Cerebellar granuleRegulateGenesProgenitorGene expressionTranscriptionalRetinalNuclear factorTemporalNFIANeurogenesisPeripheralRegulatesFunctionalNFIXVitroDevelopmentCellsRetinal neurons lostSpliceNuclearProteinsSpecificationAbstractInteractGene transcriptionReplicationExpressionActivationHumanMajorControlRole
Cerebellar granule1
- Nuclear Factor One (NFI) transcription factors regulate temporal gene expression required for dendritogenesis and synaptogenesis via delayed occupancy of target promoters in developing cerebellar granule neurons (CGNs). (umassmed.edu)
Regulate3
- We confirm that NFI transcription factors selectively activate expression of genes promoting late-stage temporal identity in primary retinal progenitors and identify other transcription factors that regulate rod photoreceptor specification in postnatal retina. (wustl.edu)
- In embryonic cells, Nfix has been shown to regulate intermediate progenitor cell (IPC) generation by promoting the transcription of the protein inscuteable (INSC). (wikipedia.org)
- We show that astrocyte maturation is promoted by extrinsic signals that induce multiple transcription factors that act largely independently to regulate distinct gene expression modules that together promote a mature astrocytic phenotype. (nature.com)
Genes7
- In this study, we use integrated single-cell RNA and single-cell ATAC sequencing (scATAC-seq) analysis in developing mouse and human retina to identify multiple interconnected, evolutionarily conserved GRNs composed of cell-type-specific transcription factors that both activate genes within their own network and inhibit genes in other networks. (wustl.edu)
- We show here that the transcription factor ETV1 directly binds to and is required for expression and NFI occupancy of a cohort of NFI-dependent genes in CGNs maturing in vivo. (umassmed.edu)
- Expression of ETV1 is low in early postnatal cerebellum and increases with maturation, mirroring NFI temporal occupancy of coregulated target genes. (umassmed.edu)
- Precocious expression of ETV1 in mouse CGNs accelerated onset of expression and NFI temporal occupancy of late target genes and enhanced Map2(+) neurite outgrowth. (umassmed.edu)
- ETV1 also activated expression and NFI occupancy of the Etv1 gene itself, and this autoregulatory loop preceded ETV1 binding and activation of other coregulated target genes in vivo. (umassmed.edu)
- These findings suggest a potential model in which ETV1 activates NFI temporal binding to a subset of late-expressed genes in a stepwise manner by initial positive feedback regulation of the Etv1 gene itself followed by activation of downstream coregulated targets as ETV1 expression increases. (umassmed.edu)
- Investigating astrocyte maturation in a cell culture model revealed that in vitro-differentiated astrocytes lack expression of many mature astrocyte-specific genes, including genes for the transcription factors Rorb, Dbx2, Lhx2 and Fezf2. (nature.com)
Progenitor1
- Summary Mammalian neural stem/progenitor cells (NSPCs) sequentially generate neurons and glia during CNS development. (prinsesmaximacentrum.nl)
Gene expression1
- Sequential transcription factor autoregulation and subsequent binding to downstream promoters may provide an intrinsic developmental timer for dendrite/synapse gene expression. (umassmed.edu)
Transcriptional1
- Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A". Biochemical and Biophysical Research Communications. (wikipedia.org)
Retinal1
Nuclear factor7
- The transcription factors nuclear factor I (NFI) A and B, essential regulators of the initiation of gliogenesis, were found to be targets of miR-153. (prinsesmaximacentrum.nl)
- Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. (wikipedia.org)
- Nuclear factor 1 A-type is a protein that in humans is encoded by the NFIA gene. (wikipedia.org)
- Nuclear factor I (NFI) proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity. (wikipedia.org)
- Entrez Gene: NFIA nuclear factor I/A". Leahy P, Crawford DR, Grossman G, Gronostajski RM, Hanson RW (March 1999). (wikipedia.org)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Nuclear Factor I/X (NFIX) in Tissue homogenates and other biological fluids. (operatiebrp.nl)
- Description: A sandwich quantitative ELISA assay kit for detection of Human Nuclear Factor I/X (NFIX) in samples from tissue homogenates or other biological fluids. (operatiebrp.nl)
Temporal1
- Mechanisms that promote NFI temporal occupancy have not been previously defined. (umassmed.edu)
NFIA1
- This study demonstrates that miR-153 controls the timing of the acquisition of gliogenic competence via direct repression of the gliogenic transcription factors NFIA and NFIB. (prinsesmaximacentrum.nl)
Neurogenesis2
- Gene regulatory networks (GRNs), consisting of transcription factors and their target sites, control neurogenesis and cell-fate specification in the developing central nervous system. (wustl.edu)
- The clinical use of tricyclic antidepressants (TCAs) or serotonin-selective reuptake inhibitors (SSRIs) is targeted at specific neurons and ignores the microenvironment of neurogenesis. (frontiersin.org)
Peripheral1
- Silent neuropathy: existence of NFI without symptoms like peripheral nerve discomfort or thickening. (researchensemble.com)
Regulates1
- NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40 in astrocytes. (wikipedia.org)
Functional1
- The presence of neurotransmitter receptors in microglia illustrates their functional connection to neurons and this receptor activation could cause microglial cells to perform different activation phenotypes ( Pocock and Kettenmann, 2007 ). (frontiersin.org)
NFIX2
- Nfix may suppress oligodendrocyte expression so cells remain committed to neuron development within the dentate gyrus. (wikipedia.org)
- Neurons produced by Nfix null IPC's do not mature, usually die, and can contribute to cognitive impairments. (wikipedia.org)
Vitro1
- Forced expression of these factors in vitro induces distinct sets of mature astrocyte-specific transcripts. (nature.com)
Development1
- Mutations may cause overproduction of radial glia, impaired and improperly timed IPC development, and underproduction of neurons. (wikipedia.org)
Cells1
- Under stress, microglial cells are induced into the M1 type, releasing inflammatory factors and causing neuroinflammatory responses. (frontiersin.org)
Retinal neurons lost2
- This study inventories cis- and trans-acting factors that control retinal development and can guide cell-based therapies aimed at replacing retinal neurons lost to disease. (wustl.edu)
- These findings may aid in designing therapies to restore retinal neurons lost to degenerative diseases. (johnshopkins.edu)
Splice1
- NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40 in astrocytes. (wikipedia.org)
Nuclear7
- Disruption of nuclear factor I transcription factors, which maintain and restore quiescence, induces Müller glia to proliferate and generate neurons in adult mice after injury. (johnshopkins.edu)
- Nuclear Factor I (NFI) transcription factors play a crucial role in neuronal development and are important for the life cycle of viruses including JC virus (JCV). (nih.gov)
- Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. (wikipedia.org)
- Nuclear factor 1 A-type is a protein that in humans is encoded by the NFIA gene. (wikipedia.org)
- Nuclear factor I (NFI) proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity. (wikipedia.org)
- Entrez Gene: NFIA nuclear factor I/A". Leahy P, Crawford DR, Grossman G, Gronostajski RM, Hanson RW (March 1999). (wikipedia.org)
- En otros palabras, descubrimos que en en las plantas, la elongación de la transcripción es más rápida de día que de noche, lo cual explica el mecanismo nuclear del control del splicing alternativo por la luz. (uba.ar)
Proteins2
- Among the proteins found to interact with NFI family members are multiple variants of histones H1 and H2A, proteins involved in chromatin remodeling and DNA repair including members of the TIP60 complex, and components of ribosomes. (nih.gov)
- Further investigation of NFI proteins and their interacting partners may offer targets for future PML therapies. (nih.gov)
Specification1
- Gene regulatory networks (GRNs), consisting of transcription factors and their target sites, control neurogenesis and cell-fate specification in the developing central nervous system. (wustl.edu)
Abstract1
- abstract = "Injury induces retinal M{\"u}ller glia of certain cold-blooded vertebrates, but not those of mammals, to regenerate neurons. (johnshopkins.edu)
Interact1
- NFI-X3 has been shown to interact with STAT3. (wikipedia.org)
Gene transcription1
- 17. Nerve growth factor- and epidermal growth factor-regulated gene transcription in PC12 pheochromocytoma and INS-1 insulinoma cells. (nih.gov)
Replication1
- They function as cellular transcription factors and as replication factors for adenovirus DNA replication. (wikipedia.org)
Expression4
- 3. Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1. (nih.gov)
- 4. Neuron-specific expression of the synapsin II gene is directed by a specific core promoter and upstream regulatory elements. (nih.gov)
- 5. Neuron-specific gene expression of synapsin I. Major role of a negative regulatory mechanism. (nih.gov)
- 19. Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors. (nih.gov)
Human1
- 12. Characterization of tissue-specific transcription by the human synapsin I gene promoter. (nih.gov)
Major1
- 14. Identification of a large bent DNA domain and binding sites for serum response factor adjacent to the NFI repeat cluster and enhancer region in the major IE94 promoter from simian cytomegalovirus. (nih.gov)
Control1
- Estamos llevando a cabo un estudio sistemático para identificar en el genoma humano sitios blanco de AGO1 con un rol en el control del splicing alternativo por siRNAs. (uba.ar)