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  • induce
  • Since the T cell never see this complex before, they identify the cell as "non-self" and induce the rejection response. (brightkite.com)
  • They can then induce the release of bioactive agents and the formation of progenitor cells in response to these changes. (wikipedia.org)
  • The stem cells and niche may induce each other during development and reciprocally signal to maintain each other during adulthood. (wikipedia.org)
  • Yet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. (wikipedia.org)
  • tumor
  • Moreover, unsupervised analysis such as a dendrogram generated after agglomerative hierarchical clustering comparing several transcriptomic data showed important similarities between the tumorigenic neural crest-derived clone and mammary tumor cell lines. (nih.gov)
  • A new study published in the journal Stem Cell Research & Therapy found that tumor growth in mice could be slowed down by injecting human stem cells into the mice. (medindia.net)
  • Transport vesicles steered by engineered peptides and nanoparticles will accompany tumor-tropic stem cells as vehicles to shuttle therapeutic payloads specifically across the otherwise impenetrable blood-brain barrier. (cns.org)
  • Likely, an upcoming era of molecular polytherapies will be guided by lineage analysis from numerous tumor cells, analyzed on a single-cell basis from each patient. (cns.org)
  • The healthy, transplanted stem cells can restore the bone marrow's ability to produce the blood cells the patient needs.In some types of leukemia, the graft-versus-tumor (GVT) effect that occurs after allogeneic BMT is crucial to the effectiveness of the treatment. (brightkite.com)
  • Duplicated segments of the LMO1 gene within neuroblastoma tumor cells have been shown to increase the risk of developing an aggressive form of the cancer. (wikipedia.org)
  • Their atomic investigation of mutant KIT receptor which emphasized on the EAL region provided a better insight into the understanding of the sunitinib resistance mechanism of the KIT receptor and could help to discover new therapeutics for KIT-based resistant tumor cells in GIST therapy. (wikipedia.org)
  • 1996
  • With the cloning of a sheep known as Dolly in 1996 by somatic cell nuclear transfer (SCNT), the idea of human cloning became a hot debate topic. (wikipedia.org)
  • assays
  • BrdU labeling of proliferative cells, biochemical assays of serum, cerebrospinal fluid and brain levels of trophic factors, growth factors, and stress-related proteins are proposed as indices of neurogenesis, while quantitative measurements of spontaneous movements will reveal psychomotor components of immobilization. (cognizantcommunication.com)
  • migrate
  • In melanogenesis, melanoblasts migrate from the neural crest to their appropriate locations in the epidermis. (wikipedia.org)
  • stroke
  • Use of various types of stem cells for conditions such as stroke, ischemia, heart diseases, Alzhemier's disease, and neurogenerative diseases in general, is explained. (springer.com)
  • Cellular therapy for stroke and neural trauma has gained worldwide attention during the last decade and has shown some promising results. (springer.com)
  • HUCBC transplantation may provide a cell source to treat stroke. (ahajournals.org)
  • mice
  • Neural crest stem cells were isolated from double transgenic Wnt1/Cre-R26R/LacZ mice and cultured under clonal conditions. (nih.gov)
  • Their study examined the fate and function of the five varieties of cells mentioned above after they were transplanted into the CNS of transgenic mice, both healthy and those modeled with CNS injury with subsequent inflammation. (cognizantcommunication.com)
  • Increased glomerular filtration rate and impaired contractile function of mesangial cells in TRPC6 knockout mice. (abcam.com)
  • 12,13 HUCB stem cells have been used to reconstitute marrow in a child with severe Fanconi anemia and to treat amyotrophic lateral sclerosis in SOD1 mice. (ahajournals.org)
  • Unlike ES and iPS cells, transplanted Muse cells in testes of immunodeficient mice -a commonly used experiment to test the tumorigenicity of stem cells- have not been reported to form teratomas, even after six months. (wikipedia.org)
  • The gene encoding stem cell factor (SCF) is found on the Sl locus in mice and on chromosome 12q22-12q24 in humans. (wikipedia.org)
  • Mice with SCF or c-Kit mutations have severe defects in the production of mast cells, having less than 1% of the normal levels of mast cells. (wikipedia.org)
  • Green fluorescent protein (GFP), whose expression is driven by the nestin regulatory element in transgenic mice, serves to mark hair follicle stem cells. (wikipedia.org)
  • nestin
  • In this model, BMP4 is responsible for the astroglial stimulation and oligodendroglial inhibition, as 1) this cytokine is present in a biologically-active form only in nestin-positive mesenchymal stem cells conditioned medium and 2) anti-BMP4 antibodies inhibit the nestin-positive mesenchymal stem cells conditioned medium inducing effect on astrogliogenesis. (biomedcentral.com)
  • Nestin (acronym for neuroectodermal stem cell marker) is a type VI intermediate filament (IF) protein. (wikipedia.org)
  • Seven genes encode for the heavy (NF-H), medium (NF-M) and light neurofilament (NF-L) proteins, nestin and α-internexin in nerve cells, synemin α and desmuslin/synemin β (two alternative transcripts of the DMN gene) in muscle cells, and syncoilin (also in muscle cells). (wikipedia.org)
  • Distribution and expression of nestin in mitotically active cells suggests it plays a role in regulation of the assembly and disassembly of intermediate filaments, which, together with other structural proteins, participate in remodeling of the cell. (wikipedia.org)
  • The role of nestin in dynamic cells, particularly structural organization of the cell, appears strictly regulated by phosphorylation, especially its integration into heterogeneous intermediate filaments together with vimentin or α-internexin. (wikipedia.org)
  • Nestin, a protein marker for neural stem cells, is also expressed in follicle stem cells and their immediate, differentiated progeny. (wikipedia.org)
  • Nestin has recently received attention as a marker for detecting newly formed endothelial cells. (wikipedia.org)