AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Chemotactic FactorsChemotaxis, LeukocyteInterleukin-8NeutrophilsInterleukin-11-(5-Isoquinolinesulfonyl)-2-MethylpiperazineTumor Necrosis Factor-alphaCells, CulturedComplement C5Chemotactic Factors, EosinophilN-Formylmethionine Leucyl-PhenylalanineChemotaxisN-FormylmethionineNeutrophil InfiltrationComplement C5aLeukotriene B4EosinophilsZymosanCarcinoma 256, WalkerCytochalasin BMonocytesAnaphylatoxinsChemokines, CLeukocytesSuperoxidesCell MovementPhagocytosisCell AdhesionPeroxidaseAntigens, CD18Leukocyte CountReceptors, Formyl PeptideRabbitsChemokine CXCL1Complement System ProteinsMacrophagesMacrophage-1 AntigenInflammationChemokines, CXCOligopeptidesReceptors, ComplementPancreatic ElastaseChemokinesPlatelet Activating FactorIsethionic AcidExudates and TransudatesTetradecanoylphorbol AcetateEncyclopedias as Topic
MonocytesReceptorsPolymorphonuclearEosinophilsChemotaxisMacrophagesPeptide receptorLeucyl-PhenylalanineActivationMacrophage ColonySecretionFibroblastsProteinEndothelialProteinsLeukocyteChemoattractantReceptorMigrationMurineReactiveLymphocyteBindAccumulationStimulationGranulocyte ColonySelectivelyPlateletActivityHumanProductionVascularMoleculesRole
Monocytes7
Receptors5
  • fMLF led to the first discovery of a leukocyte receptor for a chemotactic factor, defined three different types of fMLF receptors that have complementary and/or opposing effects on inflammatory responses as well as many other activities, and helped define the stimulus-response coupling mechanisms by which diverse chemotactic factors and their G protein coupled receptors induce cellular function. (wikipedia.org)
  • Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor which belongs to the CXC subfamily of chemokines, and are bound by the cell surface receptors IL-8RA and IL-8RB. (thermofisher.com)
  • IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. (affbiotech.cn)
  • The defective chemotactic response to IL-8 does not appear to be due to impaired chemoattractant receptor function, as the number of IL-8 receptors and chemoattractant-induced calcium influx, actin polymerization, and release of gelatinase B were comparable to those of wild- type PMNs. (elsevierpure.com)
  • The stimulatory substances, including opsonized particles, immune complexes, and chemotactic factors, bind to specific cell-surface receptors on the neutrophil. (bvsalud.org)
Polymorphonuclear2
  • N-Formylmethionyl-leucyl-phenylalanine (fMLF, fMLP or N-formyl-met-leu-phe) is an N-formylated tripeptide and sometimes simply referred to as chemotactic peptide is a potent polymorphonuclear leukocyte (PMN) chemotactic factor and is also a macrophage activator. (wikipedia.org)
  • In addition to stimulating polymorphonuclear neutrophil (PMN) production, G-CSF may have significant effects on PMN function. (elsevierpure.com)
Eosinophils1
  • The current authors have recently shown that PQ induces recruitment of inflammatory cells, such as eosinophils and neutrophils, into the lung with the lung expression of pro-inflammatory molecules such as interleukin (IL)-5 and eotaxin in vivo 24 . (ersjournals.com)
Chemotaxis4
  • Given these clues and knowledge that bacteria transcribe (see Transcription (genetics)) proteins starting with N-formylmethionine whereas eukaryotic cells mostly initiate protein synthesis with non-formylated methionine, Schiffmann, Corcoran, and Wahl theorized and then showed that N-formyl-methionine and a series N-formyl-methionyl dipeptides and tripeptides stimulated the chemotaxis of neutrophils isolated from rabbit peritoneal exudates as well as of macrophages isolated from guinea pig peritoneal exudates. (wikipedia.org)
  • In further studies of various N-formylated oligopeptides, fMLF proved the most potent in stimulating rabbit neutrophil chemotaxis. (wikipedia.org)
  • N-acetylcysteine acted by blocking neutrophil migration across both the endothelium of choroidal stromal vessels and the epithelium forming the blood-CSF barrier, without interfering with neutrophil blood count, neutrophil tropism for choroid plexus, and choroidal chemokine-driven chemotaxis. (biomedcentral.com)
  • Consistent with this, neutrophil chemotaxis in vitro and neutrophil mobilization into peripheral blood in vivo in response to the prototype N -formylpeptide fMLF (formyl-methionyl-leucyl-phenylalanine) were both absent in FPR −/− mice. (silverchair.com)
Macrophages11
  • One mechanism by which neutrophils may be selectively attracted to lung and not other tissues is via the secretion of the neutrophil-specific chemotactic factor by alveolar macrophages. (jci.org)
  • To evaluate the role of alveolar macrophages in modulating the migration of neutrophils to he lung in IPF, alveolar macrophages, obtained by bronchoalveolar lavage of patients with IPF, were evaluated for their ability to release a chemotactic factor for neutrophils. (jci.org)
  • Unstimulated alveolar macrophages from normal individuals did not release the factor. (jci.org)
  • In patients with IPF, there was a significant correlation between the proportions of neutrophils in lavage fluid and the release of a chemotactic factor for neutrophils by alveolar macrophages (p less than 0.001). (jci.org)
  • Several lines of evidence suggested that immune complexes in the lung stimulated alveolar macrophages of patients with IPF to release the chemotactic factor. (jci.org)
  • First, immune complexes stimulated normal macrophages to release the factor.Second, there was a significant correlation between the release of the chemotactic factor by IPF alveolar macrophages and the levels of immune complexes in bronchoalveolar lavage fluid. (jci.org)
  • Third, bronchoalveolar lavage fluid containing immune complexes stimulated normal macrophages to release the factor. (jci.org)
  • Fourth, IPF alveolar macrophages that released large amounts of the chemotactic factor had an apparent suppression of their immunoglobulin (Ig)G Fc receptor function, suggesting that immune complexes were bound to their surface. (jci.org)
  • In contrast, the IgG Fc receptor function of IPF alveolar macrophages that released only small amounts of the factor was similar to that of normal macrophages. (jci.org)
  • These studies suggest that neutrophils are attracted to the lung in patients with IPF by a potent chemotactic factor released by alveolar macrophages that have been stimulated, in vivo, via their IgG Fc receptor by immune complexes. (jci.org)
  • At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)
Peptide receptor3
  • Scholars@Duke publication: Changes in actin state and chemotactic peptide receptor expression in granulocytes during cytokine administration after autologous bone marrow transplantation. (duke.edu)
  • We studied the changes in actin state and chemotactic peptide receptor expression in granulocytes from patients receiving different cytokines following high dose chemotherapy and autologous bone marrow transplantation (ABMT). (duke.edu)
  • The chemotactic peptide receptor expression was significantly higher in patients treated with ABMT alone or ABMT plus G-CSF. (duke.edu)
Leucyl-Phenylalanine2
  • Cells were exposed to one of three chemotactic stimuli: platelet-activating factor (PAF), N-formyl-methionyl-leucyl-phenylalanine (FMLP), or leukotriene B4 (LTB4). (nih.gov)
  • Although the basal level of F-actin was high following ABMT, granulocytes from all patients showed an additional increase in F-actin content after stimulation with either the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) or phorbol myristate acetate (PMA). (duke.edu)
Activation3
Macrophage Colony3
  • However, in patients receiving granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF) the increase in F-actin content was much greater than in those not receiving these cytokines (159, 149, and 90% for G-CSF, M-CSF, and noncytokine group, respectively). (duke.edu)
  • Patients receiving granulocyte-macrophage colony-stimulating factor (GM-CSF) had only a 62% increase in the F-actin content, which was not statistically significant from patients undergoing ABMT without any cytokines. (duke.edu)
  • This development occurs under the influence of macrophage colony-stimulating factor (M-CSF), which is secreted by various cell types (eg, endothelial cells, fibroblasts). (msdmanuals.com)
Secretion1
  • Combining light sheet microscopy imaging of choroid plexus, a differentiated model of the blood-CSF barrier, and multiplex cytokine assays, we showed that the choroidal epithelium responds to the bacterial insult by a specific pattern of cytokine secretion, leading to a selective accumulation of neutrophils in the choroid plexus and to their trafficking into CSF. (biomedcentral.com)
Fibroblasts1
Protein4
  • Previous nomenclature for IL-8 includes neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP) and protein 3-10C. (thermofisher.com)
  • Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. (wikidoc.org)
  • Further biochemical analysis of the fibrils confirmed that they represented a novel renal amyloid protein which was identified as leukocyte chemotactic factor 2 (LECT-2). (highwire.org)
  • Monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-2 (MIP-2), and tumor necrosis factor-alpha (TNF-alpha) were increased in both strains while the B6 also had increased interleukin-6 (IL-6) protein. (cdc.gov)
Endothelial3
  • Overall, the data show that a double endothelial and epithelial check point controls the transchoroidal migration of neutrophils into the developing brain. (biomedcentral.com)
  • ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions. (research.com)
  • His scientific interests lie mostly in Platelet, Von Willebrand factor, Cell biology, Endothelial stem cell and Molecular biology. (research.com)
Proteins1
  • Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. (topsan.org)
Leukocyte1
  • A novel form of amyloidosis (ALECT2) derived from leukocyte chemotactic factor 2 (LECT-2) and primarily involving the kidneys was first described by Benson et al in 2008. (highwire.org)
Chemoattractant2
  • IL-8 functions as a chemoattractant and potent angiogenic factor. (thermofisher.com)
  • It functions as a chemoattractant, and is also a potent angiogenic factor. (affbiotech.cn)
Receptor1
Migration1
  • Here we showed in neonatal rats exposed to P3C that the migration of neutrophils into the CSF, which occurred through the choroid plexuses, is abolished following administration of the antioxidant drug N-acetylcysteine. (biomedcentral.com)
Murine1
  • Here we show that, in neutrophils, increases in Na + (high salt, HS) impair the ability of human and murine neutrophils to eliminate Escherichia coli and Staphylococcus aureus . (frontiersin.org)
Reactive3
  • High salt caused reduced spontaneous movement, degranulation and impaired production of reactive oxygen species (ROS) while leaving neutrophil viability unchanged. (frontiersin.org)
  • Anti-inflammatory effects of erythromycin and tetracycline on Propionibacterium acnes induced production of chemotactic factors and reactive oxygen species by human neutrophils. (jomos.org)
  • The process in which the neutrophil is stimulated by diverse substances, resulting in degranulation and/or generation of reactive oxygen products, and culminating in the destruction of invading pathogens. (bvsalud.org)
Lymphocyte1
  • Inhalation of GMA-SS fume caused an early, sustained macrophage and lymphocyte response followed by a gradual neutrophil influx and the magnitudes of these differed between the mouse strains. (cdc.gov)
Bind1
  • To make the most of these approaches, we have constructed chimeric mRNAs encoding single-chain IL-12 fused to single-chain fragment variable (scFv) antibodies that bind to transforming growth factor b (TGF-b) and CD137 (4-1BB). (unav.edu)
Accumulation1
  • Mechanisms of neutrophil accumulation in the lungs of patients with idiopathic pulmonary fibrosis. (jci.org)
Stimulation1
  • Stimulation of neutrophils with phorbol-12-myristate-13-acetate (PMA) overcame high salt-induced impairment in ROS production and restored antimicrobial activity of neutrophils. (frontiersin.org)
Granulocyte Colony1
  • Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor that is widely used to treat neutropenia. (elsevierpure.com)
Selectively1
  • The human platelet factor 4 kills malaria parasites within erythrocytes by selectively lysing the parasite's digestive vacuole. (wikidoc.org)
Platelet4
  • His primary area of study in Platelet is in the field of Von Willebrand factor. (research.com)
  • His Von Willebrand factor study combines topics in areas such as Thrombotic thrombocytopenic purpura and Platelet membrane glycoprotein. (research.com)
  • His Von Willebrand factor study integrates concerns from other disciplines, such as Biophysics, Thrombotic thrombocytopenic purpura and Platelet membrane glycoprotein. (research.com)
  • Platelet, Von Willebrand factor, Biophysics, Biochemistry and Molecular biology are his primary areas of study. (research.com)
Activity3
  • Although neutrophils play an important role in fighting intruding invaders, the impact of increased Na + on the antimicrobial activity of neutrophils remains elusive. (frontiersin.org)
  • Whereas inhibition of p38/MAPK did not result in improved neutrophil defense, pharmacological blockade of the phagocyte oxidase (PHOX) or its genetic ablation mimicked the impaired antimicrobial activity detected under high salt conditions. (frontiersin.org)
  • This factor is known mainly because of its chemotactic activity. (topsan.org)
Human1
Production1
  • Our findings suggest that increases in local Na + represent an ionic checkpoint that prevents excessive ROS production of neutrophils, which decreases their antimicrobial potential and could potentially curtail ROS-mediated tissue damage. (frontiersin.org)
Vascular2
  • The main factor in increasing systemic blood pressure is central and regional hemodynamic disorders: an increase in peripheral vascular resistance, a decrease in pulse blood supply to the brain, and hemodynamic disturbances in the pulmonary circulation. (artery-diseases-info.com)
  • The factors controlling vascular permeability in health and disease are poorly understood. (bvsalud.org)
Molecules1
  • Members of the ADAM family contribute to various physiological and pathophysiological processes by modulation of molecules like growth factors or cytokines. (frontiersin.org)
Role1