Neurobehavioral cocaine related disorders. Medical search. Frequent questions

Alterations in cognitive control are shared common features of different psychiatric and neurodevelopmental disorders such as schizophrenia, autism spectrum disorder, attention deficit hyperactivity disorder (ADHD), and bipolar disorder. (iit.it)
Overall, this can cause behavioral disorders, attention deficit hyperactivity disorder (ADHD), and other developmental issues. (lighthouserecoveryinstitute.com)
Although clinical uses of amphetamines exist for adolescents, most notably for Attention-Deficit/Hyperactivity Disorder, the repeated recreational or illicit use of amphetamines during this time period has implications for long-term brain and behavioral development. (springer.com)
Atomoxetine is a selective norepinephrine reuptake inhibitor indicated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD). (nih.gov)
Children who received choline had higher non-verbal intelligence, higher visual-spatial skill, higher working memory ability, better verbal memory, and fewer behavioral symptoms of attention deficit hyperactivity disorder than the placebo group. (biomedcentral.com)

Among children with Tourette's, about one in five meet the criteria for autism spectrum disorder. (psychologytoday.com)
Despite being more common than autism spectrum disorder, which has a prevalence of 0.6% [ 6 ], FASD remains under-recognized [ 7 ]. (biomedcentral.com)
Her research focuses on the etiologies, symptoms, and perceptions of autism spectrum disorder using theory and methods from social psychology, psychophysiology, cognitive science and neuroscience. (sc.edu)
Currently, her lab is exploring cross cultural differences in perceptions of autism spectrum disorder, factors that predict person first language in academic writing, and differences in object use in individuals with autism. (sc.edu)
Dr. Bradshaw's research focuses on early identification and intervention of autism spectrum disorder (ASD) in the first years of life. (sc.edu)
Specifically, she is interested in: 1) quantifying the emergence of, and interrelations between, social behavior, visual attention, and motor skills in neonates, infants, and toddlers, 2) identifying aberrant neurodevelopmental pathways that lead to the emergence of autism spectrum disorder (ASD), and 3) translating these basic findings to early detection and intervention strategies for ASD. (sc.edu)
Walking Ability is Associated with Social-Communication Skills in Infants at High Risk for Autism Spectrum Disorder. (sc.edu)

Other studies indicate that prenatal methamphetamine exposure may be associated with abnormal neurobehavioral patterns or fetal growth restriction, but these findings are not yet fully established. (merckmanuals.com)
Cognitive and functional outcomes at age 21 after prenatal cocaine/polydrug exposure and foster/adoptive care. (utah.edu)
Support Models for Addiction Related Treatment (SMART) for pregnant women: Study protocol of a cluster randomized trial of two treatment models for opioid use disorder in prenatal clinics. (umassmed.edu)
En este sentido, se hace se a ocorrência de abandono da criança pela mãe, indispensable la captación de las gestantes usuarias de ocasionando a adoção do recém-nascido por parentes crack por los profesionales de la salud y por enfermería do núcleo familiar ou a institucionalização do mesmo para la realización del control prenatal de alto riesgo, por falta de estrutura familiar. (bvsalud.org)

Morè L, Lauterborn JC, Papaleo F* , Brambilla R. Enhancing cognition through pharmacological and environmental interventions: examples from preclinical models of neurodevelopmental disorders. (iit.it)

Individuals may take these stimulants to improve specific aspects of mood or performance or to compensate for sleep deprivation or other fatigue-causing disorders. (medlink.com)
The management of disorders resulting from the use of stimulants is focused on understanding overall treatment goals and limiting untoward side effects. (medlink.com)
Chronic abstinence from stimulants may be associated with sleep disorders, including drowsiness. (medlink.com)
Although there is no established approach to the management of stimulant-dependent sleep disorders, understanding the reasons for use of the stimulants, underlying treatment goals, and optimization of drug timing may improve symptoms. (medlink.com)
Stimulant-dependent sleep disorder, recognized in the ICD-10, was originally defined as a "reduction of sleepiness or suppression of sleep by CNS stimulants and resultant alterations in wakefulness following drug abstinence. (medlink.com)
While rare, some women use drugs like cocaine, heroin, and other stimulants while pregnant. (lighthouserecoveryinstitute.com)

The significance of the genetic findings will be further investigated using the UTHealth Brain Collection for Research in Psychiatric Disorders," said Consuelo Walss-Bass , Ph.D., associate professor in the Department of Psychiatry and Behavioral Sciences at McGovern Medical School and one of the study's three lead principal investigators. (uth.edu)

Notably, cognitive deficits in these disorders are currently considered the main source of disability, having the most critical impact on the daily life of the patients and their relatives, on public health and long-term outcomes. (iit.it)
Recent studies indicate that aberrant MMP expression, localization and function may contribute to synaptic plasticity deficits associated with such disorders. (nature.com)
Deficits in synaptic remodelling are associated with psychiatric and neurological disorders, and aberrant MMP expression or function may contribute to the molecular mechanisms underlying these deficits. (nature.com)
Despite the high prevalence of fetal alcohol spectrum disorder (FASD), there are few interventions targeting its core neurocognitive and behavioral deficits. (biomedcentral.com)

He is completing a clinical trial evaluating non-abstinence outcomes in cocaine use disorder. (uky.edu)

Cocaine-related psychiatric disorders have been well-documented in the literature. (medscape.com)
Addiction is relevant in numerous contexts of civil and criminal law, and the imprecise fit between the concept of addiction and the diagnostic scheme of the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM) has been one of the challenges faced by forensic psychiatrists in navigating the boundary between clinical psychiatry and the justice system. (jaapl.org)
Several psychiatric and neurological disorders, including drug addiction, neuropathic pain syndromes and fragile X syndrome, are associated with abnormal or deficient synaptic plasticity. (nature.com)
Read more about recent research on bipolar disorder in Psychiatric News here and here . (psychnews.org)

These findings demonstrate that exposure to FLX during adolescence modulates responsiveness to emotion-eliciting stimuli in adulthood, at least partially, via long-lasting adaptations in ERK-related signaling within the VTA. (jneurosci.org)
Collectively, our proposed studies use a combination therapy approach, in which the dopamine releaser phenmetrazine and the kappa opioid receptor antagonist LY2444296 may accentuate the beneficial effects of each individual drug, with the advantage of targeting two dysregulated neurotransmitter systems post-chronic cocaine exposure, in a cocaine self-administration rat model. (grantome.com)
Accordingly, 5 d cocaine exposure both reduced striatal BDNF levels and increased CB 1 R (GABA) activity, through a mechanism dependent on D 2 Rs. (jneurosci.org)
Called Collaborative Case-Control Initiative in Cocaine Addiction, the study will look at two stressors in particular - trauma exposure and HIV infection - in combination with the genetic profile of people who are addicted to cocaine. (uth.edu)
Abstract Study Objectives: Sleep disturbances are well documented in relation to trauma exposure and posttraumatic stress disorder (PTSD), but correlates of such disturbances remain understudied in veteran populations. (researchgate.net)

Writing about a trauma one experienced can counter posttraumatic stress disorder (PTSD), at least in individuals experiencing PTSD provoked by a motor-vehicle accident, a study reported July 20 in Behavior Research and Therapy suggests. (psychnews.org)
Experiencing traumatic experiences and developing posttraumatic stress disorder (PTSD) are more frequent in patients with serious mental illness than in the general population, according to a report in the Journal of Nervous and Mental Disease . (psychnews.org)
Study objectives: This cross-sectional study aimed to characterize sleep patterns, the quality and duration of sleep, and estimate the prevalence of common sleep disorders and posttraumatic stress disorder (PTSD) in a hospital-based Veterans Affairs MOVE! (researchgate.net)

Due to indirect modulation of dopamine transmission, adenosine receptor antagonists may be useful in either treating cocaine use or improving disrupted cognitive-behavioral functions associated with chronic cocaine use. (omicsonline.org)
His research, continuously funded by NIH since 2008, evaluates the behavioral and pharmacological factors that contribute to drug use disorders, focusing primarily on stimulant drugs. (uky.edu)
She uses behavioral, eye tracking, and physiological methods to map early neurobehavioral development and identify pivotal transitions that occur between birth and 12 months of age, with a particular interest in birth through 5 months. (sc.edu)
Currently, it is unclear whether sleep disturbance is a core sequelae of mTBI or if it may be related to other behavioral health conditions that are. (researchgate.net)

Inhibition of dopamine reuptake in the CNS synapses, such as in the nucleus accumbens, contributes to the euphoria associated with cocaine. (medscape.com)
To compare and contrast the stimulant effects of adenosine antagonism to direct dopamine stimulation, we administered 150 mg and 300 mg caffeine, 20 mg amphetamine, and placebo to cocaine-dependent vs. healthy control subjects, matched on moderate caffeine use. (omicsonline.org)
Cocaine addiction is a chronic, relapsing brain disease that is intimately associated with dysregulations of the dopamine and dynorphin systems, which contributes to the dysphoric syndrome seen during withdrawal from cocaine. (grantome.com)
The cycle from abstinence to withdrawal to subsequent escalation of drug use is far too common, and even though ample therapeutics targeted at the dopamine and dynorphin systems have been created, none have yet been proven effective and approved by the FDA to treat cocaine addiction. (grantome.com)
Due to the profound dysfunction of the dopamine and dynorphin systems, we propose to use the dopamine transporter and kappa opioid receptor as possible cellular targets in the development of therapeutics for cocaine addiction. (grantome.com)
Our overarching hypothesis is to combine a dopamine releaser to enhance dopaminergic tone and a kappa opioid receptor antagonist to produce anxiolytic and antidepressant effects, ultimately to reduce motivation to take cocaine and normalize the dopamine and kappa opioid receptor systems after chronic cocaine use in rats. (grantome.com)
The proposed studies will evaluate a potential combination therapy using a dopamine releaser (phenmetrazine) and a kappa opioid receptor antagonist LY2444296 to reduce cocaine taking and seeking. (grantome.com)
The action of BDNF on CB 1 R (GABA) function was tyrosine kinase dependent and was complete even after receptor sensitization with cocaine or environmental manipulations activating the dopamine (DA)-dependent reward system. (jneurosci.org)

Maternal dietary intake is likely a contributing factor to fetal alcohol spectrum disorders (FASD). (bvsalud.org)
BACKGROUND: Pregnant women participated in multifaceted case management (MCM) to prevent Fetal Alcohol Spectrum Disorders (FASD). (bvsalud.org)

Tourette's disorder, also referred to as Tourette's syndrome, is a neurological disorder characterized by involuntary and uncontrollable tics. (psychologytoday.com)

Ersche KD, Roiser JP, Robbins TW, Sahakian BJ (2008) Chronic cocaine but not chronic amphetamine use is associated with perseverative responding in humans. (springer.com)

Blockade of reuptake of norepinephrine leads to the sympathomimetic syndrome associated with cocaine use. (medscape.com)
#Cocaine raises gut norepinephrine levels facilitating Proteobacteria colonization. (metabiom.org)

Thus, an understanding of the underlying pathophysiology may lead to more directed treatment of stimulant-dependent sleep disorder. (medlink.com)

Generally, Tourette's disorder is diagnosed by obtaining a description of the tics and evaluating family history. (psychologytoday.com)
However, Tourette's disorder is a clinical diagnosis. (psychologytoday.com)
this symptom of Tourette's disorder is called coprolalia . (psychologytoday.com)
People with Tourette's disorder can sometimes suppress their tics for a short time, but the effort is similar to that of holding back a sneeze. (psychologytoday.com)

Chronic abstinence from cocaine may lead to "occult insomnia" or an ongoing sense of fatigue. (medlink.com)

He is also characterizing the metabolic profiles of cells from patients with autism, ID, and overgrowth, as well as mental disorders such as schizophrenia, ADD/ADHD, and Tourette syndrome. (sc.edu)

The study included 102 patients with schizophrenia, bipolar disorder, or schizoaffective disorder, diagnosed using DSM-IV criteria. (psychnews.org)

In this manuscript, we assessed the sensitivity and specificity of multiple cutoff values for phosphatidylethanol (PEth) from bloodspots relative to self-report, the Alcohol Use Disorder Identification Test (AUDIT) scores, and another alcohol use biomarker ethyl glucuronide (EtG) from fingernails in a sample of 222 pregnant women in the Western Cape Province of South Africa. (bvsalud.org)
Forty-four pregnant women were defined as high-risk drinkers on the Alcohol Use Disorder Identification Test (AUDIT) by an AUDIT score ≥8 and participated in 18 months of MCM to facilitate reduction or cessation of alcohol consumption. (bvsalud.org)
The study population was 40,512 noninstitutionalized adults who took part in the National Epidemiologic Survey on Alcohol and Related Conditions and who in 2001-2002 (Wave 1) didn't meet criteria for lifetime mania or hypomania, but indicated the presence of elation and/or irritability. (psychnews.org)
She is leading NIH-funded research directed at 1) longitudinal investigations of neural connectivity in cocaine and alcohol dependent individuals undergoing substance abuse treatment, and 2) developing patient-tailored brain stimulation protocols which may either enhance cognitive control or attenuate craving in treatment seeking individuals. (musc.edu)
An estimated 110,000 students ages 18-24 are arrested every year for alcohol-related incidences or violations, such as public intoxication or driving under the influence. (behavioralhealth-centers.com)
Diagnoses were 12.9% fetal alcohol syndrome (FAS), 41.9% partial FAS, and 45.1% alcohol-related neurodevelopmental disorder. (biomedcentral.com)
For 12 years, I was the senior Native American specialist for SAMHSA, the Substance Abuse and Mental Health Services Administration Fetal Alcohol Spectrum Disorder Center for Excellence. (hhs.gov)

Glutamatergic Mechanisms in Opioid and Cocaine Co-Use (R33DA049130). (uky.edu)

An individual with brief psychotic disorder has experienced at least one of the major symptoms of psychosis for less than one month. (minddisorders.com)
Catatonic disorders are a group of symptoms characterized by disturbances in motor (muscular movement) behavior that may have either a psychological or a physiological basis. (minddisorders.com)
Cocaine use, for example, causes withdrawal symptoms among newborns that include tremors and seizures. (lighthouserecoveryinstitute.com)
Insomnia and behavioural health symptoms 1 year after traumatic brain injury (TBI) were examined in a clinical sample representative of veterans who received inpatient treatment for TBI-related issues within the Veterans Health Administration. (researchgate.net)

Circadian rhythm sleep disorder is a persistent or recurring pattern of sleep disruption resulting either from an altered sleep-wake schedule or an inequality between a person's natural sleep-wake cycle and the sleep-related demands placed on him or her. (minddisorders.com)

It is a complex disorder that affects many different areas of the child's development. (minddisorders.com)
While research is limited, marijuana use during pregnancy can cause weak fetal growth, increase the child's risk of leukemia, and neurobehavioral problems. (lighthouserecoveryinstitute.com)

Breathing-related sleep disorder is marked by sleep disruption caused by abnormal breathing during sleep. (minddisorders.com)

The study assessed 46 subjects with a diagnosis of accident-related PTSD, randomly assigned to either the writing intervention or a wait list. (psychnews.org)

Eilam D, Szechtman H (2005) Psychostimulant-induced behavior as an animal model of obsessive-compulsive disorder: an ethological approach to the form of compulsive rituals. (springer.com)

These studies will potentially provide a novel combination of targets for pharmacotherapies to treat cocaine addiction and decrease the risk of relapse. (grantome.com)
Other recent research in the area of eating disorders and their etiology has pointed to the possibility that some cases of obesity are due to a food addiction and may be linked to genetics. (psychnews.org)
In fact, binge eating disorder (BED), which has been proposed as a diagnosis to be added to the next edition of APA's Diagnostic and Statistical Manual of Mental Disorders (DSM-5), might be considered a food addiction because a major criterion for it is loss of control over eating behavior. (psychnews.org)
The five-year study of Brazilian subjects will compare 1,000 people with cocaine addiction to 1,000 controls. (uth.edu)

Suvorexant Maintenance Enhances the Reinforcing but not Subjective and Physiological Effects of Intravenous Cocaine in Humans. (uky.edu)

Cocaine use disorder affects nearly 1.9 million individuals in the United States and is involved in roughly 40% of emergency department visits involving illicit drugs. (grantome.com)

Because of poor absorption and significant first-pass metabolism, cocaine is rarely ingested. (medscape.com)
Decreased tryptophan metabolism in patients with autism spectrum disorders. (sc.edu)

A mutation in a ganglioside biosynthetic enzyme, ST3GAL5, results in salt & pepper syndrome, a neurocutaneous disorder with altered glycolipid and glycoprotein glycosylation. (sc.edu)

Brief psychotic disorder is a short-term, time-limited disorder. (minddisorders.com)
Background Psychotic disorders are a leading cause of disability in young adults. (researchgate.net)

Addressed also is the concept of public policies as factors contributing to changes in prevalence in the general population, to race and ethnic differences in prevalence, and to race- and ethnic-related historical trends. (nationalacademies.org)
Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disorders. (sc.edu)

Cocaine abuse is associated with numerous detrimental health effects. (medscape.com)
The time to peak effects of cocaine depends on the dose and route of administration. (medscape.com)
When cocaine is injected intravenously or crack is smoked, the onset of action is within seconds and peak effects occur within 5 minutes. (medscape.com)
When snorted, the onset of action of cocaine is within the first 5 minutes and its effects typically peak within 30 minutes. (medscape.com)
Cocaine has a number of pharmacologic effects on the human body. (medscape.com)
He is also leading human laboratory studies determining the role of serotonin 5-HT1b systems in the abuse related effects of cocaine and examining glutamate systems in individuals who co-use opioids and cocaine. (uky.edu)
Influence of 5-HT1b Activation on the Abuse Related Effects of Cocaine (R01DA052203). (uky.edu)
We also examined the effects of FLX on the expression of extracellular signal-regulated kinase (ERK) 1/2-related signaling within the ventral tegmental area (VTA) of adolescent mice and Sprague Dawley rats. (jneurosci.org)
The recognition of the adolescent period as a time of increased drug use and potential vulnerability to the neurobehavioral effects of repeated drug use has existed for many years. (springer.com)

Maternal drinking during pregnancy is associated with the substance use and related problems of adolescent offspring. (utah.edu)
Coy KC, Ko JY, Ondersma SJ, Gilstad-Hayden K, Zapata LB, Chang G, Yonkers K. Association of Prepregnancy Substance Use and Substance Use Disorders with Pregnancy Timing and Intention. (umassmed.edu)
Welcome to MERCYs web pages dedicated to information on Pregnancy and Medical Cannabis as well as related issues and items. (mercycenters.org)
of crack in pregnancy leads to repercussions related to the health of the newborn and repercussions related to family restructuring. (bvsalud.org)

cocaine-dependent subjects were sensitive only to 300 mg caffeine. (omicsonline.org)

Cannabis-related disorders refer to problems associated with the use of substances derived from this plant. (minddisorders.com)
Sleep Time Differs Among People who Co-Use Cocaine and Cannabis Compared to People who Only Use Cocaine. (uky.edu)
We also try to include basic cannabis and related law and policy reform links and orgs for associated areas and functions such as human rights, justice, environment, health and other issues that potentially share resources. (mercycenters.org)

Bulimia nervosa is an eating disorder characterized by binge eatingand engaging in inappropriate ways of counteracting the bingeing (using laxatives, for example) in order to prevent weight gain. (minddisorders.com)

Clinical Neuropharmacology of Cocaine Reinforcement: A Narrative Review of Human Laboratory Self-Administration Studies. (uky.edu)

Elation and irritability may seem like relatively harmless swings of behavior, but a new study finds that in some individuals these may signal a high risk for development of bipolar disorder. (psychnews.org)
In a report published online July 27 in the Journal of Affective Disorders , researchers at the University at Buffalo said that "elation and/or irritability, if accompanied by trouble concentrating, racing thoughts, or hyperactivity, may represent a prodrome of formal bipolar disorder that indicate close follow-up and cautious use of antidepressants. (psychnews.org)
Bipolar Disorder - Screen patients for bipolar disorder. (nih.gov)

In the late 19th century, Sigmund Freud proposed cocaine for the treatment of depression, cachexia, and asthma. (medscape.com)

The creation in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), of the new unidimensional spectrum diagnosis of Substance Use Disorder (SUD), which includes three Abuse criteria from DSM-IV, has resulted in a need to re-examine policies that evolved with the DSM-III-R/DSM-IV biaxial abuse-dependence conceptual paradigm. (jaapl.org)
Drug abuse also increases women's risks of lifestyle-related risks, such as infectious diseases, domestic violence, criminal prosecution, and sexual assault. (lighthouserecoveryinstitute.com)

Our results further delineate the role ERK plays in regulating mood-related behaviors across the lifespan. (jneurosci.org)

Au total, 270 consommateurs de khat (129 femmes) au Yémen se sont soumis à des entretiens en face à face et ont fourni des informations démographiques et des données sur les modes de consommation, l'humeur subjective et la qualité du sommeil. (who.int)

The specific area of concern for Norko and Fitch is the diversion of criminal defendants from prosecution to treatment settings on the basis of substance use disorders. (jaapl.org)
Yonkers KA, Altemus M, Gilstad-Hayden K, Kornstein SG, Gueorguieva R. Does Symptom-Onset Treatment With Sertraline Improve Functional Impairment for Individuals With Premenstrual Dysphoric Disorder? (umassmed.edu)
These studies have the potential to uncover potential cellular interactions that can be targeted for treatment of cocaine use disorder. (grantome.com)

The term circadian rhythm refers to a person's internal sleep and wake-related rhythms that occur throughout a 24-hour period. (minddisorders.com)

These preliminary data raise the possibility that adenosine antagonists may affect cocaine-dependent and non-dependent subjects differently. (omicsonline.org)

As a result of genetic studies in families with tic disorders, risk alleles for Tourette's and rare genetic variants have been identified. (psychologytoday.com)
Child development is permeated by innumerable performance and mental health, ranging from reduced constraints, including genetic and organic factors related ability to perform routine daily activities in a satisfactory to individual characteristics of the unborn human being, and proper manner of each stage of development, up to broader factors such as environmental, cultural and to cases of bullying, violence, prejudice, among others. (bvsalud.org)

Severe Cardiovascular Disorders that might deteriorate with clinically important increases in HR and BP. (nih.gov)

Sedatives Sedatives include benzodiazepines, barbiturates, and related drugs. (merckmanuals.com)

HOUSTON - (Oct. 2, 2017) - Studying the effect of environmental stressors on the development of cocaine use is the focus of a $2.6 million award from the National Institutes of Health (NIH) to researchers at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth). (uth.edu)
These studies will help further the understanding of how gene-environment interactions impact the severity of cocaine use disorder and lead to development of more tailored and targeted treatments for this chronic and global public health problem. (uth.edu)
This is a critical window for the development of substance use disorders (SUDs), as the brain is still developing. (behavioralhealth-centers.com)

Thomas Heller, an Austrian educator, first described childhood disintegrative disorder in 1908. (minddisorders.com)

Bupropion is an antidepressant drug used to elevate mood and promote recovery of a normal range of emotions in patients with depressive disorders. (minddisorders.com)
#Glycine depletion alters #Cocaine -induced neuroplasticity and drug responses. (metabiom.org)

The most common complaint of individuals with breathing-related sleep disorder is excessive daytime sleepiness, brought on by frequent interruptions of nocturnal, or nighttime, sleep. (minddisorders.com)
and sleep disorders (frequent awakenings or talking in one's sleep). (psychologytoday.com)

Anatomy7

Organisms8

Diseases58

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Psychiatry and Psychology94

Phenomena and Processes29

Disciplines and Occupations2

Technology, Industry, Agriculture1

Humanities1

Information Science5

Named Groups2

Health Care24

Geographicals1

Attention deficit5

Autism spectrum7

Prenatal4

Neurodevelopmental disorders1

Stimulants6

Department of Psychiatry1

Deficits4

Outcomes1

Psychiatric4

Exposure5

Posttraumatic stress d3

Behavioral4

Dopamine8

Fetal Alcohol S2

Neurological1

Chronic cocaine1

Norepinephrine2

Stimulant1

Tourette's Disorder4

Abstinence1

ADHD1

Schizophrenia1

Alcohol7

Opioid1

Symptoms4

Persistent1

Child's2

Abnormal1

PTSD1

Obsessive-compulsi1

Addiction4

Physiological1

Affects1

Metabolism2

Syndrome1

Psychotic2

Prevalence2

Effects9

Pregnancy4

Caffeine1

Cannabis3

Binge1

Clinical1

Bipolar3

Depression1

Abuse2

Behaviors1

Subjective1

Treatment3

Occur1

Dependent1

Genetic2

Increases1

Sedatives1

Development3

Childhood1

Drug2

Frequent2