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  • human neutrophils
  • The authors confirmed that fMLP induced human neutrophils to secrete LTB 4 , and Western blotting analysis showed that pharmacological blocking of LTB 4 production (by inhibiting an enzyme that metabolizes AA) or blocking the LTB 4 receptor (BLT1) with an antagonist had no effect on fMLP-induced activation of the kinases ERK1/2 and Akt. (sciencemag.org)
  • acute
  • The fundamental role played by neutrophils for an efficient, acute inflammatory response has long been appreciated, with the underlying molecular and cellular mechanisms largely elucidated over the past decades. (nih.gov)
  • It usually corresponds to a period of acute viremia and is related to virus-induced redistribution of neutrophils from the circulating to the marginal pool. (metafilter.com)
  • NADPH
  • describe that although N-formyl-methionyl-leucyl-phenylalanine (fMLF) and Platelet Activating Factor (PAF) induce similar intracellular signaling profiles, only fMLF induces interleukin-8 (IL-8) release and NADPH oxidase activity in neutrophils. (hindawi.com)
  • Several microbicidal functions of neutrophils involve the activation of the NADPH oxidase complex for production of reactive oxygen species (ROS) to mediate pathogen killing. (hindawi.com)
  • blood
  • Neutrophils are a type of white blood cell. (healthline.com)
  • Neutrophils are the most plentiful type, making up 55 to 70 percent of your white blood cells. (healthline.com)
  • Neutrophils are important because, unlike some of the other white blood cells, they aren't limited to a specific area of circulation. (healthline.com)
  • Neutrophils, along with eosinophils and basophils , constitute a group of white blood cells known as granulocytes . (britannica.com)
  • In the study, researchers found that neutrophils, a type of white blood cell, of asthmatics move more slowly than the cells of those without asthma. (mdadvice.com)
  • Previously it was impractical to use neutrophils, as it required a fair amount of blood, according to a statement from the University of Wisconsin, from which some of the researchers hail. (mdadvice.com)
  • The device can sort neutrophils from a drop of whole blood within minutes, and was used in a clinical setting to characterize asthmatic and non-asthmatic patients," the researchers wrote in the study, published in Proceedings of the National Academy of Sciences. (mdadvice.com)
  • Laboratory tests showed a total bilirubin level of 764.7 µmol/L (44.7 mg/dL) and direct bilirubin of 37 µmol/L. Hemoglobin was 178 g/L, white cell count 26.1 × 10 9 /L, neutrophils 16.1 × 10 9 /L, lymphocytes 5.8 × 10 9 /L, and monocytes 3.0 × 10 9 /L. There was no blood group incompatibility with mother. (bloodjournal.org)
  • I've had two blood tests showing very low neutrophil counts (700 followed by 439) despite all other counts being normal. (metafilter.com)
  • Neutrophils are the most common type of white blood cell in humans. (brighthub.com)
  • The neutrophil blood test is a primary investigation for diagnosing certain conditions as well as monitoring them. (brighthub.com)
  • The neutrophil blood test forms part of the differential white blood cell count which also measures other white blood cells like lymphocytes, monocytes and basophils. (brighthub.com)
  • This gives the proportion of neutrophils in the blood. (brighthub.com)
  • Neutrophils in the blood can be expressed either as absolute neutrophil count or as a percentage of the total white blood cell count. (brighthub.com)
  • Neutrophils can also be expressed as a percentage of the total whole blood cell count. (brighthub.com)
  • Neutrophils constitute 40-60% of the total white blood cells. (brighthub.com)
  • An abnormal neutrophil blood test means either an increase or decrease in the proportion of neutrophils in the blood. (brighthub.com)
  • induces
  • In a transwell assay, blocking LTB 4 production or signaling inhibited migration of neutrophils to fMLP, but not to interleukin-8, a chemokine that induces comparatively little LTB 4 secretion from neutrophils. (sciencemag.org)
  • Activation
  • Mantovani A, Cassatella MA, Costantini C, Jaillon S (2011) Neutrophils in the activation and regulation of innate and adaptive immunity. (springer.com)
  • Suratt BT, Young SK, Lieber J, Nick JA, Henson PM, Worthen GS (2001) Neutrophil maturation and activation determine anatomic site of clearance from circulation. (springer.com)
  • In steady state, their life span is approximately 1-2 days, which increases up to 3-4 days after neutrophil activation. (els.net)
  • phagocytosis
  • Neutrophils perform their function partially through phagocytosis, a process by which they "eat" other cells and foreign substances. (hon.ch)
  • populations
  • The authors demonstrate that when the neutrophil concentration approaches the critical concentration, bacterial populations in contact with them exhibit bistability. (jci.org)
  • cellular
  • Over the years, neutrophils have been shown to display both pro-tumor and antitumor effects, emphasizing an unexpected cellular heterogeneity in cancer. (emergtoplifesci.org)
  • The granules of the neutrophil are microscopic packets of potent enzymes capable of digesting many types of cellular materials. (britannica.com)
  • It's probably more true that neutrophils don't eat infected cells until, as you say, they have become cellular debris (my mistake). (metafilter.com)
  • cell
  • Tumor-infiltrating neutrophils were not striking in neuroendocrine tumors (40), serous cystadenomas (18), acinar cell carcinomas (9) or solid-pseudopapillary neoplasms (8). (nih.gov)
  • However, LTB 4 inhibition reduced the fMLP-dependent production of cAMP and phosphorylation of myosin II, which are required for neutrophil polarization and retraction of the back of the cell (uropod). (sciencemag.org)
  • type
  • Among intraductal papillary mucinous neoplasms, significant tumor-infiltrating neutrophils were identified in 4/16 pancreatobiliary type, but were uncommon in other types (1/11 oncocytic and 1/23 intestinal types had borderline tumor-infiltrating neutrophils, and 0/10 gastric type had tumor-infiltrating neutrophils). (nih.gov)
  • however, this was lost when the wild-type neutrophils were blocked from generating LTB 4 . (sciencemag.org)
  • cells
  • About 50 to 80 percent of all the white bloods cells occurring in the human body are neutrophils. (britannica.com)
  • In this study, the presence of tumor-infiltrating neutrophils within and/or adjacent to neoplastic cells was investigated in pancreatic neoplasms. (nih.gov)
  • 10 tumor-infiltrating neutrophils/100 epithelial cells were arbitrarily classified as positive. (nih.gov)
  • Also, neutrophils in tumor-bearing subjects can act to eliminate disseminated tumor cells, and thus provide antimetastatic protection ( 9 ). (pnas.org)
  • Our understanding of the origins of tissue macrophages and neutrophils, going back to self-renewing hematopoietic stem cells (HSCs), is largely based on studies not involving cancer ( 10 ⇓ ⇓ - 13 ). (pnas.org)
  • Neutrophils eat viruses and other cells infected by viruses. (metafilter.com)
  • I just wanted to point out that neutrophils are not able to destroy virus-infected cells. (metafilter.com)
  • occur
  • In conclusion, significant tumor-infiltrating neutrophils are uncommon in pancreatic ductal adenocarcinoma, and when they occur it is typically in the micropapillary and undifferentiated types with a known poor prognosis. (nih.gov)