Neural stem cells cells fetal tissue research. Medical search. Frequent questions

cDNA data suggest that GPR56 has potential to become a neural stem cell (NSC) or neural progenitor cell (NPC) marker. (nih.gov)
NeuCELL™ is an immortalized human neural progenitor cell line with the ability to readily differentiate into neurons & glial cells. (creative-biolabs.com)
Thank you for your interest in NeuCELL™ Human Neural Progenitor Cell Line, Immortalized . (creative-biolabs.com)
Anderson, L. and Caldwell, M.A. (2007) Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease. (scirp.org)
2 It is hypothesized that transcription factors that regulate stem/progenitor cell development such as Sox2 are key components in the pathogenesis of FASD. (tamhsc.edu)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)

Ghasemi-Mobarakeh L, Prabhakaran MP, Tian L, Shamirzaei-Jeshvaghani E, Dehghani L, Ramakrishna S. Structural properties of scaffolds: Crucial parameters towards stem cells differentiation. (wjgnet.com)
Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
Cells recovered from healthy individuals could provide a model for understanding how to stimulate and guide the normal processes of brain cell growth and differentiation," he said, "lending insight to how growth might be stimulated in people suffering from neurodegenerative diseases such as Alzheimer's or Parkinson's. (salk.edu)
ASCs possess a more limited differentiation potential compared to ESCs, primarily giving rise to cells specific to their tissue of origin. (mornd.com)
Differentiation and integration of grafted cells in the host tissue were validated with immunofluorescence staining using human-specific antibodies. (biomedcentral.com)
Stem cell research is, in part, a quest to understand cellular differentiation, the process by which a human being develops from one fertilized cell into a multicellular organism composed of over 200 different cell types - for example muscle, nerve, blood cell, or kidney. (jcpa.org)
Cellular differentiation begins with the fertilized egg which serves as the identifying characteristic of an embryonic stem cell. (jcpa.org)
They traced this effect to the premature differentiation of neural stem cells inside the microcephalic tissue chunks, depleting the population of progenitor cells that fuels normal brain growth. (cbc-network.org)
For childhood neoplasms, it is safe to assume that cancer is the product of degeneration in a neoplastic sense of tissues undergoing very rapid proliferation and differentiation, in which proliferative and differentiative programs are being disturbed by increasingly early (maternal-fetal) exposure to a growing number of environmental stressors and pollutants. (frontiersin.org)
At this juncture, through the present study it was found that, chicken neural retinal cells when grown alone failed to survive and contrarily when either co-cultured with chicken amniotic epithelial cells / cultured in amniotic epithelial cell conditioned medium not only survived but also showed extensive differentiation. (scielo.org.ar)
Transplantation of cells pre-treated with medicine or gene transfection to prolong graft survival or promote differentiation into the needed phenotype, was prevalent in the transplantation articles regardless of the kind of cells used. (korea.ac.kr)
Support the growth and differentiation of human pluripotent stem cells by using Vitronectin XF™, a defined and xeno-free cell culture matrix. (stemcell.com)
The directed differentiation of induced pluripotent stem cells (iPSC) into specific neuronal subtypes provides an unlimited supply of human neurons that can be used to study disease mechanisms. (researchsquare.com)
Each lot of NeuCELL™ cells has been validated for high level of expression of Nestin and Sox 2 and for their self-renewal and multi-lineage differentiation capacities. (creative-biolabs.com)
The Hirschi Lab is broadly interested in endothelial cell differentiation, proliferation, specification and function during development. (hirschilabuva.com)
The lab also uses human stem cell culture models to study the regulation of human endothelial cell differentiation and specification, and to study the functional roles of endothelial cells in regulating tissue-resident stem cells. (hirschilabuva.com)
Regulation of endothelial cell differentiation and specification. (hirschilabuva.com)
Conclusions: This study showed that an osteoblastic cell lineage may be obtained from human bone marrow derived from adherent cells, and that the presence of the rhBMP-4 seems to have an effect during the first stages of differentiation only. (bvsalud.org)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

Clare's lab recently identified a population of progenitor/stem cells in mice that, on transplantation, is sufficient to generate a fully functional thymus. (eurostemcell.org)
A standardised procedure is followed: the cells are usually obtained from a 7-8 weeks old foetus and the collected cells undergo testing to examine whether they are free from infectious agents and safe for transplantation. (wikipedia.org)
Foetal tissue transplantation is a foetal allograft procedure, using tissues from an aborted foetus and implanting it into a diseased patient's body to improve defective tissue functioning. (wikipedia.org)
In 1928, one of the first foetal tissue transplantation attempt was made in Italy using aborted foetal tissues. (wikipedia.org)
The widespread success of foetal tissue transplantation led to the use of foetal brain cells to treat neurological diseases. (wikipedia.org)
It is also found that foetal cells can produce high levels of angiogenic and neurotrophic factors, which increases their growth rate after transplantation. (wikipedia.org)
Lastly, the cells can survive in lower oxygen conditions, and tend to be more resistant to ischemic environments during transplantation or in vitro conditions. (wikipedia.org)
Moreover, hematopoietic stem cell transplantation (HSCT) continued to be a successful treatment modality for various blood disorders. (mornd.com)
Researchers focused on improving transplantation techniques and understanding stem cell niche interactions to enhance engraftment and minimize complications. (mornd.com)
By virtue of expressions of glial and neural surface markers and capability of neurotransmitter metabolism, amniotic epithelial cells are considered as candidate cell type for transplantation strategies to treat neurological disorders. (scielo.org.ar)
These findings suggested the usefulness of them as an alternate source of cells for transplantation approaches to treat neurological disorders (Sakuragawa et al. (scielo.org.ar)
Transplantation of amniotic epithelial cells in various regions of central nervous system such as caudate nucleus (Bankiewicz et al. (scielo.org.ar)
Amniotic epithelial cells transplantation in Parkinson model of rats was found to reverse the condition and prevent death in neurons (Kakishita et al. (scielo.org.ar)
2001). In our previous report, we concluded the usefulness of amniotic epithelial cells transplantation in spinal cord injury repair research. (scielo.org.ar)
We had also outlined various biological and social advantages by which, amniotic epithelial cells transplantation excels its precedent viz. (scielo.org.ar)
Recently, our conclusion of usefulness of amniotic epithelial cells transplantation to treat spinal cord injuries has been confirmed in rodent models of spinal cord injury (Zhi-yuan et al. (scielo.org.ar)
The articles published in the journal Cell Transplantation - The Regenerative Medicine Journal over the last two years reveal the recent and future cutting-edge research in the fields of regenerative and transplantation medicine. (korea.ac.kr)
Articles focusing on the transplantation of stem cell lineages encompassed almost 20% of all articles published. (korea.ac.kr)
Meanwhile, the majority of non-transplantation-based articles were related to new devices for various purposes, characterization of unknown cells, medicines, cell preparation and/or optimization for transplantation (e.g. isolation and culture), and disease pathology. (korea.ac.kr)
Both the physical and functional integration of the organoid into the rat's brain make organoid transplantation a promising technology for neural tissue repair. (yalescientific.org)
As genetic aberrations are the main causes of all forms of hereditary anemia, the optimal approach involves repairing the defective gene, possibly through the transplantation of normal hematopoietic stem cells (HSCs) from a normal matching donor or through gene therapy approaches (either in vivo or ex vivo) to correct the patient's HSCs. (sscb-stembiotech.com)
In conclusion, gene-corrected hematopoietic stem cell transplantation has promising outcomes for SCD, Fanconi anemia, and thalassemia, and it may overcome the limitation of the source of allogenic bone marrow transplantation. (sscb-stembiotech.com)

Foetal brain cell graft is a surgical procedure that can be used as a regenerative treatment for various neurological conditions, but was mainly explored and used specifically for treating Parkinson's disease (PD). (wikipedia.org)
Today, fetal tissue is still making an impact, with clinical trials underway using cells from fetal tissue to treat conditions including Parkinson's disease, ALS, and spinal cord injury," said Doug Melton, co-director of Harvard's Stem Cell Institute and president of the International Society for Stem Cell Research. (chicagotribune.com)
Between 1988 and 1994, roughly 140 Parkinson's disease patients received fetal tissue (up to six fetuses per patient), with varying results. (lozierinstitute.org)
[12] The results of these two large studies led to a moratorium on fetal tissue transplants for Parkinson's. (lozierinstitute.org)
Researchers made progress in identifying and understanding the potential of neural stem cells (NSCs) for treating neurological diseases such as Parkinson's and Alzheimer's. (mornd.com)
While there is a great deal published on the potential medical applications of stem cell research to treat or cure diseases such as diabetes, Alzheimer's disease, Parkinson's disease, cancer, and heart disease, much less has been published on the future impact of stem cell research in reproductive medicine. (jcpa.org)
Scientists have created a way to isolate neural stem cells - cells that give rise to all the cell types of the brain - from human brain tissue with unprecedented precision, an important step toward developing new treatments for conditions of the nervous system, like Parkinson's and Huntington's diseases and spinal cord injury. (medicaldaily.com)
Since rodent models cannot recapitulate many of the human disease features, human induced pluripotent stem cells derived from Parkinson's patients have been used to generate brain organoids, greatly contributing to our understanding of the disease pathophysiology. (nature.com)
To understand the multifaced aspects of Parkinson's disease, it may be desirable to expand the complexity of these models, to include different brain regions, vasculature, immune cells as well as additional diverse organ-specific organoids such as gut and intestine. (nature.com)
The use of olfactory progenitors as a cell-based therapy for Parkinson's disease (PD) would allow harvest without invasive surgery, provide an autologous cell population, eliminate need for immunosuppression and avoid the ethical concerns associated with embryonic tissues. (scirp.org)
During the past 12 years, CIRM has spent several billion dollars to fund stem cell research in hopes of finding cures for a variety of ailments including Parkinson's disease, cerebral palsy, and spinal cord injuries, but with little success . (californiafamily.org)
Since then, according to his resume , Dr. Svendsen has been involved in study after study, writing article after article regarding the use of pre-born baby brains and other fetal tissue to treat neurological diseases like Parkinson's and Lou Gehrig's disease. (californiafamily.org)

In parallel, mesenchymal stem cells (MSCs) gained attention for their regenerative potential. (mornd.com)
Evaluation the efficacy of adipose derived mesenchymal stromal cells in patients with knee osteoarthritis. (cam.ac.uk)
Many forms of stem cell therapy exist, including the use of neural, haematopoietic and mesenchymal stem cells. (sscb-stembiotech.com)
There is compelling evidence that mesenchymal stem cells (MSCs) can be utilized as delivery vehicles for cancer therapeutics. (sscb-stembiotech.com)
Undifferentiated mesenchymal stem cells are pluripotent cells that can differentiate into various phenotypes and are a source of osteogenic Cells 1,2 . (bvsalud.org)

In this category of experimentation, besides the use of locally delivered trophic factors (such as brain-derived neurotrophic factor (BDNF)-, glial cell line-derived neurotrophic factor (GDNF)-, and fibroblast growth factor (FGF)-peptides or growth factors-gene-encoding vectors) [ 8 ], regionally grafted fetal or embryonic stem cell-derived neuronal precursors are frequently used [ 9 - 18 ]. (biomedcentral.com)
Amniotic epithelial cells were known to express some of neuronal and glial cell markers (Sakuragawa et al. (scielo.org.ar)
This image is from lab-grown brain tissue - a minibrain - infected by Zika virus (white) with neural stem cells in red and neuronal nuclei in green. (wamc.org)
Her research program encompasses the early neural stem cell niche, neural tube closure, cerebrospinal fluid (CSF), metabolism, and cortical neuronal development. (stanford.edu)
Our research program encompasses the early neural stem cell niche, neural tube closure, CSF, metabolism, and cortical neuronal development. (stanford.edu)

La Jolla, CA - Salk Institute scientists have isolated cells from the brains of human cadavers that can grow, divide and form specialized classes of brain cells. (salk.edu)
I find it remarkable that we all have pockets of cells in our brains that can grow and differentiate throughout our lives and even after death," said Fred Gage , a professor at The Salk Institute and senior author of the study, which appears in the current Nature. (salk.edu)
Long-term follow-up of a few of the patients in these large studies showed that even in fetal tissue that grew in patients' brains, the grafted tissue took on signs of the disease and were not effective. (lozierinstitute.org)
Using specific antibodies and immunochemistry, we showed that GPR56 was highly expressed in nestin-positive NSC/NPCs in the ventricular/subventricular zone of human and mouse fetal brains, and in cultured neurospheres derived from both human and mouse fetal brains. (nih.gov)
Unpredictable variations and deficiencies have hampered the organoids' usefulness in research, but new techniques for creating mini-brains may change that. (nautil.us)
The neural tubes of these exposed embryos often failed to close, and later in development, the fetal mice also grew unusually small heads and brains. (livescience.com)
They have demonstrated that clumps of stem cell-derived tissue, called organoids, can successfully integrate into the damaged brains of adult rats. (yalescientific.org)

citation needed] Stem cells found in the foetal tissues can differentiate into any cell type. (wikipedia.org)
The discovery of ESCs offered hope for regenerative medicine due to their pluripotent nature, i.e., the ability to differentiate into any cell type in the body. (mornd.com)

Professor Elena Cattaneo is Director of the Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases at the Department of Pharmacological Sciences, as well as a co-founder and first appointed Director of UniStem , the Centre for Stem Cell Research of the University of Milano. (eurostemcell.org)
The cells derived from these tissues constitute a model system for studying the brain cell biology of these disorders, according to Gage. (salk.edu)
Development: For advances in developmental biology and stem cells. (lu.se)
1 Department of Cell Biology, Peking University Health Science Center, China. (nih.gov)
According to Arnold Kriegstein , director of the developmental and stem cell biology program at the University of California, San Francisco, it was difficult to get organoids to turn out uniformly even when scientists used the same growth protocol and the same starting materials. (nautil.us)
By forcing key stem cells cells into this state, called senescence, valproic acid may disrupt brain development in the womb and therefore cause cognitive and developmental disorders down the line, according to the study, published Tuesday (June 14) in the journal PLOS Biology . (livescience.com)
These organoids are created by applying an understanding of developmental biology to cause stem cells to develop in a structured manner, often mimicking an organ or part of an organ. (yalescientific.org)
As a stem cell and developmental molecular biologist, Dr. Fame is dedicated to broad collaboration focused on translating an understanding of neural development and CSF biology into regenerative strategies for the treatment of neurodevelopmental disease. (stanford.edu)
Stem cell therapy provides hope for many patients, but should be tempered with the realisation that the scientific and medical communities are still to fully unravel the complexities of stem cell biology, and to provide satisfactory data that support the rational, evidence-based application of these cells from a therapeutic perspective. (sscb-stembiotech.com)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)

Various organizations, including the International Society for Stem Cell Research (ISSCR), have formulated guidelines to provide ethical frameworks to researchers and practitioners. (mornd.com)
In what was supposed to be some sort of "bombshell," antiabortion crusaders claimed that Nucatola admitted harvesting aborted fetal parts, changing abortion procedures to accommodate the harvesting of aborted fetal parts, then illegally selling the aborted fetal parts to medical researchers. (latimes.com)
Some researchers have experimented with neural stem cells to treat spinal cord injuries. (latimes.com)
Institute researchers are involved in a number of clinical trials that show promise for the translation of stem cell research from bench to bedside. (cam.ac.uk)
Most researchers obtain embryonic stem cells from the inner mass of a blastocyst, an embryonic stage when a fertilized egg has divided into 128 cells. (jcpa.org)
The researchers found that tissue chunks cultured from stem cells derived from the skin of a single human with microcephaly did not grow as big as clumps grown from stem cells derived from a healthy person. (cbc-network.org)
Researchers at the Mayo Clinic are currently doing clinical trials for patients with ALS, using ADULT STEM CELLS. (flfamily.org)
A stained cross section through one of the cortical organoids created by researchers at the Yale Stem Cell Center shows the organization of various cell types into layers of tissue. (nautil.us)
The researchers exposed the organoids to valproic acid and found that the drug pushed the organoids' neuroepithelial cells into senescence, just as it had in the mouse embryos. (livescience.com)
Combining proteomics and mRNA transcriptional profiling, the researchers evaluated the interactome map - a whole set of molecular interactions - of the infected neural cells in order to understand the ZIKV-related impairment on cellular metabolism. (sciencebeta.com)
Known as "minibrains," these rudimentary networks of cells are small enough to fit on the head of a pin, but already are providing researchers with insights into everything from early brain development to Down syndrome, Alzheimer's and Zika. (wamc.org)
At a Sunday press conference at the neuroscience meeting, researchers said minibrains are helping them figure out how the Zika virus can disrupt human brain formation in the early stages of fetal development. (wamc.org)
As a result, the minibrains can help researchers answer questions that couldn't be answered by studying animal brain tissue. (wamc.org)
The case sent a chill through the scientific community when it came to light 15 years ago and typifies some of the hurdles researchers have faced while trying to bring stem cell therapies to the market. (ibtimes.com)
Researchers from the pharmaceutical research firm Hematech cultivated a colony of cattle cells in the lab and used a genetic engineering technique to knock out the gene that codes for the production of the prion protein. (acs.org)
To better understand how these repetitive genetic sequences influence brain development, researchers analyzed both fetal and adult brain tissue samples. (lu.se)

if the foetal neurons are not completely functionally integrated in the host, it may cause various side effects, which are the risks and limitations associated with this procedure. (wikipedia.org)
Cells dissected are glial cells that regulate the neurons' growth, and synaptic connections. (wikipedia.org)
Magnetic resonance imaging volume reconstruction and immunofluorescence analysis of grafted cell survival showed near complete injury-cavity-filling by grafted cells and development of putative GABA-ergic synapses between grafted and host neurons. (biomedcentral.com)
2001) had found amniotic epithelial cells conditioned medium showed neurotrophic effect on rat embryonic day 18 (E18) cortical neurons. (scielo.org.ar)
Using five control induced pluripotent stem cell (iPSC) lines and seven iPSC lines generated from fAD patients, we investigated the effects of mutations on the Aβ secretome in human neurons generated in 2D and 3D. (nature.com)
neurons were present but important glial cells that make up the supportive white matter of the brain were often missing. (nautil.us)
Zika virus disrupts the cellular machinery regulating cell division, and alters the expression of hundreds of genes guiding the formation and development of neurons and astrocytes , according to new research. (sciencebeta.com)
An immortalised cell line of human neural progenitors called NeuCELL™ CX may easily develop into neurons and glial cells. (creative-biolabs.com)
Astrocytes are abundant cell types in the vertebrate central nervous system and can act as neural stem cells in specialized niches where they constitutively generate new neurons. (frontiersin.org)
Therefore, finding out molecular mechanisms by which reactive astrocytes can be coaxed into neurons will be of utmost importance for regenerative therapies as these astrocytes are the imminent cell types around the lesion site. (frontiersin.org)
Le Maître TW, Dhanabalan G, Bogdanovic N, Alkass K, Druid H. Effects of Alcohol Abuse on Proliferating Cells, Stem/Progenitor Cells, and Immature Neurons in the Adult Human Hippocampus. (tamhsc.edu)
So far CIRM has given Dr. Svendsen $26 million , most of which has funded research to find treatments for Lou Gehrig's disease, also known as Amyotrophic Lateral Sclerosis (ALS) , a fatal condition that damages motor neurons in the brain and spinal cord. (californiafamily.org)

Here we characterized the effect of intraspinal grafting of clinical grade human fetal spinal cord-derived neural stem cells (HSSC) on the recovery of neurological function in a rat model of acute lumbar (L3) compression injury. (biomedcentral.com)
Tissue microarrays (TMAs) including I-IV grade clinical glioma samples was used to determine the prognostic effect of the CDC2/Cyclin B1 expression in gliomas on different grades. (biomedcentral.com)
The Midwest Stem Cell Therapy Center (MSCTC) at the University of Kansas Medical Center is only a year old, but is starting an increasing number of clinical trials and educational efforts. (flfamily.org)
The MSCTC does not do any embryonic or aborted fetal stem cell research, ONLY ADULT and NON-EMBRYONIC STEM CELL RESEARCH and CLINICAL TRIALS. (flfamily.org)
Dozens of adult stem cell treatments are moving through clinical trials and showing early success, raising hopes that some could reach the market within five years. (ibtimes.com)
Clinical presentation, diagnosis, and management of fetal alcohol spectrum disorder. (tamhsc.edu)
McCormack also confirmed fetal tissue is being used in a clinical trial CIRM is currently promoting on its website. (californiafamily.org)
A article from last fall, titled, "Ingenious CIRM-funded stem cell approach to treating ALS gets go-ahead to start clinical trial," highlights the work of Dr. Clive Svendsen, and his work to find a cure for Lou Gehrig's disease at the Cedars-Sinai Medical Center in Los Angeles. (californiafamily.org)
Dr. Svendsen received his most recent grant of $6.2 million last Fall to fund a clinical trial where "they will implant middle-man "progenitor" cells made by maturing stem cells from fetal tissue," into the spinal cords of patients with hope the damaged neural cells will be repaired. (californiafamily.org)
Leveraging multidisciplinary collaborations between fetal therapists, tissue engineers, stem cell biologists and other experts, our team is working to develop creative solutions to the current challenges in prenatal surgical repair of MMC and to design clinical studies that compare the new technique to the established standard of open fetal surgical repair. (chop.edu)
To clearly illustrate the importance of cell and gene therapy in hereditary anemia, this paper provides a review of the genetic aberration, epidemiology, clinical features, current management, and cell and gene therapy endeavors related to SCD, thalassemia, Fanconi anemia, and G6PDD. (sscb-stembiotech.com)
Moreover, we expound the future research direction of HSC derivation from induced pluripotent stem cells (iPSCs), strategies to edit HSCs, gene therapy risk mitigation, and their clinical perspectives. (sscb-stembiotech.com)
We provide an overview of the application of stem cells in neurological disease, starting with basic principles, and extending these to describe the clinical trial landscape and progress made over the last decade. (sscb-stembiotech.com)
Over 200 clinical studies applying various stem cell approaches to treat neurological disease have been registered to date (Clinicaltrials.gov), the majority of which are for multiple sclerosis, stroke and spinal cord injuries. (sscb-stembiotech.com)
We will also explore whether lower MIH will be related to higher cell-free mtDNA (ccf-mtDNA) levels and poor clinical outcomes. (bvsalud.org)
Research in the Hirschi Lab aims to uncover the developmental mechanisms of hemogenic endothelial cell specification and endothelial-to-hematopoietic transition, and apply insights gained to the generation of human HSPCs for clinical therapies. (hirschilabuva.com)
The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)

In addition to isolating single cells in order to determine if true stem cells are present in adult brain tissue, Gage also plans to transplant recovered cells into animals to test if the cells can survive and differentiate in vivo. (salk.edu)
Testing in whole animals is the only way to know if adult tissue can be a source of stem or progenitor cells for transplant purposes to treat neurodegenerative disease," said Gage. (salk.edu)
[2] The first fetal tissue transplant in the U.S. was in 1939, using fetal pancreatic tissue in an attempt to treat diabetes. (lozierinstitute.org)
Between 1960 and 1990, numerous attempts were made to transplant fetal liver and thymus for various conditions. (lozierinstitute.org)
One patient who received transplant of fetal brain tissue (from a total of 3 fetuses) died subsequently, and at autopsy was found to have various non-brain tissues ( e.g, skin-like tissue, hair, cartilage, and other tissue nodules) growing in his brain. (lozierinstitute.org)
Stem cell research can be traced back to the mid-20th century when the first bone marrow transplant was performed successfully, treating a patient with a bone marrow disorder. (mornd.com)
A stem cell transplant is a one-time treatment that can cure Sickle Cell Anemia or Thalassemia. (sscb-stembiotech.com)

Early neural progenitors respond to extrinsic cues that maintain and support their potency. (stanford.edu)
Gata3 was previously found to be a mechanism that zebrafish brain uses to injury-dependent induction of neural progenitors. (frontiersin.org)
Human adult olfactory epithelium contains neural progenitors (hONPs) which replace damaged cellular components throughout life. (scirp.org)

In comparison to adult (mature) stem cells, foetal stem cells' proliferation rate is much faster and have greater plasticity in differential potential. (wikipedia.org)
Retroviral vectors expressing short hairpin RNAs (shRNAs) against CDC2 caused efficient deletion of CDC2, cellular G2/M arrest concluding in apoptosis and inhibition of proliferation in human glioma cells U251 and SHG-44 cell lines ex vivo. (biomedcentral.com)
decreased cell proliferation, cell cycle arrest, and induction of apoptosis. (123dok.net)
It was suggested that HOXD9 contributes to both cell proliferation and/or cell survival. (123dok.net)
HOXD9 siRNA treatment of SK-MG-1 SP cells resulted in reduced cell proliferation. (123dok.net)
Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)
Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)
The thyroid gland forms as a proliferation of endodermal epithelial cells on the median surface of the developing pharyngeal floor. (medscape.com)

However, the success of fetal tissue transplants has been meager at best, and ethically-derived alternatives exist and are coming to dominate the field. (lozierinstitute.org)
The first recorded fetal tissue transplants were in 1921 in the UK, in a failed attempt to treat Addison's disease, [1] and in 1928 in Italy, in a failed attempt to treat cancer. (lozierinstitute.org)
That attempt also failed, as did subsequent similar fetal tissue transplants in 1959. (lozierinstitute.org)
Between 1970 and 1991 approximately 1,500 people received fetal pancreatic tissue transplants in attempts to treat diabetes, mostly in the former Soviet Union and the People's Republic of China. (lozierinstitute.org)
[3] Today, patients take insulin shots and pharmaceuticals to control their diabetes, and adult stem cell transplants have shown success at ameliorating the condition. (lozierinstitute.org)
[8] Subsequent reports showed that severe problems developed from fetal tissue transplants. (lozierinstitute.org)
A second large, controlled study published in 2003 showed similar results (funded by NIH), with over half of the patients developing potentially disabling tremors caused by the fetal brain tissue transplants. (lozierinstitute.org)

Foetal cells are differentiated stem cells from pluripotent embryonic stem cells. (wikipedia.org)
Furthermore, induced pluripotent stem cells (iPSCs) represent a third type, reprogrammed from adult cells by introducing specific transcription factors. (mornd.com)
The induced pluripotent stem cell breakthrough continues to be useful in the very ways that "the scientists" once said only human cloning could provide. (cbc-network.org)
Use Vitronectin XF™ with mTeSR™1 , mTeSR™ Plus , TeSR™-E8™ , or TeSR™-AOF medium to provide a defined culture system for the maintenance of human embryonic stem (ES) cells and human induced pluripotent stem (iPS) cells under feeder-free conditions. (stemcell.com)
Cell therapies derived from differentiated embryonic stem cells and induced pluripotent stem cells are also starting to feature prominently. (sscb-stembiotech.com)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)

In 2013 Madeline Lancaster , then of the Austrian Academy of Sciences, created the first true cerebral organoids when she discovered that stem cells growing in a supportive gel could form small spherical masses of organized, functioning brain tissue. (nautil.us)
To check if valproic acid could trigger senescence in human cells, the team ran a similar experiment using 3D clusters of human nerve cells, known as cerebral organoids. (livescience.com)
To reduce this heterogeneity, we generated engineered cerebral organoids (enCORs), which use a floating scaffold to increase the efficiency of neural induction and reduce heterogeneity. (researchsquare.com)
Chen and his colleagues surgically removed regions of the rats' visual cortexes and replaced them with organoids grown from human stem cells. (yalescientific.org)
Brain organoids have by far the greatest degree of brain-like structure of any neural tissue that can currently be created in the lab. (yalescientific.org)

On Wednesday, the administration also said it is not renewing an expiring contract with the University of California, San Francisco, that used fetal tissue to create a human-like immune system in mice for HIV research. (chicagotribune.com)
Now, in a study using mice and human tissue, scientists discovered that the medication locks some embryonic cells into a suspended state where they can't properly grow or divide. (livescience.com)
the same enzymes did not crop up in the cells of healthy, unexposed mice. (livescience.com)
But you can't study that in a mouse," Ming said, because mice have very few of the developing brain cells that are most vulnerable to Zika infection. (wamc.org)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
3 Mice with IUGR showed abnormal memory with reduced hippocampal volumes and fewer Sox2 + cells. (tamhsc.edu)
In tests involving lab mice, which were surgically operated on to simulate a heart attack, she and her research team discovered something astonishing: heart cells with DNA that doesn't match the mother's own. (smithsonianmag.com)
The mystery cells belong to unborn mice. (smithsonianmag.com)
The lab has even found that these cells, harvested from mouse placentas, will travel to the damaged hearts of male mice after being artificially implanted in their tails. (smithsonianmag.com)

Scientists around the country denounced the decision, saying that fetal tissue was critically needed for research on HIV vaccines, treatments that harness the body's immune system to battle cancer, and other health threats, including some to fetuses themselves. (chicagotribune.com)
Over the years, scientists have unlocked the potential of stem cells, opening up new possibilities in regenerative medicine and providing novel therapeutic approaches for currently incurable diseases. (mornd.com)
This policy is similar to that of other countries, including Israel, where scientists are funded by Government to study embryonic stem cells despite the aforementioned bioethical issue. (jcpa.org)
This is terrific but it won't stop "the scientists" from researching human cloning. (cbc-network.org)
Indeed, if every disease known to man were cured by IPSCs or adult stem cells, the scientists would shrug and keep on cloning. (cbc-network.org)
A previous study published by the same Brazilian scientists noted that the pool of infected neural stem cells was completely depleted after one week. (sciencebeta.com)
With more research, scientists will better understand how to control organoid development to yield desired structures, such as the layers of the cortex. (yalescientific.org)
Scientists discover fetal cells in the darnedest places. (smithsonianmag.com)
Scientists find rogue fetal cells while autopsying the cadavers of old women, whose babies are now middle-aged. (smithsonianmag.com)

In 2009, in a major reversal of U.S. policy, President Obama signed an executive order pledging to "vigorously support" embryonic stem cell research. (jcpa.org)
However, the ALSA has admitted that it gives some of its money to embryonic stem cell research and has no qualms about doing so in the future. (flfamily.org)
Note the ALSA page linked in the above has just recently been changed, and now notes that embryonic stem cell research "has raised ethical concerns. (flfamily.org)
Project ALS, another charity for ALS research, also funds embryonic stem cell research . (flfamily.org)
The John Paul II Medical Research Institute in Iowa City is doing research in several areas including ALS, and does not support embryonic stem cell research. (flfamily.org)
The Adult Stem Cell Technology Center, LLC is developing new methods for growth and application of adult stem cells, and does not support embryonic stem cell research. (flfamily.org)

Maternal-fetal Interactions: We are also interested in looking at how early interactions between maternal tissue and fetal tissue can influence the development of the embryo. (gulfcoastconsortia.org)
4 Mouse models of maternal binge-like alcohol drinking during gestation underwent learning acquisition tests and adult brain tissue analysis, assessing for histone acetyltransferase and deacetylase activity with ELISA. (tamhsc.edu)
The Center for Fetal Research , the research extension of CHOP's Center for Fetal Diagnosis and Treatment , continues to seek to improve prenatal treatment of MMC through a less invasive approach that would allow for application earlier in gestation, with reduction in maternal and fetal risks, and the potential for reduced neurologic injury. (chop.edu)
Multiplying in maternal chests, the fetal stem cells transform into blood vessel-like tubes and, more significant, cells that resemble full-fledged heart muscle cells, which cardiologists have struggled for decades to recreate in a lab. (smithsonianmag.com)

Outside the stem cell niches, however, these glial cells are not neurogenic. (frontiersin.org)

Note that fetal tissue has been taken in a number of cases from fetuses at developmental ages where fetal surgery is now used to correct problems and save lives, and at stages where science now demonstrates that the unborn fetus can feel pain. (lozierinstitute.org)
We investigated the affect of sign transducer and activator of transcription-3 (STAT3) on the spinal wire tissue grafts of rat fetuses with spina bifida aperta. (medmk.com)
Although the full spectrum of fetal effects of congenital Zika virus infection is not known, Zika virus has been shown to cross the placental barrier, grow in brain tissue of fetuses, infect progenitor neural cells, and increase neural cell death or attenuate their growth ( 4 , 5 ). (cdc.gov)

USDA's Agricultural Research Service (ARS) has studied eight of the cloned calves and found no apparent developmental abnormalities. (acs.org)

Cells are obtained from dead foetuses, in which their cause of death is usually due to stillbirth, abortion or atopic pregnancy through surgery. (wikipedia.org)
Ending the use of fetal tissue by the National Institutes of Health has been a priority for anti-abortion activists, a core element of President Donald Trump's political base. (chicagotribune.com)
The Susan B. Anthony List, a group that works to elect lawmakers opposed to abortion, said in a statement that taxpayer funding ought to go to promoting alternatives to using fetal tissue in medical research. (chicagotribune.com)
All of the Neuralstem trials use cells derived from abortion. (flfamily.org)
The use of baby parts for research came to the forefront front of the nation's conscience in 2015 when the Center for Medical Progress , lead by investigative journalist David Daleiden, exposed the existence of a raging aborted baby organ market between abortion clinics and research facilities. (californiafamily.org)

Neurodegeneration and neurodegenerative diseases (including the shared mechanisms of nerve cell death that contribute to many diseases), Vascular Cognitive Impairment and Dementia (VCID), NINDS tissue/cell resources, basic invertebrate neuromuscular junction (NMJ). (nih.gov)
Ongoing studies are further investigating underlying regulatory mechanisms, the role of endothelial cell cycle state in lymphatic specification, and the role of dysregulated of endothelial cell cycle state in vascular malformations and diseases. (hirschilabuva.com)

Prohibiting valuable research that uses fetal tissue that is otherwise going to be discarded doesn't make any sense," said Dr. Lawrence Goldstein, a regenerative medicine specialist at the University of California, San Diego. (chicagotribune.com)
Although stem cell research holds tremendous promise in regenerative medicine, ethical concerns have arisen due to the use of ESCs and embryo destruction. (mornd.com)
In conclusion, stem cell research has shown remarkable progress in the year 2000, resulting in significant advancements in the field of regenerative medicine. (mornd.com)
Earlier this month, Orange County State Senator John Moorlach unsuccessfully tried to persuade his fellow senators to defund the California Institute for Regenerative Medicine (CIRM) , the state's stem cell research agency, created by voters in 2004 by Proposition 71 . (californiafamily.org)
Endothelial Cell Development and Its Application to Regenerative Medicine. (hirschilabuva.com)

an ultrasound at 15 weeks of gestation demonstrated absence of the cranial vault (exencephaly) with brain tissue loss, including absence of cerebral hemispheres (anencephaly sequence). (cdc.gov)
More recently, MSCs have been isolated from fetal tissues during gestation or after birth. (sscb-stembiotech.com)

Tissue microarrays were utilized to investigate the expression of genes in a large number of tumor samples and to identify overexpressed genes which could be potentially causing tumorigenesis. (biomedcentral.com)
The cell cycle is a complex process with myriad genes involved and elaborate and complex signaling mechanisms to allow for this critical cellular process. (biomedcentral.com)
For instance, the medication changes the levels of certain chemical messengers in the brain and alters which genes can be switched on in a cell at any given time. (livescience.com)
The analysis revealed more than 500 genes/proteins altered in the infected developing brain cells. (sciencebeta.com)
In addition, genes driving cell specialization were repressed in ZIKV infected cells. (sciencebeta.com)
Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

It blocks important future research vital to the development of new therapies. (chicagotribune.com)
With a balanced approach, we explore the potential of stem cells as regenerative therapies, analyze the ethical concerns raised by their application, and propose guidelines to ensure responsible and widespread usage. (mornd.com)
They also stress the importance of rigorous research design, peer review, and patient safety in stem cell-based therapies. (mornd.com)

Clare's research focuses on development of the thymus. (eurostemcell.org)
The thymus plays a central role in the development of the body's immune system as it is the main site in which T cells are generated. (eurostemcell.org)
Foetal tissues have also been used in liver and thymus transplantations (1968). (wikipedia.org)

ESCs are derived from the inner cell mass of blastocysts, whereas ASCs are present in adult tissues and can be found in organs such as bone marrow, adipose tissue, and brain. (mornd.com)
In addition, specific proteins or biological substances can be added to these stem cell cultures to transform them in the laboratory into a large variety of specialized cell types, such as nerve, liver, muscle, bone, and blood cells. (jcpa.org)
The cells used are derived from adult tissue such as fat, or bone marrow, thereby circumventing the ethical concerns raised by the use of cells derived from embryos. (ibtimes.com)
We're actually developing products now," said Timothy Mayleben, chief executive of Aastrom, which is using cells derived from a patient's own bone marrow to develop treatments for cardiovascular disease. (ibtimes.com)
Their cells embed in our bone marrow and breasts. (smithsonianmag.com)
Objective: This study evaluated the osteogenic induction of human bone marrow cells by human recombinant bone morphogenetic protein-4 (rhBMP-4) and proteins released by Saos-2 (human osteosarcoma cell line). (bvsalud.org)
Study design: Osteoinduction in the presence or absence of Saos-2 and/or rhBMP-4 was evaluated in cultured human bone marrow cells. (bvsalud.org)
Results: Bone marrow cells were adherent since the first day of culture and were positive for osteonectin. (bvsalud.org)
Osteoblasts were obtained from human bone marrow cells even in the absence of growth factors and showed a typical morphology. (bvsalud.org)
Cells derived from bone marrow can undergo osteoinduction in vitro in the absence of osteoinductive factors such as bone morphogenetic proteins. (bvsalud.org)

Amniotic fluid and tissues from multiple fetal organs tested positive for Zika virus. (cdc.gov)
Fetal MSCs derived from amniotic fluid, amniotic membrane, umbilical cord matrix (Wharton's jelly) and umbilical cord blood are more advantageous than adult MSCs, as they can be isolated noninvasively in large numbers without the ethical reservations associated with embryo research. (sscb-stembiotech.com)

GATA3 promotes neural progenitor state but not neurogenesis. (frontiersin.org)
Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification. (hirschilabuva.com)

Studies highlighted their ability to differentiate into various cell lineages, including osteocytes, chondrocytes, and adipocytes. (mornd.com)
In response to morphogens, the hONPs differentiate along several neural lineages. (scirp.org)

Existing evidence indicates that zika virus (ZIKV) infection is associated with microcephaly - a condition in which baby's head is abnormally small, often because the brain has not developed properly - and other fetal brain defects. (sciencebeta.com)

Conditioned medium from adipose derived stem cells (ADSC-CM) stimulates both collagen synthesis and migration of fibroblasts, and accelerates wound healing in vivo. (indexindex.com)
Recently, the production and secretion of growth factors has been identified as an essential function of adipose-derived stem cells (ADSCs). (indexindex.com)

As Rebecca Taylor has pointed out , ALSA also has given money to an affiliate, NEALS, that has given money to a trial that uses stem cells derived from the spinal cord of an aborted fetus. (flfamily.org)
That trial is being run by the University of Michigan and Emory University, and sponsored by a company called Neuralstem which uses aborted fetus cells for research ("from the donated spinal cord tissue of an 8-week-old aborted fetus. (flfamily.org)
Previously, we have reported neurotrophism exhibited by human amniotic epithelial cells when transplanted after spinal cord injury in bonnet monkeys. (scielo.org.ar)
This upset seems to occur around the time that the "neural tube" - a hollow tube of tissue that later becomes the brain and spinal cord - forms and closes. (livescience.com)
9. Björklund, A., Skagerberg, G.: Evidence for a major spinal cord projection from the diencephalic A11 dopamine cell group in the rat. (lu.se)

To access the ventral midbrain for tissue dissection, cover tissues are removed from the aborted foetus. (wikipedia.org)

Tissue engineering is a multidisciplinary field that applies the principles of engineering and life-sciences for regeneration of damaged tissues. (wjgnet.com)

We also analysed matched CSF, post-mortem brain tissue, and iPSCs from the same participant with the APP V717I mutation. (nature.com)

[5] Conditions such as anemias and immunodeficiencies, for which fetal tissue attempts largely failed, are now treated routinely with adult stem cells, including umbilical cord blood stem cells, [6] even while the patient is still in the womb. (lozierinstitute.org)
Salvador, a five-year-old Portuguese boy who was diagnosed with autism spectrum disorder, recently underwent treatment using stem cells from his own umbilical cord blood with the aim of improving his condition. (sscb-stembiotech.com)

NeuCELL™ can be used in a 3D cell model of Alzheimer's Disease! (creative-biolabs.com)

An adult source of stem cells would circumvent the need to derive such cells from fetal tissue, currently an issue of ethical debate. (salk.edu)
This scientific article provides an overview of stem cell research, focusing on its historical development, types of stem cells, significant advancements in the year 2000, and ethical considerations surrounding its usage. (mornd.com)
The objective of this article is to comprehensively review scientific advancements in stem cell research in the year 2000 and discuss the ethical considerations associated with its practice. (mornd.com)
Ethical guidelines and regulatory frameworks should be in place to ensure responsible stem cell research. (mornd.com)
But there are alternatives for donations that use only ethical stem cell sources! (flfamily.org)
Donate to ethical adult stem cell research! (flfamily.org)
However, this approach carries with it the ethical questions of obtaining and using fetal tissue. (yalescientific.org)

2003). Similarly, when transplanted into ischemic cortical areas, they were found to differentiate into 'neuron-like' cells (Okawa et al. (scielo.org.ar)
The cortical area of the human foetal brain served as the source for NeuCELL™ CX. (creative-biolabs.com)

Johan Jakobsson, a professor at Lund University and research group leader at Lund Stem Cell Center, explains, "LINE-1 retrotransposons are a rich source of genetic sequences that we suspect have shaped the evolution of the human brain, and we now have the tools to explore their role in brain development. (lu.se)

The collected cells first undergo in vitro culture to check for any gene abnormalities and cell dysfunctions, then the cells will be injected into the patient through implantation surgeries. (wikipedia.org)
The harvesting of cells from foetuses are done according to the standardised stem cell protocol, this includes the following: Place isolated cells on ice Calculate cell viability Culture cells to transform into a suspension Grind to dissolve cells Number and size of clones increases over time After a week of culturing, around 40 to 50% of the cells do not survive in vitro. (wikipedia.org)

But research using fetal tissue has led to lifesaving advances , including development of vaccines for rubella and rabies and drugs to treat HIV. (chicagotribune.com)
NIH "has directed funding toward the development of alternative research methods that do not rely on human fetal tissue from elective abortions and I remain supportive of that effort. (chicagotribune.com)
NSCs were successfully isolated from human fetal brain tissue, leading to the development of new strategies for neural repair. (mornd.com)
Fibroblast Growth Factor - 2 (FGF-2) plays a critical role in retinal development especially in chicken neural retinal development. (scielo.org.ar)
That call led to studies of minibrains that showed precisely how the infection was attacking certain neural cells, especially at a point in development equivalent to the first trimester of pregnancy. (wamc.org)

Contrary to popular belief, stem cells are present in the human body throughout life and are found in many adult organs. (jcpa.org)
The increasing interest and rapid advance in bioengineering technology is highlighted by tissue engineering and bioartificial organs being ranked second again. (korea.ac.kr)
Yet, Planned Parenthood's interest might have something to do with the millions CIRM spends on research using aborted baby organs as a source of stem cells. (californiafamily.org)
It is unclear exactly how much money CIRM has spent over the years funding research using pre-born baby organs, but according to CIRM's 2016 annual report , it spent seven percent of its $262 million 2016 grant budget on stem cell research on projects designated as "Other. (californiafamily.org)
Dr. Svendsen, a native of England, started using pre-born baby organs as part of his research during his studies at University of Cambridge in the 1990s. (californiafamily.org)

To do so, human neural cells were exposed to a strain of ZIKV collected from a Brazilian patient and coaxed to become neurospheres, organized aggregates of neural cells resembling fetal brain tissue. (sciencebeta.com)

During pregnancy the fetal mouse cells cross the placenta into the mother's body, joyriding through her blood vessels until cardiac damage happens, at which point they sense inflammation and make a beeline for her wounded heart. (smithsonianmag.com)

NOTE that the second trial is in association with an Israeli company, Brainstorm Cell Therapeutics , that is developing the adult stem cell treatment for ALS and other neural conditions. (flfamily.org)

Israeli policy is based on the belief that such a pre-embyro does not confer personhood and that many therapeutic applications can be derived from such research. (jcpa.org)
However, Sox2 may be a target for future FASD research and possible therapeutic interventions. (tamhsc.edu)

Cancer stem cells: Another focus of the lab is how miR-302 may regulate the formation and maintainence of cancer stem cell populations. (gulfcoastconsortia.org)
This system allows complete control over the culture environment, resulting in more consistent cell populations and reproducible results in downstream applications. (stemcell.com)

Anatomy54

Organisms14

Diseases17

Chemicals and Drugs49

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Phenomena and Processes51

Disciplines and Occupations13

Anthropology, Education, Sociology and Social Phenomena4

Technology, Industry, Agriculture2

Humanities7

Information Science2

Named Groups2

Health Care11

Progenitor cell7

Differentiation19

Transplantation22

Parkinson's12

Mesenchymal5

Neuronal5

Brains7

Differentiate into any cell type2

Biology10

Researchers16

Neurons12

Clinical17

Transplant7

Progenitors3

Proliferation8

Transplants7

Pluripotent6

Organoids5

Mice9

Scientists9

Embryonic stem cel6

Maternal4

Glial cells1

Fetuses3

Developmental1

Abortion5

Diseases2

Regenerative medicine5

Gestation2

Genes7

Therapies3

Thymus3

Bone10

Amniotic fluid2

Promotes2

Lineages2

Defects1

Adipose2

Spinal Cord5

Midbrain1

Multidisciplinary1

IPSCs1

Umbilical cord2

Alzheimer's1

Ethical7

Cortical2

Lund University1

Vitro2

Development5

Organs5

Neurospheres1

Placenta1

Adult stem1

Therapeutic2

Populations2