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  • serotonin
  • a) The key features, including the transmembrane topology of nicotinic acetylcholine, γ‐aminobutyric acid (GABA A ), glycine and serotonin (5‐HT 3 ) receptors. (els.net)
  • A significant decrease in binding of 3H-QNB, 3H-Fluinitrazepam and 3H-Ketanserin, known to label cholinergic (muscarinic), benzodiazepine and serotonin (5HT(2A)) receptors respectively was observed at 1h exposure of PC-12 cells to HNE at 25 and 50microM concentrations. (sigmaaldrich.com)
  • Role of serotonin and other neurotransmitter receptors in brain development: basis for developmental pharmacology. (aspetjournals.org)
  • Results Hallucinogens and mefloquine bound stereoselectively and with relatively high affinity (Ki=0.71-341 nM) to serotonin (5-HT)₂ₐ but not 5-HT₁ₐ or 5-HT₂c receptors.Mefloquine but not chloroquine was a partial 5-HT₂ₐ agonist and a full 5-HT₂c agonist, stimulating inositol phosphate accumulation, with similar potency and efficacy as the hallucinogen dimethyltryptamine (DMT). (oregonstate.edu)
  • agonist
  • Here, using purified oligodendrocyte progenitors and cerebellar slice cultures, we show that norepinephrine and the beta-adrenergic receptor agonist isoproterenol also inhibited the proliferation, but in contrast to glutamate, isoproterenol stimulated progenitor lineage progression, as determined by O4 and O1 antibody staining. (biologists.org)
  • Despite the opposite effects on lineage progression, both isoproterenol and the glutamate receptor agonist kainate caused accumulation of the cyclin-dependent kinase inhibitors p27(Kip1)and p21(CIP1), and G1 arrest. (biologists.org)
  • Furthermore, the analgesic effect of acupuncture can be replicated by direct injection of an adenosine A1 receptor agonist. (chiroaccess.com)
  • The 5-HT1A and 5-HT1B receptors exhibited both high- and low-affinity states for agonist, with the majority of the receptors in a low-affinity state. (neurotransmitter.net)
  • A significantly higher affinity for agonist was observed with both receptors in the presence of alphai3 subunits compared with either alphai2 or alphao subunits, while a significantly lower concentration of alpha subunits was required for a maximal affinity shift of 5-HT1A receptors compared with 5-HT1B receptors (EC50 values of 6.4 and 12. (neurotransmitter.net)
  • The 5-HT1D and 5-HT1E receptors exhibited only a single affinity state for agonist. (neurotransmitter.net)
  • Addition of purified G protein subunits to membranes containing 5-HT1D receptors caused a small increase in affinity for agonist that was only partially reversed by guanine nucleotides while the addition of purified G protein subunits to membranes containing 5-HT1E receptors had no affect on agonist binding. (neurotransmitter.net)
  • intrinsic
  • It has now become clear, however, that the heart rate and HRV are also determined by intrinsic properties of the pacemaker cells that comprise sinoatrial node, and that these properties respond to autonomic receptor stimulation in a non-linear mode. (omicsonline.org)
  • With the exception of synaptic transmission mediated via receptors that contain intrinsic enzymatic activity, such as tyrosine kinase or guanylyl cyclase, or that form ion channels (see Chap. 10), the family of membrane proteins known as heterotrimeric G proteins may be involved in all other transmembrane signaling in the nervous system. (nih.gov)
  • stimulation
  • Electrophysiological studies have indicated that some of the transplant receptors respond to physiological and pharmacological stimulation, suggesting that they are functional. (hindawi.com)
  • G t , termed transducin, was identified as the G protein that couples rhodopsin to regulation of photoreceptor cell function (see Chap. 47), and G s and G i were identified as the G proteins that couple plasma membrane receptors to the stimulation and inhibition, respectively, of adenylyl cyclase, the enzyme that catalyzes the synthesis of cAMP (see Chap. 22). (nih.gov)
  • transporter
  • However, mefloquine was a very low potency antagonist at the D₃ receptor and mefloquine but not chloroquine or hallucinogens blocked [³H]5-HT uptake by the 5-HT transporter. (oregonstate.edu)
  • We characterized associations between central nervous system (CNS) adverse events and brain neurotransmitter transporter/receptor genomics among participants randomized to efavirenz-containing regimens in AIDS Clinical Trials Group studies in the USA. (ovid.com)
  • Efavirenz-related CNS adverse events were not associated with predicted neurotransmitter transporter/receptor gene expression levels in brain or with polymorphisms in these genes. (ovid.com)
  • Variable susceptibility to efavirenz-related CNS adverse events may not be explained by brain neurotransmitter transporter/receptor genomics. (ovid.com)
  • hippocampus
  • A third aim was to assess whether treatment with sulforaphane enhances endogenous the anti-inflammatory system, reduces neuroinflammation in the hippocampus of hyperammonemic rats, and restores spatial learning and if normalization of receptor membrane expression is associated with learning improvement. (biomedcentral.com)
  • All the receptor bindings were decreased in the left amygdala and pyrmidal cell layr of the left hippocampus. (nii.ac.jp)
  • Thus, CJP likely exerted its significant antianxiety effect by diminishing monoamine neurotransmitters and regulating mRNA expression of MR and GR in the hippocampus of our rat model of anxiety disorder. (hindawi.com)
  • localization
  • 1992 ) Beta-adrenergic receptors: astrocytic localization in the adult visual cortex and their relation to catecholamine axon terminals as revealed by electron microscopic immunocytochemistry. (biologists.org)
  • The text provides clearly structured information on the biosynthesis and degradation, localization, receptors, signal transduction pathways, and biological effects in the central nervous system, with all substances uniformly treated for an easy comparison of data. (mexmat.ru)
  • behavior
  • The G protein coupling behavior of four human 5-hydroxytryptamine receptor subtypes (5-HT1A, 5-HT1B, 5-HT1D, and 5-HT1E) has been studied in membranes from Sf9 cells expressing the individual receptors. (neurotransmitter.net)
  • activation
  • Probes for Signal Transduction-Chapter 17 focuses on reagents for investigating events-such as calcium regulation, kinase, phosphatase and phospholipase activation, and lipid trafficking-that occur downstream from the receptor-ligand interaction ( Figure 16.2.1 ). (thermofisher.com)
  • respectively
  • 80%) was achieved before H1, D2, alpha 1 and alpha 2 receptors became occupied (ED50 = 0.45, 0.66, 0.75 and 3.7 mg/kg, respectively). (nih.gov)
  • Haloperidol occupied D2 and alpha 1 receptors at low doses (ED50 = 0.13 and 0.42 mg/kg, respectively) and 5-HT2 receptors at a higher dose (ED50 = 2.6 mg/kg). (nih.gov)
  • vitro
  • Conclusions Mefloquine, but not chloroquine, shares an in vitro receptor interaction profile with some hallucinogens and this neurochemistry may be relevant to the adverse neuropsychiatric effects associated with mefloquine use by a small percentage of patients. (oregonstate.edu)
  • C-IAP.In vitro multiple tracer autoradio graphy on these adjacent sections was performed using ^3H-MK801, ^3H-QNB,^3H-Muscimol, ^3H-Ro15-1788, ^3H-5-HT.The receptor bindings were measured with image analyzer. (nii.ac.jp)
  • membrane
  • b) The G protein‐coupled receptor as viewed through the plane of the membrane. (els.net)
  • Thus when expressed in an identical membrane environment these four closely related 5-HT1 receptor subtypes exhibit different G protein coupling behaviors. (neurotransmitter.net)
  • regulate
  • Neurotransmitter is used here in its most general sense , including not only messengers that act to regulate ion channels , but also those which act on second messenger systems and those which may act at a distance from their release sites . (biology-online.org)
  • affinity
  • The alphai1, alphai2, alphai3, and alphao subunits were able to shift the receptors to a high-affinity state with either betagammabrain or betagammaretina while alphat subunits were inactive regardless of which betagamma preparation was used. (neurotransmitter.net)