AnatomyOrganismsPsychiatry and PsychologyPhenomena and ProcessesInformation Science
NeuropilArthropodsOptic Lobe, NonmammalianOlfactory PathwaysSense OrgansBrainMesopic VisionEncyclopedias as TopicRetinaPhotoreceptor Cells, VertebrateVision, OcularLightRetinal Cone Photoreceptor Cells
Neurofibrillary tanglesTangles and neuropil threadsOptic neuropilSynapticSynapsesMononuclearHippocampusAxonsNervousThreadsNerveBrainRegionsFormShowFoundVolumeRegionSmallerNeuronsDrosophilaCerebral cortexProtocerebralInterneuronsNeuronalTumorLobesOpticAbnormalSynapticNeocortexMushroomTerminatesAnteriorCompositionAnalyzeNervous systemDendriteCellStructureBodyAreaFunctionIslandsPresentDataWhiteSurfaceTypeSmallPositivePictureProvideDistribution
Neurofibrillary tangles4
  • The presentation and distribution of neurofibrillary tangles (NFT), neuropil thread‐like structures (T‐LS) and smaller structures (dots) in the spinal cord of two patients with progressive supranuclear palsy (PSP) is discussed. (elsevierpure.com)
  • They counted the number of tau-positive neurites (neuropil threads) or intrasomal neurofibrillary tangles per area, or took a measure of total tau load by tallying colored pixels on images of the stained tissue. (alzforum.org)
  • In early stages, CTE is characterized by the presence of abnormal deposits of a protein called tau in the form of neurofibrillary tangles, glial tangles and neuropil threads throughout the brain. (sciencedaily.com)
  • This sequence of events in cerebrospinal fluid (amyloid-β changes detectable prior to abnormal tau changes) contrasts with that in which both proteins develop in the brain, where intraneuronal tau inclusions (pretangles, neurofibrillary tangles, neuropil threads) appear decades before the deposition of amyloid-β plaques (diffuse plaques, neuritic plaques). (kb.se)
Tangles and neuropil threads1
  • The new study suggests that the total PET signal results from binding to both tangles and neuropil threads ( Braak and Braak, 1995 ). (alzforum.org)
Optic neuropil3
Synaptic3
  • Among these, the organization of neuropil tissue at micron scales is of particular importance since such organization has a direct potential to affect the formation of synaptic connectivity between nearby axons and dendrites, thus, serving as an important factor contributing to the brain's development and disorders. (yumishch.me)
  • In particular, presently it is not known what specific structures exist in neuropil at micron scales, what effect such structures have on synaptic connectivity, and what processes shape the neuropil's organization at micron scales. (yumishch.me)
  • Alternative polyadenylation and differential expression of Shank mRNAs in the synaptic neuropil. (mpg.de)
Synapses3
  • Relative concentrations could signify a reflection of different postsynaptic elements in the neuropil or show that axons sought out and formed synapses only with specific postsynaptic elements. (wikipedia.org)
  • To have an optimized neural system it must balance four variables-it must "minimize conduction delays in axons, passive cable attenuation in dendrites, and the length of 'wire' used to construct circuits" as well as "maximize the density of synapses", essentially optimizing the neuropil. (wikipedia.org)
  • The various gray matter brain regions contain a mass of synapses and nerve endings (called neuropils) that can change volume dynamically. (medicalxpress.com)
Mononuclear1
  • Microscopic examination revealed a diffuse mononuclear cell infiltrate with variable cell density infiltrating the neuropil rather than growing in sheets. (upmc.edu)
Hippocampus2
  • Mishchenko Y. (2016) "Application of the radial distribution function for quantitative analysis of neuropil microstructure in stratum radiatum of CA1 region in hippocampus. (yumishch.me)
  • 2011 ) Distribution of extracellular glutamate in the neuropil of hippocampus. (neurotree.org)
Axons3
  • Neuropil (or "neuropile") is any area in the nervous system composed of mostly unmyelinated axons, dendrites and glial cell processes that forms a synaptically dense region containing a relatively low number of cell bodies. (wikipedia.org)
  • White matter, which is mostly composed of myelinated axons (hence its white color) and glial cells, is generally not considered to be a part of the neuropil. (wikipedia.org)
  • A fine network of labeled axons was discovered within the MdRF,just dorsal for the IO (Figures F,G). Almost all of the terminal boutons were positioned in the neuropil,andwere not associated with counterstained somata. (signsin1dayinc.com)
Nervous1
  • Since neuropils have a diverse role in the nervous system, it is difficult to define a certain overarching function for all neuropils. (wikipedia.org)
Threads2
  • However, a precise distinction between detection of neuropil threads and tangles by flortaucipir in vivo is hard to make with the techniques at hand, Lowe wrote. (alzforum.org)
  • The assessment of progression in 7-microm-thick sections was based on assessment of IHC labeled HP-tau immunoreactive neuropil threads (NTs). (kb.se)
Nerve1
Brain4
  • The most prevalent anatomical region of neuropil is the brain which, although not completely composed of neuropil, does have the largest and highest synaptically concentrated areas of neuropil in the body. (wikipedia.org)
  • The formula predicted an optimal brain with 3/5 (60%) of its volume occupied by neuropil. (wikipedia.org)
  • While the organization of the brain at large and intermediate scales had been well studied, the microscopic organization of neuropil tissue remains largely unknown. (yumishch.me)
  • Note how the erythrocytes, or red blood cells (RBC), had leaked out of the luminal confines of the vessel, and into the surrounding brain neuropil. (cdc.gov)
Regions4
  • Neuropil has been found in the following regions: outer neocortex layer, barrel cortex, inner plexiform layer and outer plexiform layer, posterior pituitary, and glomeruli of the cerebellum. (wikipedia.org)
  • These are all found in humans, with the exception of the barrel cortex, but many species have counterparts similar to our own regions of neuropil. (wikipedia.org)
  • The concentrations of neuropil within certain regions are important to determine because simply using the proportions of the different postsynaptic elements does not verify the necessary, conclusive evidence. (wikipedia.org)
  • Conversely, mechanisms for temperature compensation in neuropil regions are relatively unexplored, despite the importance of dendritic signal propagation and summation for AP initiation. (jneurosci.org)
Form1
  • This malfunction presents itself in the form of helical filaments that tangle together in the neuropil. (wikipedia.org)
Show1
  • We use a novel statistical approach to analyze the small-scale organization of neuropil systematically and to show that such organization can be well understood in terms of disordered, random arrangement of axonal and dendritic processes without significant local order. (yumishch.me)
Found1
  • Moreover, this model is supported by postmortem studies that have found reduced neuropil without neuronal loss, in which decreased neuropil represents a loss of connections between neurons. (health.am)
Volume1
  • Researchers at Cold Spring Harbor Laboratory formulated the optimal balance of the four variables and calculated the optimal ratio of axon plus dendrite volume (i.e. the "wire" volume or neuropil volume) to total volume of grey matter. (wikipedia.org)
Region1
  • each "barrel" in the cortex is a region of neuropil where the input from a single whisker terminates. (wikipedia.org)
Smaller1
  • In this model, a reduction in the peripheral neuropil space would result in smaller minicolumns which would coalesce into discrete, isolated islands of coordinated excitatory activity. (autismone.org)
Neurons6
  • Axons of olfactory relay neurons leave the olfactory lobes to provide the olfactory globular tract (OGT, cyan) that terminates in the mushroom body calyces and more rostral neuropils of the lateral protocerebrum (LPR). (elifesciences.org)
  • The small rectangle denotes the origin of the column from the calyx, as shown in panel B. The larger rectangle corresponds to comparable lengths of columnar neuropil in panels B, E and F. ( E ) Anti-tyrosine hydroxylase (magenta) and anti-α-tubulin (cyan) immunolabelling reveals discrete synaptic domains of mushroom body output neurons (MBON) along the length of a column. (elifesciences.org)
  • Immunohistochemical analysis of ATP13A2 in Human brain, neurons and neuropils. (thermofisher.com)
  • main menu including the Get Started guide, Create/Load Tags, access to the list of visualized neurons/synapses and a list neuropils. (fruitflybrain.org)
  • 3D visualization of queried neurons/synapses and the underlying neuropils. (fruitflybrain.org)
  • To help navigating the visualized neuropils, neurons and synapses, the visualization panel provides a list of useful buttons for ease of interaction. (fruitflybrain.org)
Drosophila4
  • To assess this method's performance, we conducted calcium imaging of the neuropil of Drosophila larvae. (u-tokyo.ac.jp)
  • Origin and development of neuropil glia of the Drosophila larval and adult brain: Two distinct glial populations derived from separate progenitors. (nih.gov)
  • The Drosophila neuropil glia (NPG), subdivided into astrocyte-like (ALG) and ensheathing glia (EG), extend reticular processes which associate with synapses and sheath-like processes which surround neuropil compartments, respectively. (nih.gov)
  • In the mushroom bodies, the blue staining patterns have revealed axonal processes corresponding to Kenyon cells and showed that the Drosophila mushroom bodies are compound neuropils in which parallel subcomponents exhibit discrete patterns of gene expression. (gla.ac.uk)
Cerebral cortex2
  • Cerebral cortex with tau-reactive cellular inclusions and neuropil threads. (medscape.com)
  • The models are presently being expanded to provide a detailed picture of oxygen transport throughout the neuropil of cerebral cortex. (bcm.edu)
Protocerebral1
  • The latter is defined by the central body (CX), protocerebral bridge (PB), and associated neuropils located anterior to the deutocerebrum, which is denoted by its olfactory lobes (OL). (elifesciences.org)
Interneurons2
  • C1q, required for several of these complement-mediated activities, is present in the neuropil, microglia, and a subset of interneurons in the brain. (nih.gov)
  • E ) Functional cluster distribution of superficial interneurons (SINs) and neuropil interneurons (NINs), imaged in the elavl3:nls-GCaMP6s line (n = number of cells from three fish). (elifesciences.org)
Neuronal1
  • Neuronal loss in the substantia nigra with pigment-laden macrophages and neuromelanin pigment spilled into the neuropil background (pigment incontinence). (medscape.com)
Tumor7
  • 1. Glioneuronal tumor with neuropil-like islands. (nih.gov)
  • 2. Glioneuronal tumor with neuropil-like islands: a new entity. (nih.gov)
  • 3. Glioneuronal tumor with neuropil-like islands (GTNI): a report of 8 cases with chromosome 1p/19q deletion analysis. (nih.gov)
  • 6. Disseminated glioneuronal tumor with neuropil-like islands of the spinal cord: a distinctive entity. (nih.gov)
  • 7. Cytogenetic study of glioneuronal tumor with neuropil-like islands: a case report. (nih.gov)
  • 19. Spinal glioneuronal tumor with neuropil-like islands and meningeal dissemination: histopathological and radiological study of a pediatric case. (nih.gov)
  • There were small amounts of an eosinophilic matrix between the tumor cells in a central location, resembling neuropil. (upmc.edu)
Lobes1
  • A second prominent neuropil is the reniform body (RB), which like the columnar lobes is immunoreactive to anti-DC0. (elifesciences.org)
Optic1
  • The anterior protocerebrum, which receives the nerves of the eyes and other organs, contains centres, or neuropils , such as the optic centres and bodies known as corpora pedunculata. (britannica.com)
Abnormal1
  • and a type of abnormal dendrite structure known as neuropil threads. (nih.gov)
Synaptic2
  • In particular, presently it is not known what specific structures exist in neuropil at micron scales, what effect such structures have on synaptic connectivity, and what processes shape the neuropil's organization at micron scales. (yumishch.me)
  • Here, we propose a new method to decompose calcium imaging data of the neuropil into populations of bouton-like synaptic structures with a standard desktop computer. (u-tokyo.ac.jp)
Neocortex2
  • For example, the neocortex and olfactory bulb both contain neuropil. (wikipedia.org)
  • Neuropil has been found in the following regions: outer neocortex layer, barrel cortex, inner plexiform layer and outer plexiform layer, posterior pituitary, and glomeruli of the cerebellum. (wikipedia.org)
Mushroom1
  • This analysis uncovers age- and experience-dependent posteclosion mushroom body growth comparable to that in foraging Hymenoptera, but also identifies plasticity in several other neuropils. (cam.ac.uk)
Terminates1
  • each "barrel" in the cortex is a region of neuropil where the input from a single whisker terminates. (wikipedia.org)
Anterior1
  • The posterior tritocerebrum contains association neuropils for the second antennae (of crustaceans) and gives rise to nerves that innervate the mouthparts and the anterior digestive canal. (britannica.com)
Composition1
  • However, the degree of similarity depends upon the composition of neuropil being compared. (wikipedia.org)
Analyze2
  • We use a novel statistical approach to analyze the small-scale organization of neuropil systematically and to show that such organization can be well understood in terms of disordered, random arrangement of axonal and dendritic processes without significant local order. (yumishch.me)
  • The development of a methodology to analyze the calcium imaging data of a densely packed neuropil would provide us with new insights into the circuit dynamics. (u-tokyo.ac.jp)
Nervous system2
  • Since neuropils have a diverse role in the nervous system, it is difficult to define a certain overarching function for all neuropils. (wikipedia.org)
  • Revealing the spatiotemporal activity pattern within the neuropil would clarify how the information flows throughout the nervous system. (u-tokyo.ac.jp)
Dendrite1
  • Researchers at Cold Spring Harbor Laboratory formulated the optimal balance of the four variables and calculated the optimal ratio of axon plus dendrite volume (i.e. the "wire" volume or neuropil volume) to total volume of grey matter. (wikipedia.org)
Cell1
Structure1
  • We have therefore used various techniques to analyse the visual fibre pathways and the structure of their interrelated neuropils in several species. (uni-muenchen.de)
Body2
  • The most prevalent anatomical region of neuropil is the brain which, although not completely composed of neuropil, does have the largest and highest synaptically concentrated areas of neuropil in the body. (wikipedia.org)
  • We found that pycnogonid ocelli are innervated to first and second visual neuropils in close vicinity to an unpaired midline neuropil, i.e. possibly the arcuate body, in a way very similar to ancestral euarthropods like Euperipatoides rowelli (Onychophora) and Limulus polyphemus (Xiphosura). (uni-muenchen.de)
Area1
  • Is the Subject Area "Neuropil" applicable to this article? (plos.org)
Function1
  • Mishchenko Y. (2016) "Application of the radial distribution function for quantitative analysis of neuropil microstructure in stratum radiatum of CA1 region in hippocampus. (yumishch.me)
Islands1
  • Synaptophysin (38 kD, Dako) was conspicuously positive in the neuropil islands in a fine granular distribution (Image 04 ). (upmc.edu)
Present1
  • The present work performs an analysis of recent complete electron microscopy reconstructions of blocks of hippocampal CA1 neuropil tissue in rat to produce answers to these questions. (yumishch.me)
Data1
White1
  • A striking feature was the perpendicular arrangement of the neuropil columns extending from the pial surface to white matter similar to those seen in supratentorial examples. (utmb.edu)
Surface1
  • These precursors undergo a characteristic migration to spread over the neuropil surface while specifying/differentiating into primary ALG and EG. (nih.gov)
Type1
  • Neuropil glia of the adult (secondary NPG) are derived from type II lineages during the postembryonic phase of neurogliogenesis. (nih.gov)
Small1
Positive1
  • The neuropil was synaptophysin-positive and focally positive for MAP-2 and GFAP as well. (utmb.edu)
Picture1
  • A picture of a C. elegans neuropil stained with a fluorescent dye to visualize it in a living embryo. (nih.gov)
Provide1
  • These results demonstrate that neuropil calcium imaging and its decomposition could provide new insight into our understanding of neural processing. (u-tokyo.ac.jp)
Distribution1