Neurons and neurites. Medical search. Frequent questions

We found a correlation of sharp bends with neurite outgrowth, suggesting the hypothesis that sharp bends might proceed neurite outgrowths. (eneuro.org)
We report here that the relationship between tension and neurite outgrowth is equally initimate for embryonic chick forebrain neurons. (biologists.com)
Neurite outgrowth can be initiated de novo by experimental application of tension to the cell margin of forebrain neurons placed into culture 8-12 hours earlier, prior to spontaneous neurite outgrowth. (biologists.com)
all positive tensions stimulate neurite outgrowth. (biologists.com)
Hemolymph-supplemented media or coverslips treated with poly-l-lysine (PLL) and hemolymph also accelerated outgrowth of Aplysia dopaminergic neurons relative to PLL-treated coverslips alone 24 . (nature.com)
Among such factors, SRRM4 is an important regulator of aspects of neural differentiation including neurite outgrowth. (elsevierpure.com)
The mechanism by which SRRM4 regulates neurite outgrowth has remained poorly understood, however. (elsevierpure.com)
The resulting protein (protrudin-L) promotes neurite outgrowth during neurogenesis. (elsevierpure.com)
Deletion of exon L in Neuro2A or embryonic stem cells inhibited neurite outgrowth. (elsevierpure.com)
Our results suggest that SRRM4 controls neurite outgrowth through regulation of alternative splicing of protrudin transcripts. (elsevierpure.com)
We report here that expression of constitutively active ASK1 (ASK1DeltaN) induces neurite outgrowth in the rat pheochromocytoma cell line PC12. (nih.gov)
ASK1DeltaN-induced neurite outgrowth was strongly inhibited by treatment with the p38 inhibitor SB203580 but not with the MEK inhibitors, suggesting that activation of p38, rather than of ERK, is required for the neurite-inducing activity of ASK1 in PC12 cells. (nih.gov)
Furthermore, blocking GPM6a using a structural monoclonal anti-GPM6a antibody significantly decreased neurite outgrowth in dissociated DRG neuron cultures. (saneurociencias.org.ar)
In this tutorial, we describe a method for visualizing and quantitating neurite outgrowth in co-culture with astrocytes, utilizing a novel fluorescent label for neuronal processes and the IncuCyte ZOOM live-cell imaging system. (genengnews.com)
This kinetic, 96-well assay method provides dynamic information on neurite outgrowth that is not available from monoculture or end-point experiments and enables pharmacological studies of neuroactive agents. (genengnews.com)
In this thesis, I initially investigated whether attachment to permissive culture substrates is sufficient to promote neurite outgrowth from DRG neurons, and whether this interaction is able to enhance the response of neurons to added neurotrophic factors, such as NGF. (mun.ca)
Adult Dorsal Root Ganglion (DRG) neurons plated on surfaces coated with a thin film of laminin exhibited increased neurite outgrowth, this growth was correlated with increased expression of laminin binding integrin subunits. (mun.ca)
In three different model systems they showed dopamine neurite outgrowth was markedly increased. (sciencedaily.com)
It targets a protein called Neurite Outgrowth Inhibitor (Nogo-A), which hinders neurone regeneration. (ucl.ac.uk)
G15S actin enhanced neurite outgrowth and filopodia number. (jneurosci.org)
The focus of the present study was to develop a high-throughput 3D neurite outgrowth assay using iPSCderived neurons developed in the microfluidic OrganoPlate ® platform, with the goal of establishing 3D models for neurodegenerative diseases and neurotoxicology screens 3 . (moleculardevices.com)
To evaluate the feasibility of the OrganoPlate platform for testing neurotoxicity and neuronal development, these neuronal cultures were treated with a selection of compounds known to inhibit neurite outgrowth 7 . (moleculardevices.com)
In addition to promoting cell adhesion, poly-lysine surface treatments support neurite outgrowth and improve the survival of many central nervous system (CNS) primary cells in culture. (thomassci.com)
In three different model regimens, they were shown to significantly increase dopaminergic neurite outgrowth. (balkantravellers.com)
It has been implicated in neurite outgrowth, long-term potentiation, SIGNAL TRANSDUCTION, and NEUROTRANSMITTER release. (bvsalud.org)

The fluorescent reagent, NeuroLight Red™, specifically labels both primary neurons and human iPSC derived neurons when grown in co-culture with astrocytes, allowing for quantitation using the IncuCyte NeuroTrack™ software. (genengnews.com)
NeuroLight Red enables clear visualization and quantification of neurites from primary neurons (compare same fields shown in upper left panel and upper right panel in Figure 1 ). (genengnews.com)
The impact of self-assembling peptides on neurite growth of mouse primary neurons. (mpg.de)
We were also the first group to use primary neurons from AD transgenic mice to model Aβ accumulation in culture (Takahashi et al. (lu.se)

demonstrate through studies on induced pluripotent stem cell-derived cortical neurons that miR-33a is a potential therapeutic target for the treatment of SPG4-related hereditary spastic paraplegia. (portlandpress.com)
2001) had found amniotic epithelial cells conditioned medium showed neurotrophic effect on rat embryonic day 18 (E18) cortical neurons. (scielo.org.ar)
As E18 cortical neurons would not normally respond to neurotrophic factors other than Epidermal Growth Factor (EGF), they hypothesized that it could be EGF. (scielo.org.ar)

This is conclusive evidence that vitamin D affects the structural differentiation of dopaminergic neurons. (sciencedaily.com)
This study confirms the importance of vitamin D in the structural differentiation of dopaminergic neurons and suggests that maternal vitamin D deficiency may alter how early dopaminergic circuits are formed. (balkantravellers.com)

In mid-stage male APP L/S mice, LM11A-31 administered for 3 months starting at 6-8 months of age prevented and/or reversed atrophy of basal forebrain cholinergic neurites and cortical dystrophic neurites. (plos.org)
Importantly, a 1 month LM11A-31 treatment given to male APP L/S mice (12-13 months old) with late-stage pathology reversed the degeneration of cholinergic neurites in basal forebrain, ameliorated cortical dystrophic neurites, and normalized increased basal forebrain levels of p75 NTR . (plos.org)
Moreover, αSyn accumulates in the Lewy bodies and dystrophic neurites of all patients with idiopathic PD [ 63 , 88 ], implicating the protein in sporadic as well as familial forms of the disease. (springer.com)

Experimentally induced neurite elongation from these neurons shows the same robust linear relationship between elongation rate and magnitude of applied tension as peripheral neurons, i.e. both show a fluid-like growth response to tension. (biologists.com)

While iPSC-derived neurons show great promise for compound screening and disease modeling, use of three-dimensional (3D) cultures is emerging as a valid approach for neuronal cell based assay development. (moleculardevices.com)

Figure 2 shows data from a 96-well assay measuring neurite length over twelve days using NeuroLight Red labeled rat forebrain neurons with rat cortical astrocytes (NeuroPrime™ Cell Kit). (genengnews.com)

The team at the Queensland Brain Institute developed dopamine-like cells to replicate the process of differentiation into early dopaminergic neurons that usually takes place during embryonic development. (sciencedaily.com)

The study hypothesizes that early changes in dopaminergic neuron differentiation due to vitamin D deficiency may be the neurodevelopmental origin of dopamine dysfunction in adults who develop schizophrenia. (balkantravellers.com)

Although forebrain and sensory neurons manifest a similar distribution of growth sensitivity to tension (growth rate/unit tension), chick forebrain neurons initiated and elongated neurites at substantially lower net tensions than peripheral neurons. (biologists.com)
Consistent with this observation, chick forebrain neurons showed weak retractile behavior in response to slackening compared to sensory neurons. (biologists.com)
Neurites that were slackened showed only transient elastic behavior and never actively produced tension, as do chick sensory neurons after slackening. (biologists.com)
Sensory neurons. (mun.ca)
Synaptic transmission and excitability in Aplysia sensory neurons (SNs) are bidirectionally modulated by 5-HT and FMRFamide. (jneurosci.org)
The heart's nervous system contains around 40,000 neurons, called sensory neurites. (elephantjournal.com)

We also observed that ASK1DeltaN induced expression of several neuron-specific proteins and phosphorylation of neurofilament proteins, confirming that PC12 cells differentiated into mature neuronal cells by ASK1. (nih.gov)
Neurons also contain other types of neurotransmitter receptors, such as those coupled via G-proteins to second-messenger cascades, that can modulate synaptic transmission and/or membrane excitability. (jneurosci.org)
They then showed alterations in the distribution of presynaptic proteins responsible for dopamine release within these neurites. (sciencedaily.com)
The heart's brain is an intricate network of several types of neurons, neurotransmitters, proteins and support cells similar to those found in the brain proper. (elephantjournal.com)
The researchers found that when proteins in mitochondria at the ends of neurites were damaged by normal wear and tear, newer ones weren't coming in to replace them as quickly as they did for mitochondria near the nucleus. (upmc.com)

We conclude that tension is an important regulator of both peripheral and central neuronal growth, but that elastic behavior is much weaker for forebrain neurons than peripheral neurons from the same developing organism. (biologists.com)
The membrane neuronal glycoprotein GPM6A is involved in neuronal development and structural plasticity in the CNS, and recent evidence suggests that GPM6a interacts with molecules from the PNS and could be expressed in DRG neurons. (saneurociencias.org.ar)
In addition to rat primary forebrain neurons, NeuroLight Red can label other primary neuronal subtypes (hippocampal, cortical, and dorsal root ganglion) as well as iPSC-dervied neurons (data not shown). (genengnews.com)
CRMP expression is highest when neurons and synaptic connections mature actively during the first postnatal week, suggesting CRMPs' role in neuronal migration, differentiation and axonal growth. (wikipedia.org)
Overexpression of ClpP reduces αSyn-induced mitochondrial oxidative stress through enhancing the level of Superoxide Dismutase-2 (SOD2), and suppresses the accumulation of αSyn S129 phosphorylation and promotes neuronal morphology in neurons derived from PD patient iPS cells carrying αSyn A53T mutant. (springer.com)

NeuroLight Red is a lentiviral-based reagent that has been designed to efficiently transduce multiple types of neurons with low toxicity. (genengnews.com)

Neuritic degeneration and Golgi fragmentation were confirmed in primary cultures of dorsal root ganglia (DRG) neurons overexpressing alpha-syn. (nih.gov)
The role of Myosin Va in the neuritogenesis of dorsal root ganglia TrkA-positive neurons. (usp.br)
The dorsal root ganglia (DRG) harbor the TrkA-positive neurons. (usp.br)

Culture of forebrain neurons was unusually simple and reliable, and some of these cells undergo early events of axonal-dendritic polarity. (biologists.com)
A co-culture model containing rat E18 primary forebrain neurons grown in co-culture with rat cortical astrocytes (NeuroPrime™ Cell Kit) was used to examine neurite dynamics while capturing important cell-cell interactions. (genengnews.com)

Mechanical tension is a direct and immediate stimulus for neurite initiation and elongation from peripheral neurons. (biologists.com)
Axonal development by peripheral neurons has been shown to be intimately dependent on mechanical tension. (biologists.com)
Sequence-Optimized Peptide Nanofibers as Growth Stimulators for Regeneration of Peripheral Neurons. (mpg.de)

We have investigated Aplysia hemolymph as a source of endogenous factors to promote regeneration of bag cell neurons. (nature.com)
Isolated Aplysia neurons have also become valuable tools for investigating the basic biology of neurite growth and regeneration. (nature.com)
Enhanced regeneration of dissociated bag cell neurons was observed in the presence of central nervous system (CNS) sheath cells or arterial cells 12 , or material remaining after such cells were killed 13 . (nature.com)
Several studies have found that hemolymph can effect regeneration of isolated neurons. (nature.com)
Both the intrinsic capacity of PNS neurons to re-initiate axon growth and the reprogramming features of PNS glial cells contribute to nerve regeneration. (saneurociencias.org.ar)
In vitro , it is recruited for the regeneration process and TrkA-positive neurons neurites re-emission in the presence of NGF, being expressed in neurites at different stages of neo-neuritogenesis. (usp.br)
A nervous tissue specific protein which is highly expressed in NEURONS during development and NERVE REGENERATION. (bvsalud.org)

Flat, ribbon-like aggregates gave rise to Lewy bodies and glial inclusions similar to those seen in multiple-system atrophy, while cylindrical fibrils triggered the degeneration of dopaminergic neurons and motor problems like those that bedevil Parkinson's patients. (alzforum.org)
Ribbons spurred the formation of Lewy bodies and Lewy neurites in dopaminergic neurons, but had no other ill effects. (alzforum.org)
Fibrils did not seed Lewy bodies, but were associated with a 30 percent loss of dopaminergic neurons, and about a 25 percent loss of motor control in the rats' forepaws, even in wild-type rats. (alzforum.org)
The 2 major neuropathologic findings in Parkinson disease are loss of pigmented dopaminergic neurons of the substantia nigra pars compacta and the presence of Lewy bodies and Lewy neurites. (medscape.com)
Lewy bodies are intracytoplasmic eosinophilic inclusions, often with halos, that are easily seen in pigmented neurons, as shown in this histologic slide. (medscape.com)

Degeneration of basal forebrain cholinergic neurons contributes significantly to the cognitive deficits associated with Alzheimer's disease (AD) and has been attributed to aberrant signaling through the neurotrophin receptor p75 (p75 NTR ). (plos.org)
Previous work found that a lead p75 NTR ligand, LM11A-31, prevents degeneration of cholinergic neurites when given to an AD mouse model in the early stages of disease pathology. (plos.org)
Degeneration of basal forebrain cholinergic neurons (BFCN) and their neurites is a major contributing factor to the cognitive dysfunction associated with Alzheimer's disease (AD). (plos.org)
Cleaved forms of CRMPs have also been linked to neuron degeneration after trauma induced injury. (wikipedia.org)
Parkinson's disease (PD), one of the most common neurodegenerative disorders, is characterized by progressive degeneration of nigrostriatal dopaminergic (DA) neurons in the midbrain. (springer.com)

Overexpressing these mutant actins in mouse hippocampal neurons not only modulated growth-cone function but also neurite elongation, which was ambiguous by traditional pharmacological interference. (jneurosci.org)
CIL:40660, Rattus, hippocampal neuron. (cellimagelibrary.org)

The ability of neurons from the Aplysia central nervous system to regenerate both in vitro and in vivo has prompted a search for endogenous neurotrophic factors. (nature.com)
Here we describe a medium throughput in vitro assay providing kinetic measurements of neurite dynamics in a co-culture model of neurons and astrocytes. (genengnews.com)
An ideal in vitro method to track neurite dynamics would allow continuous, automated measurement of structural parameters, including length and number of branch points, in a nonperturbing manner. (genengnews.com)
These results indicate that functional G-protein-coupled receptors for two neuromodulators are distributed differentially along the surface of a presynaptic neuron that forms chemical connections in vitro . (jneurosci.org)

Regulated changes in axon and dendrite (neurite) morphology over days and weeks are required for the developmental organization and continual remodeling of the nervous system that supports adaptation, function, and maturation. (genengnews.com)
CRMPs are predominantly expressed in the nervous system during development and play important roles in axon formation from neurites and in growth cone guidance and collapse through their interactions with microtubules. (wikipedia.org)
During brain development, neurons pass through various phases of morphological differentiation encompassing neurite elongation, neurite differentiation in axon and dendrites, and directional navigation of growth cones toward postsynaptic targets. (jneurosci.org)

Now, using animal models and nerve cells grown in the lab, researchers from the University of Pittsburgh School of Medicine suggest a new mechanism dubbed "neuritosis" that might explain neurons shrinking in Huntington's and other neurodegenerative diseases, opening new targets for therapy. (upmc.com)
It's quite likely that neuritosis happens in nerve cells normally and doesn't result in cell death, but in neurodegenerative diseases, there are higher levels of stress to the already vulnerable neurite ends, which could push neuritosis over the edge and lead to cells dying," said Friedlander. (upmc.com)

Professor Eyles has followed the mechanisms that might relate to abnormal dopamine release and discovered that maternal vitamin D deficiency affects the early development and later differentiation of dopaminergic neurons. (sciencedaily.com)
Using innovative technology, they were able to observe that vitamin D deficiency not only alters the development of neurons, but also affects the dopamine release mechanism in the brain. (balkantravellers.com)

They occupy approximately 50% of the total volume of the central nervous system (CNS) and are estimated to outnumber neurons by more than five times. (news-medical.net)

Applications to adjacent SN neurites with few varicosities in contact with L7 axons failed to evoke a significant change in synaptic efficacy. (jneurosci.org)

To extend its potential clinical applications, we sought to determine whether LM11A-31 could reverse cholinergic neurite atrophy when treatment begins in AD mouse models having mid- to late stages of pathology. (plos.org)
2000). Following this work, we were the 1st group to report on the physical association between altered AD-linked Aβ peptides and synapses in the brain, showing that Aβ preferentially accumulates and associates with subcellular pathology within distal neurites and synapses in AD (Takahashi et al. (lu.se)

Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease. (lu.se)

and tension also mediates spontaneous initiation of axons by cultured chick sympathetic neurons ( Smith, 1994 ). (biologists.com)
In rats injected with α-synuclein ribbons, characteristic α-synuclein deposits (red) form in dopaminergic neurons (left panel), in dopaminergic axons (middle), and in oligodendrocytes (right). (alzforum.org)
Over the course of a week, all three assemblies were taken up by dopaminergic neurons, transported anterogradely down axons, and internalized by other neurons. (alzforum.org)

Depletion of SRRM4 in Neuro2A cells impaired inclusion of exon L in protrudin mRNA, resulting in the generation of a shorter protein isoform (protrudin-S) that is less effective at promoting neurite extension. (elsevierpure.com)
Here, we characterized the localization of the GPM6a protein using embryonic and adult DRG neuron cultures and immunohistochemistry of DRG explants. (saneurociencias.org.ar)
Is the appropriate distribution of G-protein-coupled receptors regulated by interactions with neurons that synthesize and release the neuromodulator? (jneurosci.org)
Spinal muscular atrophy (SMA) is a neurodegenerative disease produced by low levels of Survival Motor Neuron (SMN) protein that affects alpha motoneurons in the spinal cord. (mdpi.com)
Here, we show that the protein level of ClpP is selectively decreased in αSyn-expressing cell culture and neurons derived from iPS cells of PD patient carrying αSyn A53T mutant, and in dopaminergic (DA) neurons of αSyn A53T mice and PD patient postmortem brains. (springer.com)
This photomicrograph of a neural tissue specimen, harvested from a scrapie affected mouse, revealed the presence of prion protein stained in red, which was in the process of being trafficked between neurons, by way of their interneuronal connections, known as neurites. (cdc.gov)

In contrast, R62D reduced neurite length and impaired growth-cone filopodia formation. (jneurosci.org)
ADF/Cofilin-Mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain. (mpg.de)
Formation of neurite networks was monitored over time using transmitted light imaging. (moleculardevices.com)

Src appeared to be located upstream of the PI3-K/Akt signalling pathway and was responsible for increased neurite growth induced by the addition of laminin and NGF together. (mun.ca)

Here, we developed a work-flow and adopted algorithms to allow researchers to capture and analyze these age-dependent changes of Caenorhabditis elegans touch receptor neurons in vivo . (eneuro.org)
For decades, scientists have studied Caenorhabditis elegans - tiny, transparent worms - for clues about how neurons develop and function. (uncommondescent.com)
In C. elegans, most neurons have one or two unbranched processes which have different synapses located one next to the other. (uncommondescent.com)
C. elegans has only 302 neurons," she continued. (uncommondescent.com)

Among the five members of the CRMP family, CRMP-2 is the most highly expressed in the adult brain, especially in post-mitotic neurons of the olfactory system, cerebellum, and hippocampus. (wikipedia.org)
July 7, 2020 Researchers have found that dopamine neurons in the brain can represent the decision-making process when making economic choices. (sciencedaily.com)
They first start to disconnect from each other because their neurites - long finger-like extensions that make connections all through the brain - become smaller. (upmc.com)
In the brain of a Parkinson disease patient on the right, loss of pigmented substantia nigra due to depopulation of pigmented neurons is observed. (medscape.com)
The use of stem cell-derived dopamine neurons or deep brain stimulation (DBS) represents two alternative approaches to treat Parkinson's Disease. (lu.se)

Labeling neurons with a flueorescent reagent such as NeuroLight Red provides a means to develop a medium-throughput assay to study neurite dynamics in a co-culture setting. (genengnews.com)

Our work took a different direction from the mainstream of AD research that focused on extracellular β-amyloid (Aβ) peptides with our discovery of the accumulation of Aβ within AD vulnerable neurons of human brains (Gouras et al. (lu.se)

Confocal imaging and analysis protocols were optimized for assessing morphological phenotypes and viability of neurons cultured in a 3D matrix. (moleculardevices.com)

Increasing the traceability and quantification of these stochastic changes will aid researchers to gain mechanistic insights into the underlying biology of these age-dependent morphologic changes in aging neurons. (eneuro.org)
Neurons can be visualized in the phase image shown at the top right panel in Figure 1 , although reliable quantification of neurite length was problematic due to obscuring textures presented by astrocytes. (genengnews.com)

However, how these factors interact to stimulate optimal levels of neurite growth is largely unknown. (mun.ca)
Laminin-induced neurite growth was integrin-dependent as it was attenuated by treatment with either a cyclic Arg-Gly-Asp (RGD) peptide or a β1 integrin-blocking antibody (β1i). (mun.ca)
In performing these experiments it was observed that not all DRG neurons were responding to laminin and NGF with increased neurite growth. (mun.ca)
As neurons in the adult rat DRG can be classified into at least three separate subpopulations based on morphologic and phenotypic differences, a cell selection approach was utilized to show that laminin-induced neurite growth occurs in the absence of added trophic factors only in heavy chain neurofilament positive and calcitonin gene related peptide positive DRG neurons (NGF-responsive population). (mun.ca)
In contrast, laminin alone is not sufficient to stimulate significant neurite growth from lectin Griffonia simplicifolia 1B4 positive neurons (IB4+ve), although it is still required to elicit a growth response from these cells in the presence of Glial Cell Line Derived Neurotrophic Factor (GDNF) (e.g., neurite growth occurred only when cells were plated on laminin in the presence of GDNF). (mun.ca)
By using chemical inhibitors we demonstrated that only the PI3-K/Akt pathway was required for neurite growth from the NGF-responsive cell population. (mun.ca)
However, both the PI3-K/Akt and MEK/MAPK signalling pathways were required for neurite growth from the IB4+ve cell population. (mun.ca)
Further analysis indicated that Src was potentially a key point of collaboration between NGF and laminin induced neurite growth in NGF-responsive adult DRG neurons. (mun.ca)
In this series of studies we have identified specific signalling events and environmental requirements associated with neurite growth for different subpopulations of adult DRG neurons, pointing to potential therapeutic targets while identifying why any one treatment alone maybe insufficient to totally repair peripheral nerve damage. (mun.ca)
Myosin (MyoVa) is widely expressed in nervous tissue and is present in neurites, cell body and growth cone. (usp.br)
The research team showed that vitamin D deficiency affects the mechanisms of growth and dopamine secretion in dopamine neurons. (balkantravellers.com)

For example, in the external granular layer (EGL), where mitosis of cerebellar granular neuron occurs, CRMP-2 is highly expressed while CRMP-5 is never expressed. (wikipedia.org)

Said Zhang: "What we found is that, in some neurons, the synapses are highly organized at the sub-cellular level, and that organization is associated with local neural activity. (uncommondescent.com)

The ability to measure alterations in neurite morphology can provide information regarding changes leading to disease states or effects following exposure to toxic agents, thus providing a rationale for developing technologies to observe and quantify these events. (genengnews.com)
Studying changes in neurite morphology can be performed in vivo, however these approaches are costly and afford limited throughput. (genengnews.com)
nseg = math.ceil((sec.L / (d_lambda * h.lambda_f(frequency))) / 2) * 2 + 1 if sec.nseg % 2 == 0: nseg += 1 sec.nseg = int(nseg) def __str__(self): #string representation of object return self.name def load_morphology(self): cell = h.Import3d_Neurolucida3() cell.input(self.morphology) i3d = h.Import3d_GUI(cell, False) #import 3d i3d.instantiate(self) #construct object in neuron #use i3d.cellbuilder possible? (yale.edu)

Se la ha implicado en el crecimiento de las neuritas, la potenciación a largo plazo, la TRANSDUCCIÓN DE SEÑAL y la liberación de NEUROTRANSMISORES (Neurotoxicology 1994;15(1):41-7). (bvsalud.org)

R62D-induced phenotypes strongly resemble neurons lacking SRF (Serum Response Factor). (jneurosci.org)

The underlying biology of these subtle morphologic changes of aging neurons remain poorly understood. (eneuro.org)

A glycoprotein called laminin promotes neurite extension in cultured neurons. (medscape.com)

This differential distribution of receptors on the presynaptic neuron is regulated by a target and does not require the physical presence of neurons that release the neuromodulators. (jneurosci.org)

In vivo , at stage HH25, MyoVa was present both in cells with and without neurites and its expression persists throughout neuritogenesis. (usp.br)

Then, when the researchers looked at neurons in the spinal cords of mice, they found the same phenomenon. (upmc.com)

Neuroscientists have shown how vitamin D deficiency affects developing neurons in the brain's dopamine circuit, which may lead to the dopamine dysfunction seen in adults with schizophrenia. (sciencedaily.com)
Before, people simply thought each neuron was one functional module, so all the brain's computations depended on those modules. (uncommondescent.com)

Among dopaminergic neurons, about half died, nerve terminals in the striatum disappeared, and the rats lost about 75 percent of control in their forepaws. (alzforum.org)
ergic innervation from the A9 nigral neurons to the striatum, in particular the putamen. (lu.se)

Synapses are correlated with communication between neurons. (uncommondescent.com)

SRRM4 was found to promote splicing of protrudin pre-mRNA so as to include a microexon (exon L) encoding seven amino acids in a neuron-specific manner. (elsevierpure.com)

Our results show that GPM6a is localized in the surface of DRG neurons throughout development but not in Schwann cells. (saneurociencias.org.ar)
However, a limitation of a monoculture approach is that it does not detect the effects of glial cells on neurite development and function. (genengnews.com)
Cells were imaged in an Incucyte ZOOM and neurite length was measured using NeuroTrack software. (genengnews.com)
Amniotic epithelial cells transplantation in Parkinson model of rats was found to reverse the condition and prevent death in neurons (Kakishita et al. (scielo.org.ar)
2003). Similarly, when transplanted into ischemic cortical areas, they were found to differentiate into 'neuron-like' cells (Okawa et al. (scielo.org.ar)

Anatomy98

Organisms16

Diseases8

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Psychiatry and Psychology3

Phenomena and Processes37

Disciplines and Occupations3

Information Science2

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Outgrowth25

Primary neurons4

Cortical neurons3

Structural differentiation of dopaminergic neurons2

Dystrophic neurites3

Induced neurite elongation1

IPSC derived neurons1

Measuring neurite length1

Early dopaminergic neurons1

Dopaminergic neuron differentiation1

Sensory6

Proteins5

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Dorsal root ga3

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Regeneration7

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Degeneration5

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Vitro4

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Nervous system1

Synaptic1

Pathology2

Huntington's1

Axons3

Protein6

Formation3

Signalling pathway1

Elegans4

Brain5

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Occurs1

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19941

Phenotypes1

Poorly understood1

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Cells5