Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. (musc.edu)
This approach enabled us to nominate the gene encoding the neutral ceramidase, Asah2, as a novel candidate driver at a QTL on chromosome 19 for large HDL particles (HDL-2b). (bvsalud.org)
Ceramide2
Acid ceramidase (Ac) is part of the sphingolipid metabolism and responsible for the degradation of ceramide. (elifesciences.org)
Enhancing ceramide degradation also endows these metabolic benefits, and adiponectin exerts their antidiabetic, cardioprotective, and insulin-sensitizing actions through activating its receptors, which are ligand-activated ceramidases ( 23 ). (frontiersin.org)
Amidohydrolase1
Neutral ceramidase C also known as N-acylsphingosine amidohydrolase 2C or non-lysosomal ceramidase C or ASAH2C is a ceramidase enzyme which in humans is encoded by the ASAH2C gene. (wikipedia.org)
Actively transcribed genes1
Scaffoldattachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind toS/MAR. The encoded protein is thought to serve as a molecular base to assemble atranscriptosome complex in the vicinity of actively transcribed genes. (immune-source.com)
Acid3
Acid and neutral sphingomyelinases: roles and mechanisms of regulation. (musc.edu)
This study provides evidence that murine acid ceramidase (Ac) is required for normal erythropoiesis and the development of rodent malaria. (elifesciences.org)
Palmitic acid is a very hydrophobic molecule, practically insoluble in water and relatively neutral. (foodb.ca)
Lipid4
To refine the QTL and link them to disease risk in humans, we asked if the human homologues of genes located at each QTL were associated with lipid traits in human genome-wide association studies (GWAS). (bvsalud.org)
Luckily, we discovered a novel gene having same N-terminal motif in post synaptic lipid rafts that is brain specific, but highly expressed in acute leukemia- -BAALC (brain and acute leukemia, cytoplasmic) [1]. (symbiosisonlinepublishing.com)
From two lipid metabolism genes mutation models, we understood that the nature of biomembrane are very different between mammals and Drosophila. (symbiosisonlinepublishing.com)
Our data suggests that TMEM106B is one of a growing list of major dementia risk genes that affect glial lipid metabolism. (biomedcentral.com)
Murine1
Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5. (musc.edu)
Sphingomyelinase2
GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS. (musc.edu)
Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. (musc.edu)
Enzyme2
PLD1 is a gene in the genome of a cell that codes for an enzyme also called PLD1. (asdrp.org)
This gene then codes for a protein, specifically an enzyme. (asdrp.org)
Chromosome4
We identified a locus on mouse chromosome 7 where several phospholipids in liver showed strong genetic association to distinct gene loci. (bvsalud.org)
In this study, we integrated gene expression data with genetic association data to identify a single gene at the chromosome 7 locus as the driver of the phospholipid phenotypes. (bvsalud.org)
P53 is a key protein in tumor suppression encoded by the TP53 gene located on chromosome 17, its mutation being found in more than 50% of human cancers [ 1 ] . (encyclopedia.pub)
The genes encoding the type II cytokeratinsare clustered in a region of chromosome 12q12-q13. (thebiotechdictionary.com)
Encodes2
The gene encodes α/ß-hydrolase domain 2 (Abhd2), one of 23 members of the ABHD gene family. (bvsalud.org)
This gene encodes a DNA-binding protein which has high specificity for scaffold or matrixattachment region DNA elements (S/MAR DNA). (immune-source.com)
Dementia2
ANOVA was used to test the effect of major dementia risk alleles in the TMEM106B and APOE genes on the hippocampal proteome and lipidome, adjusting for age, gender, and post-mortem interval. (biomedcentral.com)
The increase in TMEM106B levels with ageing was specific to carriers of the rs1990622-A allele in the TMEM106B gene that increases risk for frontotemporal dementia, Alzheimer's disease, Parkinson's disease, and hippocampal sclerosis with ageing. (biomedcentral.com)
Genome1
Interestingly, the first genome-wide CRISPR interference/activation screens to discover susceptibility genes of oxidative stress in induced pluripotent stem cell (iPSC)-derived human neurons identified PSAP. (nature.com)
Lipids1
Accumulation of neutral lipids, such as triglycerides, in key insulin target tissues, has been postulated to inhibit metabolic functions, however, they are less likely to be deleterious. (frontiersin.org)
Mice2
Neutral- Ceramidase (N-CDase) nude mice do not have significant phenotype, even the N-CDase nude MEFs only show around 10% weak cytotoxic toleration as compared to wild type MEFs by FACS analysis (unpublished data), whereas Drosophila N-CDase knockout is lethal [4]. (symbiosisonlinepublishing.com)
Quantification of renal cysts Kidneys were eliminated from control mice at 12?weeks of age, fixed in 10% neutral buffered formalin and bisected before handling and paraffin embedding. (immune-source.com)
Regulation1
MicroRNAs (miRNAs) are small endogenous RNAs with an approximate length of 18-22 nucleotides and involved in the regulation of gene expression in transcriptional or post-transcriptional levels. (springeropen.com)
Expression1
Evaluating the capacity of caspases to affect gene expression and influence fate and/or behaviour of cells adjacent to apoptosis is the first fundamental step to better characterise this new function in animals. (biomedcentral.com)
Protein1
The protein encoded by this gene is a member of the keratin gene family. (thebiotechdictionary.com)
Target3
Many of the target genes by the newly identified miRNAs were associated with plant growth and development, stress response, defense and hormone signaling, and oil synthesis pathways. (springeropen.com)
These small non-coding RNAs derived from their precursor sequences, bind to their target mRNAs and negatively mediate the gene expressions in pre-transcriptional or post-transcriptional stages by impeding mRNA translation [ 12 , 13 ]. (springeropen.com)
While caspase-dependent signals emitted by apoptotic cells start to be characterised, almost no target genes are identified in receptor cells. (biomedcentral.com)
Possess1
Affected person Along with Benefits: All of us identify somebody using typical Leigh syndrome who had previously been identified to possess ingredient heterozygous mutations from the gene HIBCH (3-hydroxyisobutyryl coenzyme A new hydrolase), a great compound involved in the catabolism of valine. (dnapk-signaling.com)
Cell1
The PLD1 gene is sometimes overexpressed in a cell through mutations or extra signaling to the cell. (asdrp.org)
Type1
The type IIcytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratinchains coexpressed during differentiation of simple and stratified epithelial tissues. (thebiotechdictionary.com)
Candidate1
Integration of mouse QTL with human GWAS yielded candidate gene drivers for 18 of the 21 QTL. (bvsalud.org)
Activation1
Most protection under the law earmarked.Liquid shear strain regulates gene phrase in osteoblasts, partly by activation in the transcribing factor NF-kappa W. We all analyzed whether or not this method ended up being beneath the control over purinoceptor service. (dnapk-signaling.com)
Models1
Mass spectrometry-based proteomic and lipidomic analysis of CA1 hippocampus samples from 74 neurologically normal human donors, aged 66-104, was used in combination with multiple regression models and gene set enrichment analysis to identify age-dependent changes in the proteome and lipidome. (biomedcentral.com)
Human1
In recent years, beta-galactosidase has been researched as a potential treatment for lactose intolerance through gene replacement therapy where it could be placed into the human DNA so individuals can break down lactose on their own. (wikidoc.org)
Short1
The gene comprises a short JI-101 cytoplasmic domain name, a transmembrane region and a large extracellular domain name. (angiogenesis-blog.com)
Nature1
Footnotes Publishers note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. (angiogenesis-blog.com)
Make1
We and others have previously shown that genetic association can be used to make causal connections between gene loci and small molecules measured by mass spectrometry in the bloodstream and in tissues. (bvsalud.org)
Region1
At Stage III cattle with lymphoma, only two integration sites were generated de novo in the intergenic region of Chr1, and the intron of the CHEK2 gene on Chr17 was significantly increased. (biomedcentral.com)