• These systemic challenges also increased neuronal apoptosis in the brains of ME7 animals. (jneurosci.org)
  • The present study aimed to investigate whether the protective effect of vitexin protects against sevoflurane-induced neuronal apoptosis and the underlying mechanisms of this protective effect. (spandidos-publications.com)
  • The results demonstrated that Vitexin pretreatment significantly reduced neuronal apoptosis, and inhibited caspase‑3 activity, apoptosis regulator BAX protein expression and malondialdehyde levels in sevoflurane‑induced newborn rats. (spandidos-publications.com)
  • Together, the results of the current study suggest that the protective effect of vitexin reduces sevoflurane‑induced neuronal apoptosis through HIF‑1α‑, VEGF‑ and p38‑associated signaling pathways in newborn rats. (spandidos-publications.com)
  • Excitotoxic production of ROS elevates death-associated protein kinase (DAPK) activity, which provokes neuronal apoptosis in cerebral ischemia and seizure models 8 . (nature.com)
  • Persaud-Sawin et al found that transfecting CLN1 (ceroid lipofuscinosis, neuronal 1)- or CLN2-deficient cells with CLN deoxyribonucleic acid (DNA) constructs for either CLN1 or CLN2 was somewhat protective against etoposide-induced apoptosis in both cell types. (medscape.com)
  • The current study is to reveal the regulatory effects of Rg1 on cytoskeletal and morphological lesion in oxidative stress-induced neuronal apoptosis. (ijbs.com)
  • The results demonstrated that pre-treatment with Rg1 (0.1-10 μM) attenuated hydrogen peroxide (H 2 O 2 )-induced neuronal apoptosis and oxidative stress through reducing the intracellular reactive oxygen species (ROS) production and methane dicarboxylic aldehyde (MDA) level. (ijbs.com)
  • In conclusion, RES treatment improved cognitive dysfunction by reducing neuronal apoptosis in adult rats exposed to SEV. (bjbms.org)
  • Cl-amidine, 2′3′-cGAMP (an activator of stimulating Interferon genes (STING)), C-176 (a selective STING inhibitor), and Kira6 [a selectively phosphorylated inositol-requiring enzyme-1 alpha [IRE1α] inhibitor] were administrated to explore the mechanism by which NETs promote neuroinflammation and neuronal apoptosis after TBI. (biomedcentral.com)
  • Altogether, we are the first to demonstrate that NETs inhibition with Cl-amidine ameliorated neuroinflammation, neuronal apoptosis, and neurological deficits via STING-dependent IRE1α/ASK1/JNK signaling pathway after TBI. (biomedcentral.com)
  • Previous studies have suggested that neutrophils as the most abundant leukocytes in circulation and the first peripheral immune cells to reach the contused brain are highly involved in regulating neuroinflammatory responses and neuronal apoptosis after brain injury [ 6 ]. (biomedcentral.com)
  • Neuronal PKD1 inactivation by pharmacological inhibition or lentiviral silencing in vitro, or by genetic inactivation in neurons in vivo, strongly enhances excitotoxic neuronal death. (nature.com)
  • Subcortical band heterotopia is a condition in which nerve cells (neurons) do not move (migrate) to their proper locations in the fetal brain during early development. (medlineplus.gov)
  • In people with subcortical band heterotopia, some neurons that should be part of the cerebral cortex do not reach it. (medlineplus.gov)
  • These neurons stop their migration process in areas of the brain where they are not supposed to be and form band-like clusters of tissue. (medlineplus.gov)
  • Both genes provide instructions for making proteins that are involved in the movement of neurons to their proper locations in the developing brain, a process called neuronal migration. (medlineplus.gov)
  • Without proper neuronal migration, neurons in the developing brain can be misplaced, forming abnormal bands of tissue beneath the cerebral cortex. (medlineplus.gov)
  • Neuronal intranuclear hyaline inclusion disease is characterized by accumulation of eosinophilic intranuclear inclusions which can be found widely within both the central and peripheral nervous system including sympathetic and myenteric ganglion neurons, dorsal root ganglion neurons, and spinal motor neurons 1-3 . (radiopaedia.org)
  • Indeed, a vicious cycle could be envisioned by which pathological α-syn accumulation causes neuronal damage, neurodegeneration results in α-syn release, and extracellular α-syn becomes available for internalization into nearby neurons. (biomedcentral.com)
  • It is used widely to specifically label injured neurons and to score neuronal regeneration. (neuromics.com)
  • Susceptible neuronal populations also include inhibitory neurons in the thalamic Reticular Nucleus. (cdc.gov)
  • Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. (nature.com)
  • Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. (nature.com)
  • Varying the CR stimulation frequency (with respect to the frequency of abnormal target rhythm) and the number of separately stimulated neuronal subpopulations, we reveal parameter regions and related mechanisms where the two qualitatively different randomization mechanisms improve the robustness of long-lasting desynchronization effects of CR. (frontiersin.org)
  • Neuroprotective mechanisms, mainly the blood-brain barrier, reduce neuronal firing in response to ischemia (a common physiological cause of unresponsiveness at the end of life), which could protect the brain from irreversible brain damage under these conditions 14 . (nature.com)
  • The molecular mechanisms underlying fate decisions of human neural stem cells (hNSCs) between neurogenesis and gliogenesis are critical during neuronal development and neurodegenerative diseases. (uni-bielefeld.de)
  • While these mechanisms would involve intact healthy cells, a critical unaddressed question remains the role that neuronal injury/death may play in facilitating α-syn access into the extracellular space. (biomedcentral.com)
  • Thus, the present study was carried out to examine these mechanisms in aged animals by administering a control, 2 % SB- or 2 % BB-supplemented diet to aged Fischer 344 rats for 8 weeks to ascertain their effectiveness in reversing age-related deficits in behavioural and neuronal function. (cambridge.org)
  • In this paper we study the function of this novel form of iSTDP in the synchronization of the inhibitory neuronal network. (yale.edu)
  • There is growing evidence suggesting that synchronization changes in the oscillatory neuronal dynamics in the EEG or MEG reflect the transient coupling and uncoupling of functional networks related to different aspects of language comprehension. (mpi.nl)
  • L-DOPA-induced dyskinesia (LID) in Parkinson's disease has been linked to oscillatory neuronal activities in the cortico-basal ganglia network. (lu.se)
  • The finding that a single acute systemic inflammatory event can induce neuronal death in the CNS has implications for therapy in neurodegenerative diseases. (jneurosci.org)
  • Our results indicate that PKD1 inactivation underlies excitotoxicity-induced neuronal death and suggest that PKD1 inactivation may be critical for the accumulation of oxidation-induced neuronal damage during aging and in neurodegenerative disorders. (nature.com)
  • The neuronal ceroid lipofuscinoses (NCLs), also known as Batten disease, are a group of neurodegenerative disorders. (medscape.com)
  • Neuronal intranuclear hyaline inclusion disease (NIID) is a slowly progressive neurodegenerative disease characterized by eosinophilic hyaline intranuclear inclusions in the central and peripheral nervous system, and also in the visceral organs. (radiopaedia.org)
  • In conclusion, the data seem to suggest that syntactic unification is reflected by neuronal synchronization in the lower-beta frequency band. (mpi.nl)
  • Doesburg SM, Roggeveen AB, Kitajo K, Ward LM: Large-scale gamma-band phase synchronization and selective attention. (karger.com)
  • In this article, I suggest that alpha-band oscillations have two roles (inhibition and timing) that are closely linked to two fundamental functions of attention (suppression and selection), which enable controlled knowledge access and semantic orientation (the ability to be consciously oriented in time, space, and context). (scienceopen.com)
  • Aberrant integration and processing of incoming sensory information support the view of migraine as a neurological disorder characterized by a dysfunctional regulation of the balance between inhibition and excitation (I/E balance) within neuronal circuits of the cerebral cortex [ 4 , 5 , 6 ]. (biomedcentral.com)
  • Postmortem examination of 7 neonates with congenital Zika virus infection in Brazil revealed microcephaly, ventriculomegaly, dystrophic calcifications, and severe cortical neuronal depletion in all and arthrogryposis in 6. (cdc.gov)
  • Importantly, overexpression of PAD4 promotes neuroinflammation and neuronal death via the IRE1α/ASK1/JNK signaling pathway after TBI. (biomedcentral.com)
  • Hypersynchrony of neuronal activity is associated with several neurological disorders, including essential tremor and Parkinson's disease (PD). (frontiersin.org)
  • The abnormal brain development causes neurological problems in people with subcortical band heterotopia. (medlineplus.gov)
  • The electroencephalogram (EEG) is widely used on neurological clinic, as there are certain patterns of neuronal activity that are easily observed and may help treat a series of pathologies, including epilepsies. (usp.br)
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  • As such, alpha-band oscillations reflect one of the most basic cognitive processes and can also be shown to play a key role in the coalescence of brain activity in different frequencies. (scienceopen.com)
  • Neuronal oscillations reflect the activity of neuronal ensembles engaged in integrative cognition, and may serve as a functional measure for the cognitive impairment in schizophrenia. (harvard.edu)
  • The aim of this study was to assess the role that neuronal injury or, vice versa , cell integrity could have in facilitating interneuronal α-synuclein transfer and consequent protein spreading in an in vivo animal model. (biomedcentral.com)
  • CS2 has also been reported to bind neuronal proteins in vivo and covalently crosslink bovine serum albumin in vitro. (cdc.gov)
  • Coordinated reset (CR) stimulation is a theory-based stimulation technique that was designed to specifically counteract neuronal synchrony by desynchronization. (frontiersin.org)
  • The present results provide new insights for cognitive deficits and the underlying neuronal dysfunction in schizophrenia. (harvard.edu)
  • Recent evidence suggests that a non-resolving neuroinflammatory response and delayed neuronal injury following TBI are critical secondary injury pathogenesis that can result in chronic motor and cognitive function deficits [ 5 ]. (biomedcentral.com)
  • Evidence is presented that EEG oscillations in the alpha and theta band reflect cognitive and memory performance in particular. (scienceopen.com)
  • In this study, we assessed gamma band power in minimally treated patients with schizophrenia, their first-degree relatives and healthy controls during an oddball paradigm performance, as well as the relation between gamma power and cognitive performance. (karger.com)
  • Thus, both central and peripheral inflammation can exacerbate local brain inflammation and neuronal death. (jneurosci.org)
  • Together, these proposals comprise the "microglial priming hypothesis," which predicts that microglia, primed by an existing pathology such as synapse, axon, or neuronal cell body degeneration or by amyloid deposition can be stimulated to an aggressive state of inflammation by secondary influences, such as infection and injury, and during this window of activation can exacerbate neuronal death. (jneurosci.org)
  • Neuronal injury and degeneration did not exacerbate α-synuclein propagation. (biomedcentral.com)
  • The multilevel organization of brain oscillations integrates functional brain systems across multiple spatiotemporal scales, and thus implies a sophisticated solution for the highly precise temporal coordination between the fast local neuronal computations with external input and the global system state. (summerschoolsineurope.eu)
  • Because alpha frequency shows large interindividual differences which are related to age and memory performance, this double dissociation between alpha vs. theta and tonic vs. phasic changes can be observed only if fixed frequency bands are abandoned. (scienceopen.com)
  • The first type of effect was related to the detection of a (word category) violation in a syntactically structured sentence, and was found in the alpha and gamma frequency bands. (mpi.nl)
  • The aim of this study was to find in which frequency bands and where in the brain the neuronal LRTCs are altered in MDD on source level. (helsinki.fi)
  • They appear in the brain in various frequency bands, which may occur simultaneously and interact with one another. (summerschoolsineurope.eu)
  • or = 40 Hz), a frequency range important for several vital neuronal tasks. (yale.edu)
  • It has been proposed that certain neural oscillations are involved in speech and language processing, due to the close correspondence between the time scales of speech units and the frequency bands at which these oscillations occur: phonemic, syllabic and phrasal units on the speech side, vs. low gamma (25-35 Hz), theta (4-8 Hz) and delta (1-3 Hz) bands on the oscillations side. (theses.fr)
  • Over the last decade, a certain interest has been developed on a specific pattern occurring in frequency bands once ignored on clinical analysis. (usp.br)
  • γ Band plays a key role in the encoding of visual features in the primary visual cortex (V1). (nih.gov)
  • Neuronal oscillations have been proposed as a mechanism to flexibly gate information flow across the cortex, but whether these collective rhythms would actually contribute to quenching spiking unreliability and tame network chaos by synchronizing activity, or on the contrary, intensify chaos by acting as a common drive to the network, is not easily predictable. (biorxiv.org)
  • Lakatos P, Chen CM, O'Connell MN, Mills A, Schroeder CE: Neuronal oscillations and multisensory interaction in primary auditory cortex. (karger.com)
  • Investigating the cellular architecture of the developing cortex, we observed a loss of the radial orientation of radial glial cells, likely due to the disruption of the apical band of adherens junctions, which is the first effect observed after loss of the protein, and the consequent formation of rosette like structures in the brain parenchyma. (uni-muenchen.de)
  • Between the characteristic six-layered structure of the cortex (homotopic cortex) and the ventricle, we found a second, unlayered neuronal structure embedded in the white matter (heterotopic cortex). (uni-muenchen.de)
  • By epilepsy, a diversity of pathological neuronal conditions characterized by the occurrences of abnormal electric activity in a cortex region that, when diffunded, causes epileptic seizures. (usp.br)
  • Following treatment with the D2 agonist, narrowband gamma oscillations were detected only in forelimb motor cortex and dorsolateral striatum, while prominent oscillations in the theta band occurred in the globus pallidus and nigra reticulata. (lu.se)
  • In summary, we present a human cellular model of neuronal differentiation exhibiting a novel essential function of NF-κB-c-REL in fate choice between neurogenesis and oligodendrogenesis which will potentially be relevant for multiple sclerosis and schizophrenia. (uni-bielefeld.de)
  • Mounting evidence also suggests a role for p53 in differentiation of cells including neuronal precursors. (biomedcentral.com)
  • We conclude that receptor-mediated p53 transcriptional activity is involved in PC12 differentiation and may suggest a contributory role for p53 in neuronal development. (biomedcentral.com)
  • p53 transcriptional activity may be further involved in the differentiation of other non-neuronal cell types. (biomedcentral.com)
  • Despite data supporting the transcriptional activity of p53 protein in differentiation, few genetic targets have been described and fewer still within a neuronal context. (biomedcentral.com)
  • To do so, we advanced the tractability of large spiking networks of exactly solvable neuronal models by developing a strategy that allows for exact characterization of the dynamics on the attractor of effectively delayed network models in a system with fixed and finite degrees of freedom. (biorxiv.org)
  • Our results suggest that simple temporal dynamics of the mean activity can have a profound effect on the structure of the spiking patterns and therefore on the information processing capability of neuronal networks. (biorxiv.org)
  • Abnormal dynamics of EEG oscillations in alpha and beta bands were observed. (harvard.edu)
  • A surprisingly wide range of Cre drivers - including six different neuronal promoters as well as the adipose-specific Adipoq Cre promoter - exhibited off-target recombination in the epididymis, with a subset of drivers also exhibiting unexpected activity in other tissues such as the reproductive accessory glands. (elifesciences.org)
  • Tallon-Baudry C, Bertrand O, Peronnet F, Pernier J: Induced γ-band activity during the delay of a visual short-term memory task in humans. (karger.com)
  • Neural oscillations correspond to synchronous activity generated by neuronal assemblies, which can be naturally coupled, or coupled by a common stimulus. (theses.fr)
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  • Single studies detected novel neuronal antibodies in OCD patients and elevated oligoclonal bands in TS patients. (bvsalud.org)
  • A dose dependent increase in the appearance of multiple bands migrating between 260 and 400 kD with immunoreactivity against NF 160 and NF68 antibodies was also observed. (cdc.gov)
  • Cerebrospinal fluid anti-GM1 ganglioside antibodies and oligoclonal band were negative and the IgG index was normal. (who.int)
  • These genes are widely (perhaps ubiquitously) expressed in the nervous system and we have no evidence of additional neuronal isoforms of synaptotagmin, vamp, or rab3. (jneurosci.org)
  • The conserved structure and neuronal expression pattern of these genes indicate that they may function in processes that are required for both vertebrate and invertebrate synaptic transmission. (jneurosci.org)
  • Of note, neuronal injury and degeneration was accompanied by a substantial reduction of caudo-rostral propagation of human α-synuclein. (biomedcentral.com)
  • Computational studies on CR stimulation of plastic neuronal networks revealed long-lasting desynchronization effects obtained by down-regulating abnormal synaptic connectivity. (frontiersin.org)
  • Synaptic localization of p39, a neuronal activator of cdk5. (nih.gov)
  • Previous studies concerning gamma band power in schizophrenia have yielded diverse results. (karger.com)
  • In particular, compared with healthy controls, schizophrenia patients have smaller DFA exponent (implying weaker long-range temporal correlation) in the left fronto-temporal area and smaller DFA exponent, smaller life-time (indicating shorter oscillation burst), and smaller waiting-time in the occipital area in beta band at resting state with eyes open. (harvard.edu)
  • In addition, schizophrenia patients have larger DFA exponent, larger life-time, and larger waiting-time at some clustered channels in the temporo-parietal area in alpha band at watching video. (harvard.edu)
  • A neuronal Drosophila vamp (n-syb) is described here and is localized to chromosome band 62A. (jneurosci.org)
  • In 2001, a deletion mutation in the gene (now known as VPS13A) localized to chromosome band 9q21 was identified as the site for the defect generating the autosomal recessive form of NA. (medscape.com)
  • This lead us to the conclusion, that the neuronal misplacement is a secondary effect, which occurs due to the observed disruption of the radial glial structure. (uni-muenchen.de)
  • Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization. (nih.gov)
  • Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene. (wikipedia.org)
  • We observed a significant decrease in the intensity of protein staining and immunoreactivity of all three NF protein bands as well as decreased immunoreactive breakdown products in animals exposed to 200 ppm CS2. (cdc.gov)
  • Altered structure or function of the proteins produced by the DCX or PAFAH1B1 gene impairs important interactions that are needed for neuronal migration. (medlineplus.gov)
  • Neuronal migration is essential for normal brain development and function. (medlineplus.gov)
  • Disorders comprising a spectrum of brain malformations representing the paradigm of a diffuse neuronal migration disorder. (bvsalud.org)
  • In most cases, the bands are symmetric, which means they occur in the same places on the right and left sides of the brain. (medlineplus.gov)
  • Subcortical band heterotopia is typically found when brain imaging is done following the onset of seizures, usually in adolescence or early adulthood. (medlineplus.gov)
  • Alpha-band oscillations are the dominant oscillations in the human brain and recent evidence suggests that they have an inhibitory function. (scienceopen.com)
  • In the brain, these smoother and firmer bends are called gyri and sulci and form distinctive curved tissue patterns imposing a mechanical stimulus on neuronal networks. (rsc.org)
  • This stimulus is hypothesized to be essential for proper brain cell function but lacks in most standard neuronal cell assays. (rsc.org)
  • In contrast, curvatures in the brain span a wide physical range, leaving it unknown which precise role distinct curvatures may play on neuronal cell signaling. (rsc.org)
  • Conventional brain MRI findings of patients with neuronal intranuclear hyaline inclusion disease strongly resemble those seen in fragile X-associated tremor/ataxia syndrome (FXTAS) , including symmetric white matter involvement in combination with hyperintense changes of the middle cerebellar peduncles 4 . (radiopaedia.org)
  • The main topic of the summer school is the new developments in neurophysiology and neuroscience to study the brain's ability to generate and maintain neuronal oscillations and the possibility to modulate them with the non-invasive brain stimulation. (summerschoolsineurope.eu)
  • However, therapeutic options for posttraumatic neuroinflammation and ongoing neuronal death remain limited and are often ineffective, indicating a lack of understanding of the pathophysiological mechanism of secondary brain injury post-TBI and targeted treatment approaches. (biomedcentral.com)
  • In addition to the grossly visible malformations, microscopic sections of normal-appearing brain may show disorganization of the normal laminar neuronal arrangement. (msdmanuals.com)
  • The functional roles of the two bands and the neural circuits originating them are not completely clear yet. (nih.gov)
  • In rodents V1 two ranges within the γ band are sensitive to contrast: a broad γ band (BB) increasing with contrast, and a narrow γ band (NB), peaking at ∼60 Hz, decreasing with contrast. (nih.gov)
  • Amongst the several concepts applied to the mental model, the most adequate one for this research refers to the formation and strengthening of the neuronal net through the presence of more synapses associated to stimulus that modify the concepts and the relationship between the subject and his environment (Merrill, 2000). (bvsalud.org)
  • More than 200 cases of subcortical band heterotopia have been reported in the scientific literature. (medlineplus.gov)
  • Mutations in the DCX or PAFAH1B1 gene cause subcortical band heterotopia. (medlineplus.gov)
  • Most individuals with subcortical band heterotopia have DCX gene mutations. (medlineplus.gov)
  • The inheritance pattern of subcortical band heterotopia depends on its genetic cause. (medlineplus.gov)
  • When subcortical band heterotopia is caused by mutations in the DCX gene, it is inherited in an X-linked pattern. (medlineplus.gov)
  • Most males with subcortical band heterotopia have a DCX gene mutation that is not inherited and is present in only some of the body's cells, a situation known as mosaicism. (medlineplus.gov)
  • When subcortical band heterotopia is caused by a PAFAH1B1 gene mutation, it is generally not inherited but arises from a mutation in the body's cells that occurs after conception, which leads to mosaicism. (medlineplus.gov)
  • Our results demonstrate how sensitive neuronal cell function may be linked and controlled through specific curved geometric features. (rsc.org)
  • Here we report a hydrogel-based multi-curvature design consisting of over twenty bands of distinct parallel curvature ranges to precisely engineer neuronal networks' growth and signaling under patterns of arcs. (rsc.org)
  • We find that, below the transition to collective oscillations, neuronal networks have a stereotypical dependence on the delay so far only described for scalar systems and low-dimensional maps. (biorxiv.org)
  • In addition to analyzing the correlations between neuronal LRTCs and depression severity in parcel level, we studied correlations in functional networks to get a better understanding of the system level alterations in MDD. (helsinki.fi)
  • Oscillations are inherent feature of neuronal networks. (summerschoolsineurope.eu)
  • This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. (wikipedia.org)
  • In addition, Cl-amidine exerted neuroprotective effects by attenuating BBB disruption, inhibiting immune cell infiltration, and alleviating neuronal death after TBI. (biomedcentral.com)
  • POT1 mutation carriers had a range of benign and malignant neoplasms involving epithelial, mesenchymal, and neuronal tissues in addition to B- and T-cell lymphoma and myeloid cancers. (cdc.gov)
  • In the ventricle, I bands were most heavily labeled, indicating a probable association of radioactive amine with thin filaments. (rupress.org)
  • Within the PC12 neuronal context, putative p53-occupied genomic loci spanned the entire Rattus norvegicus genome upon NGF treatment. (biomedcentral.com)
  • Kann O , 2018 , 'Metabolic modulation of neuronal gamma-band oscillations. (edu.au)
  • In order to rule out spinal cord pathol- lar immune derangements that potentially ogy, craniospinal magnetic resonance imag- result in neuronal injury and demyelina- ing (MRI) was obtained immediately. (who.int)
  • In addition c-REL impairment further produced a significant decrease in neuronal survival. (uni-bielefeld.de)