Neural stem cells and progenitor cells. Medical search. Frequent questions

NPCs can be differentiated from embryonic stem cells (ESCs) but also from induced pluripotent stem cells (iPSCs) (PMID: 11731782). (sanbio.nl)
A potentially pre-clinical aspect of this thesis is detailed in paper №4 where I describe a robust protocol for the generation of functional mesDA neurons from human embryonic stem cells that are functional in a rat model of PD. (lu.se)
the EST, which assesses the effects of compounds on the differentiation of mouse embryonic stem cells into contracting cardiomyocytes, can be used to rank the potency of chemicals within a series of alkoxyacetic acid metabolites formed from The implementation of the European REACH (Registration, glycol ethers. (cdc.gov)

Virtually all of the neurons and glia that populate the mature brain arise from neural precursors (NPs) that reside immediately adjacent to the lateral ventricles. (karger.com)
These factors hinder neural regeneration at the injury site and impede the potential reorganization of neural connections between host and graft neurons. (biomedcentral.com)
Their findings showed that this manipulation caused a significant enlargement of brain size and a remarkable rise in the number of neurons, indicating the survival of otherwise unfit stem cells during development. (phys.org)
Figure 3) or PSA-NCAM are markers frequently used for intermediate progenitor cells and early immature neurons (PMID: 29625071). (sanbio.nl)
Here we show that cortical deletion of Gli3 results in enlarged brain and folding structures in the cortical midline at the postnatal stage, which is mainly caused by the increased percentage of intermediate progenitors (IPs) and newborn neurons. (frontiersin.org)
Neural stem cells (NSCs) serve as a source for new neurons in both the developing and adult brain. (elifesciences.org)
ReNcell CX Immortalized Cells (SCC007): ReNcell CX is an immortalized human neural progenitor cell line with the ability to readily differentiate into neurons and glial cells. (thomassci.com)
Studies suggest that in the brain, it helps direct the movement (migration) of nerve cells (neurons) during early development. (medlineplus.gov)
CRT aims to replace neurons that have degenerated in PD, with donor cells that have the potential to functionally re-integrate into the host circuitry. (lu.se)
This involves transplantation of developing midbrain cells from aborted fetuses, (the part that form mesDA neurons), into the striatum of a PD patient. (lu.se)
Current efforts in the Lund PD transplantation program are focused on the use of dopamine neurons derived from pluripotent stem cells, using a protocol that has been devloped here in Lund ( publications 9 below ). (lu.se)
Our current focus is to learn how to direct and efficiently drive controlled differentiation of human stem cells into subtype-specific neurons. (lu.se)
In addition to the olfactory neurons, the epithelium is composed of supporting cells, Bowman glands and ducts unique to the olfactory epithelium, and basal cells that allow for the regeneration of the epithelium, including the olfactory sensory neurons. (medscape.com)

The tissue-specificity of DSCM-gel was evaluated both in vitro, using neural stem/progenitor cell (NSPC) culture, and in vivo, using various materials and biological analyses, including transcriptome and proteomics. (physiciansweekly.com)
Investigating astrocyte maturation in a cell culture model revealed that in vitro-differentiated astrocytes lack expression of many mature astrocyte-specific genes, including genes for the transcription factors Rorb, Dbx2, Lhx2 and Fezf2. (nature.com)
We previously identified Macrophage Migration Inhibitory Factor (MIF) as a novel factor that can support the proliferation and/or survival of NSPCs based on in vitro functional cloning strategy and revealed that MIF can support the proliferation of human brain tumor-initiating cells (BTICs). (elsevierpure.com)
In 2015, Dr. Qiang returned to Drexel University, where he now leads a research laboratory that focuses on using human induced pluripotent stem cell (hiPSC) based technologies to develop in vitro and ex vivo cellular and tissue models. (drexel.edu)
ReNcell NSC Maintenance Medium (SCM005): ReNcell Neural Stem Cell (NSC) Maintenance Medium is a defined serum-free, growth factor-free medium that has been optimized for the growth and in vitro differentiation of ReNcell immortalized human neural progenitor cells. (thomassci.com)
To characterize HNF4a function in immunity, we measured the effect of HNF4α antagonists on immune cell responses in vitro and in vivo. (bvsalud.org)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
Watch the lecture where Malin Parmar tells about the long history of transplantation trials in Lund and how they have been able to differentiate stem cells into specific dopaminergic cells in vitro. (lu.se)
In vitro toxicity data of these metabolites derived in the development of validated and accepted in vitro and in silico embryonic stem cell test were used as input in the PBK model to extrapolate in vitro concentration-response curves to predicted approaches is urgently needed. (cdc.gov)

In this study, we used iPSC-derived neural progenitor cells (NPCs) from individuals with ASD of known and unknown genetic cause as well as from neurotypical controls to examine the effects of exogenous IL-17a on NPC proliferation, migration and neuronal differentiation, and whether IL-17a and genetic risk factors for ASD interact exacerbating alterations in NPC function. (figshare.com)

Here, we show that conditional knockout of Mef2c in nestin-expressing neural stem/progenitor cells (NSCs) impaired neuronal differentiation in vivo, resulting in aberrant compaction and smaller somal size. (ca.gov)
We performed gain and loss of function studies for leukemia inhibitory factor (LIF) and showed a depletion of NSCs, a subset of multipotential neural precursors and immature oligodendrocytes in LIF null mice. (karger.com)
Astrocytes are generated from neural stem cells (NSCs) during late embryonic and early postnatal stages. (nature.com)
What are neural stem cells (NSCs), neural progenitors, and neural precursors (NPCs)? (sanbio.nl)
Neural stem cells (NSCs) are undifferentiated neural cells with the capacity for long-term self-renewal and for differentiation into all types of neuronal and glial cells. (sanbio.nl)
A subset of NSCs is present in the developed nervous system and acts as a reservoir of cells for cell replacement and nervous tissue regeneration (PMID: 20110496). (sanbio.nl)
Symmetric division of NSCs maintains the population of undifferentiated NSCs, while asymmetric division gives rise to neural progenitors. (sanbio.nl)
NSCs and neural progenitors are often regarded as neural precursors (NPCs). (sanbio.nl)
Blood vessels (BVs) are considered an integral component of neural stem cells (NSCs) niches. (elifesciences.org)

This study aimed at elucidating the effect of major non-THC phytocannabinoids on the fate of adult neural stem progenitor cells (NSPCs), which are an essential component of brain function in health as well as in pathology. (nih.gov)
Although several T3 target genes have been identified in the brain, the changes in the transcriptome in response to T3 specifically in neural stem and progenitor cells (NSPCs) during the early steps of NSPCs activation and neurogenesis have not been studied in vivo. (unab.cl)
One of the key areas in stem cell research is the identification of factors capable of promoting the expansion of Neural Stem Cell/Progenitor Cells (NSPCs) and understanding their molecular mechanisms for future use in clinical settings. (elsevierpure.com)
Using gene manipulation (over or downregulation of TPT1) techniques including CRISPR/Cas9-mediated heterozygous gene disruption showed that TPT1 contributed to the regulation of cell proliferation/survival in mouse NSPCs, human embryonic stem cell (hESC) derived-NSPCs, human-induced pluripotent stem cells (hiPSCs) derived-NSPCs and BTICs. (elsevierpure.com)
There is a strong link between neural stem/progenitor cells (NSPCs) and endothelial cells (ECs) [ 7 ]. (hindawi.com)
The TMDU-led research team set out to investigate the effects of low oxygen conditions within the neural stem cell niche using a cell culture model of NSPCs isolated from the forebrains of embryonic mice. (news-medical.net)
We found that NSPCs treated with VEGF-A showed lower rates of cell death and increased cell proliferation,' says senior author Tetsuya Taga. (news-medical.net)

STEMdiff™ Neural Progenitor Medium is a defined and serum-free medium for the expansion of neural progenitor cells (NPCs) derived from human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells using STEMdiff™ Neural Induction Medium (Catalog #05835). (stemcell.com)
B-D) NPCs maintained in STEMdiff™ Neural Progenitor Medium express the CNS-type NPC markers PAX6 (B, D, red), SOX1 (C, red) and NESTIN (C, green), but not the neural crest marker SOX10 (D, green, single channel shown in inset). (stemcell.com)
During human forebrain development, neural progenitor cells (NPCs) in the ventricular zone (VZ) undergo asymmetric cell divisions to produce a self-renewed progenitor cell, maintaining the potential to go through additional rounds of cell divisions, and differentiating daughter cells, populating the developing cortex. (elifesciences.org)
Using a novel, recombination-induced tag exchange-based genetic tool to birthdate and track the segregation of centrosomes over multiple cell divisions in human embryonic stem cell-derived regionalised forebrain organoids, we show the preferential inheritance of the older mother centrosome towards self-renewed NPCs. (elifesciences.org)
Thus, the data described here use a novel genetic approach to birthdate centrosomes in human cells and identify asymmetric inheritance of centrosomes as a mechanism to maintain self-renewal properties and to ensure proper neurogenesis in human NPCs. (elifesciences.org)
During human brain development, neural progenitor cells (NPCs) undergo two modes of cell division. (elifesciences.org)
Exogenous IL-17a did not induce abnormal proliferation and migration of ASD and control NPCs but, on the other hand, it significantly increased the expression of synaptic (Synaptophysin-1, Synapsin-1) and neuronal polarity (MAP2) proteins in these cells. (figshare.com)
In a study published in Developmental Cell , a group led by Prof. Wu Qingfeng from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences demonstrated the presence of cell competition between neural progenitor cells (NPCs) during neurodevelopment. (phys.org)
Wu and his team systematically investigated the potential regulators, spatial properties, molecular features, mechanism and physiological role of cell competition between NPCs. (phys.org)
To investigate cell competition between NPCs, the researchers first developed a novel strategy for genetic mosaic induction and clonal tracking based on a dual-color labeling system. (phys.org)
This approach enabled the researchers to induce genetic mosaicism in NPCs, allowing NPCs to carry different fluorescent proteins, and to track cell fate during the developmental continuum. (phys.org)
To determine whether cell competition naturally occurs in the developing brain , the researchers collected more than 1,000 mouse brains with clonal labeling of NPCs and studied their fate using short- and long-term lineage tracing. (phys.org)
Since the inherent differential expression of cell competition drivers is what triggers the competitive interaction and natural selection of NPCs, the researchers determined to ameliorate cell competition by reducing the expression of these drivers to the same level. (phys.org)
The identification of endogenous cell competition among NPCs provides a fundamental basis for comprehending the developmental origin of neuronal vulnerability as well as improving brain health. (phys.org)
NPCs are distinct from differentiated cells of the nervous system at the molecular level. (sanbio.nl)
Immunofluorescent staining of PAX6 ( 12323-1-AP , 1:250 dilution) with 4% PFA fixed control human-induced pluripotent stem cell (hiPSC)-derived NPCs. (sanbio.nl)
NPCs can additionally be obtained by direct reprogramming of somatic cells from different cell lineage (PMID: 22445518). (sanbio.nl)
Alternatively, NPCs can be isolated from fresh nervous tissues using cell sorting with NPC markers (PMID: 11121071). (sanbio.nl)

Intrathecal injection of MSC-NPs correlated with reduced immune cell infiltration, reduced area of demyelination, and increased number of endogenous nestin-positive progenitor cells in EAE mice. (listlabs.com)
To isolate the effect of remyelination from other possible regenerative benefits of the grafted cells, NS/PCs obtained from myelin-deficient shiverer mutant mice (shi-NS/PCs) were used in this work alongside wild-type NS/PCs (wt-NS/PCs). (elsevierpure.com)
Knockdown of microRNA (miRNA) miR-7 can rescue abnormal brain morphology in Gli3 knockout mice by recovering progenitor specification, neuronal production and migration through a counter-balance of the Gli3 activity. (frontiersin.org)
However, GFAP-IL6/sgp130 mice had decreased pY 705 -STAT3 in the brain due to a reduction in the total number of pY 705 -STAT3-positive cells and a marked loss of pY 705 -STAT3 in specific cell types. (jneurosci.org)
Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice. (bvsalud.org)
I also describe the development of a novel behavioural task that is predictive of mesDA neuron cell loss in mice. (lu.se)

30 nm in diameter, establish direct membrane-to-membrane contact with endothelial cells in specialized areas of irregular endothelial basement membrane and enriched with vesicular activity. (elifesciences.org)

and directed neuronal subtype differentiation and core long-distance circuit formation via molecular manipulation of endogenous neural progenitors and pluripotent cells (ES/iPS). (wikipedia.org)
The acute-phase HGF-treated group exhibited vascularization, diverse anti-inflammatory effects, and activation of endogenous neural stem cells after SCI, which collectively contributed to tissue preservation. (biomedcentral.com)

ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development. (ox.ac.uk)
In this study, we show that ASPP2 controls the polarity and proliferation of neural progenitors in vivo, leading to the formation of neuroblastic rosettes that resemble primitive neuroepithelial tumors. (ox.ac.uk)

He is the Max and Anne Wien Professor of Life Sciences in the Department of Stem Cell and Regenerative Biology and Center for Brain Science at Harvard University, Professor of Neurology [Neuroscience] at Harvard Medical School, and on the Executive Committee and a Member of the Principal Faculty of the Neuroscience / Nervous System Diseases Program at the Harvard Stem Cell Institute. (wikipedia.org)
In 2007, Macklis was appointed Professor of Stem Cell and Regenerative Biology at Harvard University, in both the Faculty of Arts and Sciences and Harvard Medical School, physically based on the main Harvard University campus in Cambridge, Massachusetts. (wikipedia.org)
In 2014, He was appointed the Max and Anne Wien Professor of Life Sciences, Harvard University, in the department of Stem Cell and Regenerative Biology, and Center for Brain Science. (wikipedia.org)
1 Department of Cell Biology, Peking University Health Science Center, China. (nih.gov)
This new discovery in stem cells-a result so surprising that the team initially believed it to be an error in the lab-has potential translational impacts in cancer biology and associated targeted treatments. (phys.org)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)
My group works with translational stem cell biology. (lu.se)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)

Human induced pluripotent stem cell-derived neural stem/progenitor cell (hiPSC-NS/PC)-based cell transplantation has emerged as a groundbreaking method for replacing damaged neural cells and stimulating functional recovery, but its efficacy is strongly influenced by the state of the injured spinal microenvironment. (biomedcentral.com)

These results identify ASPP2 as a regulator of Par-3, which plays a key role in controlling cell proliferation, polarity, and tissue organization during CNS development. (ox.ac.uk)

PRC1 and PRC2 block access to certain areas of the genetic library, such that a neuron cell won't have access to muscle genes, and it doesn't get confused in its cellular identity. (phys.org)
Enjoy the comics, based on Malin Parmars research, about how a skin cell can be turned into a neuron. (lu.se)

While irradiation can effectively treat brain tumors, this therapy also causes cognitive impairments, some of which may stem from the disruption of hippocampal neurogenesis. (scite.ai)
To study how radiation affects neurogenesis, we combine phenotyping of subpopulations of hippocampal neural stem and progenitor cells with double- and triple S-phase labeling paradigms. (scite.ai)
In male rats, TRAP significantly increased hippocampal neurogenesis, while in females, TRAP increased granule cell layer width. (nature.com)

In line with these studies, we observe a signi cant decrease in doublecortin, a marker for neuronal precursor cells/neurogenesis, in the subgranular zone in the dentate gyrus of the hippocampus, a major site of neurogenesis in the mouse brain, following irradiation, which remains reduced following monocyte in ltration ( Fig. (scite.ai)

To gain deeper insight, the researchers generated phenotype-, genotype- and transcriptotype-dependent datasets through single-cell and bulk RNA sequencing, developed a loser signature scoring system and identified the molecular characteristic of loser cells. (phys.org)
This work elucidates the drivers, properties, molecular features and physiological function of cell competition in the context of neural stem/progenitor cells during early neurodevelopment. (phys.org)
2023) Molecular Cell. (phys.org)
The team has published the work today in journal Molecular Cell . (phys.org)
Adrian P. Bracken, PRC2.1 and PRC2.2 Specific Accessory Proteins Drive Recruitment of Different Forms of Canonical PRC1, Molecular Cell (2023). (phys.org)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)

In a new study published in Inflammation and Regeneration , researchers from Tokyo Medical and Dental University (TMDU) investigated the effects of hypoxic (low oxygen) conditions on the neural stem cell niche during development. (news-medical.net)

Sozzi E, Nilsson F, Kajtez J, Parmar M, Fiorenzano A. Generation of Human Ventral Midbrain Organoids Derived from Pluripotent Stem Cells . (lu.se)

ReNcell CX was developed by the ReNeuron Group plc, a biotech company that specializes in using human somatic stem cells for therapeutics. (thomassci.com)

Listen to a podcast where Malin Parmar talks about her study published in Cell Stem Cell. (lu.se)

Stem cells rely on extracellular signals produced by the niche, which dictate their ability to self-renew, expand and differentiate. (karger.com)
Neural progenitors are precursor cells able to further differentiate into various neuronal and glial cells. (sanbio.nl)
Dental pulp stem cells have been isolated from deciduous and permanent teeth and have the potential to self-renew and differentiate. (bvsalud.org)

Xue-Lian Sun et al, Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development, Developmental Cell (2023). (phys.org)
2023) Organization of self-advantageous niche by neural stem/progenitor cells during development via autocrine VEGF-A under hypoxia. (news-medical.net)
Cell Reports, Available online 14 November 2023. (lu.se)

Understanding the role of tissue-specific decellularized spinal cord matrix hydrogel for neural stem/progenitor cell microenvironment reconstruction and spinal cord injury. (physiciansweekly.com)
Decellularized tissue matrices (DTMs) have shown their unique and beneficial characteristics in promoting neural tissue regeneration, especially those derived from the nervous system. (physiciansweekly.com)
Background Microglia, the primary resident myeloid cells of brain, play critical roles in immune defense by maintaining tissue homeostasis and responding to injury or disease. (scite.ai)
Similarly, in multicellular organisms, competitive interactions also occur between cells, creating a cell selection mechanism that eliminates less fit cells within the local tissue environment. (phys.org)
Fetal cell/tissue transplantation has been arduously studied as a potential way to repair the injured brain. (jneurosci.org)
performed additional studies to compare the effect of 7 d delay and immediate transplantation on survival and integration of grafted cells into host brain tissue at 4, 7, and 14 d after transplantation. (jneurosci.org)
Use of human fetal tissue raises several ethical issues, but are there alternative cell sources that can substitute effectively? (lu.se)
Through understanding functional recovery in terms of neuronal subtype and connectivity, the work presented in this thesis aims to bring the prospect of CRT closer to the clinic, I also describe the generation of a very promising alternative cell source that could rival fetal tissue. (lu.se)
Niches are special microenvironments in tissue where stem cells are located. (bvsalud.org)
Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)

Altogether our FACS (fluorescence-activated cell sorter) analyses reveal that the neonatal subventricular zone is far more heterogeneous than previously suspected and our studies provide new insights into the signals and mechanisms that regulate their self-renewal and proliferation. (karger.com)
To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)

These self-renewing cells, which are capable of giving rise to any cell type in the body, reside in specialized microenvironments known as niches. (news-medical.net)
Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)

Astrocytes are the most abundant glial cells in the mammalian central nervous system and they serve essential functions in brain development and homoeostasis. (nature.com)
This work also highlights the physiological role of cell competition in regulating mammalian organ size. (phys.org)

The focus of my research is to understand cell fate specification in the developing brain and in human neural progenitor cells, using cell-based models of neuronal differentiation. (lu.se)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)
2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)

A team of scientists led by those in Trinity College Dublin has discovered new mechanisms involved in establishing cellular identity, a process that ensures the billions of different cells in our bodies do the correct job. (phys.org)

The repair of spinal cord injury (SCI) highly relies on microenvironment remodeling and facilitating the recruitment and neuronal differentiation of endogenous stem/progenitor cells. (physiciansweekly.com)
Previous reports of functional recovery from spinal cord injury (SCI) in rodents and monkeys after the delayed transplantation of neural stem/progenitor cells (NS/PCs) have raised hopes that stem cell therapy could be used to treat SCI in humans. (elsevierpure.com)

Brain morphogenesis requires precise regulation of multiple genes to control specification of distinct neural progenitors (NPs) and neuronal production. (frontiersin.org)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

Previous work in the embryonic rodent brain suggested that the preferential inheritance of the pre-existing (older) centrosome to the self-renewed progenitor cell is required to maintain stem cell properties, ensuring proper neurogenesis. (elifesciences.org)

During a subsequent phase of maturation in the first few postnatal weeks, immature astrocytes exit the cell cycle and aquire a fully mature phenotype 1 . (nature.com)
The heart begins to pump plasma around day 20, and on the next day, fetal red blood cells (RBCs), which are immature and nucleated, appear. (msdmanuals.com)

Based on a previous report, we studied the potential involvement of the adenosine A1 receptor in the effect of CBC on these cells and found that the selective adenosine A1 receptor antagonist, DPCPX, counteracted both ERK1/2 phosphorylation and up-regulation of nestin by CBC, indicating that also adenosine is involved in these effects of CBC, but possibly not in CBC inhibitory effect on GFAP expression. (nih.gov)
Conclusions These findings provide insight into better understanding the role and complexity of myeloid cells in the brain, including their regulation of other CNS cells and functional outcomes. (scite.ai)
The main aims of this study were to investigate the effects of CPF and CPO on the stability of neurites in pre-differentiated mouse N2a neuroblastoma and human ReNcell CX neural stem cells, and to relate toxicity to the regulation of cytoskeletal proteins involved in neural differentiation. (ntu.ac.uk)

In an effort to develop cell therapy-based strategies for progressive MS, we investigated the pre-clinical efficacy of bone marrow mesenchymal stem cell-derived neural progenitors (MSC-NPs) as an autologous source of stem cells. (listlabs.com)
MSC-NPs consist of a subpopulation of bone marrow MSCs with neural progenitor and immunoregulatory properties, and a reduced capacity for mesodermal differentiation, suggesting that this cell population may be appropriate for clinical application in the CNS. (listlabs.com)
Methods Using whole body irradiation, bone marrow transplant, and colony-stimulating factor 1 receptor inhibition, we achieve long-term and brain-wide (~ 80%) engraftment and colonization of peripheral bone marrow-derived myeloid cells (i.e. monocytes) in the brain parenchyma and evaluated the long-term effects of their colonization in the CNS. (scite.ai)

Furthermore, in vivo assessments confirmed that DSCM-gel provides a suitable microenvironment for endogenous stem/progenitor cell recruitment and axonal regeneration for bridging the lesion site after a completely transected SCI. (physiciansweekly.com)

ReNcell CX Human Neural Progenitor Cell Line & Culture Media Kit ReNcell CX Kit contains human neural progenitor cells, optimized maintenance media & freezing media for culture of human neural stem cells. (thomassci.com)
ReNcell CX cells have been obtained in a legal and ethical manner, compliant with current local informed consent procedures. (thomassci.com)

It is essential to have sensitive and reproducible methods of either quantifying or isolating these stem cells and progenitors to understand their intrinsic properties and how extrinsic signals regulate their development. (karger.com)
Background: The thyroid hormones-thyroxine (T4) and 3,5,3′triiodothyronine (T3)-regulate the development of the central nervous system (CNS) in vertebrates by acting in different cell types. (unab.cl)
Cell polarity plays a key role in the development of the central nervous system (CNS). (ox.ac.uk)
Consistent with its role in cell polarity, ASPP2 influences interkinetic nuclear migration and lamination during CNS development. (ox.ac.uk)
The Studer laboratory investigates human stem cells as tools to understand normal and pathological development in the nervous system and to develop cell-based strategies for regenerative medicine. (uctv.tv)
While other factors may also contribute to NSPC maintenance, these results shed new light on the composition of the neural stem cell niche during development, and may serve as a foundation for further studies of self-organization of the hypoxic niche. (news-medical.net)
Enteric ganglion cells are derived from the neural crest during embryonic development. (medscape.com)
Heanue TA, Pachnis V. Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies. (medscape.com)

Our data suggest that GPR56 can be used as an NSC/NPC marker within the neural cell lineage, especially in combination with nestin. (nih.gov)

Extrinsic neural afferents to the ENS contain cholinergic and adrenergic fibers. (medscape.com)

Following cell transplantation into a favorable environment, the transplanted NS/PCs survived well, facilitating remyelination and neuronal regeneration in host tissues. (biomedcentral.com)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)

Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. (ca.gov)

Survival analysis revealed that a low NRP1 expression in adrenocortical carcinoma (ACC), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), low-grade glioma (LGG), and stomach adenocarcinoma (STAD) was associated with poor prognosis. (hindawi.com)

Notably, stem cells that were eliminated at an early developmental stage had no chance of contributing any cells to adult organs. (phys.org)
There are two types of stem cell manufacturing: embryonic stem cell production, derived from early-stage embryos, and induced pluripotent stem cell (iPSC) production, which reprograms adult cells to an embryonic-like state. (imarcgroup.com)

Histologic subtypes of medulloblastoma include: (1) desmoplastic/nodular type, (2) medulloblastoma with extensive nodularity, and (3) large-cell/anaplastic medulloblastoma. (medscape.com)
1] Several subtypes of medulloblastoma have been recognized including: (1) desmoplastic/nodular type, (2) medulloblastoma with extensive nodularity, (3) large-cell variant, and (4) anaplastic medulloblastoma. (medscape.com)

A high NRP2 expression in bladder urothelial carcinoma (BLCA), kidney renal papillary cell carcinoma (KIRP), and mesothelioma (MESO) was associated with poor prognosis. (hindawi.com)
Genome-wide association analysis revealed that the NRP1 expression was strongly associated with kidney renal clear cell carcinoma (KIRC), whereas the NRP2 expression was closely associated with BLCA. (hindawi.com)
TF expression was boosted by immune cell activation, regulated by environmental MS risk factors and higher in MS immune cells compared to controls. (bvsalud.org)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)

The global stem cell manufacturing market is influenced by increasing investments in stem cell research and regenerative medicine by governments and private organizations. (imarcgroup.com)
The global stem cell manufacturing market is experiencing a significant upsurge due to the substantial investments pouring into stem cell research and regenerative medicine. (imarcgroup.com)

These findings establish the biological importance of remyelination by graft-derived cells for functional recovery after the transplantation of NS/PCs into the injured spinal cord. (elsevierpure.com)
These strategies range from cell transplantation to the administration of growth factors. (jneurosci.org)
Their results showed that delaying transplantation increased cell proliferation, without increasing apoptosis, consequently leading to increased graft size in the delayed condition. (jneurosci.org)
We still do not know what specific factors contribute to the success in transplantation i.e. what cells are responsible for motor recovery? (lu.se)
The aim of this thesis was to understand how particular factors such as neuronal content, placement and cell source, affect functional outcome after transplantation into the rodent brain. (lu.se)

Neural Progenitor Cells Derived from XCL-1 DCXp-GFP are a neuronal lineage reporter cell line that can be used in neuronal differentiation and drug screening. (atcc.org)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
The nature of the stem cell substates and their relationship to commitment to differ- entiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors. (lu.se)
This requirement strongly limits the number of solutions or entiation and lineage-specification, programmed cell death, and ``states'' for the system. (lu.se)

In 2004, Macklis was the founding Program Head of the Neuroscience / Nervous System Diseases Program at the Harvard Stem Cell Institute at Harvard University, which he directed until 2013. (wikipedia.org)

Anatomy59

Organisms20

Diseases9

Chemicals and Drugs65

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Phenomena and Processes53

Disciplines and Occupations3

Technology, Industry, Agriculture2

Information Science2

Embryonic Stem3

Neurons13

Vitro9

IPSC-derived neural1

NSCs9

NSPCs7

NPCs18

Mice6

Endothelial cells1

Endogenous neural2

Proliferation of neural2

Biology9

Pluripotent stem cell-de1

Controlling cell proliferation1

Neuron2

Hippocampal3

Dentate gyrus1

Molecular6

Inflammation and Regeneration1

Derived from Pluripotent Stem1

Somatic Stem1

Malin Parmar1

Differentiate3

20233

Tissue10

Self-renewal2

Niches2

Mammalian2

Fate5

Mechanisms1

Spinal cord i2

Genes2

Neurogenesis1

Immature2

Regulation3

Bone marrow3

Axonal1

ReNcell CX2

Development8

Nestin1

Extrinsic1

Regeneration2

Maturation1

Survival1

Adult2

Anaplastic medulloblastoma2

Expression5

Regenerative2

Transplantation5

Lineage4

Neuroscience1