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  • transplantation
  • For patients facing a lifetime of paralysis, the prospect that neural stem cell transplantation may one day help restore some degree of function offers new hope', Dr Curt said. (bionews.org.uk)
  • Laminin and fibronectin scaffolds enhance neural stem cell transplantation into the injured brain. (nih.gov)
  • Cell transplantation offers the potential to treat central nervous system injuries, largely because multiple mechanisms can be targeted in a sustained fashion. (nih.gov)
  • Together these results suggest that the use of appropriate extracellular matrix-based scaffolds can be exploited to improve cell transplantation therapy. (nih.gov)
  • The potential of using stem cell replacement as a strategy to combat radiation-induced cognitive decline was addressed by irradiating athymic nude rats followed 2 days later by intrahippocampal transplantation with human neural stem cells (hNSC). (aacrjournals.org)
  • Unbiased stereology revealed that 23% and 12% of the engrafted cells survived 1 and 4 months after transplantation, respectively. (aacrjournals.org)
  • therapies
  • These and other experiments demonstrate not only the promise of therapies based on stem and progenitor cells, but also the importance of providing these cells with the proper signaling environment, or "niche. (dana.org)
  • Being able to mimic the physiologic environment of neural and other stem cells is going to be crucial in developing therapies," says Celeste Simon , a cell biologist and stem cell researcher at the University of Pennsylvania. (dana.org)
  • The study, published in Nature Neuroscience , reveals a novel gene regulatory system that may advance stem cell therapies and gene-targeting treatments for neurological diseases such as Alzheimer's disease, Parkinson's disease, and mental health disorders that affect cognitive abilities. (eurekalert.org)
  • Being able to maintain viable stem cells in the brain could lead to regenerative therapies to treat injury and disease," says Jing Crystal Zhao, Ph.D., assistant professor at SBP. (eurekalert.org)
  • She is a co-founder and scientific director for The Neural Stem Cell Institute and is a professor of Neuroscience and Neuropharmacology at Albany Medical College Temple is also the principal investigator in her laboratory that focuses on neural stem cells and therapies for neurological-related disorders Temple received her B.A. from Cambridge University. (wikipedia.org)
  • Temple's current laboratory focuses primarily on neural stem cells and the development for therapies related to eye, brain, and spinal cord disorders. (wikipedia.org)
  • This may have a huge impact on neurological therapies using stem cells as a future of medicine. (wikipedia.org)
  • Nestin
  • ReNcell CX cells ( SCC007 ) are grown as monolayers (A) and express NSC markers, Nestin ( MAB5326 ) and Sox-2 ( AB5603 ). (sigmaaldrich.com)
  • Serial sectioning through the scaffold channels in NSC- and SC-treated groups revealed the presence of nestin, neurofilament, S-100, and betaIII tubulin-positive cells. (rutgers.edu)
  • Slow Proliferating Cells (Type B): express Nestin and GFAP, and function to ensheathe migrating Type A Neuroblasts 4. (wikipedia.org)
  • genes
  • Additional therapeutic benefits in these animals can be provided by stem cell-mediated gene transfer of therapeutic genes such as neurotrophic factors and enzymes. (ovid.com)
  • Researchers map learning-induced chromatin alterations in mouse brain cells, and find that many affect autism-associated genes. (the-scientist.com)
  • It belongs to the Fanconi anaemia complementation group (FANC) family of genes of which 12 complementation groups are currently recognized and is hypothesised to operate as a post-replication repair or a cell cycle checkpoint. (wikipedia.org)
  • BMI1 (B lymphoma Mo-MLV insertion region 1 homolog) has been reported as an oncogene by regulating p16 and p19, which are cell cycle inhibitor genes. (wikipedia.org)
  • GFAP
  • GFAP-positive cells were only seen at the spinal cord-scaffold border. (rutgers.edu)
  • These cells also express less glial and neural cell markers such as GFAP or β-tubulin. (wikipedia.org)
  • The secondary layer (Layer II) provides for a hypocellular gap abutting the former and has been shown to contain a network of functionally correlated Glial Fibrillary Acid Protein (GFAP)-positive astrocytic processes that are linked to junctional complexes, yet lack cell bodies except for the rare neuronal somata. (wikipedia.org)
  • Researchers
  • Researchers at the Salk Institute for Biological Studies in La Jolla, California have identified the safeguards preventing neural stem cells from dividing indefinitely, ensuring that a pool of such cells remain available to the brain throughout each person's entire life. (thefutureofthings.com)
  • Japanese researchers have overcome a major obstacle to treating severe spinal cord injuries using stem cells taken from the brain. (bionews.org.uk)
  • In a Phase I trial, researchers show that neural stem cells transplanted into humans can differentiate and begin producing myelin. (the-scientist.com)
  • This biomarker of early cells allows researchers to identify immature cells so that they can be used for further research and possible treatment. (ucdavis.edu)
  • olfactory bulb
  • He traced the migration of labeled cells from the SVZ, which is situated throughout the lateral walls of the lateral ventricles, rostrally to the main olfactory bulb. (wikipedia.org)
  • Scaffolds
  • Cells delivered within the scaffolds were more widely distributed in the injured brain compared to cells delivered in media alone. (nih.gov)
  • however, by 8 weeks post-transplant, cells delivered within the scaffolds showed improved survival compared to those transplanted in media alone. (nih.gov)
  • protein
  • The recent study focused on the hippocampus region of the brain and the role bone morphogenetic factor protein plays in controlling stem cell growth in the area. (thefutureofthings.com)
  • The research team led by Dr. Fred Gage discovered active signaling of bone morphogenetic factor protein (BMP), indicating activity between the protein and its receptors, when the neural stem cells are not dividing whereas the same signaling is inactive whenever the stem cells are dividing. (thefutureofthings.com)
  • Further, the scientists were able to move neural stem cells from inactive to active stages by introducing another protein which binds with the BMP, preventing it from binding to the receptors and initiating the signaling. (thefutureofthings.com)
  • Engrafted cells migrated extensively, differentiated along glial and neuronal lineages, and expressed the activity-regulated cytoskeleton-associated protein (Arc), suggesting their capability to functionally integrate into the hippocampus. (aacrjournals.org)
  • In cells, FANCA involvement in this 'FA core complex' is required for the activation of the FANCD2 protein to a monoubiquitinated isoform (FANCD2-Ub) in response to DNA damage, catalysing activation of the FA/BRCA DNA damage-response pathway, leading to repair. (wikipedia.org)
  • In Physcomitrella patens the PcG protein FIE is specifically expressed in stem cells such as the unfertilized egg cell. (wikipedia.org)
  • Polycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is a protein that in humans is encoded by the BMI1 gene (B cell-specific Moloney murine leukemia virus integration site 1). (wikipedia.org)
  • It was observed that CRABP1 regulated extracellular signal regulated kinase (ERK1/2) which in turn activates the protein phosphatase 2A (PP2A) that induces apoptosis of cancer cells and lengthens the cell cycle of embryonic stem cells. (wikipedia.org)
  • expression
  • Adult neural stem cells are nuclear receptor TLX-positive and TLX expression in these cells is crucial in maintaining their undifferentiated state. (wikipedia.org)
  • The Polycomb gene FIE is expressed in unfertilised egg cells of the moss Physcomitrella patens and expression ceases after fertilisation in the developing diploid sporophyte. (wikipedia.org)
  • The re-expression of CRABP1 in CRABP1 null cells brought back the induced apoptotic activity. (wikipedia.org)
  • cultures
  • describe this product as a growth factor supplement that is able to grow FGF2 dependent stem cell cultures in a more efficient way. (wikipedia.org)
  • adherent
  • compositions of matter, again regardless of the source of the cells and regardless of whether the cells were grown in either suspension or adherent culture or derived from induced pluripotent stem (iPS) cell technologies. (cnbc.com)