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  • Neck
  • Neuroblastoma may also begin in the abdomen, in the chest, in nerve tissue near the spine in the neck, or in the spinal cord. (cigna.com)
  • 2001
  • Approximately 7.5% of the childhood cancers diagnosed in 2001 were neuroblastomas, affecting one in 80, 000 to 100, 000 children in the United States . (encyclopedia.com)
  • lymph nodes
  • Regional neuroblastoma has extended beyond its original site, to regional lymph nodes, and/or surrounding organs or tissues, but has not spread to distant sites in the body. (encyclopedia.com)
  • About 2 out of 3 neuroblastomas have already spread to the lymph nodes or other parts of the body by the time they are found. (cancer.org)
  • MYCN
  • Malfunction of the MYCN transcription factor is a key feature of neuroblastoma biology and is involved in almost every aspect of tumor formation such as unrestricted proliferation, differentiation inhibition, reprogramming of cellular energetics, angiogenesis, infiltration/metastasis and genomic instability. (dkfz.de)
  • In addition, we use high-throughput si/shRNA screens to disclose neuroblastoma-specific vulnerabilities associated with distinct genetic aberrations, such as amplified MYCN, TERT rearrangements, or ATRX deletions (project NB Achilles). (dkfz.de)
  • The progress of pathology research in this disease also includes an establishment of a new concept, MYC family-driven neuroblastoma (including large-cell neuroblastoma) defined by augmented expression of MYCN and/or MYC protein of neuroblastic cells. (springer.com)
  • genetic
  • Neuroblastomas are associated with some congenital abnormalities and genetic diseases such as Hirschsprung disease, central hypoventilation and neurofibromatosis. (eapsa.org)
  • clinical
  • This review will clearly indicate the importance of angiogenesis in the pathogenesis of malignant neuroblastoma, its prevention as a promising therapy in preclinical models of malignant neuroblastoma, and prospective clinical trials. (hindawi.com)
  • Neuroblastoma is characterized by its intriguing clinical behaviors that include spontaneous differentiation and regression, maturation into benign ganglioneuroma, and deadly metastatic tumor. (hindawi.com)
  • survive
  • Those who survive neuroblastoma may develop certain persistent problems including hearing loss, retardation of growth and development, learning difficulties and thyroid disorder. (news-medical.net)
  • ultrasound
  • In rare instances, neuroblastoma is found before birth during an ultrasound, a test that uses sound waves to create an image of the internal organs of a fetus. (cancer.org)