Neuropsychiatric systemic lupus. Medical search. Frequent questions

Neuropsychiatric syndromes associated with systemic lupus erythematosus are common, but diverse in etiology and presentation. (medscape.com)
The University of Florida Medical School has shown that in animals, squalene alone can induce production of antibodies specifically associated with systemic lupus erythematosus," writes Matsumoto. (infiniteunknown.net)
Central nervous system vasculitis that is associated with SYSTEMIC LUPUS ERYTHEMATOSUS. (bvsalud.org)

Neuropsychiatric systemic lupus erythematosus or NPSLE refers to the neurological and psychiatric manifestations of systemic lupus erythematosus. (wikipedia.org)
PURPOSE The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) invites applications for research on the pathogenesis of neuropsychiatric manifestations of systemic lupus erythematosus (NP-SLE) and on the development of innovative therapeutic approaches and diagnostics for this form of lupus. (nih.gov)
This RFA is based in part on the scientific opportunities identified in the conference "CNS Manifestations of Systemic Lupus Erythematosus. (nih.gov)
This RFA was based in part on the scientific opportunities identified in the workshop "Neuropsychiatric Manifestations of Systemic Lupus Erythematosus" held at NIH in May 1999. (nih.gov)
In 10% of people, manifestations of systemic lupus-for example, those affecting the joints, kidneys, and brain-may occur. (msdmanuals.com)
Management of inflammatory neurologic and psychiatric manifestations of systemic lupus erythematosus: A systematic review. (nih.gov)

Systemic lupus erythematosus (SLE) is a multi-system rheumatic disease with a wide variety of associated clinical neurological and psychiatric syndromes including cognitive, behavioral, affective, and/or motor manifestations that may affect up to 75 percent of SLE patients. (nih.gov)
To describe the prevalence, characteristics, attribution, and clinical significance of neuropsychiatric (NP) events in an international inception cohort of systemic lupus erythematosus (SLE) patients. (johnshopkins.edu)
Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by antibodies to nuclear and cytoplasmic antigens, multisystem inflammation, protean clinical manifestations, and a relapsing and remitting course. (medscape.com)
Cognitive Dysfunction in Neuropsychiatric SLE , Michael Lockshin, M.D., Hospital for Special Surgery, New York, N.Y. This research will combine clinical, biological and imaging approaches to identify subgroups of SLE patients. (nih.gov)
Class IV-S versus class IV-G lupus nephritis: clinical and morphologic differences suggesting different pathogenesis. (dergipark.org.tr)
Clinical, laboratory and neuroimage findings in juvenile systemic lupus erythematosus presenting involvement of the nervous system. (dergipark.org.tr)
Antiphospholipid syndrome (APS), a common disease in rheumatology and immunology, is an autoimmune disease caused by antiphospholipid antibody (APL), with clinical manifestations such as habitual abortion, neuropsychiatric symptoms, venous and arterial thrombosis, and thrombocytopenia [ 1 ]. (hindawi.com)
The aim of this study was to study the clinical profile of systemic lupus erythematosus (SLE) patients from a tertiary care center in Northwest Punjab. (aujmsr.com)
OBJECTIVE: To determine the frequency, clinical characteristics, associations, and outcomes of different types of peripheral nervous system (PNS) disease in a multiethnic/multiracial, prospective inception cohort of systemic lupus erythematosus (SLE) patients. (ox.ac.uk)
Central Nervous System Systemic Lupus Erythematosus: Pathophysiologic, Clinical, and Imaging Features. (nih.gov)
Diagnosis, Monitoring, and Treatment of Systemic Lupus Erythematosus: A Systematic Review of Clinical Practice Guidelines. (nih.gov)
Table of Contents Introduction Pathophysiology of the diseases Clinical manifestations Medical Management Prognosis References Introduction Systemic lupus erythematosus and multiple sclerosis are some of the diseases common among young people. (123essaywriting.com)
Clinical manifestations Systemic lupus erythematosus is associated with a wide range of clinical manifestations. (123essaywriting.com)
C20993 Clinical Assessment Tool C121340 C118468 C121336 American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus ACR Classification Criteria for SLE The classification of systemic lupus erythematosus based on eleven criteria. (nih.gov)
Intended to be used as inclusion criteria for clinical studies, a person is defined as having systemic lupus erythematosus if any four or more of the eleven criteria are present, serially or simultaneously, during any interval of observation. (nih.gov)

In a cohort of 43 SLE patients (19 with inactive and 24 with active SLE) and 20 healthy controls, serial measures of soluble vascular cell adhesion molecule (sVCAM-1) were significantly associated with SLE disease activity, scored using the British Isles Lupus Assessment Group index. (who.int)
Ces mesures ont été effectuées selon l'indice du British Isles Lupus Assessment Group (Groupe d'évaluation du lupus des îles britanniques). (who.int)
Data obtained after 52 weeks of treatment from two phase III trials (BLISS-52 and BLISS-76) comparing belimumab 1 and 10 mg/kg versus placebo, plus standard therapy, in 1684 autoantibody-positive patients were analysed post hoc for changes in British Isles Lupus Assessment Group (BILAG) and Safety of Estrogens in Lupus National Assessment-Systemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI) organ domain scores. (nih.gov)

The primary objective of this study is to demonstrate efficacy of BIIB059 (litifilimab) compared with placebo in participants with active systemic lupus erythematosus (SLE), who are receiving background lupus standard of care (SOC) therapy in reducing disease activity. (clinicaltrials.gov)
To assess the pharmacokinetic parameters of anifrolumab in Chinese participants with active systemic lupus erythematosus(SLE). (astrazenecaclinicaltrials.com)

Autoantibodies in neuropsychiatric lupus.Autoimmunity 2002;35(2):79-86. (dergipark.org.tr)

For diagnosis of NPSLE, it must be determined whether neuropsychiatric symptoms are indeed caused by SLE, whether they constitute a separate comorbid condition, or whether they are an adverse effect of disease treatment. (wikipedia.org)
Nerve system disease in SLE includes neurologic and psychiatric events, collectively termed neuropsychiatric SLE (NPSLE). (bmj.com)
Methods To understand the pathogenesis of NPSLE, we analysed the medical records of 1131 patients with SLE, and conducted experiments by using lupus-prone mice and mice with intracisternal injections of lupus serum containing high level of autoantibody and mice with gene deficiency. (bmj.com)
Scientists at the Hokkaido University in Japan have identified a stress-induced molecular pathway that affects neuropsychiatric systemic lupus erythromatosus (NPSLE). (genengnews.com)
NPSLE is a severe form of the autoimmune disorder, systemic lupus erythematosus (SLE) where the immune system attacks the body's own cells and tissues. (genengnews.com)
She was diagnosed with neuropsychiatric lupus syndrome (NPSLE) and pulmonary arterial hypertension (PAH), and was successfully treated using immunosuppressive therapy. (nih.gov)
Although neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the recalcitrant complications of the disease, its pathogenesis still remains unclear. (altmetric.com)

The study was conducted by the Systemic Lupus International Collaborating Clinics (SLICC). (johnshopkins.edu)
The Systemic Lupus International Collaborating Clinics (SLICC) group recently developed another set of revised criteria. (biomedcentral.com)
Twenty-five patients classified to be suffering from SLE as per standard classification criteria (Systemic Lupus International Collaborating Clinics [SLICC]) were enrolled after obtaining consent for the same. (aujmsr.com)

The outlook for patients with lupus nephritis has not dramatically changed over the last years, as 10% of patients still progress to end-stage renal disease ( 8 ). (frontiersin.org)
1. History or current diagnose of clinically significant non-SLE related vasculitis, severe or unstable neuropsychiatric SLE, active severe SLE-driven renal disease, catastrophic anti-phospholipid syndrome, inflammatory joint or skin disease other than SLE, non-SLE disease that has required treatment of certain dosage of corticosteroid. (astrazenecaclinicaltrials.com)

In addition, onset of neuropsychiatric symptoms may happen prior to the diagnosis of lupus. (wikipedia.org)
To investigate the application value of combined detection of anti-beta 2-glycoprotein I antibody (anti- β 2-GPI), anti-cardiolipin antibody (ACL), and lupus anticoagulant (LA) in the diagnosis of patients with antiphospholipid syndrome (APS). (hindawi.com)
Central nervous system lupus--diagnosis and treatment. (nih.gov)
According to Lupus organisation, the diagnosis is based on the lupus check list provided to the patient to fill in with the presenting symptoms under the Rheumatologist care [7]. (lupinepublishers.com)

It is estimated that over half of people with SLE have neuropsychiatric involvement. (wikipedia.org)
Objectives: To assess the utility of a combined neuroimaging approach in the follow up of patients affected by systemic lupus erythematosus (SLE) with and without neuropsychiatric (NP) involvement. (unife.it)
The existence of a strong and specific "lupus headache" has been debated for decades, and it is still controversial whether this type of headache is a reality or a myth, and whether headache in SLE is caused by the disease's brain involvement, something that may have implications for the treatment of SLE in the individual patient. (uib.no)
The causes of anxiety and depression in SLE are complex, ranging from neuropsychiatric involvement to drug adverse effects. (biomedcentral.com)
Microstructural Changes in the Corpus Callosum in Systemic Lupus Erythematous Cells, Volume 12, Issue January 2023, 355 Central nervous system (CNS) involvement in childhood-onset systemic lupus erythematosus (cSLE) occurs. (unicamp.br)
Systemic lupus erythematosus (SLE) is the prototypic autoimmune disorder with multisystemic involvement. (aujmsr.com)
Neuropsychiatric involvement in systemic lupus erythematosus: A review. (nih.gov)

A close association of IgG antibodies with P proteins and with cardiolipin was seen in lupus sera (p=0.0009, odds ratio 18.33). (bmj.com)
Anti-P antibodies from 9 of 12 anti-P lupus serum samples could be affinity purified and none of the affinity purified fractions cross reacted with ELISA plate coated cardiolipin. (bmj.com)
Anti-P antibodies are strongly clustered with IgG anticardiolipin antibodies in lupus sera, even if they are independently elicited. (bmj.com)
Antibodies that bind to the DNA of people with lupus can also bind to the NR2 receptor on neurons and cause cell death. (nih.gov)
Association between microscopic brain damage as indicated by magnetization transfer imaging and anticardiolipin antibodies in neuropsychiatric lupus. (dergipark.org.tr)
Neuropsychiatric manifestations and antiphospholipid antibodies in pediatric onset lupus: 14 years of experience from a tertiary center of North India. (dergipark.org.tr)
APLs are autoimmune antibodies that act on phospholipid-binding proteins, phospholipids, or their complexes, recognize and bind with phospholipid-binding proteins on platelets and endothelial cell membranes, and are mainly composed of anti-beta 2-glycoprotein I antibody (anti- β 2-GPI), anti-cardiolipin antibody (ACL), and lupus anticoagulant (LA) [ 6 ]. (hindawi.com)
The number and variety of antibodies that can appear in lupus are greater than those in any other disorder. (msdmanuals.com)
Other antiphospholipid antibodies like prothrombin activator complex, lupus anticoagulant as well as anti-cardiolipin antibodies can lead to abnormal clotting as well as loss of pregnancy. (lupinepublishers.com)

The findings were published in an article titled " Pathogenic neuropsychiatric effect of stress-induced microglial interleukin-12/23 axis in systemic lupus erythematosus " in the journal Annals of the Rheumatic Diseases , on July 11, 2022. (genengnews.com)
Neuropsychiatric manifestations in childhood-onset systemic lupus erythematosus The Lancet Child & Adolescent Health, Volume 6, Issue 1, August 2022, 571-581 Neuropsychiatric manifestations occur frequently and are challenging to diagnose. (unicamp.br)

This meningitis is dependent on dose of IgG but not associated with kinds of autoantibodies and systemic disease activity. (bmj.com)
Determinants of discordance between patients and physicians in their assessment of lupus disease activity. (jrheum.org)
To evaluate the effects of belimumab versus placebo, plus standard systemic lupus erythematosus (SLE) therapy, on organ domain-specific SLE disease activity. (nih.gov)
Subjects with anxiety and depression were assessed for disease activity using the Mexican Systemic Lupus Erythematosus Systemic Disease Activity (Mex-SLEDAI), and blood samples were collected to test complement C3 and C4 levels. (biomedcentral.com)

Discoid lupus erythematosus (DLE), sometimes called chronic cutaneous lupus erythematosus, is a form of lupus that affects only the skin. (msdmanuals.com)
Subacute cutaneous lupus erythematosus (SCLE) is a form of lupus that affects mostly the skin, causing various rashes that are widespread, come and go, and may worsen with exposure to sunlight. (msdmanuals.com)
The Lupus Foundation of America estimates that 1.5 million Americans, and at least five million people worldwide, have a form of lupus. (lupinepublishers.com)

Vasculitis del sistema nervioso central que se asocia con el LUPUS ERITEMATOSO SISTÉMICO. (bvsalud.org)

Cutaneous manifestations of SLE include malar rash, photosensitivity, and discoid lupus. (medscape.com)
1] There are four types of lupus accepted and they are Systemic lupus, cutaneous lupus, drug-induced lupus (mainly by drugs like hydralazine, Isoniazid. (lupinepublishers.com)

Editorial: Treatment of central nervous system lupus erythematosus. (nih.gov)

Given the considerable heterogeneity between individuals as well as within the same individual over time, several aspects of lupus remain uncertain and create substantial unmet medical need. (frontiersin.org)
Five new research grants on the neuropsychiatric aspects of lupus have been funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) at the National Institutes of Health (NIH), a part of the Department of Health and Human Services (DHHS). (nih.gov)

Recent advances point to an underlying autoimmune etiology that may be relevant for many movement and neuropsychiatric diseases ( 2 , 4 , 16 ). (frontiersin.org)

Retrospective analysis of mortality and morbidity of pediatric systemic lupus erythematosus in the past two decades. (dergipark.org.tr)

Kidney outcomes for children with lupus nephritis. (dergipark.org.tr)
Outcome of lupus nephritis in childhood onset SLE in North and Central India: single-centre experience over 25 years. (dergipark.org.tr)

60 patients with systemic lupus erythematosus (SLE), 32 systemic sclerosis, 46 primary Sjögren's syndrome, 16 poly/dermatomyositis, 11 rheumatoid arthritis, 8 undifferentiated CTD, 72 overlap CTD, and 22 primary antiphospholipid syndrome were studied. (bmj.com)
8. Neuropsychiatric syndromes in patients with systemic lupus erythematosus and rheumatoid arthritis. (nih.gov)
According to award-winning investigative journalist Gary Matsumoto, there's a "close match between the squalene-induced diseases in animals and those observed in humans injected with this oil: rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus. (infiniteunknown.net)
In secondary SjS (sSjS), the disease is associated with another autoimmune disorder, frequently Multiple Sclerosis (MS), Rheumatoid Arthritis (RA) or Systemic Lupus Erythematosus (SLE) [ 5 - 7 ]. (longdom.org)

To further complicate the management of the disease, there are number of multi-systemic manifestations specifically peripheral neuropathy associated with later stage of disease onset. (longdom.org)

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect almost any organ system. (medscape.com)
Background and Aims Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterised by high levels of autoantibodies and multi-organ tissue damage including damage of the central system. (bmj.com)
Systemic lupus erythematosus (SLE) is chronic autoimmune disease with multiple organ damage and is associated with poor prognosis and high mortality. (researchsquare.com)

Lupus is an autoimmune disease while the autoimmune nature of multiple sclerosis is not proved. (123essaywriting.com)
While the investigations on the nature of lupus proved its hereditary nature, a genetic aspect of multiple sclerosis is still not fully explored. (123essaywriting.com)
However, the pathophysiology of multiple sclerosis remains more elusive than the nature of lupus. (123essaywriting.com)

Comorbidities of antiphospholipid syndrome and systemic lupus erythematosus in children. (dergipark.org.tr)

Difference in disease features between childhood-onset and adult-onset systemic lupus erythematosus. (dergipark.org.tr)
Childhood-onset systemic lupus (SL) is a rare multifactorial autoimmune disease belonging to connectivitis. (bvsalud.org)

Belimumab is a monoclonal antibody against soluble B-lymphocyte stimulator, an essential growth factor for B-cell maturation and activation, which was approved by the US FDA in 2011 for patients with active autoantibody-positive systemic lupus erythematosus (SLE) who have failed standard treatment. (nih.gov)

in 1986, [ 1 ] it has become widely accepted that cognitive dysfunction is prevalent among patients with systemic lupus erythematosus (SLE). (medscape.com)
Cite this: Cognitive Dysfunction in Neuropsychiatric Systemic Lupus Erythematosus - Medscape - Nov 01, 2002. (medscape.com)
Anti-endothelial cell autoantibodies and soluble markers of endothelial cell dysfunction in systemic lupus erythematosus. (jrheum.org)
Brain Connections , Michelle Petri, M.D., Johns Hopkins University, Baltimore, Md. Investigators in this multicenter study will measure cognitive dysfunction and biological changes and will perform brain imaging in newly diagnosed neuropsychiatric lupus patients. (nih.gov)
By studying the biological mechanisms underlying lupus brain injury, this research will assist in redefining the progression of cognitive dysfunction in SLE patients and will suggest new targets for treatment. (nih.gov)

Identifying Genes for Neuropsychiatric Lupus , Mishra Nilamadhab, M.D., Wake Forest University School of Medicine, Winston-Salem, N.C. This study seeks to discover the genes responsible for the neurological symptoms of lupus by examining mouse models. (nih.gov)
Symptoms of lupus vary greatly from person to person. (msdmanuals.com)

International criteria for SLE and pSS, for neuropsychiatric syndromes in SLE, and for headache classification were used. (uib.no)
The 1982 revised criteria for the classification of the systemic lupus erythematosus. (dergipark.org.tr)
The classification of systemic lupus erythematosus based on eleven criteria. (nih.gov)

The incidence and prevalence of neuropsychiatric syndromes in pediatric onset systemic lupus erythematosus. (dergipark.org.tr)
We found a striking difference in the prevalence of pleuropulmonary features, neuropsychiatric features, Leukopenia, and thrombocytopenia in our subgroup of population as compared to the earlier studies from central and southern parts of India thus further emphasizing the fact that ethnic backgrounds predispose a patient for different phenotype. (aujmsr.com)

There are several possible mechanisms that underlie the nervous system manifestations of lupus. (wikipedia.org)
The mechanisms responsible for cell death in the brains of autoimmune mice with lupus-like neuropsychiatric symptoms will be investigated. (nih.gov)

By the most conservative estimates, lupus affects at least 239,000 Americans. (nih.gov)
Systemic lupus erythematosus (SLE) is an autoimmune disease that mainly affects women of childbearing age. (nih.gov)
NP-SLE affects more than 20 percent of lupus patients and is one of the major causes of death among people with lupus. (nih.gov)

In addition, there are a wide variety of associated neurological and psychiatric syndromes, which have been placed under the heading of Neuropsychiatric-SLE (NP-SLE). (nih.gov)

NEUROPSYCHIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS Release Date: July 17, 2001 RFA: RFA-AR-01-007 National Institute of Arthritis and Musculoskeletal and Skin Diseases Letter of Intent Receipt Date: November 2, 2001 Application Receipt Date: December 14, 2001 THIS RFA USES "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. (nih.gov)

Systemic lupus erythematosus (SLE) is an autoimmune disease of diverse manifestations, with onset usually in young women in the third to fourth decade of life. (biomedcentral.com)
Late-onset systemic lupus erythematosus: a personal series of 47 patients and pooled analysis of 714 cases in the literature. (qxmd.com)
While the cause of the disease is not determined, environmental factors are believed to provoke the onset of lupus. (123essaywriting.com)

Clinically active serologically quiescent systemic lupus erythematosus. (jrheum.org)

Participants who are receiving background nonbiologic lupus SOC therapy will receive BIIB059 matching placebo, SC Q4W, up to Week 48 with an additional dose at Week 2. (clinicaltrials.gov)

Mouse models of SLE will be studied using brain imaging and other measurements to test antibody binding to the NR2 receptor as a possible pathway to the neurological symptoms some people with lupus experience. (nih.gov)

Neuropsychiatric symptoms can be particularly distressing for people with lupus and their families," said Stephen I. Katz, M.D., Ph.D., director of the NIAMS. (nih.gov)
All people with lupus need hydroxychloroquine and people with lupus that is continuing to cause damage (active lupus) also need corticosteroids and other drugs that suppress the immune system. (msdmanuals.com)
Most people with lupus have mild symptoms affecting mostly the skin and joints. (msdmanuals.com)

The disease is more common among women, as 9 of 10 patients with lupus are female. (123essaywriting.com)

Peripheral Nervous System Disease in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study. (ox.ac.uk)

Monocyte/macrophage, complement and selectin are involved in the development of meningitis induced by lupus serum. (bmj.com)
Severity of meningitis induced by lupus serum IgG was significantly reduced in TNF deficient mice compared to wild mice. (bmj.com)

Systemic lupus erythematosus (SLE, or lupus) is one of more than 80 autoimmune diseases identified by scientists. (nih.gov)
The most heterogeneous of the autoimmune diseases, lupus is also one of the most difficult to understand and treat. (nih.gov)

Lupus-prone mice spontaneously develop meningitis. (bmj.com)
Lupus-prone model mice subjected to sleep deprivation stress, exhibit abnormal neuronal growth. (genengnews.com)
Upon subjecting lupus-prone model mice to sleep deprivation to simulate stress, the researchers analyzed behavioral phenotypes, histopathology, and the expression of genes and proteins to assess neuroimmunological changes. (genengnews.com)
Sleep deprivation in lupus-prone mice, the authors observed, resulted in abnormal activation of the medial prefrontal cortex (mPFC) of the brain. (genengnews.com)
Blocking IL-12 and IL-23 pathways in these sleep-deprived mice models inhibited the stress-induced neuropsychiatric symptoms. (genengnews.com)

2,3 PCI has been described in the literature in association with various connective tissue diseases, including scleroderma, mixed connective tissue disease, Sjögren's disease and systemic lupus erythematosus. (the-rheumatologist.org)

Background Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease which can affect multiple organs. (uib.no)
In ancient times, lupus means a disease that eats away, bites and destroys the skin and various organs. (lupinepublishers.com)

Anatomy1

Diseases3

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Associated with systemic lupus erythem3

Manifestations of systemic6

Clinical15

British Isles Lupus Assessment Group3

Active systemic lupus erythem2

Autoantibodies in neuropsychiatric1

NPSLE7

International Collaborating Clinics3

Renal2

Diagnosis4

Involvement7

Antibodies9

20222

Disease activity4

Form of lupus3

Vasculitis1

Cutaneous2

Central Nervous Syst1

Aspects of lupus2

Etiology1

Retrospective1

Nephritis2

Rheumatoid4

Multi-systemic1

Chronic autoimmune disease3

Multiple sclerosis3

Antiphospholipid syndrome1

Childhood-onset2

Autoantibody1

Dysfunction5

Symptoms of lupus2

Classification3

Prevalence2

Mechanisms2

Affects3

Psychiatric1

Musculoskeletal1

Onset3

Quiescent1

Placebo1

Neurological1

People with lupus3

Patients with lupus1

Cohort study1

Serum2

Autoimmune diseases2

Mice5

Connective1

Organs2