Neurons genes mef2 transcription factors. Medical search. Frequent questions

We show that myocyte enhancer factor 2 (MEF2) transcription factors suppressed excitatory synapse number in a neuronal activity- and calcineurin-dependent manner as hippocampal neurons formed synapses. (elsevierpure.com)
We have characterized a model of synapse elimination in CA1 neurons of organotypic hippocampal slice cultures that is induced by expression of the active transcription factor Myocyte Enhancer Factor 2 (MEF2) and relies on postsynaptic FMRP. (bvsalud.org)

We demonstrate that the GTPase Rem2 is regulated at the transcriptional level by calcium influx through L-VGCCs and inhibits dendritic arborization in cultured rat cortical neurons and in the Xenopus laevis tadpole visual system. (jneurosci.org)
Fragile X Messenger Ribonucleoprotein (FMRP) is necessary for experience-dependent, developmental synapse elimination and the loss of this process may underlie the excess dendritic spines and hyperconnectivity of cortical neurons in Fragile X Syndrome, a common inherited form of intellectual disability and autism. (bvsalud.org)

Myocyte enhancer binding factor 2B (MEF2B) is a transcription factor part of the MEF2 gene family including MEF2A, MEF2C, and MEF2D. (wikipedia.org)

Fiore R, Khudayberdiev S, Christensen M, Siegel G, Flavell SW , Kim TK , Greenberg ME , Schratt G. Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. (neurotree.org)
Our results suggest a model where MEF2 regulates posttranslational modifications of FMRP via APC/Cdh1 to regulate translation of proteins necessary for synapse elimination. (bvsalud.org)

In response to increased neuronal activity, calcium influx into neurons induced the activation of the calcium/calmodulin-regulated phosphatase calcineurin, which dephosphorylated and activated MEF2. (elsevierpure.com)
Emerging themes in neuronal activity-dependent gene expression. (neurotree.org)
Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. (neurotree.org)
Widespread transcription at neuronal activity-regulated enhancers. (neurotree.org)
Overexpression of ClpP reduces αSyn-induced mitochondrial oxidative stress through enhancing the level of Superoxide Dismutase-2 (SOD2), and suppresses the accumulation of αSyn S129 phosphorylation and promotes neuronal morphology in neurons derived from PD patient iPS cells carrying αSyn A53T mutant. (springer.com)

MEF2B is directly involved in smooth muscle myosin heavy chain (SMHC) gene regulation. (wikipedia.org)
To better understand these mechanisms involved in gene regulation, we pursue two questions: 1) what are the roles of the chromatin remodeler CHD7 in cerebellar development and 2) what are the roles of the MEF2 TF family in cerebellar function. (wustl.edu)
Thus, TFs also play a vital role in proper gene regulation. (wustl.edu)
Finally, motor activity induces a switch from non-compensatory to compensatory MEF2-dependent gene regulation. (wustl.edu)
Regulation of gene expression plays a central role in embryonic development. (biomedcentral.com)

The latter part of this dissertation will address the roles of paralogous transcription factors, MEF2A and MEF2D, and their roles in cerebellar function. (wustl.edu)

The long-term effects of cocaine on behavior are accompanied by structural changes in excitatory glutamatergic synapses onto the medium spiny neurons of the striatum. (biomedcentral.com)

A key feature of the CNS is structural plasticity, the ability of neurons to alter their morphology and connectivity in response to sensory experience and other changes in the environment. (jneurosci.org)

MEF2A and MEF2D are highly expressed in cerebellar granule cells, the most abundant neuron in the brain. (wustl.edu)
Using single and double conditional knockout of MEF2 family TFs, we find that MEF2A and MEF2D play functionally redundant roles in cerebellar-dependent motor learning. (wustl.edu)
Importantly, sites experiencing compensatory MEF2A occupancy are concentrated within open chromatin and undergo functional compensation for genomic activation and gene expression. (wustl.edu)

Purkinje neurons are among the largest in the brain, with elaborate dendritic arbor. (epiphanyasd.com)
Each type of neuron in the mammalian CNS has a distinctive dendritic arbor that is typically extensively branched, and that instructs the specific function of the neuron in part by ensuring that the proper synaptic connections are formed ( Elston, 2000 ). (jneurosci.org)

Despite the expression of multiple Rho GDP/GTP exchange factors (GEFs) in the nervous system, the Kalrn gene, which encodes multiple isoforms of Kalirin, plays an essential, non-redundant role. (biomedcentral.com)
This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. (en-academic.com)
1992). "A conserved retina-specific gene encodes a basic motif/leucine zipper domain" . (en-academic.com)

Genes, Brain and Behavior. (nebraska.edu)

However, MEF2B is distant from the other three branches of MEF2 genes as it lacks the protein-coding Holliday junction recognition protein C-terminal (HJURP_C) region in vertebrates. (wikipedia.org)
In most single gene autisms (Rett, Fragile-X, Pitt Hopkins etc) the underlying problem is that a faulty gene does not do its job of producing the expected protein. (epiphanyasd.com)
For example, in Timothy Syndrome the mutation in the gene produces too much of the protein, in this case the L-type calcium channel Cav1.2. (epiphanyasd.com)
These molecular signatures were supported by analysis of oxidative phosphorylation protein complex expression in mouse brain and assays of mitochondrial function in engineered cell lines, which revealed a lack of metabolic flexibility and a contribution of the 3q29 gene PAK2. (bvsalud.org)
Here, we show that the protein level of ClpP is selectively decreased in αSyn-expressing cell culture and neurons derived from iPS cells of PD patient carrying αSyn A53T mutant, and in dopaminergic (DA) neurons of αSyn A53T mice and PD patient postmortem brains. (springer.com)
Protein-coding genes are shown in blue with the different shades further indicating direction of transcription. (flybase.org)
Non-protein-coding genes are shown in red, tRNA genes in purple and pseudogenes in pink. (flybase.org)
For protein-coding genes, coding regions are shown in orange and untranslated regions in gray. (flybase.org)
Neural retina-specific leucine zipper protein is a protein that in humans is encoded by the NRL gene . (en-academic.com)

Although both TFs are highly expressed in granule neurons, transcriptomic analyses show MEF2D is the predominant genomic regulator of gene expression in vivo. (wustl.edu)

Precise control of gene expression is essential for neural development and function. (wustl.edu)

This control is regulated by the interplay of chromatin remodelers and transcription factors (TFs). (wustl.edu)
The recruitment of chromatin remodelers to specific regions is accomplished by multiple factors including transcription factors. (wustl.edu)
These studies have set the basis for understanding how TFs and chromatin remodelers control gene expression. (wustl.edu)
The major event of MBT was the activation of a large group of histones and other genes that modify chromatin structure preceding massive gene expression changes. (biomedcentral.com)

The 1.6-megabase deletion at chromosome 3q29 (3q29Del) is the strongest identified genetic risk factor for schizophrenia, but the effects of this variant on neurodevelopment are not well understood. (bvsalud.org)

We find that MBNL forms motile and anchored granules in neurons and myoblasts, and selectively associates with kinesins Kif1bα and Kif1c through its zinc finger (ZnF) domains. (bvsalud.org)

Recurrent mutations in this gene have been associated with cases of diffuse large B-cell lymphoma. (wikipedia.org)
Mutations of MEF2B enhance its transcriptional activity due to either a disruption with its corepressor CABIN1 or causing the gene to become insensitive to inhibitory signaling events. (wikipedia.org)
Multiple mutations affecting embryonic development have been induced by chemical and insertional mutagenesis resulting in the identification of genes with important roles in development in Drosophila [ 23 - 25 ]. (biomedcentral.com)
Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. (en-academic.com)

Maternal to zygotic transition (MZT) is the key event during embryogenesis marked by the switch of control from the maternal and possibly paternal transcripts to the newly synthesized embryonic gene products [ 9 - 11 ]. (biomedcentral.com)

Using a bimolecular ubiquitin-mediated fluorescence complementation (UbFC) assay, we demonstrate that MEF2 promotes ubiquitination of FMRP in CA1 neurons that relies on activity and interaction with APC/Cdh1. (bvsalud.org)

New Molecular Insights into the Excitation-Transcription Coupling. (neurotree.org)

Additionally, we show that CHD7 reduces accessibility of enhancers with corresponding reduction in enhancer activity and proximal gene expression. (wustl.edu)

RNA binding proteins (RBPs) act as critical facilitators of spatially regulated gene expression. (bvsalud.org)
Transcriptomic analyses provide an efficient approach to explore the temporal gene expression profiles in embryos and to search for the developmental regulators. (biomedcentral.com)
Early ontogeny is associated with dramatic gene expression changes that underlie and determine the developmental processes. (biomedcentral.com)
These were correlated with gene expression, which was measured by RNA-tag profiling. (flybase.org)

these multidomain guanine nucleotide exchange factors (GEFs) contain additional domains known to interact with phosphatidylinositides as well as with a number of different proteins. (biomedcentral.com)
CUX1 isoforms are transcription factors, whereas CASP are Golgi proteins that share with CUX1 the N-terminal region but not the DNA binding motifs [ 2 ]. (nature.com)
A hallmark of events observed during segmentation was the induction of multiple transcription factors, including a large group of homeobox proteins in pace with decay of a large fraction of maternal transcripts. (biomedcentral.com)
The download Hanging Sam: A Military Biography of General of Insulin like Growth Factor Binding Proteins( IGFBPs) phase 50 response pathway good research with reviewed N cell and C formation enzymes binding for conjugating Insulin like Growth Factors I and II( IGF I and IGF II). (evakoch.com)

p200 CUX1 acts as a transcriptional repressor, whereas short CUX1 isoforms can activate or suppress transcription [ 1 , 3 ]. (nature.com)
Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. (thermofisher.com)

Upon assessing transcriptomic and epigenomic functions of CHD7, we find CHD7 to regulate gene programs implicated in human disorders of brain folding. (wustl.edu)

For each annotated gene, all transcripts are shown with the complete intron/exon structure (exons indicated by wider bars, introns by black lines). (flybase.org)

Collectively, our studies on CHD7 and MEF2 provide further understanding of the roles of two critical classes of gene regulators in cerebellar development and function. (wustl.edu)

In this syndrome Nav1.8 is over expressed as a downstream consequence of a mutation in the TCF4 gene. (epiphanyasd.com)
Gene span''' Shows the extent of all annotated gene models with direction of transcription indicated by a small arrow at the downstream edge. (flybase.org)
RNA''' Like the Gene:transcript view track, this track shows the complete intron/exon structure (exons indicated by wider bars, introns by black lines) of each annotated transcript with direction of transcription indicated by a small arrow at the downstream edge. (flybase.org)

HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors. (neurotree.org)

The MEF2 gene family is expressed in muscle-specific gene activation and maintenance during development. (wikipedia.org)

CN has a number of targets but its most prominent are the NFAT (nuclear factor of activated T cells) transcription factors. (pancreapedia.org)

2009. Gene Profiling of Human Adipose Tissue During Evoked Inflammation In Vivo . (umd.edu)

MEF2-induced synapse elimination is deficient in Fmr1 KO CA1 neurons, and is rescued by acute (24 h), postsynaptic and cell autonomous reexpression of FMRP in CA1 neurons. (bvsalud.org)
Numerous genes transcribed in oocytes are involved in multiple aspects of cell maintenance and protection, including metabolism, signal perception and transduction, RNA processing, cell cycle, defense against pathogens and DNA damage. (biomedcentral.com)
Enthesis development has historically been studied with lineage tracing of individual genes selected a priori, which does not allow for the determination of single-cell landscapes yielding mature cell types and tissues. (elifesciences.org)

Development Genes and Evolution. (wikipedia.org)
Genes & Development. (wikipedia.org)
2011. Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and FailureClinical Perspective . (umd.edu)

Most known CUX1 functions derive from studies on cancer cells, where the gene can act as an oncogene or a haploinsufficient tumor suppressor gene [ 12 ]. (nature.com)

1( small) neurons that live region fusions have consumed restricted. (evakoch.com)

Furthermore, transcription factors can bind accessible regions and recruit other factors important for transcription to occur. (wustl.edu)

Anatomy30

Organisms13

Diseases2

Chemicals and Drugs119

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes65

Disciplines and Occupations2

Information Science3

Enhancer factor2

Cortical neurons2

Myocyte enhancer1

Regulates2

Neuronal5

Regulation5

Paralogous1

Synapses1

Morphology1

MEF2A3

Dendritic2

Encodes3

Behavior1

Protein9

MEF2D1

Neural1

Chromatin4

Risk factor for schizophrenia1

Selectively1

Mutations4

Embryonic1

Promotes1

Molecular1

Enhancers1

Expression4

Proteins4

Isoforms2

Brain1

Transcripts1

Roles1

Downstream3

Regulate1

Activation1

Nuclear1

Human1

Cell3

Development3

Cells1

Region1

Important1