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  • vivo
  • Finally, similar effects are observed in vivo by analyzing the morphology of green fluorescent protein-labeled neuroblasts in brain slices from mice treated with CB 1 or CB 2 antagonists. (jneurosci.org)
  • We observed distinct phases of neuroblast activation as is known to occur after in vivo ischemia. (core.ac.uk)
  • migratory neuroblasts
  • We now show that mouse migratory neuroblasts express cannabinoid receptors, diacylglycerol lipase α (DAGLα), the enzyme that synthesizes the endocannabinoid 2-arachidonoylglycerol (2-AG), and monoacylglycerol lipase, the enzyme responsible for its degradation. (jneurosci.org)
  • Both pharmacological and genetic manipulations revealed that NKCC1 maintains high [Cl - ] i and regulates the resting membrane potential of migratory neuroblasts whilst its functional expression is strongly reduced at the time cells reach the GCL. (biomedcentral.com)
  • embryo
  • Yet the origin of type II neuroblasts remains mysterious: do they form in the embryo or larva? (biologists.org)
  • Here, we present molecular and clonal data showing that all type II neuroblasts form in the embryo, produce INPs and express known temporal transcription factors. (biologists.org)
  • regulate
  • Interestingly, there is also evidence that two members of the temporal transcription factor series may regulate the overall number of divisions that a neuroblast undergoes. (biologists.org)
  • brain
  • Klu is necessary for the maintenance of type I and II brain neuroblasts, as klu mutant larvae showed progressive loss of both types of neuroblast. (biologists.org)
  • Our Brain Awareness Week event, "NeuroBLAST" is 3 hours of hands-on interaction about your brain. (fav-store.net)
  • School of Medical Sciences (https://medicalsciences.med.unsw.edu.au/news-events /neuroblast-brain-dissection) Massachusetts General Hospital Open main navigation Main Navigation. (fav-store.net)
  • transcription
  • We identify the transcription factor Klumpfuss (Klu) as distinguishing a type II neuroblast from an INP in larval brains. (biologists.org)
  • The vast majority of SVZ neuroblasts as well as newly born young and mature neurons in the damaged striatum constitutively express the transcription factor Sp8, but do not express transcription factors characteristic of medium-sized spiny neurons, the primary striatal projection neurons lost after stroke. (jneurosci.org)
  • Early in development, neuroblasts switch through a temporal series of transcription factors modulating neuronal fate according to the time of birth. (biologists.org)
  • This raises the issue of whether there are additional temporal transcription factors expressed in neuroblasts during postembryonic stages. (biologists.org)
  • dorsoventral
  • When combined with the anteroposterior and dorsoventral positional information defining neuroblast type (reviewed by Skeath and Thor, 2003 ), this temporal tag confers a unique cell identity to each GMC and its progeny. (biologists.org)
  • numb
  • Enforced expression of a phospho-mimetic form of Numb (Numb-TS4D) or genetic manipulation that boosts phospho-Numb levels, attenuates endogenous Numb activity and causes ectopic neuroblast formation (ENF). (core.ac.uk)
  • https
  • Massachusetts General Hospital, Boston, MA (https://www.massgeneral.org/neurology/forms/neurolo gy-enewsletter-signup.aspx) Neuroblast information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. (fav-store.net)