Neutrophil receptors leukocyte adhesion. Medical search. Frequent questions

Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. (icr.ac.uk)
activates SYK and mediates neutrophils and macrophages integrin-mediated activation (By similarity). (icr.ac.uk)
involved in neutrophils and macrophages integrin-mediated activation (By similarity). (icr.ac.uk)
This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. (proconsortium.org)
The Hellman Group studies TLR-dependent pathways expressed by macrophages as well as non-conventional inflammatory cells, including endothelial cells, in Inflammatory Critical Illness, focusing on their roles in coagulopathy, vascular permeability, neutrophil trafficking to organs, and organ injury and failure. (ucsf.edu)
Receptors able to mediate phagocytosis are expressed almost exclusively in neutrophils, monocytes and macrophages, and receptor clustering is thought to occur upon particle binding which in turn generates a phagocytic signal, activating the phagocytic process [ 3345 ]. (nanomedicine.com)
Soon after, neutrophils and macrophages may still be recruited in response to local inflammatory stimuli that persist for 2-3 days [ 6 ]. (biomedcentral.com)
Siglec F is expressed mostly on eosinophils and alveolar macrophages and lower levels of this receptor have also been reported on immature myelomonocytic cells. (fishersci.com)
Neutrophils are much more numerous than the longer-lived monocyte /macrophages. (bionity.com)
Being highly motile, neutrophils quickly congregate at a focus of infection , attracted by cytokines expressed by activated endothelium , mast cells and macrophages . (bionity.com)

This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
Variants of leukocyte adhesion deficiency have also been reported, including fully expressed but nonfunctional CD18 and an E selectin that is expressed but rapidly cleaved from the cell surface (only present in soluble form). (medscape.com)
CD18, in association with integrin α chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and α X β 2 , respectively, and plays an important role in leukocyte adhesion. (biolegend.com)
Mutations in the β2 intergrin ( ITGB2 ) gene lead to absent, reduced, or aberrant CD18 protein expression, resulting in subnormal levels of β2 intergrins on leukocyte membranes. (guidetopharmacology.org)
2000) Inhibition of in vivo neutrophil transmigration by a novel humanized anti-CD11/CD18 monoclonal antibody. (guidetopharmacology.org)
1998) Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia. (guidetopharmacology.org)
ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. (thermofisher.com)
Rare, autosomal recessive disorder caused by deficiency of the beta 2 integrin receptors (RECEPTORS, LEUKOCYTE-ADHESION) comprising the CD11/CD18 family of glycoproteins. (lookformedical.com)
Children with leukocyte adhesion deficiency type I are at risk for overwhelming infection because their neutrophils lack surface beta 2 integrins (CD18/CD11) that normally interact with endothelial cell adhesion molecules and mediate migration to sites of bacterial invasion. (ox.ac.uk)
In vitro studies of phagocytic cells from an infant with leukocyte adhesion deficiency type I demonstrated that complement receptor 3 (CD18/CD11b) mediates nonopsonic phagocytosis of some Pseudomonas aeruginosa strains and might play a control role in the control of Pseudomonas infections at sites where there are low levels of opsonins. (ox.ac.uk)

This adhesion molecule is a 97-115 kDa type I transmembrane glycoprotein that is encoded by the SELE gene. (bdbiosciences.com)
CD62E is also known as E-selectin, Endothelial-leukocyte adhesion molecule-1 (ELAM-1), and Leukocyte endothelial cell adhesion molecule 2 (LECAM-2). (bdbiosciences.com)
Bevilacqua MP, Stengelin S, Gimbrone MA Jr, Seed B. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. (bdbiosciences.com)
CD31 is a 130-140 kD glycoprotein, also known as platelet endothelial cell adhesion molecule (PECAM-1), EndoCAM, and gpIIa. (biolegend.com)
Intercellular Adhesion Molecule-3 (ICAM-3) is a member of the immunoglobulin supergene family and functions as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1). (biovendor.com)
Three counter-receptors have been described for LFA-1, intercellular adhesion molecule 1 (ICAM-1), ICAM-2 and ICAM-3. (biovendor.com)
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). (dianova.com)
Hence NO can be viewed as an anti-inflammatory molecule insofar since it is certainly instrumental in clearing international invaders and preventing leukocyte adhesion. (tam-receptor.com)
Lung cell apoptosis was determined by a terminal deoxynucleotidyl transferase dUTP nick-end labeling assay, and lymphocyte influx and intercellular adhesion molecule-1 (ICAM-1) expression were assessed by immunohistochemistry. (cdc.gov)
Kokuludag A, Sin A, Terzioglu E, Saydam G, Sebik F. Elevation of serum eosinophil cationic protein, soluble tumor necrosis factor receptors and soluble intercellular adhesion molecule-1 levels in acute bronchial asthma. (edu.pk)
This Mouse Endothelial Leukocyte Adhesion Molecule 1 (E-Selectin) ELISA Kit from Innovative Research is intended for quantitative detection of mouse soluble E-Selectin in cell culture supernates, serum and plasma (heparin, citrate). (innov-research.com)
Expression system for standard: E-selectin, also called endothelial-leukocyte adhesion molecule-1(ELAM-1), is a cell surface glycoprotein expressed by cytokine-activated endothelium that mediates the adhesion of blood neutrophils. (innov-research.com)
A structurally and functionally related group of genes, lymph node homing receptor(LHR), granule membrane protein 140(GMP-140), and endothelial leukocyte adhesion molecule 1(ELAM-1) are shown to constitute a gene cluster on mouse and human chromosome 1. (innov-research.com)
SIGLEC5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. (fishersci.com)

Beta2-integrins are essential for leukocyte extravasation to sites of infection ( i.e. leukocyte trafficking), and other immunological processes including neutrophil phagocytosis and ROS production, and T cell activation. (guidetopharmacology.org)
Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). (icr.ac.uk)
Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). (icr.ac.uk)
Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). (dianova.com)
Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells, PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). (dianova.com)
Adherence reaction mediated through the CR receptors on phagocytes lead to stimulation of phagocytosis, activation of metabolism and secretory function and movement of phagocytes into the inflammatory site. (dadamo.com)
Nonopsonic phagocytosis of Pseudomonas aeruginoas: insights from an infant with leukocyte adhesion deficiency. (ox.ac.uk)
Once physical contact with a phagocyte has occurred, particle binding to specific cell surface receptors is the first step in the phagocytosis of a medical nanorobot. (nanomedicine.com)
Several pathways of phagocytic signal transduction have been identified [ 3345 ], including the activation of tyrosine kinases or serine/threonine kinase C, leading to phosphorylation of the receptors and other proteins which are recruited at the sites of phagocytosis. (nanomedicine.com)
The membrane-active drug procaine inhibits the phagocytosis of latex particles by normal monocytes and the proliferation of lymphocytes in an allogeneic mixed leukocyte culture [ 3361 ]. (nanomedicine.com)
This inhibitory effect is maximized at 0.1 nM concentration [ 3365 ], and inhibition of neutrophil mobility and phagocytosis "could be carried out through an increase of the intracellular cAMP levels" [ 3319 , 3365 ]. (nanomedicine.com)

LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. (wikipedia.org)
The adhesion between endothelial CD62E molecules and a carbohydrate ligand on neutrophils is inhibited by the mAb 68-5H11. (bdbiosciences.com)
These findings support the notion that the newly uncovered properties of ALP to interfere with cytokine signalling and upregulation of adhesion molecules in endothelial cells are likely to contribute to the therapeutic potential of ALP in immune-complex-induced tissue injury. (biomedcentral.com)
While the expression and shedding of pro-inflammatory molecules can induce post-transfusion adverse effects, stored-dependent loss of adhesion receptors by ectodomain shedding or microvesiculation may attenuate post-transfusion adhesive functions of platelets causing their premature clearance from circulation. (biomedcentral.com)
LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and receptors, which suggests that their roles in adaptive immunity are far more extensive than previously realized. (jci.org)
Cell surface receptors are able to detect chemical gradients of molecules such as interleukin-8 (IL-8), interferon gamma (IFN-gamma), and C5a which these cells use to direct the path of their migration. (bionity.com)
Apart from being an acidic medium containing an assortment of antimicrobial molecules including antibodies (IgA and IgG), mucins, β-defensins, secretory leucocyte protease inhibitor (SLPI), neutrophil gelatinase-associated lipocalin (NGAL), surfactant protein etc. (frontiersin.org)
Rabbit vascular endothelial adhesion molecules: ELAM-1 is most elevated in acute inflammation, whereas VCAM-1 and ICAM-1 predominate in chronic inflammation. (cdc.gov)

ICAM-3 was found to be involved in the regulation of LFA-1/ ICAM-1 dependent leukocyte intercellular interactions. (biovendor.com)

CD62E plays a role in leucocyte extravasation by promoting leucocyte rolling on activated endothelial cells during inflammation. (bdbiosciences.com)
A research from TLR4-deficient mice confirmed the essential role of TLR4 in mediating neutrophil migratory phagocytic functions, attenuating inflammation, reducing reactive oxygen species generation, and enhancing bacterial clearance ( 13 ). (frontiersin.org)
Other reported functions of CD31 are neutrophil emigration to sites of inflammation, and angiogenesis. (biolegend.com)
Airway inflammation is present during an acute exacerbation of asthma, and is characterized by infiltration and activation of both eosinophils and neutrophils 2 . (edu.pk)
To determine the central pathway in mediating complex organic dust-induced airway inflammation, this study targeted the common adaptor protein, myeloid differentiation factor 88 (MyD88), and investigated the relative contributions of receptors upstream from this adaptor. (cdc.gov)
Studies in mice with disrupted BLT1 gene indicate a major role for BLT1 in acute inflammation and immediate hypersensitivity, as well as in leukocyte functions such as chemotaxis and firm adhesion to endothelium in response to LTB4. (multispaninc.com)
Hydrocortisone decreases inflammation by suppressing migration of PMN leukocytes and reversing increased capillary permeability. (medscape.com)
Finally, we made the intriguing observation in vitro that ERK1/2 activation reduces endothelial inflammation induced by LPS and TNFα, in contrast to its role in promoting leukocyte inflammation. (ucsf.edu)
However, during the acute phase of inflammation , particularly as a result of bacterial infection , neutrophils leave the vasculature and migrate toward the site of inflammation in a process called chemotaxis . (bionity.com)
Neutrophils react within an hour of tissue injury and are the hallmark of acute inflammation. (bionity.com)
However, because neutrophil antimicrobial products can also damage host tissues , other authorities feel that their short life is an adaptation to limit damage to the host during inflammation . (bionity.com)
Neutrophils undergo a process called chemotaxis that allows them to migrate toward sites of infection or inflammation. (bionity.com)

The expression of beta-2 integrins on the surface of neutrophils is increased in response to IL-8 and to certain components of complement during CPB. (medscape.com)
2019) Beta2-Integrins and Interacting Proteins in Leukocyte Trafficking, Immune Suppression, and Immunodeficiency Disease. (guidetopharmacology.org)
On the basis of its potential to block anti-collagen type II (CII) antibody-induced arthritis (CAIA) and to suppress the conformational activation of β 2 -integrins in leukocytes, the present study was undertaken to investigate its interference with leukocyte adherence to cytokine-activated endothelium. (biomedcentral.com)
The downmodulation of stimulation-induced F-actin assembly in neutrophils through the interaction of ALP with the actin-bundling protein l-plastin caused a blockade of the conformational activation of β 2 -integrins [ 5 ]. (biomedcentral.com)
Physiologically, upon platelet activation, uncontrolled propagation of thrombosis is prevented by regulating mechanisms which affect the expression and function of either platelet adhesion receptors or integrins. (biomedcentral.com)

ICAM-3 is expressed on resting lymphocytes, monocytes and neutrophils, representing the major LFA-1 ligand on these cells. (biovendor.com)
It is expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. (fishersci.com)

ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex. (bdbiosciences.com)
Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). (icr.ac.uk)
The high-affinity human leukocyte LTB4 receptor, BLT1 (or LTB4R) mediates aggregation, chemotaxis, chemokinesis, and increased adherence to surfaces, whereas the low-affinity receptor mediates degranulation and increased oxidative metabolism. (multispaninc.com)
2000) BLTR mediates leukotriene B4-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis. (multispaninc.com)

These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
LFA-1, an alpha-beta complex, is a member of the leukocyte integrin family which mediate lymphocyte adhesion. (biovendor.com)
Adherent receptors mediate adherence of cells and other particles with bound C3b or C4b fragments and are known as CR1 to CR5. (dadamo.com)

Lundahl J, Halldén G, Hed J. Differences in intracellular pool and receptor-dependent mobilization of the adhesion-promoting glycoprotein Mac-1 between eosinophils and neutrophils. (edu.pk)

Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
Leucocyte typing VI : white cell differentiation antigens : proceedings of the sixth international workshop and conference held in Kobe, Japan, 10-14 November 1996. (bdbiosciences.com)
Leucocyte typing V : white cell differentiation antigens : proceedings of the fifth international workshop and conference held in Boston, USA, 3-7 November, 1993. (bdbiosciences.com)
Immunologists recognized the importance of lymphatic vessels as channels for leukocyte trafficking from peripheral sites to their draining LNs ( 4 - 6 ), and as conduits for soluble antigens that can be taken up directly by LN-resident B cells and immature DCs ( 7 - 10 ), which help regulate the kinetics of antigen presentation. (jci.org)

During established infection, the neutrophil count remains elevated, with equal numbers in the marginal and the circulating pool. (medscape.com)
During an infection, chemotactic agents are generated that attract neutrophils to the site of infection, which in turn play a critical role in phagocytosing and killing microorganisms. (medscape.com)
During early infection, the neutrophil count may actually decrease briefly because of margination of cells from the blood. (medscape.com)
[ 1 , 2 ] The clinical picture is characterized by marked leukocytosis and localized bacterial infections that are difficult to detect until they have progressed to an extensive level secondary to lack of leukocyte recruitment at the site of infection. (medscape.com)
This disrupts neutrophil migration (extravasation) to sites of infection resulting in recurrent infections. (guidetopharmacology.org)
Toll-like receptors are transmembrane glycoproteins, which recognize many PAMPs with extracellular domains and aggravate the exaggerated inflammatory response to bacterial infection through activating nuclear factor (NF)-κB ( 12 ). (frontiersin.org)
The syndrome is characterized by abnormal adhesion-dependent functions, especially defective tissue emigration of neutrophils, leading to recurrent infection. (lookformedical.com)
The family of Toll-like receptors (TLRs) recognize different microbial components and endogenous host factors, and are critical in initiating inflammatory responses to infection. (ucsf.edu)
In vitro studies show that Leishmania infection decreases the adhesion of inflammatory phagocytes to connective tissue by a mechanism dependent on the modulation of integrin function. (biomedcentral.com)
However, we know little about the influence of this reduction in leukocyte adhesion on parasite dissemination from the infection site. (biomedcentral.com)
Additionally, there is concomitant production of mucins, immunoglobulins (secretory IgA and IgG), secretory leucocyte protease inhibitor (SLPI), neutrophil gelatinase-associated lipocalin (NGAL), and β-defensins, and other antimicrobial proteins, which all together provide a formidable first line of defense against infection. (frontiersin.org)
Human granulocytic anaplasmosis is a tickborne rick- chemical tests for Ehrlichia chaffeensis , the causative ettsial infection of neutrophils caused by Anaplasma agent of human monocytic ehrlichiosis (HME) were nega- phagocytophilum . (cdc.gov)

The events that follow leukocyte extravasation are perhaps less well characterized, although significant advances have been made with the advent of high-resolution intravital microscopy and the development of more sophisticated culture systems to investigate leukocyte migration and interactions in three dimensions. (hindawi.com)
We believe that successfully combining our current knowledge about leukocyte extravasation, three-dimensional migration through the stroma and the sequential interactions with parenchymal cell barriers, which include adopting unified experimental models, will help shed light on the entire migratory route of each immune cell type and on the specificity of the innate inflammatory responses in each type of tissue. (hindawi.com)

Leukocyte rolling and firm adhesion to the synovial endothelium in an early response to the anti-CII antibody transfer were significantly decreased in ALP-pretreated mice. (biomedcentral.com)
Preventive administration of ALP as a single dose of 100 μg per mouse led to a significant suppression of leukocyte rolling on, and of firm adhesion to, the synovial venular endothelium. (biomedcentral.com)
4. The effects of TLR2 activation on the vascular endothelium, including on endothelial inflammatory responses, leucocyte trafficking, coagulation pathways and permeability: Endothelial cell (EC) activation, coagulopathy, and vascular leak contribute to sepsis-induced organ failure. (ucsf.edu)
Upon activation, they marginate (position themselves adjacent to the blood vessel endothelium), undergo selectin dependent capture followed by integrin dependent adhesion in most cases, after which they migrate into tissues, where they survive for 1-2 days. (bionity.com)

There was no consistent decrease in the migration of CD11b + F4/80 + (macrophage) or SSC hi GR-1 + (neutrophil) populations. (biomedcentral.com)

This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed in all leukocytes. (wikipedia.org)
CD62L is expressed on neutrophils, monocytes, T- and B-lymphocyte subsets and NK cells. (bdbiosciences.com)
It thus defines L-selectin as a human lymphocyte homing receptor for peripheral lymph node HEV. (bdbiosciences.com)

1987) Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency. (guidetopharmacology.org)

Here we review evidence showing that apicobasal polarity regulates the inflammatory response: various polarized epithelia asymmetrically secrete chemotactic mediators and polarize adhesion receptors that dictate the route of leukocyte migration within the parenchyma. (hindawi.com)
The first stage of this immune steeplechase, the leukocyte transendothelial migration, is a multi-step cascade of interactions that have been extensively studied in recent years in different vascular beds and experimental models, and some comprehensive reviews on this topic can be found in this special issue [ 1 - 5 ]. (hindawi.com)
So far, most of the in vivo and in vitro approaches to study leukocyte migration across the tissue parenchyma have addressed the role of each single tissue barrier that immune cells encounter in their journey to the inflammatory focus. (hindawi.com)
Endothelial and epithelial barriers determine the different stages of leukocyte migration in its journey towards the inflammatory focus in complex tissues. (hindawi.com)
The parenchymal three-dimensional organization contributes to establish an haptotactic and chemotactic gradient (1) Leukocyte adhesion and transendothelial migration or diapedesis. (hindawi.com)
Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). (dianova.com)
Methylprednisolone exerts anti-inflammatory effects by suppressing the migration of polymorphonuclear leukocytes and reversing increased capillary permeability. (medscape.com)

This disease is a defect in fucose metabolism (lack of fucosylation of the carbohydrate selectin ligands) that results in failure to express the ligand for E and P selectin, sialyl Lewis-X (CD15s) expressed on leukocytes and endothelial cells. (medscape.com)
RU486), suggesting the functional importance of the ligand-receptor complex. (ashpublications.org)

In the case of receptor-mediated phagocytic binding, dansylcadaverine, amantadine, and rimantadine induce inhibition of endocytosis of complement-coated zymosan particles by human peripheral PMN leukocytes. (nanomedicine.com)
In the case of nonreceptor phagocytic binding, medical nanorobots could emit or expose on their surfaces chemical surfactants which would repel the lipid bilayer wall, e.g., by reducing the nanorobot's coefficient of adhesion to very low or even to negative values ( Section 9.2.3 ). (nanomedicine.com)

Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). (dianova.com)
Furthermore certain thiol groupings on the top of endothelial cells and/or polymorphonuclear neutrophils are usually required for regular leukocyte-endothelial cell adhesion as well as the result of dinitrogen trioxide with these thiol groupings can develop (8). (tam-receptor.com)
2. The immunomodulatory role of the endocannabinoid system in inflammatory activation of endothelial cells and leukocytes: We recently discovered that the endocannabinoid N-arachidonoyl dopamine (NADA) can negatively regulate endothelial cell activation by a variety of inflammatory agonists. (ucsf.edu)

Human eosinophils express, relative to other circulating leukocytes, large amounts of secretory 14-kD phospholipase A2. (edu.pk)

Polymorphonuclear neutrophils (PMNs) contribute to postischemic reperfusion damage in many organs and tissues, a prerequisite being adhesion of PMNs to vascular endothelial cells. (silverchair.com)

Neutrophil activation during cardiopulmonary bypass (CPB) surgery may occur because of the release of complement chemotactic products or the local release of interleukin (IL)-8. (medscape.com)
Different fragments, released from individual components during complement activation, operate by a non-cytolytic mechanism through specific receptors present on various cell types. (dadamo.com)
From the functional standpoint, complement receptors can be divided into two types: the adherent type and the other receptors. (dadamo.com)
The second group of receptors reacts with small complement fragments (C4a, C3a, C5a) as well as with C1q, Ba, Bb and factor H. Stimulation of these receptors results in various biological effects (chemotaxis, secretion of vasoactive amines, mediators of the inflammatory and anaphylactic reaction etc. (dadamo.com)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)

Neutrophil granulocytes , generally referred to as neutrophils , are the most abundant type of white blood cells in humans and form an integral part of the immune system . (bionity.com)
Neutrophil granulocytes have an average volume of 330 femtoliters (fl) and a diameter of 12-15 micrometers (µm) in peripheral blood smears . (bionity.com)

On the other hand, these barriers contain damaged or infected cells that are part of the inflammatory focus and the endpoint of the leukocyte migratory journey, so some sort of footprint, which is not completely understood, must exist in these cells to promote a preferential adhesion with infiltrated leukocytes. (hindawi.com)

Leukocyte recruitment into the inflamed parenchyma requires successive interactions with cellular and stromal barriers that establish mechanical, chemotactic and haptotactic gradients to guide immune cells towards the inflammatory focus. (hindawi.com)
The potential of recombinant ALP to block the interactions of leukocytes with the endothelial lining was concomitantly investigated in vitro and in vivo . (biomedcentral.com)
Thus potential function of ICAM-3 at the initiation phase of LC-leukocyte interactions taking place during skin localized immune reactions can be postulated. (biovendor.com)
Because adhesion processes involve orderly interactions of membrane proteins, it appeared possible that "membrane effects" of volatile anesthetics could interfere. (silverchair.com)

In acute infections, leukocyte counts typically are 15-25 × 10 9 /L. Infections such as typhoid fever, parathyroid fever, mumps, measles, and tuberculosis usually are not associated with leukocytosis. (medscape.com)
Interleukin-8 secretion and neutrophil recruitment accompanies induced sputum eosinophil activation in children with acute asthma. (edu.pk)

May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. (icr.ac.uk)
Platelets firmly adhere to the sub-endothelial matrix through the engagement of collagen receptors α2β1 and GPVI (Adhesion) . (biomedcentral.com)

Although the mechanism of action of volatile anesthetics remains unclear in these preliminary studies, their inhibitory effect on ischemia-induced adhesion of PMNs may be beneficial for the heart during general anesthesia. (silverchair.com)

We also discuss recent findings showing that the loss of apicobasal polarity increases leukocyte adhesion to epithelial cells and the consequences that this could have for the inflammatory response towards damaged, infected or transformed epithelial cells. (hindawi.com)

These cells include dermal resident dendritic cells (DC), epidermal Langerhans cells, neutrophils and monocytes, which are released from the blood when the dermal capillary is disrupted and a reputed blood lake is formed [ 3 - 6 ]. (biomedcentral.com)

Upregulation of ICAM-1 highlights an underlying mechanism for leucocyte influx, and could also explain the predisposition to respiratory tract viral infections following NO 2 exposure since ICAM-1 is a major receptor for rhino and respiratory syncytial viruses. (bmj.com)
Bronchoalveolar lavage fluid was collected to quantitate leukocyte influx and cytokine/chemokine (TNF-a, IL-6, chemokine [C-X-C motif] ligands [CXCL1 and CXCL2]) concentrations. (cdc.gov)
ODE-induced AHR was significantly attenuated in MyD88 KO mice, and neutrophil influx and cytokine/chemokine production were nearly absent in MyD88 KO animals after ODE challenges. (cdc.gov)
Mice deficient in TLR9, TLR4, and IL-18R, but not IL-1IR, demonstrated partial protection against ODE-induced neutrophil influx and cytokine/chemokine production. (cdc.gov)

The finding that adhesion of resting T lymphocytes to LFA-1 occurs primarily via ICAM-3 combined with the fact that ICAM-3 is much better expressed than other LFA-1 ligands on monocytes and resting lymphocytes implies an important role for ICAM-3 in the initiation of immune responses. (biovendor.com)

The firm adhesion of platelets to the site of injury forms a monolayer which serves as a reactive site for further recruitment of free-flowing platelets. (biomedcentral.com)

Alternatively, further activation of platelets is associated with microvesiculation as a none-selective mechanism which leads to the loss of membrane- bearing receptors. (biomedcentral.com)
In a non-physiological condition, the storage of therapeutic platelets has also shown to be associated with the unwilling activation of platelets which triggers receptors down-regulation via aforementioned different mechanisms. (biomedcentral.com)

The endotoxin-induced myocardial dysfunction probably depends on the toll-like receptor (TLR) 4-induced cytokines release as a delay in onset of myocardial depression after endotoxin administration ( 10 ). (frontiersin.org)

SIGLEC5 is found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. (fishersci.com)

It is heterodimeric cell surface receptor expressed on all leukocytes. (biolegend.com)
An IL-1β-activated endothelial layer formed by a murine glomerular cell line (glEND.2) was used to assay the interaction with human leukocytes in vitro . (biomedcentral.com)
Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. (icr.ac.uk)
Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. (icr.ac.uk)
It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. (icr.ac.uk)
In addition to its function downstream of BCR plays also a role in T-cell receptor signaling. (icr.ac.uk)
Also functions downstream of receptors mediating cell adhesion. (icr.ac.uk)
This Review summarizes the emergent evidence that LECs are important in maintaining peripheral tolerance, limiting and resolving effector T cell responses, and modulating leukocyte function. (jci.org)
But this internalization does not diminish the number of receptors on the cell surface and has no effect on receptor-mediated uptake [ 3354 ]. (nanomedicine.com)

The primary ligands for CD31 have been reported to be CD38 and the vitronectin receptor (α v β 3 integrin, CD51/CD61). (biolegend.com)
The apparently anomalous binding data were clarified by the fact that washed platelets (1) contained mineralocorticoid receptor and that (2) it was associated with GR. Taken together, our data suggest that platelet GR forms a heterodimeric complex with the mineralocorticoid receptor that is susceptible to differential activation by specific receptor ligands. (ashpublications.org)

Thus, intravital fluorescence microscopic imaging of leukocyte rolling and firm adhesion to postcapillary venules were performed in the knee joints of DBA1/J mice after intravenous injection of anti-CII mAbs. (biomedcentral.com)

Some experts feel that the short lifetime of neutrophils is an evolutionary adaptation to minimize propagation of those pathogens that parasitize phagocytes. (bionity.com)
Neutrophils are phagocytes, capable of ingesting microorganisms or particles. (bionity.com)

2002) Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival. (multispaninc.com)
Receptor ectodomain shedding is an elective mechanism which is mainly involved in down-regulation of adhesion receptors GPIbα and GPVI. (biomedcentral.com)

Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. (icr.ac.uk)
Two types of plasma membrane receptors for LTB4 have been described on human neutrophils. (multispaninc.com)

Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). (dianova.com)

The human Sp110 gene is a member of the nuclear body (NB) components that functions as a nuclear hormone receptor transcriptional coactivator and plays an important role in immunoprotective mechanisms against pathogens in humans. (biomedcentral.com)
More study is ic and serologic studies indicated a close or identical rela- needed to define the immunology and pathogenetic mech- anisms and to understand why severe disease develops in tionship to the veterinary pathogens of neutrophils, E . equi some persons and why some animals become long-term and E . ( Cytoecetes ) phagocytophila . (cdc.gov)

Another reported type of leukocyte adhesion deficiency involves dysfunction in platelet aggregation in addition to a defect in leukocyte adhesion. (medscape.com)
However, while prednisolone (1-10 μM) reduced adenosine diphosphate (ADP, 4 μM) and thromboxane A 2 receptor agonist U46619 induced platelet aggregation (up to 75%), dexamethasone had no effect. (ashpublications.org)

Sp110 expression is induced in human peripheral blood leukocytes and spleen but not in other tissues [ 8 ]. (biomedcentral.com)

Here, we report for the first time that human platelets contain the glucocorticoid receptor (GR) as identified by a combination of biochemical and functional techniques. (ashpublications.org)

These receptors, present on the other cells of the immune system, are involved in a variety of immunoregulatory reactions. (dadamo.com)

The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. (icr.ac.uk)

This interaction leads to permutations of neutrophil was recognized as distinct from E . chaffeensis . (cdc.gov)

Toll-like receptor 2 (TLR2) and TLR4 only partly account for the innate response to these complex dust exposures. (cdc.gov)
Wild-type, MyD88, TLR9, TLR4, IL-1 receptor I (RI), and IL-18R knockout (KO) mice were challenged intranasally with organic dust extract (ODE) or saline, according to an established protocol. (cdc.gov)

Anatomy29

Organisms7

Diseases11

Chemicals and Drugs75

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes34

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science4

Macrophages10

CD1812

Molecule14

Phagocytosis11

Molecules8

Intercellular1

Inflammation12

Integrins5

Monocytes and neutrophils2

Mediates4

Mediate3

Glycoprotein1

Antigens4

Infection12

Extravasation2

Endothelium4

CD11b1

Lymphocyte3

P150,951

Migration7

Ligand2

Phagocytic2

Endothelial cell3

Eosinophils1

Polymorphonuclear1

Complement5

GRANULOCYTES2

Migratory1

Interactions4

Acute2

Collagen2

Inhibitory1

Inflammatory response1

Dendritic cells1

Influx4

Lymphocytes1

Recruitment1

Activation of platelets2

Cytokines1

Lymph node1

Cell9

Ligands2

Firm adhesion1

Phagocytes2

Mechanism2

Plasma membrane2

Membrane1

Pathogens2

Platelet aggregation2

Peripheral Blood Leukocytes1

Platelets1

Immune system1

Proteins1

Interaction1

TLR42