Loading...
  • receptor
  • Design, Synthesis, and Evaluation of a Diazirine Photoaffinity Probe for Ligand-Based Receptor Capture Targeting G Protein-Coupled Receptors. (abcam.com)
  • The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cobra-1 recruitment. (etis.ee)
  • Part of this expansion consists of genes encoding proteins with unusual domain architectures, which often contain both upstream receptor and downstream activator domains, suggesting a potential role for direct connections (shortcuts) that bypass usual signal transduction pathways. (beds.ac.uk)
  • The group of proteins involved in apoptosis, members of which incorporate the death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) [ 1 ], and the group of proteins involved in innate immunity, members of which incorporate the Toll/interleukin-1 receptor (TIR) domains [ 2 , 3 ], represent excellent examples of such networks. (beds.ac.uk)
  • vertebrates
  • The repertoire of several families of innate immunity proteins is expanded in amphioxus compared to both vertebrates and protostome invertebrates. (beds.ac.uk)
  • downstream
  • Protein networks are often 'joined' (or 'connected') by specialized protein-protein interaction domains that specifically recognize their targets and thus connect upstream and downstream elements of the network. (beds.ac.uk)
  • family
  • Since their discovery almost 20 years ago, the Inhibitor of Apoptosis (IAP) family of proteins have gathered growing interest as possible drug targets in a wide range of malignancies. (omicsonline.org)
  • Avian Interferon-Inducible Transmembrane Protein Family Effectively Restricts Avian Tembusu Virus Infection. (abcam.com)
  • Structurally, NLRs share a typical tripartite architecture with a conserved central nucleotide-binding domain, which restrains the catalytic activity of NLR family proteins. (frontiersin.org)
  • transcription
  • METHODS: Pulp tissues were subjected to reverse transcription-polymerase chain reaction (PCR) detection for transporter isoforms belonging to organic anion transporting polypeptide (Oatp), organic anion transporter (Oat), organic cation transporter (Oct), multidrug resistance-associated protein (Mrp), and multidrug resistance protein (Mdr) families. (biomedsearch.com)
  • SMN1
  • The SMN1 protein has been associated with the assembly of spliceosomal ribonucleoproteins, which are critical to messenger RNA processing. (medscape.com)
  • human
  • You can also "Select all" mouse superfamily members to obtain their protein sequences and the protein sequences for all mouse, human and rat homologs of the mouse superfamily members. (jax.org)
  • Therefore it is important to develop alternative models that correctly recapitulate the complex pattern of proteins in human AD. (annexpublishers.co)
  • Cancer
  • Out of a total data set of 3048 identified proteins, 32 proteins were at least twofold up-regulated in the colon cancer stem cells when compared with the differentiated cells. (mcponline.org)
  • Class
  • For mouse superfamily members not included in any HomoloGene Class, only the mouse protein sequence is returned. (jax.org)
  • Domain
  • The extent of such arrangements in the innate immune network of amphioxus suggests that domain shuffling, which is an important mechanism in the evolution of multidomain proteins, has also shaped the development of immune systems. (beds.ac.uk)
  • B. NALP3: verschiedene hereditäre, autoinflammatorischer Syndrome, „nucleotide-binding oligomerization domain containing protein 2"/NOD2: M. Crohn, Blausyndrom). (springer.com)
  • mRNA
  • RIAP2 mRNA content and protein levels did not change when cells were switched from 25 to 5 mM potassium. (deepdyve.com)
  • role
  • INTRODUCTION: Membrane transport proteins (transporters) play a crucial role in the transmembrane uptake and/or efflux of various compounds such as inorganic ions, endogenous bioactive substances such as prostaglandins (PGs), and drugs such as nonsteroidal anti-inflammatory drugs. (biomedsearch.com)
  • region
  • At the C-terminal region of NLR proteins are a series of leucine-rich repeats (LRRs) that are believed to initiate NLR activation after recognition of the appropriate signal, although this mechanism is still unclear ( 3 ). (frontiersin.org)
  • markers
  • Exosomes are known as a representative subset of EVs and are seen as cup-like shaped nanovesicles (30-200 nm) by transmission electron microscope, characterized by the presence of exosome-enriched protein markers (e.g. (springer.com)
  • In this cross-sectional study, "BforSMA" (Biomarkers for SMA), candidate protein and metabolite markers were identified. (plos.org)