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  • dopaminergic neurons
  • FDOPA is diagnostic PET agent, which has been used for decades in imaging the loss of dopaminergic neurons in Parkinson's disease, and more recently to detect, stage and restage neuroendocrine tumours and to search for recurrence of viable glioma tissue. (scielo.br)
  • Here we show in human SH-SY5Y cells, in dopaminergic neurons, and in wild-type mice that l -dopa results in a reduced SAM/SAH ratio that is associated with hypomethylation of PP2A and increased phosphorylation of Tau (p-Tau) at the Alzheimer's disease-like PHF-1 phospho-epitope. (jneurosci.org)
  • several
  • Recently, the clinical usefulness of fluoroDOPA-(18F) or FDOPA, an aminoacid labelled with the same positron emitter fluorine-18, has been evaluated and recognised in France and subsequently in several EU countries. (scielo.br)
  • cell
  • The neurotransmitter diffuses across the synapse to the membrane of the neighboring cell and activates ion channels that open transmembrane pores, initiating an electrical signal that will travel along the postsynaptic neuron. (hhmi.org)