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  • graft-versus-
  • The markedly enriched pathways in males were identified to be signaling pathways for graft-versus-host disease as well as the immune and inflammatory systems that parallel the reported poorer outcome of male fetuses. (jove.com)
  • SNPs
  • In this study, led by first author Mingyao Li, no single SNP accounted for disease susceptibility, but instead they found multiple SNPs making up four common haplotypes, two associated with increased risk, and two that were protective. (alzforum.org)
  • genetic risk
  • Determining genetic risk is an exceedingly complicated proposition, the study indicates, and finding all the risk alleles for common diseases will likely involve a thorough analysis of hundreds or thousands of cases. (alzforum.org)
  • murine
  • Moreover, Th17 differentiation of CD4+CD25- lymphocytes from distinct murine knockout/disease models can contribute to our understanding of cell fate plasticity. (jove.com)
  • mainly
  • Niemann-Pick type C disease (NPC) is a neurovisceral lipid storage disorder mainly characterized by unesterified cholesterol accumulation in lysosomal/late endosomal compartments, although there is also an important storage for several other kind of lipids. (jove.com)
  • Lung
  • Haplotype-based computational genetic analysis and gene expression profiling of lung tissue obtained from fibrosis-susceptible and -resistant strains identified laminin α1 (Lama1) as a genetic modifier for susceptibility to IPF. (stanford.edu)
  • several
  • Genesis of both neurodegenerative diseases has not been elucidated and several endogenous (genetic) and exogenous (environment) factors contribute to the onset and/or development of these illnesses, which highlights the necessity to expand the research on identifying the environmental risk factors that predispose to the development of these neurodegenerative diseases. (frontiersin.org)
  • Alleles that change a gene's expression level without altering protein structure have been implicated in several other neurodegenerative diseases, revealing an increasing role for regulatory polymorphisms (see ARF related news story ). (alzforum.org)
  • cellular
  • DNA damaging agents can promote aging, disease and cancer and they are ubiquitous in the environment and produced within human cells as normal cellular metabolites. (jove.com)
  • diagnosis
  • Therefore more research for better definition of exposure, as well as for the identification of early specific biomarkers for the diagnosis of these diseases is needed. (frontiersin.org)
  • found
  • Unexpectedly, the strongest disease association they found within the CFH gene was not the previously observed Y402H SNP, but an intronic SNP that did not affect protein sequence. (alzforum.org)
  • The only correlation found was an increase in IL-6 gene expression in patients with progressive disease. (cellmedicine.com)
  • development
  • This requires the continued development of strategies to study brain function in health and disease as the 'system', greater than the sum of its parts. (ox.ac.uk)
  • The zebrafish model has emerged as a relevant system to study kidney development, regeneration and disease. (jove.com)
  • inflammatory
  • A role for the complement cascade was not suspected in the disease until the genetic association was made, but since then much work has cemented the idea that the macula is destroyed by complement-stimulated inflammatory and/or angiogenic processes. (alzforum.org)
  • factors
  • More worryingly is the evidence that pre- and post-natal exposures to environmental factors predispose to the onset of neurodegenerative diseases in later life. (frontiersin.org)
  • An advantage of using animal models is that both genetic and environmental factors that may influence the course of a particular disease can be controlled. (jove.com)
  • brain
  • SAMP8 has remarkable pathological similarities to AD and may prove to be an excellent model for acquiring more in-depth knowledge of the age-related neurodegenerative processes behind brain senescence and AD in particular. (hindawi.com)
  • studies
  • 14 Human and in vitro studies produced the important genetic, biochemical, and lifestyle information and hypotheses that are elucidating the disease. (pcrm.org)
  • One particular SNP, which changed a tyrosine (Y402) to histidine, was strongly associated with disease in all the studies. (alzforum.org)
  • review
  • Uhlmann WR, Peñaherrera MS, Robinson WP, Milunsky JM, Nicholson JM, Albin RL: Biallelic mutations in Huntington disease: A new case with just one affected parent, review of the literature and terminology AmJ Med Genet A 167A(5): 1152-1160, 2015. (umich.edu)