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  • vitro
  • Knocking down PcG proteins precluded the induction of ischemic tolerance, whereas in an in vitro model, overexpressing the PcG proteins SCMH1 or BMI1 induced tolerance to ischemia without preconditioning. (pubmedcentralcanada.ca)
  • TLR4 activation leads to extensive neuronal death in vitro that depends on the presence of microglia. (pnas.org)
  • vascular
  • Vascular compression by pneumatic compression may improve local perfusion by enhancing venous and lymphatic drainage and relieving mild and otherwise subclinical ischemia, the researchers said. (medpagetoday.com)
  • selective
  • Global ischemia and cardiopulmonary resuscitation resulted in: (1) selective oxidation and hydrolysis of CLs, (2) accumulation of lyso-CLs and oxygenated free FAs, (3) activation of caspase 3/7 in the brain, and (4) motor and cognitive dysfunction. (jove.com)
  • infection
  • Both hypoxia-ischemia and infection trigger an inflammatory response in the brain. (frontiersin.org)
  • Systemic infection is associated with sustained worsening in many diseases of the CNS, yet the molecular and cellular relationship between infection outside the CNS and potential neuronal loss within the CNS is elusive. (pnas.org)
  • currents
  • Furthermore, PcG proteins decreased potassium currents in cultured neuronal cells and knocking down potassium channels elicited tolerance without preconditioning. (pubmedcentralcanada.ca)
  • Alternative
  • Here, we report an alternative pathway whereby cereberal ischemia-reperfusion triggered oxygenation of a mitochondria-specific phospholipid, cardiolipin (CL), is followed by its hydrolysis to yield monolyso-CLs and oxygenated derivatives of fatty (linoleic) acids. (jove.com)