EGFREpidermalHER2LigandLigandsErbB3ERBB2RTKsSignalingColorectal CancerTumorProteinsNRG1TumorsPhosphorylationDimersErbB4Kinase domainHigh affinityCarcinomasSignal transductionTyrosine residuesHER3PancreaticFamilyProteinTissuesCellsOVARIAN-CANCERVarious cancersInhibitorsTherapiesDifferentiationAvianInducesResistanceBind
EGFR19
- HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. (wikipedia.org)
- ErbB-2 was named for its similarity to ErbB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR. (wikipedia.org)
- Evidence has also implicated HER2 signaling in resistance to the EGFR-targeted cancer drug cetuximab. (wikipedia.org)
- non-canonical EGFR-Met interactions are implicated in resistance to anti-cancer drugs but have not been previously detected in drug-naïve cells. (nature.com)
- ErbB receptors comprise a family of four RTKs (EGFR/ErbB1, Her2/ErbB2, Her3/ErbB3 and Her4/ErbB4) with important roles in normal cell physiology and in cancer 1 . (nature.com)
- Here we exploit the multiplexing capabilities of Exchange-PAINT, a multiplexed variant of DNA-PAINT 14 , to image simultaneously five RTKs (EGFR, ErbB2, ErbB3, IGF-1R and Met) at endogenous levels of expression in BT20 cancer cells and to examine how receptor distribution changes following ligand stimulation. (nature.com)
- Inside the nucleus, HER family members (EGFR, HER2, and HER3) have been shown to function as co-transcriptional activators for various cancer-promoting genes. (plos.org)
- The ErbB/HER family of receptor tyrosine kinases (RTKs) consists of four family members: the epidermal growth factor receptor (EGFR/ErbB1), HER2 (ErbB2/Neu), HER3 (ErbB3), and HER4 (ErbB4). (plos.org)
- Several members of the Epidermal Growth Factor Receptor (EGFR) family, have been identified in the nucleus and nucleolus of many cancer cells, but their function in these compartments remains unexplored. (biomedcentral.com)
- We focused our research on the nucleolar function that a specific member of EGFR family, the ErbB3 receptor, plays in glioblastoma, a tumor without effective therapies. (biomedcentral.com)
- Since the EGFR signalling promotes proliferation in tumor the EGFR receptors often represent a marker of resistance with poor prognosis. (biomedcentral.com)
- The EGFR proteins are receptor tyr kinases (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. (umbc.edu)
- C-erbB-2/HER-2 is a member of the EGFR family. (neobiotechnologies.com)
- Ligands that bind HER4 fall into two groups, the neuregulins (or heregulins) and some EGFR (HER1) ligands including betacellulin, HBEGF, and epiregulin. (umbc.edu)
- Gene amplification, overexpression and hyperactivity of the epidermal growth factor receptor (EGFR) is frequently observed in non-small cell lung cancer (NSCLC), head and neck cancer (HNSCC), breast and colorectal cancer (CRC). (wisc.edu)
- Therefore, the EGFR has been one of the most targeted receptors in all of oncology. (wisc.edu)
- Targeting EGFR has been intensely pursued in the last decade as a cancer treatment strategy. (wisc.edu)
- ERBB3 has received attention in recent as it is responsible for tumor resistance to therapeutic agents targeting EGFR or ERBB2 has illuminated its critical role in cancer. (creativebiolabs.net)
- ERBB3 involves in tumor development through interaction with other molecules, for instance, it forms heterodimeric with EGFR in melanoma and pancreatic carcinoma, and co-expresses with ERBB2 in breast cancer and breast cancer derived cell lines. (creativebiolabs.net)
Epidermal12
- The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340). (wikipedia.org)
- HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. (wikipedia.org)
- ErbB4, also called Her4 (human epidermal growth factor receptor 4), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. (rndsystems.com)
- ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. (rndsystems.com)
- Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. (aaoc.org.ar)
- It is also frequently called HER2 (from human epidermal growth factor receptor 2 ) or HER2/neu . (iiab.me)
- This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. (arigobio.com)
- Although neither kinase-dead human epidermal growth factor receptor (HER)3 nor orphan HER2 can be activated by HER-related ligands on their own, the formation of HER2/HER3 heterodimers creates the most mitogenic and transforming receptor complex within the HER (erbB) family of transmembrane receptor tyrosine kinases. (biomedcentral.com)
- The notion that breast cancer disease can be viewed as a biological process that is driven by overactive human epidermal growth factor receptor (HER)1/2 receptor tyrosine kinases (RTKs) has led to development of various anti-HER tyrosine kinase agents. (biomedcentral.com)
- Trastuzumab is a humanised monoclonal antibody against the human epidermal growth factor receptor (HER2), a tyrosine kinase receptor overexpressed at the time of diagnosis in 15 % of breast cancer (BC) and up to 20-30 % of metastatic BC, 4 which is associated with more aggressive disease, poor response to therapy and survival. (touchoncology.com)
- Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)
- Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases. (umbc.edu)
HER230
- But contrary to other members of the ERBB family, HER2 does not directly bind ligand. (wikipedia.org)
- HER2 activation results from heterodimerization with another ERBB member or by homodimerization when HER2 concentration are high, for instance in cancer. (wikipedia.org)
- Molecular cloning of the gene showed that HER2, Neu, and ErbB-2 are all encoded by the same orthologs. (wikipedia.org)
- HER2 can heterodimerise with any of the other three receptors and is considered to be the preferred dimerisation partner of the other ErbB receptors. (wikipedia.org)
- Signaling pathways activated by HER2 include: mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase (PI3K/Akt) phospholipase C γ protein kinase C (PKC) Signal transducer and activator of transcription (STAT) In summary, signaling through the ErbB family of receptors promotes cell proliferation and opposes apoptosis, and therefore must be tightly regulated to prevent uncontrolled cell growth from occurring. (wikipedia.org)
- however, drug agents targeting HER2 in breast cancer have significantly and positively altered the otherwise poor prognosis of the historically problematic difficulties associated with HER2-positive breast cancer. (wikipedia.org)
- HER2 is over-expressed in approximately 7-34% of patients with gastric cancer and in 30% of salivary duct carcinomas. (wikipedia.org)
- HER2 is colocalised and most of the time, coamplified with the gene GRB7, which is a proto-oncogene associated with breast, testicular germ cell, gastric, and esophageal tumours. (wikipedia.org)
- HER2 mutations have been found in non-small-cell lung cancers (NSCLC) and can direct treatment. (wikipedia.org)
- El trastuzumab es un anticuerpo monoclonal dirigido contra el receptor del factor de crecimiento epidérmico humano (Her2), el cual se encuentra sobreexpresado en aproximadamente el 20% del cáncer de mama invasivo. (aaoc.org.ar)
- Los mecanismos de resistencia al trastuzumab se pueden agrupar en 4 categorías principales: A. Obstáculos para la unión del trastuzumab al dominio extracelular del Her2. (aaoc.org.ar)
- HER2 and responsiveness of breast cancer to adjuvant chemotherapy. (aaoc.org.ar)
- Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. (aaoc.org.ar)
- Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. (aaoc.org.ar)
- Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. (aaoc.org.ar)
- BCIRG 006 phase III trial comparing AC→T with AC→TH and with TCH in the adjuvant treatment of HER2-amplified early breast cancer patients: third planned efficacy analysis. (aaoc.org.ar)
- Trastuzumab after adjuvant chemotherapy in HER2- positive breast cancer. (aaoc.org.ar)
- The HER2 receptor does not bind to any known ligands, however, its dimerization arm is innately positioned in an open conformation. (plos.org)
- however, drug agents targeting HER2 in breast cancer have significantly positively altered the otherwise poor-prognosis natural history of HER2-positive breast cancer. (iiab.me)
- Immunohistochemistry: Formalin-fixed and paraffin-embedded Human breast cancer tissue stained with ARG66357 anti-ERBB2 / HER2 antibody [SQab1890] at 1:500 dilution. (arigobio.com)
- in particular, HER3 signalling buffered against incomplete inhibition of HER2 kinase activity has been suggested to be the mechanism that allows HER2 over-expressing breast cancer cells to escape HER TKIs. (biomedcentral.com)
- It remains to be elucidated whether reactivation of HER3 signalling can also account for the poor efficacy of HER TKIs in treating breast carcinomas that contain low overall levels of HER2 receptors. (biomedcentral.com)
- However, it appears that regardless of the mechanism that triggers the formation of oncogenic HER2/HER3 heterodimers (HER2 over-expression or overall low HER2 but high levels of the HER3 ligand heregulin), HER3 transphosphorylation is a common response of breast cancer cells upon treatment with current inhibitors of the HER receptor tyrosine kinase network. (biomedcentral.com)
- Failure to reverse breast cancer progression despite apparent inhibition of HER1 and HER2 kinase functions in cell-based assays as well as in patient tissues and tumours is an enigma that is not yet resolved [ 6 ]. (biomedcentral.com)
- It is used for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 (ErbB2). (hmdb.ca)
- Phase III study designed to assess lapatinib in combination with chemotherapy for advanced HER2-positive gastric cancer in 2013 failed to meet the primary endpoint of improved overall survival (OS) against chemotherapy alone. (hmdb.ca)
- The outcome of this study resulted in a somewhat complex and rather specific initial indication for lapatinib-use only in combination with capecitabine for HER2-positive breast cancer in women whose cancer have progressed following previous chemotherapy with anthracycline, taxanes and trastuzumab. (hmdb.ca)
- ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. (bio-techne.com)
- Upon binding to neuregulin 1 (NRG1), ERBB3 preferentially dimerizes with HER2 (ERBB2), in turn inducing aggressive features in several cancer types. (unibo.it)
- Similar results were obtained by the analysis of basal-like/triple-negative breast cancer cellular models, MDA-MB-468 and MDA-MB-231 cells, in which NRG1β induced anchorage-independent cell growth that in turn was prevented or reduced by the simultaneous administration of anti-HER2 neutralizing antibodies. (unibo.it)
Ligand8
- Furthermore, diverse structural alterations have been identified that cause ligand-independent firing of this receptor, doing so in the absence of receptor over-expression. (wikipedia.org)
- Signal transduction by receptor tyrosine kinases (RTKs) involves complex ligand- and time-dependent changes in conformation and modification state. (nature.com)
- However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. (arigobio.com)
- Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. (arigobio.com)
- GP30 is a potential ligand for this receptor. (arigobio.com)
- Also, the growth-inhibitory effects of HER1/2 tyrosine kinase inhibitors (TKIs) were previously found to be attenuated in the presence of heregulin, which is a high-affinity combinatorial ligand for HER3. (biomedcentral.com)
- Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. (neobiotechnologies.com)
- Usually, the ligand neuregulins (NRG), also known as Heregulins (HRG), bind to ERBB3 and ERBB4. (creativebiolabs.net)
Ligands3
- ErbB4 ligands include the neuregulins, beta-cellulin and heparin-binding EGF-like growth factor (HB-EGF). (rndsystems.com)
- Classically, HER family members function from the cell surface, where binding to cognate ligands can induce receptor homo- or hetero-dimerization with other HER family receptors [3] . (plos.org)
- The ERBB family of type 1 receptor tyrosine kinases and their ligands have crucial functions during mammopoiesis, but the signaling networks that ultimately regulate ERBB activity in the breast have remained elusive. (silverchair.com)
ErbB312
- Because ErbB3 contains a defective kinase domain, the kinase domain of ErbB2 is responsible for initiating the tyrosine phosphorylation signal through the heterodimeric receptor. (rndsystems.com)
- Here, Neuregulin 1 mediated proliferative stimuli, promotes ErbB3 relocalization from the nucleolus to the cytoplasm and increases pre-rRNA synthesis. (biomedcentral.com)
- These results highlight the potential role for the nucleolar ErbB3 receptor, as a new target in glioblastoma. (biomedcentral.com)
- ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system. (bio-techne.com)
- ERBB3, also known as HER3, is a tyrosine kinase transmembrane receptor of the ERBB family. (unibo.it)
- The analysis of a dataset of breast cancer patients unveiled that higher ERBB3 mRNA expression correlates with shorter relapse-free survival in basal-like breast cancers, despite low ERBB3 expression in this breast cancer subtype. (unibo.it)
- We suggest that the NRG1/ERBB3/ERBB2 pathway promotes the anchorage-independent growth of basal-like breast cancer cells. (unibo.it)
- Our results pave the way towards the development of novel anticancer strategies for basal-like breast cancer patients based on the interception of the NRG1/ERBB3/ERBB2 signaling axis. (unibo.it)
- Duligotuzumab also known as RG7597 or MEHD7945A, is a recombinant humanized antibody to human receptor tyrosine-protein kinase erbB-3 (ERBB3). (creativebiolabs.net)
- ERBB3 is a member of ERBB family which play important roles in modern precision therapy as they always be aberrantly activated in multiple cancers. (creativebiolabs.net)
- The therapeutic potential of ERBB3 has long been underappreciated due in part to its impaired kinase activity though it highly express in certain human cancers. (creativebiolabs.net)
- The binding of NRG and ERBB3 result in receptor dimerization, then activating the downstream reaction tyrosine kinases and c-terminal tail phosphorylation of tyrosines. (creativebiolabs.net)
ERBB29
- Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. (wikipedia.org)
- Amplification, also known as the over-expression of the ERBB2 gene, occurs in approximately 15-30% of breast cancers. (wikipedia.org)
- Typically, heterodimerization with ErbB2 forms the high affinity receptor complex. (rndsystems.com)
- Receptor tyrosine-protein kinase erbB-2 , also known as CD340 (cluster of differentiation 340), proto-oncogene Neu , Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (iiab.me)
- ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. (bio-techne.com)
- ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. (bio-techne.com)
- Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with HER-2 Mouse Monoclonal Antibody (ERBB2/3078). (neobiotechnologies.com)
- SDS-PAGE Analysis Purified HER-2 Mouse Monoclonal Antibody (ERBB2/3078). (neobiotechnologies.com)
- Analysis of Protein Array containing more than 19,000 full-length human proteins using HER-2 Mouse Monoclonal Antibody (ERBB2/3078). (neobiotechnologies.com)
RTKs6
- High resolution structures are available for individual receptors dimers, but less is known about receptor clusters that form in plasma membranes composed of many different RTKs with the potential to interact. (nature.com)
- We report the use of multiplexed super-resolution imaging (Exchange-PAINT) followed by mean-shift clustering and random forest analysis to measure the precise distributions of five receptor tyrosine kinases (RTKs) from the ErbB, IGF-1R and Met families in breast cancer cells. (nature.com)
- Nuclear localized HER family receptor tyrosine kinases (RTKs) have been observed in primary tumor specimens and cancer cell lines for nearly two decades. (plos.org)
- This family of RTKs has been highly implicated in the formation and progression of various cancers via aberrant overexpression, kinase activation, and mutation [1] , [2] . (plos.org)
- While the classical membrane-bound functions of HER family RTKs have been extensively studied, accumulating data suggest that these receptors can be found in the cell's nucleus where they can function as co-transcriptional activators [4] , [5] . (plos.org)
- Monoclonal antibody therapy has been developed over the past 30 years to target receptor tyrosine kinases (RTKs), which sit on the outer membrane of cancerous cells. (wisc.edu)
Signaling6
- Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways. (wikipedia.org)
- Membrane-bound HER receptors activate numerous tumor promoting signaling cascades via this mechanism, including the PI3K/AKT, Ras/Raf/Mek/Erk, PLCγ/PKC, and signal transducer and activator of transcription (STAT) pathways [1] , [2] . (plos.org)
- In summary, signaling through the ErbB family of receptors promotes cell proliferation and opposes apoptosis, and therefore must be tightly regulated to prevent uncontrolled cell growth from occurring. (iiab.me)
- Included under this heading are signaling receptors, non-signaling receptors and accessory proteins required for receptor signaling. (edu.au)
- Mechanism underlying resveratrol's attenuation of paclitaxel cytotoxicity in human breast cancer cells: Role of the SIRT1-FOXO1-HER3 signaling pathway. (cuhk.edu.cn)
- We have previously shown that three related Ras proteins (the classic Ras proteins) are highly activated in malignant peripheral nerve sheath tumor (MPNST) cells with neurofibromin loss and that they drive cancer cell proliferation and survival by activating multiple cellular signaling pathways. (biomedcentral.com)
Colorectal Cancer3
- HER3- A key survival pathway and an emerging therapeutic target in metastatic colorectal cancer and pancreatic ductal adenocarcinoma. (nih.gov)
- Cetuximab exhibits promising antitumor activity as monotherapy or in combination with chemotherapy and/or radiation in head and neck cancer and metastatic colorectal cancer. (wisc.edu)
- In addition, duligotuzumab also had been investigated in the treatment of colorectal cancer, and the safety and efficacy of it plus folfiri versus cetuximab plus folfiri as second line therapy in participants with kras wild-type metastatic colorectal cancer (mCRC) had been studied. (creativebiolabs.net)
Tumor8
- Persons with the most common pediatric brain malignancy, medulloblastoma, fare only slightly better than average, with a 71.9% 5-year survival, though the most common adult brain tumor, glioblastoma multiforme (GBM), incurs a mere 5.1% 5-year survival rate 2 . (nature.com)
- Thus, there is an urgent need to innovate new strategies to safely manage or treat brain cancers and therein a substantial need for a better understanding of how brain tumor dissemination can be limited or controlled. (nature.com)
- The concept of a non-contact force being able to direct a cell's motility is potentially interesting for brain cancer therapy when you consider that controlling tumor dispersion-or possibly undoing it-could be a major boon to the management of brain tumors. (nature.com)
- Toxicity mediated by T4+ T cells results from target recognition in both tumor and healthy tissues, leading to release of both human (IL-2/IFN-γ) and murine (IL-6) cytokines. (kcl.ac.uk)
- Tumor suppressors, oncogenes and alternatively deregulated upstream signalling pathways can directly influence the RNA polymerase I activity inducing hyper activation of rRNA transcription in cancer cells. (biomedcentral.com)
- Like sorafenib, lapatinib is a protein kinase inhibitor shown to decrease tumor-causing breast cancer stem cells. (hmdb.ca)
- A 45-kilodalton protein heregulin-alpha (HRG-alpha) that specifically induced phosphorylation of p185erbB2 was purified from the conditioned medium of a human breast tumor cell line. (embl.de)
- Scatchard analysis of the binding of recombinant HRG to a breast tumor cell line expressing p185erbB2 showed a single high affinity binding site [dissociation constant (Kd) = 105 +/- 15 picomolar]. (embl.de)
Proteins3
- Generally, these receptors explain their function on the cell membrane where, after the binding with growth factors or neuregulin undergo to homo or hetero oligomerization with the activation of the intrinsic tyrosine kinase activity and the subsequent recruitment of proteins involved in the cytoplasmic signalling pathways. (biomedcentral.com)
- In addition to plexins, various other proteins have been implicated either as receptors for semaphorins or as components of the semaphorin receptor complex ( Pasterkamp and Kolodkin, 2003 ). (rupress.org)
- loss of neurofibromin could cause these Ras proteins to become persistently active, leading to the development of cancer. (biomedcentral.com)
NRG13
- All four neuregulins (NRG1-4) interact with HER4. (umbc.edu)
- As a postsynaptic receptor of NRG1, HER4 plays an important role in synaptic plasticity and maturation. (umbc.edu)
- Administration of neuregulin 1 beta (NRG1β) significantly affected neither cellular proliferation nor the basal migratory ability of basal-like/triple-negative quasi-normal MCF10A breast cells, cultured in mono-layer conditions. (unibo.it)
Tumors5
- Even with continual advances in drug discovery and delivery technologies that have substantially improved outcomes in systemic cancers, there has been disappointingly little impact on tumors of the brain. (nature.com)
- The ErbB network is dysregulated in many solid tumors. (kcl.ac.uk)
- Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. (arigobio.com)
- Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. (nih.gov)
- In the Wheeler lab, we use state of the art molecular biology, proteomics and mouse modeling to understand how tumors become resistant to cancer drugs. (wisc.edu)
Phosphorylation3
- This process leads to the activation of each receptors' tyrosine kinase and the subsequent phosphorylation of tyrosine residues located on their C-terminal tails. (plos.org)
- Binding of Sema4D to plexin-B1 stimulates the intrinsic tyrosine kinase activity of ErbB-2, resulting in the phosphorylation of both plexin-B1 and ErbB-2. (rupress.org)
- Our data indicate that ErbB-2 is an important component of the plexin-B receptor system and that ErbB-2-mediated phosphorylation of plexin-B1 is critically involved in Sema4D-induced RhoA activation, which underlies cellular phenomena downstream of plexin-B1, including axonal growth cone collapse. (rupress.org)
Dimers1
- To exploit this, we have developed a chimeric Ag receptor (CAR) named T1E28z that targets several pathogenetically relevant ErbB dimers. (kcl.ac.uk)
ErbB44
- ErbB4 is expressed in normal skeletal muscle, heart, pituitary, brain and several breast carcinomas. (rndsystems.com)
- ErbB4 appears to play important roles in neuronal development, development of the heart and cancer. (rndsystems.com)
- ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation. (proquest.com)
- Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. (proquest.com)
Kinase domain2
- lacks kinase domain), and erbB-4. (wikipedia.org)
- This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. (nih.gov)
High affinity1
- It first binds with high affinity to specific cell-surface receptors and then induces their dimerization, which is essential for activating the tyrosine kinase in the receptor cytoplasmic domain, initiating a signal transduction that results in DNA synthesis and cell proliferation. (embl.de)
Carcinomas4
- HER-2 is over-expressed in approximately 7-34% of patients with gastric cancer [20] [21] and in 30% of salivary duct carcinomas. (iiab.me)
- Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
- 1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
- c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary. (neobiotechnologies.com)
Signal transduction1
- Phosphorylated tyrosine residues recruit various intracellular adaptor and effector molecules that result in the propagation of growth promoting signal transduction cascades [1] , [2] . (plos.org)
Tyrosine residues1
- Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). (arigobio.com)
HER35
- The current study aimed to map the putative transactivation domains (TADs) of the HER3 receptor. (plos.org)
- To understand how the B 1 and B 2 regions influenced the transcriptional functions of nuclear HER3, we performed cyclin D1 promoter-luciferase assays in which HER3 deleted of the B 1 and B 2 regions was severely hindered in regulating this promoter. (plos.org)
- Brand TM, Iida M, Luthar N, Wleklinski MJ, Starr MM, Wheeler DL (2013) Mapping C-Terminal Transactivation Domains of the Nuclear HER Family Receptor Tyrosine Kinase HER3. (plos.org)
- Transphosphorylation of kinase-dead HER3 and breast cancer progression: a new standpoint or an old concept revisited? (biomedcentral.com)
- Because kinase-inactive HER3 is not presently an amenable target for forthcoming HER TKIs, molecular approaches that can efficiently block heregulin-triggered HER3 transactivation or nucleocytoplasmic trafficking of heregulin might offer novel strategies with which to manage HER-driven breast cancer disease. (biomedcentral.com)
Pancreatic1
- S3-Guidelines "Exocrine pancreatic cancer" 2007. (mdc-berlin.de)
Family4
- The ErbB family consists of four individual plasma membrane-bound receptor tyrosine kinases. (wikipedia.org)
- A family of structurally-related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. (edu.au)
- Here, we show that plexin-B family members stably associate with the receptor tyrosine kinase ErbB-2. (rupress.org)
- However, it does form heterodimers with other EGF receptor family members which do have kinase activity. (nih.gov)
Protein8
- In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. (wikipedia.org)
- The Her-2/neu gene and protein in breast cancer 2003: biomarker and target of therapy. (aaoc.org.ar)
- Pathologic finding from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein expression in primary breast cancer. (aaoc.org.ar)
- Association of c-erbB-2 protein over-expression with high rate of cell proliferation, increased risk of visceral metastasis and poor long-term survival in breast cancer. (aaoc.org.ar)
- Thus, the control of ribosome assembly and protein synthesis is essential for the survival of cancer cells. (biomedcentral.com)
- WHG, Wang P , Zhu BT (2022) Mechanism of erastin-induced ferroptosis in MDA-MB-231 human breast cancer cells: evidence for a critical role of protein disulfide isomerase. (cuhk.edu.cn)
- Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition. (mdc-berlin.de)
- Recognizes a protein of 185kDa, which is identified as c-erbB-2/HER-2/neu. (neobiotechnologies.com)
Tissues4
- These dismal survival rates are due in part to a lack of available therapies for cancers in neural tissues, as the brain is a particularly difficult organ to treat. (nature.com)
- However, ErbB receptors are also expressed in several healthy tissues, raising concerns about toxic potential. (kcl.ac.uk)
- Breast cancer tissues. (neobiotechnologies.com)
- Heregulin transcripts were identified in several normal tissues and cancer cell lines. (embl.de)
Cells12
- In this study we investigate the properties of populations of brain cancer undergoing electrotaxis, a phenomenon whereby cells are directed to migrate under control of an electrical field. (nature.com)
- Preclinical In Vivo Modeling of Cytokine Release Syndrome Induced by ErbB-Retargeted Human T Cells: Identifying a Window of Therapeutic Opportunity? (kcl.ac.uk)
- T1E28z is coexpressed with a chimeric cytokine receptor named 4αβ (combination termed T4), enabling the selective expansion of engineered T cells using IL-4. (kcl.ac.uk)
- Human T4+ T cells exhibit antitumor activity against several ErbB+ cancer types. (kcl.ac.uk)
- Furthermore, our findings argue that ErbB-retargeted T cells can achieve therapeutic benefit in the absence of unacceptable toxicity, providing that route of administration and dose are carefully optimized. (kcl.ac.uk)
- 2 However, even these new target drugs have been shown to have a cardiotoxic potential, especially when used as combination therapies, by inhibition of transduction pathways in normal or non-cancerous cells. (touchoncology.com)
- Measured by its ability to inhibit the biological activity of Neuregulin-1-beta 1 on MCF‑7 human breast cancer cells. (bio-techne.com)
- Hepatocyte growth factor/scatter factor (HGF/SF), the c-met receptor and the behaviour of epithelial cells. (wikidata.org)
- Jiang L, Zhang Y, Guo L, Liu C, Wang P , Ren W. (2021) Exosomal microRNA-107 reverses chemotherapeutic drug resistance of gastric cancer cells through HMGA2/mTOR/P-gp pathway. (cuhk.edu.cn)
- Resistance to drugs that target cancers cells is one of the most pressing problems in all of oncology. (wisc.edu)
- These receptors are responsible for activating key pathways in cancer cells that lead to their proliferation and survival. (wisc.edu)
- In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)
OVARIAN-CANCER1
- Abrogated energy-dependent uptake of cisplatin in a cisplatin-resistant subline of the human ovarian cancer cell line IGROV-1. (wikidata.org)
Various cancers1
- Gain of function alterations, through their overexpression, deletions, or point mutations in their kinase domains, have been implicated in various cancers. (umbc.edu)
Inhibitors1
- These receptors are targets of many small molecule inhibitors and monoclonal antibodies used in cancer therapy. (umbc.edu)
Therapies1
- Over the last 20 years, considerable progress has been made in the management of cancer due to the introduction of targeted molecular therapies. (touchoncology.com)
Differentiation1
- Pro-fibrotic fibroblasts were transcriptionally similar to cancer associated fibroblasts and expressed high levels of collagens and periostin (POSTN), thymocyte differentiation antigen 1 (THY-1), and endothelin receptor A (EDNRA) predicted to be driven by a RUNX1 gene regulatory network. (bvsalud.org)
Avian1
- ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. (wikipedia.org)
Induces1
- Cetuximab (IMC- C225, Erbitux) prevents receptor activation and dimerization and ultimately induces receptor internalization and. (wisc.edu)
Resistance2
- 2021) The clinicopathological features and resistance mechanisms in HIP1-ALK non-small-cell lung cancer: A multicenter study in China. (cuhk.edu.cn)
- My laboratory is focused on understanding mechanisms of resistance to molecular targeting agents directed against receptor tyrosine kinases. (wisc.edu)
Bind1
- Cellular receptors that bind the human immunodeficiency virus that causes AIDS. (edu.au)