Neurodegenerative DiseasesNerve DegenerationHuntington DiseaseAlzheimer DiseaseNeuronsBrainParkinson Diseasealpha-Synucleintau ProteinsAmyotrophic Lateral SclerosisHeredodegenerative Disorders, Nervous SystemNerve Tissue ProteinsTauopathiesNeuroprotective AgentsDisease Models, AnimalInclusion BodiesSynucleinsAmyloid beta-PeptidesPrionsSpinocerebellar AtaxiasMice, TransgenicMicrogliaPrion DiseasesTrinucleotide Repeat ExpansionProteostasis DeficienciesNeuronal Ceroid-LipofuscinosesCell DeathMutationOxidative StressFrontotemporal DementiaFrontotemporal Lobar DegenerationParkinsonian DisordersMitochondriaFriedreich AtaxiaLewy Body DiseaseAutophagyDementiaAmyloidAgingTrinucleotide RepeatsNeurotoxinsNeurofibrillary TanglesCells, CulturedLewy BodiesAstrocytesPeptidesMice, Inbred C57BLProtein FoldingHippocampusGuamSubstantia NigraAtaxiaModels, Biologicalbeta-SynucleinSuperoxide DismutaseIntranuclear Inclusion BodiesCerebral CortexMultiple System AtrophySupranuclear Palsy, ProgressiveDopaminergic NeuronsNeurogliaMitochondrial DiseasesAxonal TransportCentral Nervous SystemUbiquitinPick Disease of the BrainMachado-Joseph DiseaseNuclear ProteinsProteasome Endopeptidase ComplexAtrophyAmyloid beta-Protein PrecursorCell SurvivalCentral Nervous System DiseasesSignal TransductionMotor NeuronsNervous System DiseasesIron-Binding ProteinsGliosisPrPSc ProteinsMotor Neuron DiseasePrPC ProteinsCorpus StriatumRotarod Performance TestGene Expression RegulationApoptosisSpinocerebellar DegenerationsPlaque, AmyloidImmunohistochemistryMuscular Atrophy, SpinalPhenotypeCreutzfeldt-Jakob SyndromeMolecular ChaperonesAnimals, Genetically ModifiedBlotting, WesternReactive Oxygen SpeciesNitro CompoundsCyclin-Dependent Kinase 5Mice, KnockoutCerebellumAxons