• Background Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. (qedbio.com)
  • Perineuronal nets (PNNs) are specialized aggregations of extracellular matrix (ECM) molecules surrounding specific neurons in the central nervous system (CNS). (biomedcentral.com)
  • A specialized form of the ECM are the perineuronal nets (PNNs), a pericellular cover that tightly enwraps somata, proximal dendrites, and axon initial segments of specific neurons thereby leaving meshes occupied by synaptic terminals. (biomedcentral.com)
  • Thus, it remains largely elusive whether PNN-specific chondroitin-sulfated proteoglycans (CSPGs) of the lectican family (aggrecan, brevican, neurocan, and versican) are expressed within the cochlea at all. (biomedcentral.com)
  • Brevican is a member of the lectican protein family. (wikipedia.org)
  • Remarkably, these effects are not associated with changes in the expression of GABAergic and glutamatergic synaptic components, but with a reduction of parvalbumin (PV) neuron density and PV mRNA levels. (biorxiv.org)
  • In addition to neurons and glia, the extracellular matrix (ECM) forms a fundamental, non-cellular component of the nervous system. (biomedcentral.com)
  • Brevican core protein is a protein that in humans is encoded by the BCAN gene. (wikipedia.org)
  • Immunogen Fusion protein corresponding to aa 219-655 of rat Brevican (accession no. (qedbio.com)
  • Brevican is secreted from astrocytes and neurons as a145kDa core protein that bears up to three covalently-linked CS chains. (qedbio.com)
  • Description Western Blot analysis of Rat Brain Membrane showing detection of ~140 kDa Brevican protein using Mouse Anti-Brevican Monoclonal Antibody, Clone S294A-6 (56541). (qedbio.com)
  • In accordance, systemic injection of dopamine receptor D1 agonists in vivo promote rapid cleavage of the ECM protein brevican 16 . (nature.com)
  • PNNs are supposed to control synaptic transmission and are frequently associated with neurons firing at high rates, including principal neurons of auditory brainstem nuclei. (biomedcentral.com)
  • These ECM baskets potentially contribute to control of synaptic transmission at IHCs and might be functionally related to PNNs of neurons in the CNS. (biomedcentral.com)
  • In both cases, these changes are manifested at the level of circuits and individual neurons as a reordering of gene expression profiles, synaptic strength, and circuit connectivity. (frontiersin.org)
  • For example, cuprizone-induced demyelination promotes hyper- and depolarizing shifts of the resting membrane potential of auditory thalamocortical pathway neurons and reduction in action potential firing of primary auditory cortex (A1) neurons 7 . (biorxiv.org)
  • The origin of high-frequency activity of auditory brainstem neurons is the indefatigable sound-driven transmitter release of inner hair cells (IHCs) in the cochlea. (biomedcentral.com)
  • Moreover, it has recently been appreciated that myelin is also present on inhibitory neurons 14 but the role of myelin for inhibitory circuits in unknown. (biorxiv.org)
  • Brevican is localised to the surface of neurons in the brain. (wikipedia.org)
  • BDNF and its pro-peptide are stored in presynaptic large dense core vesicles in brain neurons. (kcl.ac.uk)
  • This classic lesion provided some of the first evidence for structural plasticity following injury in the CNS, and also provides an opportunity to examine the injury response of some of the most highly plastic neurons in the brain, adult-generated newborn granule cells. (frontiersin.org)
  • Given the increasing role of adult-generated new neurons in the function of the dentate gyrus, we also compare the response of newborn and mature granule cells following lesioning of the perforant path. (frontiersin.org)
  • Description Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Brevican Monoclonal Antibody, Clone S294A-6 (56541). (qedbio.com)
  • 2016) are affected by proteoglycan deficiency in brevican (BC) mutant mice. (synage.de)
  • 2015 ) Neurons and glia modify receptor protein-tyrosine phosphatase ζ (RPTPζ)/phosphacan with cell-specific O-mannosyl glycans in the developing brain. (neurotree.org)
  • Previously, we cloned a cDNA fragment that lies in the most conserved link-domain of the lamprey lecticans and found that lectican mRNAs are expressed widely in lamprey glia and neurons. (nsf.gov)
  • Because of the lack of strict one-to-one orthology with the jawed vertebrate lecticans, the four lamprey lecticans were named simply A, B, C, and D. Using probes that distinguish these four lecticans, we now show that they all are expressed in glia and neurons but at different levels. (nsf.gov)
  • Multiple cells, including glia, neurons, ependymal cells and microglia/macrophages, expressed lectican mRNAs in the peripheral zone and lesion center after SCI. (nsf.gov)
  • Moreover, neurons, glia, ependymal cells, and microglia/macrophages, are responsible for the increase in CSPGs during the formation of the glial scar after SCI. (nsf.gov)
  • 2020 ) The Role of BEHAB/Brevican in the Tumor Microenvironment: Mediating Glioma Cell Invasion and Motility. (neurotree.org)
  • 2014 ) Brevican knockdown reduces late-stage glioma tumor aggressiveness. (neurotree.org)
  • Se encuentra muy hiperexpresado en los TUMORES ENCEFÁLICOS primarios y en modelos experimentales de GLIOMA. (bvsalud.org)
  • The origin of high-frequency activity of auditory brainstem neurons is the indefatigable sound-driven transmitter release of inner hair cells (IHCs) in the cochlea. (biomedcentral.com)
  • There was a strong correlation between the progressive decline of soluble APPα and brevican levels. (bvsalud.org)
  • Depending on the acoustic input, these neuron types are able to operate at very high discharge rates. (biomedcentral.com)