Loading...
  • Blocking Agents
  • Regardless, all in all some 30,000 patients had been given tubocurarine by 1941, although it was Griffith and Johnson's 1942 publication that provided the impetus to the standard use of neuromuscular blocking agents in clinical anesthestic practice - a revolution that rapidly metamorphosized into the standard practice of "balanced" anesthesia: the triad of barbiturate hypnosis, light inhalational anesthesia and muscle relaxation. (wikipedia.org)
  • Present clinical anesthetic practice still employs the central principle of balanced anesthesia though with some differences to accommodate subsequent technological advances and introductions of new and better gaseous anesthetic, hypnotic and neuromuscular blocking agents, and tracheal intubation, as well as monitoring techniques that were nonexistent in the day of Gray and Halton: pulse oximetry, capnography, peripheral nerve stimulation, noninvasive blood pressure monitoring, etc. (wikipedia.org)
  • tubocurarine
  • Curare had been used as a source of arrow poison by South American natives to hunt animals, and they were able to eat the animals' contaminated flesh subsequently without any adverse effects because tubocurarine cannot easily cross mucous membranes.Thus, tubocurarine is effective only if given parenterally, as demonstrated by Bernard, who also showed that the site of its action was at the neuromuscular junction. (wikipedia.org)
  • In this sense, tubocurarine is the prototypical adjunctive neuromuscular non-depolarizing agent. (wikipedia.org)
  • neurosurgery
  • Therefore, the investigators performed a randomized controlled trial to evaluate the effect of changing NMB agent on the variability of MEP amplitude during neurosurgery. (clinicaltrials.gov)
  • relaxation
  • They also have a longer duration of action, making them more suitable for maintaining neuromuscular relaxation during major surgical procedures. (pharmacycode.com)
  • Maintenance for continued surgical relaxation (only after return of neuromuscular function): Intermittent dosing: 0.01 to 0.015 mg/kg or continuous infusion of 0.8 to 1.2 mcg /kg/ minute (0.048 to 0.072 mg /kg/ hour ). (drugs.com)