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  • neurogenesis
  • Axolotls have contributed as a bridge organism between invertebrates and mammals, as the species has the regenerative capacity to undergo complete neurogenesis forming a wide range of neuronal populations not limited to a small niche, yet the complexity and architecture is complex and analogous in many ways to human neural development. (wikipedia.org)
  • molecular
  • This new view has given them an intriguing clue that a protein deficient in Fragile X syndrome, an autism-related disorder that causes intellectual disability, is responsible for moving at least some of this molecular cargo up and down the stem cells. (eurekalert.org)
  • The moving molecules we saw in these stem cells could be crucial for their function -- including their decision to become neurons," said the study's senior investigator Debra Silver, an assistant professor of molecular genetics and microbiology at the Duke University School of Medicine. (eurekalert.org)
  • The results suggest that neural stem cells are highways for molecular transport, carrying not just mRNAs but also many other types of proteins, Silver said. (eurekalert.org)
  • Researchers from Yale University have discovered evidence that tiny hairs found on mammals' brain cells have an important role in transmitting molecular signals. (thefutureofthings.com)
  • University of Oregon scientists studying neural stem cells in the fruit fly Drosophila have uncovered a molecular change experienced by stem cells as they age. (phys.org)
  • mice
  • Transplantation of reprogrammed neural stem cells into the brains of genetically modified mice, which cannot form myelin. (mpg.de)
  • They exposed stem cells from the peripheral nervous system of embryonic or postnatal mice to different culture conditions. (mpg.de)
  • In the brains of mice at different developmental stages, the reprogrammed stem cells mainly developed into oligodendrocytes, which form the myelin layer around the neurons of the central nervous system and are, therefore, indispensable for the transmission of electrical stimuli. (mpg.de)
  • At present, we only know that these stem cells in mice also have the potential to produce oligodendrocytes," says Hermann Rohrer. (mpg.de)
  • This change was sufficient to help Zika virus infect brain cells from both humans and mice efficiently. (curiouscascade.com)
  • Zika infection kills off neural stem cells in adult mice bred to be vulnerable to the virus, researchers at the Rockefeller University and the La Jolla Institute for Allergy and Immunology report August 18 in Cell Stem Cell . (eurekalert.org)
  • In previous studies, cultured neurospheres have been transplanted into the brains of immunodeficient neonatal mice and have shown engraftment, proliferation, and neural differentiation. (wikipedia.org)
  • Imitola has received multiple awards for his research in stem cells including the John N. Whitaker, MD Award for Multiple Sclerosis research http://give.brighamandwomens.org/stories/entry/ann-romney-center-work Imitola J, Côté D et al, Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice.J Biomed Opt. (wikipedia.org)
  • Sox2 overexpression cooperates with loss of Lkb1 expression to promote squamous cell lung cancer in mice. (wikipedia.org)
  • therapies
  • It could provide a safe platform for research into stem cell therapies using the latest, novel nanotechnology, and also help boost the development of regenerative medicine. (news-medical.net)
  • xv) Progress in neural stem cell based therapies for status epilepticus induced injury and chronic temporal lobe epilepsy. (eurekalert.org)
  • Furthermore, this reprogramming system provides great potential to design customized patient-specific stem cell therapies with economic feasibility [ 19 ]. (hindawi.com)
  • humans
  • It is not yet clear, to what extent these basic research findings will contribute to the development of cell therapy for humans. (mpg.de)
  • This would require that similar stem cells are present and accessible in the peripheral nervous system of humans, and that these can be propagated and reprogrammed in culture. (mpg.de)
  • fetal
  • Neural stem cells derived from federally approved human embryonic cells are inferior to stem cells derived from donated fetal tissue, a new study found. (phys.org)
  • Gibco Rat Fetal Neural Stem Cells (Cat. (thermofisher.com)
  • When cells reach 75-90% confluency (3-4 days after seeding), the rat fetal NSC cultures are ready to be passaged. (thermofisher.com)
  • Using the Golgi method, Giuseppe Magini then studied the mammalian fetal cerebral cortex in 1888, confirming the similar presence of elongated radial cells in the cortex (also described by Kölliker just before him), and observing "various varicosities or swellings" on the radial fibers. (wikipedia.org)
  • genes
  • Interestingly, this molecule is one of the genes widely used now to reprogram adult non-stem cells into pluripotent stem cells. (wikipedia.org)
  • Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. (wikipedia.org)
  • show that two genes encoding for has-miR-9 are significantly hypermethylated in clear cell renal carcinoma tumours. (wikipedia.org)
  • REST is expressly involved in the repression of neural genes in non-neuronal cells. (wikipedia.org)
  • It is assumed that REST represses genes that promote cell death and Alzheimer's disease pathology, and induces the expression of stress response genes. (wikipedia.org)
  • Ischaemia, which results from reduced blood profusion of tisssues, decreasing nutrient and oxygen supply, induces REST transcription and nuclear accumulation, leading to the epigenetic repression of neuronal genes leading to cell death. (wikipedia.org)
  • Both terms were coined by Imitola and Evan Y. Snyder to denote the regenerative (micro-environments) areas created after CNS damage and the ability to visualize these areas by using stem cells expressing reporter genes (i.e. (wikipedia.org)
  • Sox2 is a key upregulated factor in lung squamous cell carcinoma, directing many genes involved in tumor progression. (wikipedia.org)
  • tumors
  • But the potential of hESCs has been constrained by a number of practical problems, not least among them the difficulty of growing sufficient quantities of stable, usable cells and the risk that some of these cells might form tumors. (phys.org)
  • These tumors can be present in major brain areas not associated with the main cerebral hemispheres, including the cerebellum, optic nerve, cauda equina, hypothalamus, and brain stem. (wikipedia.org)
  • Gonzalez-Perez conducts numerous research efforts on elucidating the role of stem cells in the origin of brain tumors and the potential role stem cells can play in fighting brain cancer and regaining neurological function in the Neurosurgery Brain Tumor Stem Cell Lab at the Johns Hopkins University. (wikipedia.org)