• ManNAc therapy may increase sialic acid production and subsequently increase sialylation of glomerular proteins. (wikipedia.org)
  • Sialic acid in the form of polysialic acid is an unusual posttranslational modification that occurs on the neural cell adhesion molecules (NCAMs). (wikipedia.org)
  • Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. (genecards.org)
  • Modification of cell surface molecules with sialic acid is crucial for their function in many biologic processes, including cell adhesion and signal transduction. (wikipedia.org)
  • When influenza virus replicates, it attaches to the interior cell surface using hemagglutinin, a molecule found on the surface of the virus that binds to sialic acid groups. (wikipedia.org)
  • In humans the brain has the highest sialic acid concentration, where these acids play an important role in neural transmission and ganglioside structure in synaptogenesis. (wikipedia.org)
  • The numbering of the sialic acid structure begins at the carboxylate carbon and continues around the chain. (wikipedia.org)
  • The name "neuraminic acid" was introduced by German scientist E. Klenk in 1941, in reference to the brain lipids from which it was derived as a cleavage product. (wikipedia.org)