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  • MNTI
  • Very little is known about the etiology of MNTI and this report advances knowledge of these rare tumors by providing the first comprehensive genomic, transcriptomic and epigenetic characterization of a case. (ox.ac.uk)
  • mutation
  • Whole-exome analysis of genomic DNA from both the tumor and blood indicated no somatic, non-synonymous coding mutations within the tumor, but a heterozygous, unique germline, loss of function mutation in CDKN2A (p16(INK4A), D74A). (ox.ac.uk)
  • embryonal
  • Multiple chromosomal translocations were identified by RNA-Seq, and fusion genes included RPLP1-C19MC, potentially deregulating the C19MC cluster, an imprinted locus containing microRNA genes reactivated by gene fusion in embryonal tumors with multilayered rosettes. (ox.ac.uk)
  • variants
  • SNP-array CGH on DNA samples revealed the tumor to be euploid, with no detectable gene copy number variants. (ox.ac.uk)
  • stromal
  • There is also increasing evidence that macrophages play an important role in establishing the "premetastatic niche," altering the stromal environment at sites far from the primary tumor and enhancing extravasation and growth of metastatic cells. (feinsteininstitute.org)
  • gene
  • SNP-array CGH on DNA samples revealed the tumor to be euploid, with no detectable gene copy number variants. (ox.ac.uk)
  • An important gene associated with Bednar Tumor is PDGFB (Platelet Derived Growth Factor Subunit B), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers . (malacards.org)
  • group
  • Lymphomas are a group of malignant blood cell tumors that develop from lymphocytes. (jomfp.in)
  • Lymphomas are a group of malignant blood cell tumors that develop from lymphocytes representing 2.2% of all malignant neoplasms of the head and neck. (jomfp.in)
  • Diffuse large B-cell lymphomas (DLBCLs) are a heterogeneous group of tumor and the most common type of all non-Hodgkin's lymphomas (NHLs). (jomfp.in)
  • bone
  • brown tumor a giant-cell granuloma produced in and replacing bone, occurring in osteitis fibrosa cystica and due to hyperparathyroidism. (thefreedictionary.com)
  • cell
  • Among them, stem-like cells (hMB-SLCs) represent a fraction of the tumor cell population with the potential of self-renewal and proliferation and have been associated with tumor poor prognosis. (readbyqxmd.com)
  • overall
  • Treatment varies based on the severity of the condition, the location of the tumor and the overall health of the affected person. (malacards.org)
  • approximately
  • Prematurely erupted teeth with a firm, non-ulcerated, reddish-bluish tumor approximately 4 cm × 4 cm in size, extending from the alveolar ridge to the hard palate and covered by intact mucosa. (biomedcentral.com)
  • studies
  • TAM-induced malignant progression is reflected by a number of studies on various human tumor specimens that correlate overexpression of macrophage chemoattractants, as well as increased numbers of infiltrating macrophages, with worse prognoses. (feinsteininstitute.org)