• Neuroendocrine carcinoma of the cervix is best defined separately:Neuroendocrine: Of, relating to, or involving the interaction between the nervous system and the hormones of the endocrine glands.Carcinoma: An invasive malignant tumor derived from epithelial tissue that tends to metastasize to other areas of the body. (wikipedia.org)
  • However, nonfunctioning pancreatic endocrine tumors are the most common enteropancreatic neuroendocrine tumor. (medscape.com)
  • BACKGROUND: Mixed acinar-neuroendocrine carcinoma (MANEC) of the pancreas is a rare tumor. (bvsalud.org)
  • Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor, typically described as an asymptomatic violet, dome-shaped nodule found in a sun-exposed area. (uchub360.com)
  • Nonfunctioning neuroendocrine neoplasms can still cause symptoms relating to tumor size and location such as obstruction or internal bleeding. (rarediseases.org)
  • However, the tumor biopsy revealed a malignant neoplasm that originating from neuroendocrine cells. (biomedcentral.com)
  • Utility of a ready-to-use PCR system for neuroendocrine tumor diagnosis. (cdc.gov)
  • Patients with SCA, specially with this pseudo solid-appearance, such as the present case, may have imaging findings that closely resemble those of patients with pancreatic neuroendocrine neoplasms (pNENs), metastatic renal cell carcinoma, solid pseudopapillary tumor or acinar cell carcinomas (1,4). (spg.pt)
  • CONCLUSION: In asymptomatic patients and when biochemical and clinical suspicion of neuroendocrine tumor is strong, you have to perform anatomical and functional investigations to detect these neoplasms. (unime.it)
  • An insular or trabecular growth of round uniform cells, separated by a fibrovascular stroma, is a typical look for a neuroendocrine tumor. (surgpath4u.com)
  • Moran CA, Suster S. Neuroendocrine carcinomas (carcinoid tumor) of the thymus. (surgpath4u.com)
  • In neuroendocrine tumors (NETs), liver metastases (LM) represent the most crucial prognostic factor, irrespective of the primary tumor site. (oaepublish.com)
  • Circulating tumor cell heterogeneity in neuroendocrine prostate cancer by single cell copy number analysis. (cornell.edu)
  • Neuroendocrine tumors with small cell cervical represent less than 2% of cervical cancers, and if their evolution depends on the volume and tumor stage, prognosis is generally dark Morphological characteristics and clinical features of these tumors are comparable with neuroendocrine tumors of the lung. (issr-journals.org)
  • Carcinoid heart disease (CHD) is a rare and potentially lethal manifestation of an advanced carcinoid (neuroendocrine) tumor. (karger.com)
  • It is a high-grade and poorly differentiated neuroendocrine tumor, usually diagnosed in advanced stages, with a poor prognosis and few therapeutic options in that setting. (mdpi.com)
  • Pancreatic neuroendocrine neoplasms (pNENs) are an increasingly common group of malignancies that arise within the endocrine tissue of the pancreas. (rarediseases.org)
  • Lower gastrointestinal neuroendocrine neoplasms associated with hereditary cancer syndromes: a case series. (cdc.gov)
  • Neuroendocrine tumors (NETs) are rare neoplasms originating from diffuse neuroendocrine cells. (oaepublish.com)
  • Highly aggressive, poorly differentiated neoplasms were defined as Grade-3 neuroendocrine carcinomas (NECs) when originating from the gastrointestinal tract, or as small- or large-cell NECs when appearing in the lung. (oaepublish.com)
  • [ 2 ] Well- to moderately differentiated neuroendocrine neoplasms (WMD-NEN) are a highly heterogeneous group of tumors comprising low-grade (G1) and intermediate-grade (G2) NETs of the gastrointestinal tract, typical and atypical carcinoids of the lung and thymus, and other cancers such as medullary thyroid carcinoma and pheochromocytoma/paraganglioma. (oaepublish.com)
  • Small-cell carcinoma (SCC) of the cervix is an exceptional member of the neuroendocrine group of cervical carcinomas that is frequently intermixed with a non-SCC component in the form of an adenocarcinoma (ADC) or squamous carcinoma. (wikipedia.org)
  • In addition of the categories of squamous dysplasia and carcinoma in situ , two additional lesions were added to the group of pre-invasive lesions: atypical adenomatous hyperplasia (AAH) and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). (ersjournals.com)
  • The following review highlights the topics of actinic keratoses, basal cell carcinoma, squamous cell carcinoma, Kaposi's sarcoma, and Merkel cell carcinoma. (jcadonline.com)
  • MCC is about 30 times less common than melanoma and far less common than basal or squamous cell carcinoma, and the clinical features of MCC are not extremely specific. (medscape.com)
  • To evaluate the expression of E-cadherin (E-cad) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). (ijpmonline.org)
  • Immunohistochemistry was used to detect E-cad expression in 20 cases each of normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma. (ijpmonline.org)
  • We observed a significant decrease in E-cad expression from dysplasia to poorly differentiated squamous cell carcinoma suggesting that loss of expression of E-cad is closely related to carcinoma. (ijpmonline.org)
  • Because of the distinct natural history of small cell carcinoma of the uterine cervix, and because patients with this condition are considered to have a systemic disease, the treatment strategies for this disease are different from those of other carcinomas" (ajronline.org). (wikipedia.org)
  • Large-cell carcinoma (LCC), like small-cell carcinoma (SCC) is very rare and only accounts for about 5% of all cervical cancers. (wikipedia.org)
  • A month later, this mass was surgically excised and the histology examination showed a poorly differentiated small cell carcinoma, with histopathologic features of a Merkel cell carcinoma. (springeropen.com)
  • Large cell neuroendocrine carcinoma (LCNEC) is now recognized as a histologically high grade non small cell carcinoma showing histopathological features of neuroendocrine differentiation as well as immunohistochemical neuroendocrine markers. (ersjournals.com)
  • Extrapulmonary small-cell carcinoma (SCC) is a rare neoplasm that shares certain features with its pulmonary counterpart and occurs predominantly in the gastrointestinal tract (GIT). (mdpi.com)
  • Type 2 multiple endocrine neoplasia (MEN2) , in contrast, is caused by mutations in the RET proto-oncogene and typically presents as medullary thyroid carcinoma, hyperparathyroidism, or pheochromocytoma. (medscape.com)
  • Complicated Case Presentation: Management of Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1. (cdc.gov)
  • The neuroendocrine system is made up of cells that "connect" the nervous system and the endocrine system. (medifocus.com)
  • There are two types of neuroendocrine carcinomas of the cervix: small-cell and large-cell. (wikipedia.org)
  • The main histological types of carcinoma cervix are: 1. (drsushiljain.com)
  • We report two new cases of neuroendocrine carcinoma of the cervix small cell and through the literature data we review the different aspects of this rare entity. (issr-journals.org)
  • It is probable that more people may actually have carcinoid tumors but because carcinoids are often asymptomatic, an individual may never know that a carcinoid has developed. (medifocus.com)
  • Its early detection is challenging due to the organ's deep-seated location and the often asymptomatic nature of the disease in its initial stages. (healthtrip.com)
  • Clinical hallmarks of VHL disease include the development of retinal and central nervous system (CNS) hemangioblastomas (blood vessel tumors), pheochromocytomas , multiple cysts in the pancreas and kidneys, and an increased risk for malignant transformation of renal cysts into renal cell carcinoma. (medscape.com)
  • Early identification of VHL is important because of the increased risk of serious complications (eg, renal cell carcinoma) to foster more effective treatment options and better prognoses. (medscape.com)
  • The relationship between blood pressure and risk of renal cell carcinoma. (who.int)
  • Epidemiology of Renal Cell Carcinoma: 2022 Update. (who.int)
  • Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort. (who.int)
  • Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. (who.int)
  • Carcinoid tumors are neuroendocrine origin neoplasm and may produce serotonin or other functional peptide hormones. (biomedcentral.com)
  • However, the pathological finding suggested a malignant neoplasm originating form neuroendocrine cells (Fig. 2A ). (biomedcentral.com)
  • According to the WHO classification, SCNs are classified into microcystic SCA, macrocystic SCA, solid serous adenoma, von Hippel-Lindau-associated serous cyst neoplasm, and mixed serous-neuroendocrine neoplasm (2). (spg.pt)
  • Microcystic serous cystadenoma mimicking pancreatic neuroendocrine neoplasm: report of a resected case with preoperative diagnostic difficulty and review of the literature. (spg.pt)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • Hepatocellular carcinoma (HCC) was considered based on the image findings and underlying HBV infection. (biomedcentral.com)
  • PHCT presents as a small and single nodule, is extremely rare and is difficult to differentiate from hepatocellular carcinoma (HCC), particularly in a region with high prevalence of HCC. (biomedcentral.com)
  • The size of the mass can vary from 1-20 cm in diameter and the risks of malignant transformation into hepatocellular carcinoma liver cancer increases significantly at 4 cm. (drpapoulas.com)
  • Hepatocellular carcinoma (HCC) is the most common primary liver cancer.Hepatocellular carcinoma is a major cause of morbidity and mortality in patients with background liver disease. (drpapoulas.com)
  • Genetic Characteristics of Colorectal Neuroendocrine Carcinoma: More Similar to Colorectal Adenocarcinoma. (cdc.gov)
  • Another change is the subclassification of adenocarcinoma: the definition of bronchioalveolar carcinoma has been restricted to noninvasive tumours. (ersjournals.com)
  • As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
  • [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
  • The Hystologic exam has revealed an ulcerative polypoid gastric carcinoma with cell poorly cohesive and infiltration of the muscular gastric wall and an incidental parietal gastric lesion which was a paraganglioma with immunocytochemical investigations positive for NSE and negative for CD117, S100, CD34 e SMA. (unime.it)
  • Some authors prefer carcinoid , atypical carcinoid, small cell and large cell neuroendocrine carcinomas whereas others prefer well, moderately and poorly differentiated neuroendocrine carcinoma. (surgpath4u.com)
  • Merkel Cell Carcinoma (MCC) is an uncommon neuroendocrine cutaneous carcinoma which is characterized by high incidence of early loco-regional relapse and distant metastases (Poulsen 2004 ). (springeropen.com)
  • Twenty-two of 26 metastases were high grade and often were not histologically suggestive of prostate carcinoma. (citationimpact.com)
  • Consensus on management of advanced medullary thyroid carcinoma on behalf of the Working Group of Thyroid Cancer of the Spanish Society of Endocrinology (SEEN) and the Spanish Task Force Group for Orphan and Infrequent Tumors (GETHI). (cdc.gov)
  • Merkel cell carcinoma (MCC) is an uncommon neuroendocrine cutaneous carcinoma. (springeropen.com)
  • While still in preliminary stages, agents, such as ingenol mebutate, vismodegib, and sirolumus, may become integral drugs in the armamentarium of managing cutaneous carcinoma. (jcadonline.com)
  • Carcinoid tumors were initially identified in 1888 and were thought to clinically and histologically (cellular appearance under a microscope) resemble carcinoma cells (highly malignant cancer cells) but behave in a more benign fashion than true cancer cells. (medifocus.com)
  • Histologically confirmed urothelial carcinoma with metastatic disease or with unresectable, locally advanced disease. (bcan.org)
  • The adaptation of cells to hypoxia appears to be mediated via hypoxia inducible factor-1α (HIF-1α) which is also said to be associated with malignant transformation of epithelial cells in various other carcinomas like prostate and cervical carcinoma. (ijpmonline.org)
  • Large cell neuroendocrine carcinoma (LCNEC) is a rare type of lung cancer that accounts for approximately 3% of lung cancers. (e-acfs.org)
  • Large cell neuroendocrine carcinoma (LCNEC) is a rare subtype of lung cancer, accounting for 1% to 3% of all lung cancers, and is known for its aggressive behavior [ 1 ]. (e-acfs.org)
  • There has been substantial evolution of concepts in neuroendocrine lung tumour classification. (ersjournals.com)
  • The Clinical Utility of a Novel Blood-Based Multi-Transcriptome Assay for the Diagnosis of Neuroendocrine Tumors of the Gastrointestinal Tract. (cdc.gov)
  • This book brings together recognized experts in the field to describe their current techniques for the surgical treatment of diseased thyroid, parathyroid, and adrenal glands, as well as neuroendocrine tumors of small bowel, pancreas, liver, and skin. (nshealth.ca)
  • There are many types of tumors that arise from the neuroendocrine system of which carcinoid tumors are the most common. (medifocus.com)
  • Finally, a new class was defined called carcinoma with pleomorphic, sarcomatoid, or sarcomatous elements, which brings together a number of proliferations characterized by a spectrum of epithelial to mesenchymal differentiation. (ersjournals.com)
  • The clinical applications of a multigene liquid biopsy (NETest) in neuroendocrine tumors. (cdc.gov)
  • The NETest: The Clinical Utility of Multigene Blood Analysis in the Diagnosis and Management of Neuroendocrine Tumors. (cdc.gov)
  • The clinical utility of circulating neuroendocrine gene transcript analysis in well-differentiated paragangliomas and pheochromocytomas. (cdc.gov)
  • This update on the cutting-edge clinical and dermpathologic research will assist the dermatologist in approaching, diagnosing, and managing nonmelanoma skin carcinoma. (jcadonline.com)
  • [ 3 - 5 ] Metastatic spread to the liver may be accompanied by a wide spectrum of clinical presentations, from asymptomatic disease incidentally discovered during radiologic workup for other reasons, to debilitating symptoms caused by acid hypersecretion, serotonin syndrome, or carcinoid syndrome. (oaepublish.com)
  • In its early stages, neuroendocrine carcinoma is asymptomatic (not showing or producing indications of a disease or other medical condition). (wikipedia.org)
  • Gallbladder cancer often remains undetected in its early stages due to its asymptomatic nature. (healthtrip.com)
  • Primary hyperparathyroidism in MEN1 can have a long-term asymptomatic course and is usually diagnosed by the incidental finding of elevated serum parathyroid hormone level in a patient with hypercalcemia or, in some cases, with normocalcemia. (medscape.com)
  • Asymptomatic liver cysts do not require surgical intervention.Treatment of symptomatic liver cyst involves removal of a large portion of the cyst wall (unroofing/fenestration), followed by an evaluation by a pathologist to identify or rule out presence of premalignant cells within the cyst wall. (drpapoulas.com)
  • Therapeutic options in patients with progressive and disseminated metastatic neuroendocrine gastroenteropancreatic (GEP) tumors are often limited, and prognosis is often poor ( 1 , 2 ). (snmjournals.org)
  • This case report discusses a diagnosis of bilateral optic nerve sheath meningoceles in a man aged 82 years with stable visual acuity and asymptomatic bilateral choroidal folds. (jamanetwork.com)
  • Xanthogranulomatous cholecystitis (XGC) mimics Gallbladder carcinoma (GBC) in both preoperative and intra-operative settings and the patient may undergo an unnecessary radical cholecystectomy which is associated with a greater morbidityrather than a cholecystectomy alone.We postulated that a pre-operative diagnosis of XGC might benefit patients by avoiding radical procedures and attempted to identify the features of XGC which would differentiate it from GBC before and during surgery. (medicinelakex1.com)
  • Immunologic and genetic research into nonmelanoma skin carcinoma has paved the way for novel therapeutic options for patients who were previously without any viable treatment alternatives. (jcadonline.com)
  • The histopathology examination showed infiltration of the thyroid gland by a neuroendocrine carcinoma with characteristics compatible with MCC. (springeropen.com)
  • Most MEN1 tumors are not aggressive, and many of them (particularly nonfunctioning tumors) follow a long-term indolent course, remaining asymptomatic for years. (medscape.com)
  • Gastrinomas, seen in the image below, are the most common functional pancreatic neuroendocrine tumors and occur in 40-55% of patients. (medscape.com)
  • Clinically actionable findings on surveillance EGD in asymptomatic patients with Lynch syndrome. (cdc.gov)
  • Patients are generally asymptomatic and SCAs typically follow a benign course (2). (spg.pt)
  • The majority of patients with hepatic adenoma are asymptomatic. (drpapoulas.com)
  • Most patients are asymptomatic or minimally symptomatic, and hypercalcemia is detected by biochemical screening. (medilib.ir)
  • Therapeutic options in patients with advanced-stage gastroenteropancreatic (GEP) neuroendocrine tumors are limited. (snmjournals.org)
  • atypical adenomatous hyperplasia and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. (ersjournals.com)
  • Metastatic prostate carcinoma should be ruled out by using immunoperoxidase for PSA and PSAP in all men over 45 presenting with carcinoma of unknown primary origin in left-sided supradiaphragmatic lymph nodes, even in the absence of bony disease, elevated serum acid phosphatase (SAP), abnormal rectal examination, and a histologic picture suggesting prostate carcinoma. (citationimpact.com)
  • During the next 10 months the patient was asymptomatic, serum markers values were normal and CT scans findings were stable. (springeropen.com)
  • Neuroendocrine cells release hormones (sometimes called peptides ) into the circulatory system in response to a stimulus received from the nervous system. (medifocus.com)