• Following reports, the disease's spectrum was enlarged to encompass neurologic problems, as well as a severe variant with dwarfism, gonadal hypoplasia, and learning disabilities, in addition to the classic symptoms of XP. (news-medical.net)
  • In this podcast with nurse Anne Fulton, Nurse Alice, from the Ask Nurse Alice podcast, talks about early signs and symptoms of clinical deterioration and how the Modified Early Warning Score (MEWS) can be implemented. (films.com)
  • Neurologic symptoms may vary and are fully reversible. (medscape.com)
  • 1 In most cases (85%-90%), the disease initially presents with episodic neurologic symptoms, which are described as a clinically isolated syndrome. (psychiatrist.com)
  • This includes the same diagnoses as subitem (2), however, this category applies when there is a history of progressive deterioration in the neurologic symptoms and physical findings which include worsening sensory loss, increasing muscle weakness, or progressive reflex changes. (mn.gov)
  • Moreover, rheumatologic, ophthalmologic and neurologic symptoms and signs have been described in up to 20% of the patients with LS. (hindawi.com)
  • Although disability and quality-of-life scales were collected, deterioration was loosely defined as any self-reported change in disease-related symptoms. (neurology.org)
  • Her neurologic symptoms improved gradually, and she achieved a full clinical recovery, with radiological evidence of recanalization of the straight sinus at follow-up. (surgicalneurologyint.com)
  • Patients with neurologic symptoms usually carry a higher disease burden than patients with only liver symptoms. (medscape.com)
  • The loss of these cells results in the deterioration of nervous system functions (neurodegeneration) and causes the movement problems, weakness, and other signs and symptoms of spastic paraplegia type 5A. (medlineplus.gov)
  • Patients who are symptomatic present with episodic deterioration of neurologic and dermatologic manifestations. (medscape.com)
  • Clinical manifestations are limited to photo-induced deterioration of the skin and eyes. (proteopedia.org)
  • Clinical manifestations present more commonly in children than adults include serious and recurrent bacterial infections, GI tract infections, chronic parotid swelling, lymphocytic interstitial pneumonitis and early onset of progressive neurologic deterioration. (theseoultimes.com)
  • Multiple sulfatase deficiency (MSD) is a very rare and fatal lysosomal storage disease characterized by a clinical phenotype that combines the features of different sulfatase deficiencies (whether lysosomal or not) that can have neonatal (most severe), infantile (most common) and juvenile (rare) presentations with manifestations including hypotonia, coarse facial features, mild deafness, skeletal anomalies, ichthyosis, hepatomegaly, developmental delay, progressive neurologic deterioration and hydrocephalus. (orpha.net)
  • This outcome was significantly more likely in patients who had neurologic manifestations at the time of WD diagnosis than in other clinical subgroups. (medscape.com)
  • Moreover, a large IVBDA may induce brain stem compression due to the position adjacent to the brain stem, which might result in a neurologic deficit. (ajnr.org)
  • Radicular pain, with or without regional low back pain, with static or no neurologic deficit. (mn.gov)
  • Without resection, they may result in permanent neurologic deficit or death. (cns.org)
  • Wilson disease is a disorder of copper metabolism that, when untreated, can present with hepatic, neurologic, or psychiatric disturbances - or a combination of these - in individuals ages three years to older than 70 years. (nih.gov)
  • After their pregnancies, 93% of patients had unchanged status, 6% experienced only hepatic deterioration, and 1% experienced neurologic deterioration. (medscape.com)
  • Seizures are most frequently observed, but focal neurologic deficits, movement disorders, trigeminal neuralgia, and mimics of hemiplegic migraines have been reported. (hindawi.com)
  • In these cases, neurologic findings on history and physical examination are either absent or do not show progressive deterioration. (mn.gov)
  • Neurologic findings consisted of myelopathy affecting the lumbar intumescence (1 dog) and T3-L3 myelopathy (2 dogs). (avma.org)
  • Furthermore, some patients have neurologic and ophthalmologic deterioration with time. (news-medical.net)
  • The significantly higher rate of neurological deterioration associated with intensive treatment in patients with initial systolic blood pressure of 220 mm Hg or more warrants caution against broad recommendations for intensive systolic blood pressure reduction in patients with intracerebral hemorrhage," the investigators, led by Iryna Lobanova, MD, Zeenat Qureshi Stroke Institute, University of Missouri, in Columbia, write. (medscape.com)
  • Treating physicians may have responded to neurological deterioration by adjustment in the rate of (or avoidance of any further) SBP decline, which could have prevented irreversible ischemia and long-term adverse outcomes," the investigators write. (medscape.com)
  • Background Early neurological deterioration occurs frequently after subarachnoid haemorrhage (SAH). (bmj.com)
  • In a multicenter, single-arm, open-label phase 2 study on patients with relapsed or refractory B-precursor acute lymphoblastic leukemia, the distribution of any grade neurologic ir-AEs frequency was 52% among patients receiving blinatumomab, and grade 3 or 4 neurologic ir-AEs occurred in 11% and 2% patients, respectively [ 19 ]. (hindawi.com)
  • 2004) that tracheostomies in acute SCI individuals may not increase the risk of neurologic deterioration or surgical site infection. (scireproject.com)
  • Several factors have been associated with clinical deterioration, including aneurysm rebleeding, hydrocephalus, delayed cerebral ischaemia from vasospasm, and seizures. (bmj.com)
  • We have used ECT successfully in our clinic for patients with MS. However, there are concerns about the potential effects of ECT on neurologic and cognitive function. (psychiatrist.com)
  • Dementia with Lewy bodies is chronic cognitive deterioration characterized by cellular. (msdmanuals.com)
  • They were 65 or older, with no previous history of psychotic disturbance, schizophrenia, neurodegenerative condition, institutionalization or neurologic treatment for cognitive alterations. (bvsalud.org)
  • Toxicity of 1-BP is poorly understood, but it may be a neurologic, reproductive, and hematologic toxin. (cdc.gov)
  • RVCL is associated with progressive deterioration in visual acuity due to multifocal microvascular disease, retinal neovascularization leading, and/or glaucoma. (wikipedia.org)
  • Progressive neurologic deterioration unresponsive to systemic immunosuppression including corticosteroid therapy and chemotherapeutic agents. (wikipedia.org)
  • Once considered an exclusive cutaneous disorder, the neurologic involvement present in LScs has been described in several case reports. (hindawi.com)
  • Evidence of the disorder may be noted from birth, although neurologic deterioration progresses with age. (medscape.com)
  • The patient's cervical disorder was found before neurologic deterioration and treated with one operation to decompress and fuse the spine from the front and the back of the neck. (cincinnatichildrens.org)
  • Orofacial pain and TMD can be associated with pathologic conditions or with disorders related to somatic and neurologic structures, such as primary headache disorders and rarely have a solitary cause and numerous factors have been implicated 15 . (bvsalud.org)
  • This paper mainly reviews the clinical features, pathogenesis, and therapeutic strategies of neurologic ir-AEs. (hindawi.com)
  • Investigators found that ICH patients whose initial SBP was 220 mmHg and who underwent intensive BP lowering had twice the relative risk for neurologic deterioration at 24 hours without any reduction in hematoma expansion or 3-month risk for death and disability compared to their counterparts who underwent standard SBP lowering. (medscape.com)
  • The incidence rate for any grade ICIs-related neurologic ir-AEs in patients included in clinical trials has been reported to be approximately 3.8% to 12% [ 20 ]. (hindawi.com)
  • The distribution of grade 3-4 neurologic ir-AEs frequency was 0.7% among patients receiving anti-CTLA-4 (ipilimumab and tremelimumab), 0.4% among patients receiving anti-PD1 (nivolumab, pembrolizumab, lambrolizumab, and pidilizumab), and 0.7% among patients receiving a combination therapy (anti-CTLA-4 + anti-PD1) [ 20 ]. (hindawi.com)
  • 62.3% of patients experienced any grade neurologic ir-AEs [ 21 ]. (hindawi.com)
  • Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia. (easy-immune-health.com)
  • Background: Ventral brainstem compression secondary to complex craniovertebral junction abnormality is an infrequent cause of neurologic deterioration in pediatric patients. (edgehill.ac.uk)
  • The purpose of this study was to evaluate the surgical outcomes of pediatric patients who underwent posterior occipitocervical decompression and instrumentation followed by endoscopic endonasal odontoidectomy performed to relieve neurologic impingement involving the ventral brainstem and craniocervical junction. (edgehill.ac.uk)
  • Immediately after surgery, all dogs were paraplegic with pelvic limb neurologic dysfunction consistent with myelopathy affecting the L4 through caudal spinal cord segments. (avma.org)
  • It is important to separate SSD from CRS or other forms of dysraphism as SSD is unlikely to benefit significantly from detethering procedures because the neurologic disturbance is related to the congenital hypoplasia of a segment of the cord rather than to cord tethering. (bioline.org.br)
  • The American Spinal Injury Association (ASIA) defines a complete neurologic lesion as an absence of sensory and motor function below the level of injury including the lowest sacral segment2. (jortho.org)
  • Secondary outcomes included neurologic deterioration, as determined by the Glasgow Coma Scale or the NIH Stroke Scale , as well as hematoma expansion and hypotension. (medscape.com)
  • Flynn JM, Otsuka NY, Emans JB, Hall JE, Hresko MT. Segmental spinal dysgenesis: Early neurologic deterioration and treatment. (bioline.org.br)
  • By the conclusion of this session, participants should be able to: 1) Describe the importance of intramedullary spinal cord tumor resection in preventing further quality of life deterioration. (cns.org)
  • However, the accumulation of evidence suggests that immunotherapy also induces severe and complex neurologic immune-related adverse events (ir-AEs) and even leads to immunotherapy-related death, which arouses the concern of clinicians. (hindawi.com)
  • This study serves as reinforcement of the safety of pregnancy in people with Wilson disease who wish to get pregnant and do not have excessively severe liver or neurologic disease," Dr. Fred Askari, director of the Wilson Disease Center of Excellence at the University of Michigan, Ann Arbor, told Reuters Health by email. (medscape.com)
  • Why Seizures Are a Neurologic Emerg. (films.com)
  • We also suspected that generalized epilepsy might cause the neurologic deterioration, and she was treated with phenytoin. (surgicalneurologyint.com)
  • In scleroderma en coup de sabre (LScs) the atrophic lesion in frontoparietal area is the disease hallmark. (hindawi.com)
  • Three of the dogs showed signs consistent with poisoning, including vomiting, neurologic signs, and rapid deterioration. (cdc.gov)
  • Our study showed that treatment with HBO significantly decreased the expressions of TLR4, NF-κ B and the downstream inflammatory agents, such as TNF-α, IL-6, IL-1β and ICAM-1, and also improved brain edema, blood-brain barrier permeability and neurologic function. (karger.com)
  • While resection did not significantly improve QOL, resection of these tumors is necessary to halt further QOL deterioration. (cns.org)
  • The present study reveals that surgical resection is necessary to halt, but no reverse, quality of life deterioration. (cns.org)
  • Signs of clinical deterioration often start appearing hours before an adverse event or arrest. (films.com)
  • The incidence of the neurologic ir-AEs has varied in different immunotherapeutic agents. (hindawi.com)
  • Any grade CAR-T-related neurologic ir-AEs, by contrast, have the highest incidence. (hindawi.com)
  • It is characterized by hypersensitivity of the skin to sunlight, followed by high incidence of skin cancer and frequent neurologic abnormalities. (proteopedia.org)
  • Doctors around the world leave different periods of time following initial neurologic deterioration before they declare brain death. (lifeissues.net)
  • The most common presenting neurologic feature is asymmetric tremor, which is variable in character and may be predominantly resting, postural, or kinetic. (medscape.com)
  • If unrecognized, the neurologic deterioration becomes irreversible and may result in death. (easy-immune-health.com)
  • Routine referrals are usually seen within 10 working days while emergencies with rapid neurologic deterioration are seen as soon as possible. (bccancer.bc.ca)
  • While neurologic problems get the spotlight, more subtle nitrous oxide effects happen to EVERYONE exposed to nitrous oxide anesthesia. (easy-immune-health.com)