Neurons caenorhabditis elegans proteins. Medical search. Frequent questions

Alternative splicing is the primary mechanism by which a limited number of protein-coding genes can generate proteome diversity. (biologists.com)
As the genomes of different organisms are sequenced and annotated it is becoming apparent that the complexity of an organism does not depend on the total number of protein-coding genes. (biologists.com)
Rhombotin 1 (RBTN1 or TTG-1) and rhombotin-2 (RBTN2 or TTG-2) are proteins of about 160 amino acids whose genes are disrupted by chromosomal translocations in T-cell leukemia. (embl.de)
Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. (nih.gov)
Two of these genes code for proteins that form curli, one type of bacterial amyloid fibers. (hku.hk)
Signals from TGF-beta superfamily receptors are transduced to the nucleus by Smad proteins, which transcriptionally activate target genes. (wikigenes.org)
Mutations that alter egg-laying frequency have identified genes encoding a number of signaling proteins that act with Gα o , but the receptors that activate Gα o remain mostly uncharacterized. (elsevierpure.com)
The authors identify 12 genes that code for RNA-binding proteins important for dendrite development. (genestogenomes.org)
By purifying and analysing mitochondria from different cell types, we show that PINK-1 and PDR-1 are required to set heteroplasmy differences between major somatic tissue groups in C. elegans and that removal of these genes equalises ΔmtDNA heteroplasmy across the organism. (biorxiv.org)

a protein required for the differentiation of the set of six touch receptor neurons in this nematode. (embl.de)
We leveraged Caenorhabditis elegans ' touch receptor neurons as a simple model amenable to in vivo whole-cell patch-clamp recording and an integrated experimental-computational approach to dissect the mechanisms underlying the spatial and temporal dynamics we observed. (nih.gov)
This paper claims to identify a long-sought ligand for the receptor protein tyrosine phosphatase Lar that mediates its functions in neuromuscular junction development, mushroom body development, and photoreceptor axon targeting. (sciety.org)
Receptor-like protein-tyrosine phosphatases (RPTPs) have cytoplasmic phosphatase domains and cell adhesion molecule (CAM)-like extracellular domains that interact with cell-surface ligands and/or co-receptors. (sciety.org)
use an assay in which alkaline phosphatase-tagged cell surface proteins are used to stain live embryos overexpressing other cell surface proteins to identify Sticks and stones (Sns) as a possible ligand for the Lar receptor protein tyrosine phosphatase. (sciety.org)
To further analyze Gα o signaling, we cloned the egl-47 gene, which was identified by two dominant mutations that severely inhibit egg laying, egl-47 encodes two orphan G-protein-coupled receptor isoforms, which share all seven transmembrane domains but have different extracellular N termini. (elsevierpure.com)
Moresco, JJ & Koelle, MR 2004, ' Activation of EGL-47, a Gα o -coupled receptor, inhibits function of hermaphrodite-specific motor neurons to regulate Caenorhabditis elegans egg-laying behavior ', Journal of Neuroscience , vol. 24, no. 39, pp. 8522-8530. (elsevierpure.com)
Firstly, the research team has identified a C. elegans gene (named NHR -69), which acts as a testosterone receptor. (uco.es)

The process of IFT has been best characterized in the biflagellate alga Chlamydomonas reinhardtii as well as the sensory cilia of the nematode Caenorhabditis elegans. (wikipedia.org)
Here, we found that UPRMT activation in four astrocyte-like glial cells in the nematode, Caenorhabditis elegans, can promote protein homeostasis by alleviating protein aggregation in neurons. (bvsalud.org)
In their publication "In-planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation" in Nature Aging , they showed that a synthetic enzyme derived from plants -stromal processing peptidase (SPP)-reduces the clumping of proteins responsible for the pathological changes in models of Huntington's disease in human cells and the nematode Caenorhabditis elegans. (phys.org)

A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function. (nih.gov)
This molecule regulates the genetic program of olfactory neurons and, afterwards, degradation processes in the digestive tract. (medindia.net)
Our results suggest that EGL-47 regulates egg laying by activating Gα o in the HSN motor neurons to inhibit their activity. (elsevierpure.com)

Mammalian LH-2, a transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types. (embl.de)

Here, we show that C. elegans males exhibit an altered, male-specific expression pattern of daf-7 in the ASJ sensory neuron pair with the onset of reproductive maturity, which functions to promote male-specific mate-searching behavior. (elifesciences.org)
performed a candidate genetic screen for RNA-binding proteins that regulate dendrite morphogenesis in the multidendritic PVD sensory neuron (green) in Caenorhabditis elegans. (genestogenomes.org)

PICK1 is a peripheral membrane protein conserved from Caenorhabditis elegans to the human. (karger.com)
The PDZ domain of PICK1 binds to a large number of membrane proteins, especially proteins with C-terminal type II PDZ-binding motifs. (karger.com)
With its PDZ domain interacting with membrane proteins and its BAR domain binding to lipids, the unique structure of PICK1 enables it to couple membrane proteins to protein-trafficking machinery. (karger.com)
In neurons, the ER extends all through all mobile processes, forming a number of contacts with the plasma membrane (PM) to fine-tune neuronal physiology. (aabioetica.org)
Lysosomal membrane proteins and proteins that interact with lysosomes (stably or transiently) can be accurately quantified in this method with excellent intracellular spatial resolution in live human neurons. (jove.com)
membrane-resident proteins typically stay in the endoplasmic reticulum (ER) until accessory subunits are available, and may undergo selective degradation when they are not. (jneurosci.org)
SCs were seeded based on backbone atoms from each run of a neuron either does or does not communicate its continuous membrane potential directly because it can provide http://bookcollaborative.com/can-i-get-pristiq-over-the-counter/ insight into pristiq price without insurance other biologically-plausible, spiking learning models. (mister-finch.com)

Neuronal homeodomain-interacting protein kinase (HPK-1) extends longevity and promotes healthspan. (elifesciences.org)
Predicted to enable protein kinase regulator activity. (wormbase.org)
Among them, the sirtuin, AMP-activated protein kinase, mammalian target of rapamycin, p53, and insulin/insulin-like growth factor-1 signaling pathways are most widely studied. (frontiersin.org)
We found that the conserved PTEN-induced putative kinase (PINK1/PINK-1) and the E3 ubiquitin-protein ligase parkin (PDR-1), which are required for mitochondrial autophagy (mitophagy), underlie stereotyped differences in heteroplasmy of a deleterious mitochondrial genome mutation (ΔmtDNA) between major somatic tissues types in Caenorhabditis elegans . (biorxiv.org)

Lar is expressed in larval and pupal Kenyon cells, but Sns is not, so Lar-Sns interactions in this system must be in trans (between neurons). (sciety.org)
Caenorhabditis elegans displays sleep-like quiescence of locomotion and feeding during a larval transition stage called lethargus and feeds during active larval and adult stages. (korea.ac.kr)
Through the large-scale isolation of neurons from the first larval stage of Caenorhabditis elegans, C. elegans neuronal circRNA profile was analyzed for the first time by RNA sequencing of the whole-transcriptome. (oist.jp)

Hilbert and Kim showed that the biological sex in combination with multiple other inputs - including the animal's past diet and age - regulate how the DAF-7 signal is expressed in C. elegans . (elifesciences.org)
Different classes of RNA granules share some protein components and may use similar mechanisms to regulate mRNA translation/decay. (rupress.org)
Importantly, orthologs of these proteins have previously been implicated in dendrite development in Drosophila, and human orthologs are expressed in the brain, suggesting that they may regulate dendrites in humans as well. (genestogenomes.org)
Thirteen RNA binding proteins were screened as trans elements that regulate the formation of circRNAs in C. elegans. (oist.jp)

Lar and Sns reporters are both expressed in motor neurons and not in muscles, so Lar and Sns likely act in cis (in the same neurons). (sciety.org)

neurons experiencing mitochondrial stress can coordinate the induction of protective cellular pathways, such as the mitochondrial unfolded protein response (UPRMT), between tissues. (bvsalud.org)
We demonstrate that tissues prone to accumulating ΔmtDNA have lower mitophagy responses than those with low mutation levels, such as neurons. (biorxiv.org)
Heteroplasmy differences between tissues have also been observed in C. elegans . (biorxiv.org)

It has been suggested based on localization studies that IFT proteins also function outside of cilia. (wikipedia.org)
A full-length functional DAF-3/GFP fusion protein is predominantly cytoplasmic, and this localization is independent of activity of the upstream TGF-beta-related pathway. (wikigenes.org)
More precisely, I have been focusing on cellular localization and sequestration of RNAs and proteins in so-called "RNA granules" that include stress granules, processing bodies (P-bodies), and perinuclear granules (P-granules). (umaine.edu)
The researchers used CRISPR to endogenously fluorescently label subunit proteins to visualize the localization of CaV2 channel subunits in vivo and made various mutations. (jneurosci.org)
The results showed that UNC-2 trafficking to the presynaptic terminal did not require the CCB-1 and UNC-36 subunits, but that those proteins were needed for stable synaptic localization and structural integrity. (jneurosci.org)

The researchers then showed that bacterial curli enters the neurons to cross-seed the human amyloid α-synuclein and promote its aggregation, which leads to proteotoxicity, mitochondrial dysfunction, and neuronal death. (hku.hk)

Molecular genetic analysis of the switch-like regulation of daf-7 expression in the ASJ neuron pair reveals a hierarchy of regulation among multiple inputs-sex, age, nutritional status, and microbial environment-which function in the modulation of behavior. (elifesciences.org)
It is also possible to analyze the underlying factors that contribute to behavior in C. elegans , because it has a relatively simple and well-defined nervous system. (elifesciences.org)
These inputs all converge onto a single pair of sensory neurons, which integrate the inputs and enable the worm to assess its current and past experiences and alter its behavior accordingly. (elifesciences.org)
Caenorhabditis elegans egg-laying behavior is inhibited by neurotransmitter signaling through the neural G-protein Gα o and serves as a model for analyzing Gα o signaling. (elsevierpure.com)
A team of scientists from the city of Cordoba has studied the effect of testosterone on behavior of the worm Caenorhabditis elegans, with the aim to analyze at the molecular level the interaction between the male hormone and the nervous system. (uco.es)
The research study, entitled "Epigenetic effect of testosterone in the behavior of C. elegans. (uco.es)
The research group Genetics and Behavioral Disorders from the Maimonides Institute for Biomedical Research (IMIBIC) and the University of Cordoba has analyzed the effects of testosterone on the behavior of the nematode ("worm") Caenorhabditis elegans. (uco.es)
This research study, published in the journal Frontiers in Cellular Neuroscience as "Epigenetic effect of testosterone in the behavior of C. elegans. (uco.es)

Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. (nih.gov)
Cytoplasmic RNA granules in germ cells (polar and germinal granules), somatic cells (stress granules and processing bodies), and neurons (neuronal granules) have emerged as important players in the posttranscriptional regulation of gene expression. (rupress.org)
Jerome Goudeau team published a paper entitled "Addendum: A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage" using our strain PHX798 gld-1(syb798) . (sunybiotech.com)

The main advantage of this worm is its simplicity: its body is about one millimeter, it has 302 neurons and 959 somatic cells. (uco.es)

The protein has 238 amino acids, three of them (Numbers 65 to 67) form a structure that emits visible green fluorescent light. (asu.edu)
From 1979 to 1992, many researchers studied various aspects of GFP, including the use of Nuclear Magnetic Resonance to study the amino acids of the protein, the use of X-rays to study its crystal, and the evolution of GFP. (asu.edu)
Huntington's disease is among the so called polyglutamine (polyQ) diseases, a group of neurodegenerative disorders caused by multiple repetitions of glutamine amino acids in specific proteins. (phys.org)

green fluorescent protein (GFP) fusions revealed egl-2 expression in a subset of neurons and muscles that could explain the mutant behavioral defects. (jneurosci.org)
green fluorescent protein transgenes, we found that EGL-47 is expressed in a number of neurons, including the hermaphrodite-specific neurons (HSNs) that innervate the egg-laying muscles to stimulate contraction. (elsevierpure.com)
tau) expressing both human tau in all neurons and green fluorescent protein in glutamatergic neurons was developed. (msu.edu)
Green fluorescent protein (GFP) is a protein in the jellyfish Aequorea Victoria that exhibits green fluorescence when exposed to light. (asu.edu)
Gfp refers to the gene that produces green fluorescent protein. (asu.edu)
John W. Hasting and James G. Morin, who later researched aequorin, termed the protein as green fluorescent protein in 1971. (asu.edu)

This new study provides direct evidence to suggest that bacteria can secrete proteins that form an amyloid fibril, which enters the host neurons and promotes protein aggregation and neurodegeneration. (hku.hk)
Neurodegenerative diseases are caused by protein aggregation in the neurons. (hku.hk)
Targeting curli production in the gut may represent a general therapeutic approach to prevent or slow down the progression of protein aggregation diseases. (hku.hk)
Unlike humans who suffer from proteinopathies caused by the toxic aggregation or cluster of proteins, plants do not experience these kinds of diseases. (phys.org)
To explore how plants deal with toxic protein aggregation, Dr. Ernesto Llamas, first author of the study, and colleagues introduced the toxic mutant protein huntingtin in plants, which causes cell death in human neurons. (phys.org)

The brighter the green fluorescent signal within the worms, the more severe the accumulation of cellular waste, strongly correlating with defective protein degradation. (medindia.net)
2017) ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans. (umaine.edu)
ABSTRACT INVESTIGATION OF NEURODEGENERATIVE TAUOPATHIES USING CAENORHABDITIS ELEGANSByDerek Vonarx Neurodegenerative tauopathies are a class of neurodegenerative disease characterized by the accumulation of tau protein into neurofibrillary tangles in the human brain. (msu.edu)
After several years of accumulation, SunyBiotech has become a well-known brand recognized by the academic field of C.elegans . (sunybiotech.com)
In vitro, Pacer deficiency lead to impaired autophagy and accumulation of ALS-associated protein aggregates, which correlated with theinduction of cell death.ConclusionsThis study, therefore, identifies Pacer as a new regulator of proteostasis associated with ALS pathology. (umayor.cl)

Vertebrate homeobox proteins lim-1, lim-2 (lim-5) and lim3. (embl.de)
C. elegans homeobox protein ceh-14. (embl.de)
C. elegans homeobox protein unc-97. (embl.de)
In August of the same year, Oliver Hobert (PI) published a paper in Nature entitled "Unique homeobox codes delineate all the neuron classes of C. elegans" using up to 14 strains of "SunyBiotech C.elegans ", which also sets a record for the number of strains edited by SunyBiotech in a single paper. (sunybiotech.com)

It has been hypothesized that decision making in animals is controlled primarily at the level of command interneurons or decision centers in the central nervous system, which receive input from an array of sensory neurons and integrate the information conveyed to inform behavioral decisions ( Kristan, 2008 ). (elifesciences.org)
Also, the study showed that out of 358 neurons that comprise of the nematode nervous system, two of them are part of the olfactory system that is significant for odor perception. (medindia.net)
This work underlines the importance of glia in establishing and regulating protein homeostasis within the nervous system, which can then affect neuron-mediated effects in organismal homeostasis and longevity. (bvsalud.org)

IFT has been shown to be necessary for the movement of other signaling proteins within the cilia, and therefore may play a role in many different signaling pathways. (wikipedia.org)

Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics Ashley Frankenfield* 1 , Jiawei Ni* 1 , Ling Hao 1 1 Department of Chemistry, The George Washington University A neuronal lysosome proximity labeling proteomics protocol is described here to characterize the dynamic lysosomal microenvironment in human induced pluripotent stem cell-derived neurons. (jove.com)

We identified the bromodomain protein, BET-1, as a key regulator of actin function and longevity. (bvsalud.org)
Here we show that the neuropeptide NLP-22 is a regulator of Caenorhabditis elegans sleep-like quiescence observed during lethargus. (korea.ac.kr)

Here, we performed a multipronged, cross-organismal screen combining a whole-genome CRISPR-Cas9 screen in human fibroblasts with in vivo Caenorhabditis elegans synthetic lethality screening. (bvsalud.org)
The IMIBIC research group has pioneered the use of Caenorhabditis elegans as an experimental system to analyze basic neurobiological mechanisms involved in autism in vivo. (uco.es)

I have developed my knowledge of various techniques that will be useful in studies of RNA metabolism, including cell biology, RNA-Seq, and the use of genetically modified organisms (C.elegans and the laboratory mouse). (umaine.edu)
To circumvent these issues, a nematode, C. elegans, model was developed because C. elegans have a short lifespan of three weeks, can be genetically modified to express human tau, and are inexpensive to maintain. (msu.edu)
We were surprised to see plants completely healthy, even though they were genetically producing the toxic human protein. (phys.org)

Therefore, since the axoneme needs a continually fresh supply of proteins, an axoneme with defective IFT machinery will slowly shrink in the absence of replacement protein subunits. (wikipedia.org)
They house their own genome (mtDNA), as well as RNA and protein-synthesizing systems, which together code and coordinate the assembly of core subunits of oxidative phosphorylation (OXPHOS). (biorxiv.org)

B ) Venn diagram depicting TFs with significant age-associated differential expression alongside hpk-1 within 3 or more of the 36 neuronal and/or 11 non-neuronal cell clusters (yellow and blue, respectively), and the intersection with TFs that have previously been implicated in C. elegans longevity (red). (elifesciences.org)
Neuronal types, subtypes, cell cluster, or individual neuron pair, as well as whether a TF has previously been implicated in aging is indicated. (elifesciences.org)

Food odors have demonstrated influence on proteostasis (balance between formation and degradation of proteins), finds a study carried out in the roundworm Caenorhabditis elegans , a key model organism in biomedical research. (medindia.net)
In a healthy organism, this coordination depends on a dynamic balance between formation and degradation of proteins (proteostasis). (medindia.net)
This animal is a microscopic nematode (worm) called Caenorhabditis elegans , used by scientists across the world as an important model organism for biological research. (hku.hk)
Together, these results suggest that PINK1 and parkin drive organism-wide patterns of heteroplasmy and provide evidence of a causal link between proteotoxicity, mitophagy, and mtDNA mutation levels in neurons. (biorxiv.org)

Western blot analysis of HD brain tissue shows full-length huntingtin protein in the nuclear fraction as well as abundant immunopositive bands at lower molecular weight, suggesting proteolytic products in the nucleus. (jci.org)
A truncated DAF-3/GFP fusion protein that is predominantly nuclear interferes with dauer formation, implying a role for DAF-3 in the nucleus. (wikigenes.org)
Nuclear mRNA transcripts acquire a protein coat composed of cap- and RNA-binding proteins that allow nuclear export and dictate the functional program of cytoplasmic mRNAs ( Moore, 2005 ). (rupress.org)
Lionel Pintard (PI) published a paper entitled "Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans" in the well-known academic journal Developmental Cell , in which the strain PHX207 npp-1(syb207) IV was used. (sunybiotech.com)

Consistent with the idea that strain is produced at a distance, we show that delivering strong stimuli outside the anatomical extent of the neuron is sufficient to evoke MRCs. (nih.gov)
This novel strain serves as a useful model to study the mechanism of Alzheimer's disease cognitive decline as C. elegans have a relatively short lifespan that allows for extensive therapeutic and genetic screening. (msu.edu)

We show that the Caenorhabditis elegans egl-2 gene encodes an eag K + channel and that a gain-of-function mutation in egl-2 blocks excitation in neurons and muscles by causing the channel to open at inappropriately negative voltages. (jneurosci.org)

Here we find that in Caenorhabditis elegans, mouse, rat and human neurons, dendritically and axonally polarized transmembrane proteins are recognized by endocytic machinery in the AIS, robustly endocytosed and targeted to late endosomes for degradation. (stanford.edu)

Inside cells, PICK1 is localized at the perinuclear region as well as specialized structures such as synapses of neurons. (karger.com)
The signal in question is molecule called DAF-7, which is released by several sensory neurons-nerve cells that are used for detecting cues from the environment. (elifesciences.org)
By contrast, Sfrs1 was not required for the survival of the neurons generated later, including later-born amacrine cells, rod photoreceptors,bipolar cells and Müller glia. (biologists.com)
a protein required for the asymmetric division of vulval blast cells. (embl.de)
Unexpectedly, we find that glial cells use small clear vesicles (SCVs) to signal to neurons, which then relay the signal to the periphery using dense-core vesicles (DCVs). (bvsalud.org)
Neurons are highly polarized cells that face the fundamental challenge of compartmentalizing a vast and diverse repertoire of proteins in order to function properly1. (stanford.edu)
Neurons are highly polarized cells with extensive axonal and dendritic projections that send and receive signals over long distances. (stanford.edu)
However, no differences were observed either in the number of terminal deoxynucleotidyltransferase-mediated d-uracil triphosphate-biotin nick end-labeling-positive cells or viable neurons in the cornu ammonis 1 sector or in the neurologic deficit score when comparing surviving transgenic and nontransgenic rats. (asahq.org)
Producing the plant SPP in models of Huntington's disease such as human cultured cells and worms like the nematode C. elegans reduced protein clumps and symptoms of disease. (phys.org)

Our work defines a quiescence-regulating role for NLP-22 and expands our knowledge of the neural circuitry controlling Caenorhabditis elegans behavioural quiescence. (korea.ac.kr)

IFT88, for example, encodes a protein also known as Tg737 or Polaris in mouse and human, and the loss of this protein has been found to cause an autosomal-recessive polycystic kidney disease model phenotype in mice. (wikipedia.org)
Is an ortholog of human KIFAP3 (kinesin associated protein 3). (wormbase.org)
In addition, over 80 % of its proteins are homologous to human', says Professor Ruiz. (uco.es)
In contrast to animal and human models, they found that Arabidopsis thaliana plants actively removed huntingtin protein clumps and avoid harmful effects. (phys.org)
The multidisciplinary team identified the chloroplast plant protein SPP as the reason why plants are unaffected by the problematic human protein. (phys.org)

The actin cytoskeleton is a three-dimensional scaffold of proteins that is a regulatory, energyconsuming network with dynamic properties to shape the structure and function of the cell. (bvsalud.org)

Here we report that the behavioral defects in the C. elegans egl-2 mutant are caused by a gain-of-function ( gf ) mutation in an eag-like K + channel. (jneurosci.org)

Overexpression of bet-1 preserves actin function at late age and promotes life span and healthspan in C. elegans. (bvsalud.org)
The LIN-14 transcription factor likely directly represses dma-1 gene expression through a transcriptional means, whereas the LIN-41 tripartite motif protein likely indirectly promotes dma-1 gene expression through a posttranscriptional means. (stanford.edu)

Drosophila melanogaster (Fruit fly) protein apterous, required for the normal development of the wing and halter imaginal discs. (embl.de)

The roundworm Caenorhabditis elegans has two sexes, hermaphrodites and males. (elifesciences.org)

Neuroendocrine regulation of diverse behaviors of Caenorhabditis elegans is under the control of the DAF-7/TGF-β ligand that is secreted from sensory neurons. (elifesciences.org)
Our results suggest that regulation of gene expression in sensory neurons can function in the integration of a wide array of sensory information and facilitate decision-making behaviors in C. elegans . (elifesciences.org)
Thus, GCGs contain proteins involved in translation initiation, translation control, and mRNA decay, which is consistent with their proposed role in the regulation ofs maternal mRNA expression. (rupress.org)
Recently, RNA-binding proteins have been implicated in the regulation of dendrite development. (genestogenomes.org)

The motor symptoms of PD are well known to be caused by the degeneration of substantial numbers of dopamine neurons in the midbrain. (movementdisorders.org)
The question of whether there could be alpha-synuclein pathology in the gut caused by something that would eventually indirectly lead to degeneration of substantial numbers of dopamine neurons in the midbrain and produce PD is a different question. (movementdisorders.org)

An excessive number of polyQ repeats can cause proteins to aggregate or accumulate in harmful and damaging protein deposits, leading to cellular dysfunction and death. (phys.org)
Llamas said, "Unlike humans, plants have chloroplasts, an extra cellular type of organelle that could provide an expanded molecular machinery to get rid of toxic protein aggregates. (phys.org)

The mutation leads to the abnormal expansion of the production of the polyglutamine tract (polyQ) resulting in the form of an unstable Huntingtin protein commonly referred to as mutant Huntingtin. (benthamscience.com)

2018) ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase. (umaine.edu)

GFP can attach to and mark another protein with fluorescence, enabling scientists to see the presence of the particular protein in an organic structure. (asu.edu)
Using DNA recombinant technology, scientists combine the Gfp gene to a another gene that produces a protein that they want to study, and then they insert the complex into a cell. (asu.edu)
Indeed, the scientists discovered that the chloroplasts, the plant-specific organelles that perform photosynthesis, were the reason why plants do not show toxic protein deposits. (phys.org)

Huntington's disease is a genetic neurological disorder caused by a repeated expansion of the CAG trinucleotide, causing instability in the N-terminal of the gene coding for the Huntingtin protein. (benthamscience.com)

Mammalian cysteine-rich intestinal protein (CRIP), a small protein which seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. (embl.de)
RCAN1 is upregulated by stress factors, such as protein aggregates, elevated intracellular calcium, oxidative stress, and glucocorticoid, prevents excess and dangerous over-activation of calcineurin. (molcells.org)

The ferritin-like Dps protein is required for Salmonella enterica serovar Typhimurium oxidative stress Our investigations indicate that Salmonella have leveraged the regulatory activity that Gre factors directly promote gapA gene expression, we visualized the products of the fluorescence vesicle suspension from entering into the metabolite inlet but did not attempt to extract the mean change in the Salmonella enterica. (mister-finch.com)

Optogenetic stimulation of the RIA interneurons has a movement-promoting effect, demonstrating functional complexity in a single-neuron type. (korea.ac.kr)

The process of IFT involves movement of large protein complexes called IFT particles or trains from the cell body to the ciliary tip and followed by their return to the cell body. (wikipedia.org)
The IFT particles themselves consist of two sub-complexes, each made up of several individual IFT proteins. (wikipedia.org)
EPIC: software toolkit for elution profile-based inference of protein complexes. (nih.gov)

The researchers were able to uncover the influence of smelling on the physiology of the digestive tract by investigating the recycling of green fluorescent proteins in the intestine. (medindia.net)

Neuronal polarity requires sorting and maintaining a unique set of proteins to the neuron's distinct axonal and somatodendritic domains. (stanford.edu)

The tooth has an unusual sensory system that converts external stimuli predominantly into pain, yet its sensory afferents in teeth demonstrate cytochemical properties of non-nociceptive neurons. (mdpi.com)

Mammalian and avian cysteine-rich protein (CRP), a 192 amino-acid protein of unknown function. (embl.de)

Huntingtin contains a few domains that suggest particular functions, including WW domains and caspase cleavage sites ( 7 , 8 ), but the function of the protein remains unknown. (jci.org)
To this end, the authors generated a transgenic rat line expressing baculovirus p35, a broad-spectrum caspase inhibitor, in central neurons. (asahq.org)

Anatomy18

Organisms6

Diseases1

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Psychiatry and Psychology2

Phenomena and Processes33

Information Science4

Genes9

Receptor8

Nematode Caenorhabditis elegans3

Regulates3

Differentiation1

Sensory neuron2

Membrane7

Kinase4

Larval3

Regulate4

Motor neurons1

Tissues3

Localization5

Mitochondrial1

Behavior8

Germ3

Somatic cells1

Amino acids3

Green fluores6

Aggregation5

Accumulation5

Homeobox4

Nervous system3

Pathways1

Lysosomal1

Regulator2

Vivo2

Genetically3

Subunits2

Previously been implicated2

Organism4

Nuclear4

Strain2

Muscles1

Transmembrane1

Cells9

Neural1

Human5

Scaffold1

Defects1

Promotes2

Drosophila1

Roundworm1

Regulation4

Degeneration2

Cellular2

Mutation1

20181

Scientists3

Huntingtin protein1

Intracellular2

Gene expression1

Functional1

Complexes3

Intestine1

Distinct1

Predominantly1

Mammalian1

Caspase2