OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Boron Neutron Capture TherapyBoronNeutron Capture TherapyBoron CompoundsNeutronsBoranesBorohydridesIsotopesPhenylalanineRadiation-Sensitizing AgentsSpectrometry, Mass, Secondary IonBrain NeoplasmsGliomaFast NeutronsSulfhydryl CompoundsDeuteroporphyrinsNeutron DiffractionRats, Inbred F344Tissue DistributionMelanoma, ExperimentalGlioblastomaSpectrometry, Gamma
BNCTThermal neutronsIrradiationCompounds2023Protons and neutronsEpithermal neutron beamBoric acidAtoms in a singleTumorsSlow neutronsMalignantGliomaEfficacyProtonSupramolecular cuboctahedronNucleusNucleiNanoelectronicAbsorberRadiationStableTumourGlioblastoma multiformeTumor cellsUptakeCarbideTherapeuticParticlesFissionReactSodiumCancer therapyHalidesCarbonVivoTreatmentTransplanted gliomasNuclearSynthesisOrganicClinicalChad MirkinAtomicAgentsBiologyTissuesEvaluationIPENRoutes
BNCT38
  • Boron Neutron Capture Therapy (BNCT) is a noninvasive therapeutic modality for treating locally invasive malignant tumors such as primary brain tumors and recurrent head and neck cancer. (biomedcentral.com)
  • Locally recurrent HN cancer after full-dose irradiation poses a therapeutic challenge, and boron neutron capture therapy (BNCT) may be a soluti. (biomedcentral.com)
  • The development of new accelerators has given a new impetus to the development of new drugs and treatment technologies using boron neutron capture therapy (BNCT). (cancer.org)
  • Given that morbidity and mortality of cancer continue to remain at relatively constant levels, we believe that a new cancer therapy, boron neutron capture therapy (BNCT), deserves to be further developed [ 1 ]. (cancer.org)
  • The principles of BNCT and the key milestones in its development are described in details, covering the mechanism of BNCT-induced cell death, the role of BNCT as a treatment modality for different cancers, the characteristics of the currently available boron preparations, and approaches to the delivery of isotope 10B to tumor cells. (cancer.org)
  • He proposed the principle of BNCT based on the selective concentration of boron in tumors and its irradiation by thermal neutrons. (cancer.org)
  • en] This study was undertaken in an attempt to interpret the disappointing results obtained in the renewed clinical trials in boron neutron capture therapy (BNCT) at the Brookhaven Medical Research Reactor (BMRR) at the Brookhaven National Laboratory (BNL) during the mid to late 1990s. (iaea.org)
  • A tumor to blood boron uptake ratio was used for estimating the boron dose to tumor during the BNCT irradiation. (iaea.org)
  • We evaluated safety and efficacy of boron neutron capture therapy (BNCT) in the treatment of such cancers. (nih.gov)
  • Boron neutron capture therapy (BNCT) is a form of radiation therapy mediated by the short-range (less than 10 microns) energetic alpha (4He) and lithium-7 (7Li) ionizing particles that result from the prompt disintegration by slow neutrons of the stable (nonradioactive) nucleus boron-10 (10B). (isnct.net)
  • Recent advances in radiobiological and toxicological evaluation of tumour-affinitive boron-containing drugs and in optimization of the energies of neutrons in the incident beam have spurred interest in BNCT. (isnct.net)
  • 1. Boron phenyl alanine targeted chitosan-PNIPAAm core-shell thermo-responsive nanoparticles: boosting drug delivery to glioblastoma in BNCT. (nih.gov)
  • 3. Boron neutron-capture therapy (BNCT) for glioblastoma multiforme (GBM) using the epithermal neutron beam at the Brookhaven National Laboratory. (nih.gov)
  • 5. Quantitative evaluation of boron neutron capture therapy (BNCT) drugs for boron delivery and retention at subcellular-scale resolution in human glioblastoma cells with imaging secondary ion mass spectrometry (SIMS). (nih.gov)
  • 9. Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA). (nih.gov)
  • 15. PET pharmacokinetic analysis to estimate boron concentration in tumor and brain as a guide to plan BNCT for malignant cerebral glioma. (nih.gov)
  • Additionally, we have recently started developing a quantitative imaging technique for boron neutron capture therapy (BNCT). (mdanderson.org)
  • DESCRIPTION (provided by applicant): We propose to develop a commercial neutron source for the treatment of brain and liver cancer based on boron neutron capture therapy (BNCT). (sbir.gov)
  • Boron neutron capture therapy (BNCT) is a targeted radiation therapy under clinical trial in Taiwan. (ncl.edu.tw)
  • In 2009, Prof. Fong-In Chou of National Tsing Hua University found, in addition to borophenylalanine (BPA) and borocaptate (BSH), boric acid (BA) could also be the boron carrier for BNCT. (ncl.edu.tw)
  • The presence of a large number of boron atoms in boron clusters make them attractive tools for the treatment of cancer using boron neutron capture therapy (BNCT). (researchgate.net)
  • Since the quantity of boron atoms present in the target cell directly affects the effectiveness of BNCT, the idea of gathering a high number of boron atoms in a single entity has emerged. (researchgate.net)
  • IPEN facility for researches in BNCT (Boron Neutron Capture Therapy) uses IEA-R1 reactor's irradiation channel number 3, where there is a mixed radiation field neutrons and gamma. (usp.br)
  • The obtained values show that the fluxes of thermal and epithermal neutrons flux are appropriate for studies in BNCT, however, the dose due to gamma radiation is high, indicating that the facility should be improved. (usp.br)
  • TOKYO-Sumitomo Heavy Industries, Ltd. (TOKYO:6302)(President: Shinji Shimomura, referred to as "SHI" hereinafter) announced today, two Japanese BNCT facilities have started clinical treatments by BNCT (Boron Neutron Capture Therapy) *1) for an unresectable, locally advanced, and recurrent carcinoma of the head and neck region under the national health insurance system. (shi.co.jp)
  • Dose calculation of BNCT essentially requires Monte Carlo method which enables to reproduce reactions between neutron and atoms in human body in detail. (shi.co.jp)
  • In this therapy method, a boron medical agent for BNCT is given to cancer patients whereby cancer cells selectively absorb boron (Boron-10). (shi.co.jp)
  • Boron neutron capture therapy (BNCT) is a binary form of cancer treatment wherein 10 B nuclei, when irradiated with thermal neutrons, produce high energy transfer particles. (tennessee.edu)
  • Potential BNCT agents reported in the literature include boron-containing amino acids, nucleic acids, nucleosides, antibodies, and other biomolecules. (tennessee.edu)
  • Other less extravagant boron-based compounds have already been researched as high-energy materials, nanoelectronic components, agents for boron neutron capture therapy (BNCT), and in liposomes, dendrimers, nanowires, and nanotubes. (chemistryviews.org)
  • The team highlights the simplicity of their approach compared with laborious organic synthetic routes to such boron-rich compounds and is now pursuing leads for new BNCT. (chemistryviews.org)
  • Based on these considerations, we developed the antiangiogenic hypoxic cell radiosensitizers, TX-1877, TX-1898 and the hypoxic cytotoxin TX-402 that inhibits the HIF-1α pathway We will also discuss our research involved with the development of other drugs to exploit tumor hypoxia, including a hypoxia-targeting boron carrier for boron neutron capture therapy (BNCT) and a p53 inhibiting radiosensitizer. (go.jp)
  • September 10th, 2019 - Atlanta, Georgia U.S.A.SAH Global and neutron Therapeutics Inc (NTI) have entered into agreement to develop Boron Neutron Capture Therapy (BNCT). (sahglobal.com)
  • According to Genezini and Saxena, at present only three of the stations have equipment installed: the high-resolution neutron diffractometer, real-time neutron imaging systems, and the experimental system for boron neutron capture therapy (BNCT). (sbpmat.org.br)
  • The appearance of hospital-based epithermal neutron sources has made boron neutron capture therapy (BNCT) a dedicated focus of innovative developments in radiation oncology. (dgbnct.com)
  • Shortly after the discovery of the neutron in 1932, some scientists recognized the potential of boron neutron capture therapy (BNCT) as a cancer treatment. (newatlas.com)
  • BNCT traditionally involves injecting tumors with the non-radioactive boron-10 isotope capture agent that is then radiated with a beam of epithermal neutrons that interact with the capture agent to produce a biologically destructive nuclear caption reaction. (newatlas.com)
  • Although numerous clinical studies have demonstrated the safety of BNCT, the challenge has been finding more tumor-selective boron delivery agents. (newatlas.com)
Thermal neutrons6
  • The researches in progress require the radiation fields, in the position of the irradiation of sample, to have in its composition maximized thermal neutrons component and minimized, fast and epithermal neutron flux and gamma radiation. (usp.br)
  • In order to achieve this objective, a methodology for the dosimetry of thermal neutrons and gamma radiation in mixed fields of high doses, which was not available in IPEN, was implemented in the Center of Nuclear Engineering of IPEN, by using thermoluminescent dosimeters TLDs 400, 600 and 700. (usp.br)
  • A technique for the treatment of neoplasms, especially gliomas and melanomas in which boron-10, an isotope, is introduced into the target cells followed by irradiation with thermal neutrons. (nih.gov)
  • Its (n,alpha) reaction cross-section for thermal neutrons is about 3840 barns (for 0.025 eV neutron). (material-properties.org)
  • Isotope 11B has absorption cross-section for thermal neutrons about 0.005 barns (for 0.025 eV neutron). (material-properties.org)
  • Most of (n,alpha) reactions of thermal neutrons are 10B(n,alpha)7Li reactions accompanied by 0.48 MeV gamma emission. (material-properties.org)
Irradiation3
  • Therefore, the most crucial information that is needed to prescribe a therapeutic dose for the patient and affect successful therapy is the concentration of boron present in the tumor during the irradiation interval relative to that in the surrounding normal tissues. (iaea.org)
  • 2. Accelerator-based boron neutron capture therapy for malignant glioma: a pilot neutron irradiation study using boron phenylalanine, sodium borocaptate and liposomal borocaptate with a heterotopic U87 glioblastoma model in SCID mice. (nih.gov)
  • For these reasons, we hypothesized the differences between tumor and normal cells microenvironment may cause differential uptake of boron/BA into the liver cancer cells prior neutron irradiation. (ncl.edu.tw)
Compounds9
  • Because of poor neutron penetration in deeply seated tumors, in addition to non-selective accumulation of boron compounds in the tumor, these experiments failed. (cancer.org)
  • As the lightest element of the boron group it has three valence electrons for forming covalent bonds, resulting in many compounds such as boric acid, the mineral sodium borate, and the ultra-hard crystals of boron carbide and boron nitride. (wikipedia.org)
  • Boron is primarily used in chemical compounds. (wikipedia.org)
  • Boron compounds were relatively rarely used until the late 1800s when Francis Marion Smith's Pacific Coast Borax Company first popularized and produced them in volume at low cost. (wikipedia.org)
  • Evaluation of boron compounds for use in neutron capture therapy of brain tumors. (isnct.net)
  • Ten organic boron compounds and boric acid have been evaluated in mice for toxicity. (isnct.net)
  • Boron-containing compounds are injected into a patient's bloodstream and accumulate in a malignant tumor. (sbir.gov)
  • The major global industrial-scale use of boron compounds (about 46% of end-use) is in production of glass fiber for boron-containing insulating and structural fiberglasses. (material-properties.org)
  • In the most familiar compounds, boron has the formal oxidation state III. (material-properties.org)
20231
  • Between 25 - 29 Sept, 2023 the Budapest Neutron Centre (BNC) and the Institute of Nuclear Techniques of the Budapest University for Technology and Economics (BME) organized a hands-on training school on nuclear data measurement at Research Reactors in Budapest. (bnc.hu)
Protons and neutrons1
  • As a result, the nuclei of the uranium atoms are divided into two, while two or three neutrons and a large amount of energy are released (that very strong energy that holds the protons and neutrons together in the nucleus of the atom). (sbpmat.org.br)
Epithermal neutron beam2
  • For the speedy implementation of BCNT in medical practice, it is necessary to develop more selective boron delivery agents and to generate an epithermal neutron beam with definite characteristics. (cancer.org)
  • In particular, the speedy implementation of this method in clinical practice will require the development of more selective boron delivery agents and an epithermal neutron beam with suitable characteristics. (cancer.org)
Boric acid1
  • By oxidizing boron with air, they showed that boric acid is its oxidation product. (wikipedia.org)
Atoms in a single1
  • The previous record for the most boron atoms in a single molecular species was a heptanuclear silver aggregate reported by Lars Wesemann in 2010, but this species only contained 88 boron atoms. (chemistryworld.com)
Tumors10
  • Boron values at 4 hours after convection-enhanced delivery of N5-2OH to mice bearing intracerebral implants of L929 (wt) or L929 thymidine kinase-1(-) tumors were 39.8 ± 10.8 and 12.4 ± 1.6 μg/g, respectively, and the corresponding normal brain values were 4.4 and 1.6 μg/g, thereby indicating that there was selective retention by the thymidine kinase-1(+) tumors. (johnshopkins.edu)
  • Boron-neutron capture therapy for tumors / edited by H. Hatanaka. (who.int)
  • Advances in molecular biology help to explain differences in biologic behavior and response to therapy of brain tumors in the elderly compared with younger patients. (medscape.com)
  • The number of elderly patients who desire and receive therapy for brain tumors and are included in clinical trials is increasing. (medscape.com)
  • This article reviews the literature on the epidemiology, clinical aspects, and therapy of brain tumors, with emphasis on the older patient population. (medscape.com)
  • Surgery, radiation therapy, and chemotherapy can benefit elderly patients with brain tumors with favorable histologies, tumor location, and good performance status. (medscape.com)
  • Brain tumors in the elderly have specific characteristics that determine their biologic behavior and response to therapy. (medscape.com)
  • Small interfering RNAs (siRNAs) can be targeted to tumors and one example is the suppression of H-ras gene expression indicating the potential for application in therapy of ovarian cancer. (researchandmarkets.com)
  • 13. Boron neutron capture therapy of brain tumors: enhanced survival and cure following blood-brain barrier disruption and intracarotid injection of sodium borocaptate and boronophenylalanine. (nih.gov)
  • The team's study, entitled "Boron neutron capture therapy demonstrated in mice bearing EMT 6 tumors following selective delivery of boron by rationally designed liposomes," was recently published in The Proceedings of the National Academy of Science (PNAS). (newatlas.com)
Slow neutrons1
  • It is a two-step procedure: first, the patient is injected with a tumor localizing, non-radioactive boron-10 containing drug that has a high propensity to capture slow neutrons. (biomedcentral.com)
Malignant1
  • The tumor microenvironment is now recognized as a major factor that influences not only the response to conventional anti-cancer therapies but also helps define the potential for malignant progression and metastasis. (go.jp)
Glioma4
  • At 2.5 hours after convection-enhanced delivery, the boron values for the F98 glioma and normal brain were 16.2 ± 2.3 and 2.2 μg/g, respectively, and the tumor to brain ratio was 8.5. (johnshopkins.edu)
  • 4. Boron phenyl alanine targeted ionic liquid decorated chitosan nanoparticles for mitoxantrone delivery to glioma cell line. (nih.gov)
  • 8. Boron neutron capture therapy induces apoptosis of glioma cells through Bcl-2/Bax. (nih.gov)
  • Biopsy of diffuse midline glioma is safe and impacts targeted therapy: a systematic review and meta-analysis. (amedeo.com)
Efficacy1
Proton7
  • *2) Beryllium is used for the translation from proton to neutron in order to realize safety and reliable system which shall be required by hospitals. (shi.co.jp)
  • Vice President Mike Pence visited the Hampton University Proton Therapy Institute (HUPTI) on Wednesday, February 19 to support the University's efforts in providing state-of-the-art cancer research. (sahglobal.com)
  • During the Oncology Conference organized by Lacort Medical in Medellin, Colombia, Mr Feroz AGAD explained in an interview how SAH brings cutting-edge cancer technology like Proton Therapy to. (sahglobal.com)
  • Our chairman Feroz Agad has been asked to deliver the Keynote presentation on our vision to establish oncology centers including proton therapy during the business forum with the Punjab Board of. (sahglobal.com)
  • We are pleased to announce a partnership between SAH Global ("SAH") and Lacort Medical ("Lacort"), to bring Comprehensive Oncology, including Proton Beam Cancer Therapy. (sahglobal.com)
  • Don't miss the Keynote Speech by Mr Feroz AGAD - Founder, Chairman, and Chief Executive Officer of SAH Global & SAH Care - on November 13th in Dubai on the role of Proton Therapy in. (sahglobal.com)
  • There are 13 known isotopes of boron, the shortest-lived isotope is 7 B which decays through proton emission and alpha decay. (material-properties.org)
Supramolecular cuboctahedron1
  • The unique supramolecular cuboctahedron contains 240 boron atoms and was synthesised by Chad Mirkin and colleagues at Northwestern University in Evanston, Illinois, via coordination-driven assembly. (chemistryworld.com)
Nucleus2
  • This research filed uses beams of free neutron (neutrons that were separated from the nuclei of the atoms), generated in the nucleus of the reactor through the nuclear fission process. (sbpmat.org.br)
  • Boron is a chemical element with atomic number 5 which means there are 5 protons in its nucleus. (material-properties.org)
Nuclei1
  • The results is that low-energy neutrons are radiated which in turn causes fission of the boron (Boron-10) nuclei inside the body. (shi.co.jp)
Nanoelectronic1
Absorber2
Radiation10
  • In theory, it is an ideal type of radiation therapy since it is both physically and biologically targeted. (biomedcentral.com)
  • A type of radiation therapy. (cancer.org)
  • The patient then receives radiation therapy with atomic particles called neutrons. (cancer.org)
  • The existence of the neutron was the first postulated in 1932 by Chadwick [ 2 ], who explored the properties of the penetrating radiation emitted from beryllium and boron when bombarded by the alpha particles of polonium. (cancer.org)
  • The primary research focus of the Cho Laboratory has been the development of novel applications of metal-based nanostructures, such as gold nanoparticles (GNPs), for x-ray imaging and radiation therapy. (mdanderson.org)
  • This results in the formation of boron 11 with the release of lethal radiation in the form of alpha particles (helium-4) and lithium ions that kill the tumor. (newatlas.com)
  • Hawthorne and his team tested this new form of radiation therapy on mice, which resulted in successful remission of cancer. (newatlas.com)
  • When it is built, MU will have the first radiation therapy of this kind in the world. (newatlas.com)
  • To increase cancer-free survival rates, it is recommended to combine personalized radiation therapy methods with TME-targeting drugs, including immune checkpoint inhibitors. (bvsalud.org)
  • Enriched boron or 10B is used in both radiation shielding and is the primary nuclide used in neutron capture therapy of cancer. (material-properties.org)
Stable2
Tumour1
Glioblastoma multiforme1
Tumor cells3
  • The boron collects in tumor cells. (cancer.org)
  • The neutrons react with the boron to kill the tumor cells without harming normal cells. (cancer.org)
  • Boron-10 delivered into the tumor cells disintegrates after capturing a neutron, and the high energy heavy charged particles produced from the nuclear event destroy cancer cells, with only marginal damage to the surrounding normal tissues. (ncl.edu.tw)
Uptake3
  • Based upon these assumptions of linearity, arithmetic normalization was applied to the measured boron values yielding tumor boron uptake values that were higher than those actually measured and a higher tumor to blood ratio. (iaea.org)
  • The highest boron uptake was seen with N7-2OH by the MRA 27 melanoma and L929 wild-type (wt) cell lines. (johnshopkins.edu)
  • Consequently, our experimental data implied glucose metabolic condition and acidic environment might regulate the uptake of boron/BA by the liver cancer cells. (ncl.edu.tw)
Carbide1
  • Boron carbide (chemical formula approximately B4C) is an extremely hard boron-carbon ceramic and covalent material. (material-properties.org)
Therapeutic1
  • In 1936, Locher [ 3 ] published a work about neutrons which had therapeutic possibilities. (cancer.org)
Particles1
  • In the second step, the patient is radiated with epithermal neutrons, which after losing energy as they penetrate tissue, are absorbed by the boron-10, and the resulting nuclear capture and fission reactions yield high-energy alpha particles, thereby killing the cancer cells. (biomedcentral.com)
Fission1
  • The bottom of the pool houses the reactor core, in which uranium is bombarded with neutrons, generating nuclear fission reactions. (sbpmat.org.br)
React1
Sodium1
  • Based on these favorable in vitro and in vivo data, neutron capture therapy studies will be initiated using N5-2OH in combination with two non-cell cycle dependent boron delivery agents, boronophenylalanine and sodium borocaptate. (johnshopkins.edu)
Cancer therapy1
Halides1
  • citation needed] Pure boron can be prepared by reducing volatile boron halides with hydrogen at high temperatures. (wikipedia.org)
Carbon3
  • The primary use of the element itself is as boron filaments with applications similar to carbon fibers in some high-strength materials. (wikipedia.org)
  • The word boron was coined from borax, the mineral from which it was isolated, by analogy with carbon, which boron resembles chemically. (wikipedia.org)
  • It is therefore surprising that, in comparison to the myriad of methods for making carbon-rich nanostrucutres, there are relatively few strategies for making boron-rich ones. (chemistryworld.com)
Vivo1
  • The purpose of the present study was to evaluate both in vitro and in vivo a series of boron-containing nucleosides that potentially could be used as delivery agents for neutron capture therapy. (johnshopkins.edu)
Treatment2
  • The response rates to available therapies are less favorable than in younger patients, and only a small number of elderly patients are enrolled in clinical studies addressing new treatment modalities. (medscape.com)
  • 11. Evaluation of fluorine-18-BPA-fructose for boron neutron capture treatment planning. (nih.gov)
Transplanted gliomas1
  • Tumor: brain boron ratios have been studied in animals with subcutaneous transplanted gliomas. (isnct.net)
Nuclear2
  • While in the nuclear plants the released energy is harnessed, in the research reactors the most important product is the neutrons, the reason why the reactor components aim at preserving the free neutrons. (sbpmat.org.br)
  • While X-rays interact with matter through electromagnetic forces, neutrons basically interact via nuclear forces," explains Reynaldo Pugliesi, an IPEN researcher responsible for neutron imaging equipment, designed and built at IPEN and installed in one of the IEA-R1 stations. (sbpmat.org.br)
Synthesis1
  • Mirkin's team are now pursuing the synthesis of other boron-rich supramolecular assemblies. (chemistryworld.com)
Organic2
  • A few boron-containing organic pharmaceuticals are used or are in study. (wikipedia.org)
  • Boron-containing organic antibiotics are known. (wikipedia.org)
Clinical1
  • Not willing to give up their baby daughter so easily, Layla's family agreed to put Layla through a new clinical trial involving a form of gene therapy, referred to as gene editing, in 2015. (paperap.com)
Chad Mirkin1
  • A supramolecular assembly shaped like a paddle wheel with copper(II) ions at the nodes and containing an astounding 240 boron atoms has been synthesized and characterized by Chad Mirkin and colleagues, Northwestern University, Evanston, IL, USA. (chemistryviews.org)
Atomic2
  • Boron is a chemical element with the symbol B and atomic number 5. (wikipedia.org)
  • Isotopes are nuclides that have the same atomic number and are therefore the same element, but differ in the number of neutrons. (material-properties.org)
Agents2
  • Pharmacological companies and research laboratories should have access to accelerators for large-scale screening of new, more specific boron delivery agents. (cancer.org)
  • These include antiangiogenic agents, immunotherapy, bacterial agents, viral oncolysis, targeting of cyclic-dependent kinases and tyrosine kinase receptors, antisense approaches, gene therapy and combination of various methods. (researchandmarkets.com)
Biology2
Tissues1
  • Subsequently, several researchers compared the effects of neutrons and X-rays on normal and tumor tissues. (cancer.org)
Evaluation1
  • 16. Long-term infusions of p-boronophenylalanine for boron neutron capture therapy: evaluation using rat brain tumor and spinal cord models. (nih.gov)
IPEN1
  • According to Frederico Genezini and Rajendra Narain Saxena, IPEN researchers and current and former manager of the Research Reactor Center (CRPq), respectively, neutrons have a very specific feature of interacting with matter. (sbpmat.org.br)
Routes1
  • The earliest routes to elemental boron involved the reduction of boric oxide with metals such as magnesium or aluminium. (wikipedia.org)