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  • pathways
  • Asymmetrically dividing Drosophila neuroblasts utilize two spatially and temporally independent cytokinesis pathways. (nih.gov)
  • In most metazoan cells, contractile ring placement is regulated by the mitotic spindle through the centralspindlin complex, and potentially also the chromosomal passenger complex (CPC).Drosophila neuroblasts, asymmetrically dividing neural stem cells, but also other cells utilize both spindle-dependent and spindle-independent cleavage furrow positioning pathways.However, the relative contribution of each pathway towards cytokinesis is currently unclear. (nih.gov)
  • Drosophila neuroblasts, asymmetrically dividing neural stem cells, but also other cells utilize both spindle-dependent and spindle-independent cleavage furrow positioning pathways. (nih.gov)
  • phenotype
  • In addition, the introduction of msps , another regulator of microtubule growth, to arl2- deficient neuroblasts was able to rescue the phenotype observed. (duke-nus.edu.sg)
  • essential
  • These results describe a novel role for the endocannabinoid system in neuroblast migration in vivo , highlighting its importance in regulating an additional essential step in adult neurogenesis. (jneurosci.org)
  • In-depth knowledge of the factors that regulate neuroblast migration is therefore essential to facilitate translational research in this area. (jneurosci.org)
  • reveals
  • Detailed analysis of primary neuroblast migration by time-lapse imaging reveals that nucleokinesis, as well as the length and branching of the migratory processes are under dynamic control of the eCB system. (jneurosci.org)
  • cell
  • Here, we show that eCB signaling is required for the migration of an NS cell line in a wound closure assay and for the migration of neuroblasts out of cultured RMS explants. (jneurosci.org)
  • brain
  • Because neuroblasts have been shown to migrate to areas of brain injury, understanding the cues regulating this migration could be important for brain repair. (jneurosci.org)
  • Loss
  • We discuss the role of p53 loss in maintaining self-renewal in both normal and Albany Street, New Brunswick, NJ malignant cells. (scribd.com)
  • express
  • We now show that mouse migratory neuroblasts express cannabinoid receptors, diacylglycerol lipase ╬▒ (DAGL╬▒), the enzyme that synthesizes the endocannabinoid 2-arachidonoylglycerol (2-AG), and monoacylglycerol lipase, the enzyme responsible for its degradation. (jneurosci.org)