful neutrophil chemoattractant ability. (bl.uk)
Infection9
- During established infection, the neutrophil count remains elevated, with equal numbers in the marginal and the circulating pool. (medscape.com)
- During an infection, chemotactic agents are generated that attract neutrophils to the site of infection, which in turn play a critical role in phagocytosing and killing microorganisms. (medscape.com)
- During early infection, the neutrophil count may actually decrease briefly because of margination of cells from the blood. (medscape.com)
- for most scientists, a neutrophil was simply a cell that during infection would destroy bacteria by producing oxidants to break down the tissues and would then die very quickly. (inserm.fr)
- Remarkably, during studies on vitamin A deficiency, our lab has uncovered an unsuspected role forSLC11A1 in control of systemic S. Typhimurium infection by neutrophils. (usda.gov)
- Our rigorous studies of SLC11A1 in neutrophil response to infection will providefundamental knowledge in the fields of microbiology and immunology, thereby advancing biomedical research.Further, this project will have broad implications for translation to improve human health, as polymorphisms inSLC11A1 make certain patients more susceptible to disease. (usda.gov)
- On April 17, 2023, the FDA approved omidubicel-onlv, brand name Omisirge, for use in adult and pediatric patients 12 years and older with hematologic malignancies who are planned for umbilical cord blood transplantation following myeloablative conditioning to reduce the time to neutrophil recovery and the incidence of infection. (fda.gov)
- Granulocytes are typically transfused daily for 5 or more consecutive days and should be continued until infection resolves or absolute neutrophil count remains >500/uL for 48 hours. (medscape.com)
- Congenital neutrophil defects (i.e., chronic granulomatous disease) and documented refractory bacterial or fungal infection failing to respond to appropriate antimicrobial therapy for more than 24 to 48 hours may be considered for granulocyte transfusion. (medscape.com)
Mouse neutrophils1
- It has been reported that mouse neutrophils can release catecholamines. (doaj.org)
Attract neutrophils1
- The signal often comes from the bacteria themselves, from complement proteins, or from damaged tissue, all of which produce substances that attract neutrophils to a trouble spot. (msdmanuals.com)
Antimicrobial4
- Neutrophils are rapidly recruited to infected tissues and can engulf bacteria directly or produce toxic antimicrobial mediators. (nature.com)
- Whereas inhibition of p38/MAPK did not result in improved neutrophil defense, pharmacological blockade of the phagocyte oxidase (PHOX) or its genetic ablation mimicked the impaired antimicrobial activity detected under high salt conditions. (frontiersin.org)
- Our findings suggest that increases in local Na + represent an ionic checkpoint that prevents excessive ROS production of neutrophils, which decreases their antimicrobial potential and could potentially curtail ROS-mediated tissue damage. (frontiersin.org)
- However, strong evidence for a role of SLC11A1 asessential in neutrophil antimicrobial response is needed to establish this novel concept. (usda.gov)
Immature3
- Here, the authors used mathematical tools combined with high resolution multiplex imaging mass cytometry to show an association between immature neutrophils, CD8 T cells and proliferating alveolar epithelial cells in areas of maximal alveolar damage in COVID-19 lungs. (nature.com)
- No increase in immature (nonsegmented) neutrophils occurs, because no change occurs in the inflow of neutrophils from the marrow. (medscape.com)
- A left shift is characterized by the appearance of more immature neutrophil forms in the blood. (medscape.com)
Neutropenia1
- Periodontitis is one of the typical symptoms of both neutropenia and defect neutrophil functionality, suggesting an important role for these cells in maintenance of periodontal health. (avhandlingar.se)
Systemic1
- Recent research has shown that neutrophils, particularly NETs released upon activation, have critical roles in the onset and progression of systemic autoimmune disorders and in the development of complex inflammatory responses that cause organ damage. (news-medical.net)
Modulates1
- Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a symbiont cell, the directed killing of a symbiont target cell by a neutrophil. (mcw.edu)
Activation5
- Neutrophil activation during cardiopulmonary bypass (CPB) surgery may occur because of the release of complement chemotactic products or the local release of interleukin (IL)-8. (medscape.com)
- Closed eye neutrophils have demonstrated increased prevalence in dry eye disease, but the phenotype and extent of activation of these cells has yet to be described. (physiciansweekly.com)
- Tear leukocytes were isolated and peripheral blood was collected, and stained with a panel of fluorescently-labeled antibodies to determine the activation phenotype of neutrophils. (physiciansweekly.com)
- Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982. (aspetjournals.org)
- Activation of neutrophils by soluble and insoluble immunoglobulin aggregates from synovial fluid of patients with rheumatoid arthritis. (bmj.com)
Endothelial5
- Methods were initially developed to examine the adhesion of neutrophils to monolayers of a cultured endothelial cell line (ECV304) after periods of hypoxia and reoxygenation. (bl.uk)
- Neutrophil migration in response to factors secreted by the treated endothelial cells was then assessed. (bl.uk)
- The genesis of an inappropriate oxidative burst by the neutrophil upon exposure to endothelial chemoattractants and adhesion molecules was also measured. (bl.uk)
- ROS generation in turn caused the release of a soluble factor (s) which induced a conformational change on the neutrophil surface allowing it to bind to the intercellular adhesion molecule 1 (ICAM-1) on the endothelial cell. (bl.uk)
- When neutrophils were exposed to both hypoxic/reoxygenated endothelial cells and the soluble factor (s) released by them a large oxidative burst was elicited. (bl.uk)
Lung4
- Neutrophils, though increasingly linked to the development of inflammatory disorders, have been less well studied in relation to TB-induced lung pathology. (frontiersin.org)
- Neutrophils mode of action and their specialized functions can be directly linked to TB-specific lung tissue damage observed on patient chest X-rays at diagnosis and contribute to long-term pulmonary sequelae. (frontiersin.org)
- In lung cancers, tumor-associated neutrophils (TANs) are part of the inflammatory cell population found in the lung tumor microenvironment, but the role of these cells in tumor progression is unclear. (medicalxpress.com)
- Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer, J Clin Invest . (medicalxpress.com)
Granules2
- Human neutrophil challenge with A. actinomycetemcomitans induced exocytosis of neutrophil granule subtypes: secretory vesicles, specific granules, gelatinase granules, and azurophilic granules. (doaj.org)
- Neutrophils contain granules that release enzymes to help kill and digest these cells. (msdmanuals.com)
Rheumatoid arthritis1
- Particularly in the initial phases of the disease, rheumatoid arthritis patients have an abundance of neutrophils in their inflamed joints that might produce NETs locally. (news-medical.net)
Inflammatory mediators1
- Finally, we propose that some MMPs, ROS, MPO, S100A8/A9 and Glutathione are neutrophil-related inflammatory mediators with promising potential as targets for developing host-directed therapies for TB. (frontiersin.org)
Congenital1
- Here we discuss these primordial neutrophil functions, which also play key roles in tissue injury, by providing details of neutrophil cytotoxic functions and congenital disorders of neutrophils. (nih.gov)
Phenotype1
- shows that tumour-associated neutrophils in glioblastoma originate from skull bone marrow and acquire an antigen-presenting cell phenotype intratumorally in the presence of local T cells. (nature.com)
Migration4
- Here we investigate the role of water influx in neutrophil migration. (elifesciences.org)
- This fundamental study significantly advances our understanding of the role of water influx and swelling in neutrophil migration. (elifesciences.org)
- Neutrophil migration inhibitory properties of polyunsaturated fatty acids. (jci.org)
- Preexposure of neutrophils for 15-30 min to 1-10 micrograms/ml PUFA reduced the random and chemotactic migration to both FMLP- and fungi-activated complement. (jci.org)
Acute1
- Objective We aimed to investigate whether preoperative serum neutrophil gelatinase-associated lipocalin (sNGAL pre-op ) predicted postoperative acute kidney injury (AKI) during hospitalisation and 1-year cardiovascular and all-cause mortality following adult cardiac surgery. (bmj.com)
Granule2
- Based on our findings, we propose that A. actinomycetemcomitans promotes azurophilic granule exocytosis by neutrophils as an epinephrine source to promote bacterial survival. (doaj.org)
- Tear neutrophils from dry eye subjects had increased expression of membrane receptor CD66b, a marker associated with secondary granule degranulation. (physiciansweekly.com)
Subpopulations1
- They are formed from stem cells in the bone marrow and differentiated into subpopulations of neutrophil-killers and neutrophil-cagers. (wikipedia.org)
Chemotaxis1
- Neutrophil chemotaxis. (avhandlingar.se)
Chemotactic1
- Since leukocyte emigration is an essential component of the inflammatory response, we have examined the effects of the n-3 PUFA (eicosapentaenoic and docosahexaenoic acids) on neutrophil random and chemotactic movement. (jci.org)
Engulf bacteria1
- found that the capacity of neutrophils to engulf bacteria is reduced when simple sugars like glucose, fructose as well as sucrose, honey and orange juice were ingested, while the ingestion of starches had no effect. (wikipedia.org)
Peripheral blood1
- Peripheral blood mononuclear cells (PBMC) transcriptome before and after HSCT and transcriptome of sorted normal-density neutrophils and LDGs were determined using the NanoString nCounter gene expression panels. (bvsalud.org)
Defense1
- The adequate production and distribution of normally functioning neutrophils is vital to host defense. (medscape.com)
Markers1
- We hypothesize that neutrophils, which share many HPC markers, are one of the cell types that establish a pre-metastatic niche. (acponline.org)
Cells7
- Whereas basophilic white blood cells stain dark blue and eosinophilic white blood cells stain bright red, neutrophils stain a neutral pink. (wikipedia.org)
- The nucleolus disappears as the neutrophil matures, which is something that happens in only a few other types of nucleated cells. (wikipedia.org)
- During the recovery phase, the flow of cells from the marrow decreases, with a resultant decrease in the number of neutrophils. (medscape.com)
- Present in the cytoplasm, it controls programmed neutrophil death, and in leukemia cells, it promotes their resistance to treatment. (inserm.fr)
- Preventing cell spreading by depolymerizing the actin cytoskeleton with Latrunculin B abrogates this initial volume loss in neutrophil-like differentiated HL-60 (dHL-60) cells ( fig. S1F ). (elifesciences.org)
- Neutrophil adhesion to ECV304 cells, which had been hypoxic for 4 hours and then reoxygenated for 30 minutes, was significantly increased. (bl.uk)
- Viscum album agglutinin-induced aggregation of blood cells and the lectin effects on neutrophil function. (harvard.edu)
Recruitment2
- S100A8 and S100A9 are cytosolic alarmins with autocrine functions that facilitate neutrophil recruitment. (nature.com)
- Visualization of neutrophil recruitment in capillaries proximal to S. aureus beads. (cellimagelibrary.org)
Populations2
- As the condition worsens, neutrophil-specific gene expression is enriched in the neutrophil populations of SLE patients relative to healthy controls. (news-medical.net)
- Neutrophil and low-density granulocyte (LDG) populations were analyzed by flow cytometry . (bvsalud.org)
S100A81
- Neutrophils can release S100A8/S100A9 as an alarmin via gasdermin D pores. (nature.com)
Phagocytes2
- Some experts feel that the short lifetime of neutrophils is an evolutionary adaptation to minimize propagation of those pathogens that parasitize phagocytes. (bionity.com)
- Neutrophils are phagocytes, capable of ingesting microorganisms or particles. (bionity.com)
Staphylococcus1
- Here we show that, in neutrophils, increases in Na + (high salt, HS) impair the ability of human and murine neutrophils to eliminate Escherichia coli and Staphylococcus aureus . (frontiersin.org)