• Neural stem cells (NSCs) are self-renewing, multipotent cells that firstly generate the radial glial progenitor cells that generate the neurons and glia of the nervous system of all animals during embryonic development. (wikipedia.org)
  • NSCs are stimulated to begin differentiation via exogenous cues from the microenvironment, or stem cell niche. (wikipedia.org)
  • Transplantation of human NSCs (hNSCs) derived from human pluripotent stem cells at the SCI sites has been considered a promising therapeutic strategy to compensate for the loss of spinal neurons, and could feasibly enable their connectivity with host neurons, leading to spinal cord recovery. (genengnews.com)
  • Abstract for "Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB" by Chiara Rolando, Andrea Erni, Alice Grison, Robert Beattie, Anna Engler, Paul J. Gokhale, Marta Milo, Thomas Wegleiter, Sebastian Jessberger, and Verdon Taylor in Cell Stem Cell . (neurosciencenews.com)
  • Adult neural stem cells (NSCs) are defined by their inherent capacity to self-renew and give rise to neurons, astrocytes, and oligodendrocytes. (neurosciencenews.com)
  • In the adult mammalian subventricular zone (SVZ), GFAP-positive neural stem cells (NSCs) generate neuroblasts that migrate tangentially along the rostral migratory stream (RMS) toward the olfactory bulb (OB). (jneurosci.org)
  • What are neural stem cells (NSCs), neural progenitors, and neural precursors (NPCs)? (sanbio.nl)
  • Neural stem cells (NSCs) are undifferentiated neural cells with the capacity for long-term self-renewal and for differentiation into all types of neuronal and glial cells. (sanbio.nl)
  • Symmetric division of NSCs maintains the population of undifferentiated NSCs, while asymmetric division gives rise to neural progenitors. (sanbio.nl)
  • NSCs and neural progenitors are often regarded as neural precursors (NPCs). (sanbio.nl)
  • We performed gain and loss of function studies for leukemia inhibitory factor (LIF) and showed a depletion of NSCs, a subset of multipotential neural precursors and immature oligodendrocytes in LIF null mice. (karger.com)
  • Blood vessels (BVs) are considered an integral component of neural stem cells (NSCs) niches. (elifesciences.org)
  • Neural stem cells (NSCs) serve as a source for new neurons in both the developing and adult brain. (elifesciences.org)
  • We are interested in therapeutic potential of neural stem cell in transplantation treatment against PD, the midbrain-derived neural stem cells (mNSCs) were studied by in vitro culture in focusing on their proliferative, differentiation and neurotrophic properties and in comparing with hippocampus-derived NSCs (hNSCs). (omicsonline.org)
  • Next, we investigated the metabolite's effects on mouse subventricular zone-derived neural stem cells (NSCs). (eur.nl)
  • To bridge this gap, we used three model cell types to study miRNA expression patterns: human embryonic stem cells (hESCs), hESCs-derived self-renewing neural stem cells (NSCs), and differentiating NSCs. (muni.cz)
  • 1. Introduction to Neural Stem Cells (NSCs) and neurogenesis. (unipi.it)
  • 7. NSCs and neurogenesis in vitro: pluripotent stem cell-derived neural systems. (unipi.it)
  • Beyond the structural replacement of injured CNS cells , our work has shown that transplanted NSCs engage in complex stem cell graft-to-host communication programs , overall leading to trophic support and modulation of adaptive and innate immune responses ( Bacigaluppi et al. (nbscience.com)
  • The adult neurogenic niche in the hippocampus is maintained through activation of reversibly quiescent neural stem cells (NSCs) with radial glia-like morphology (RGLs). (unimib.it)
  • These NSCs express typical markers of cerebral cortex neural stem and progenitor cells, such as PAX6 , FOXG1 and Nestin, and when they are laid in a single layer, they will spontaneously form a polarized neural tube rosette structure. (creative-biolabs.com)
  • There are two basic types of stem cell: adult stem cells, which are limited in their ability to differentiate, and embryonic stem cells (ESCs), which are pluripotent and have the capability of differentiating into any cell type. (wikipedia.org)
  • MADISON - The great promise of induced pluripotent stem cells is that the all-purpose cells seem capable of performing all the same tricks as embryonic stem cells, but without the controversy. (scienceblog.com)
  • That means that at this point there is still some work to be done to generate ideal induced pluripotent stem cells for application. (scienceblog.com)
  • Embryonic stem cells are considered the "gold standard" for all pluripotent stem cells, which are cells that can differentiate into all of the 220 cell types in the human body. (scienceblog.com)
  • Some of the induced stem cell lines tested in the study were made using techniques that bypassed the use of genes that had been used to reprogram skin cells to become pluripotent stem cells. (scienceblog.com)
  • It tells us the techniques for generating induced pluripotent stem cells are still not optimal. (scienceblog.com)
  • The approach, named microfluidic-controlled stem cell regionalization (MiSTR), exposes pluripotent stem cells to signaling gradients that mimic developmental patterning. (nature.com)
  • Induced pluripotent stem cells for neural tissue engineering. (ca.gov)
  • Induced pluripotent stem cells (iPSCs) hold great promise for cell therapies and tissue engineering. (ca.gov)
  • Zhang, MD, PhD, S.-C. Neural Subtype Specification from Human Pluripotent Stem Cells . (wisc.edu)
  • The researchers showed that human pluripotent stem cell (hPSC)-derived neural stem cells engineered with reduced expression of a gene called SOX9 differentiate preferentially into spinal motor neurons. (genengnews.com)
  • Whether you're starting from primary cells, tissue samples, or pluripotent stem cells, explore our complete portfolio of products to support your neural culture workflow. (stemcell.com)
  • They transplanted human Fragile X neural cells differentiated from induced pluripotent stem cells into brains of neonatal mice and then testing for FMR1 reactivation. (fraxa.org)
  • and (b) leucine-rich repeat kinase 2 (LRRK2) gene identified patient induced pluripotent stem cells (iPSCs), which were used to isolate EMVs and begin to characterize their cargoes. (nih.gov)
  • Immunofluorescent staining of PAX6 ( 12323-1-AP , 1:250 dilution) with 4% PFA fixed control human-induced pluripotent stem cell (hiPSC)-derived NPCs. (sanbio.nl)
  • NPCs can be differentiated from embryonic stem cells (ESCs) but also from induced pluripotent stem cells (iPSCs) (PMID: 11731782). (sanbio.nl)
  • We found that differentiating induced pluripotent stem cells (iPSC) to DA neuron progenitors followed by transplantation into the rat brain may enable differentiation into DA neurons. (suny.edu)
  • And while in human pluripotent stem cells, miRNAs have been directly linked to the core pluripotency network, including the cell cycle regulation and the maintenance of the self-renewing capacity, their role in the onset of differentiation in other contexts, such as determination of neural cell fate, remains poorly described. (muni.cz)
  • 2012). The direct reprogramming into iNSCs avoids the laborious progression through a pluripotent state and subsequent differentiation into desired lineages described for induced pluripotent stem cell ( iPSC ) technology ( Meyer et al. (nbscience.com)
  • Creative Biolabs human iPSC-derived neural stem cells (NSC) are derived from integration-free, induced pluripotent stem cells (iPSC) under fully defined neural induction conditions. (creative-biolabs.com)
  • Pluripotent embryonic stem cells can give rise to neuroectodermal derivatives in culture. (dundee.ac.uk)
  • To complement the in vivo system of chick embryos, we employ patient omics data, single cell RNA sequencing, human and mouse embryos, human cancer cell cultures, human pluripotent stem cells, chick embryo neural crest-derived in vitro crestosphere cultures, and zebrafish and mouse in vivo models. (lu.se)
  • This strategy provides a useful tool for visualization and identification of neural progeny derived from human pluripotent stem cells. (lu.se)
  • Given this, human pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripo- tent stem cells (hiPSCs), have become a unique cell source for study- ing early human brain development. (lu.se)
  • However, current protocols for deriving neurons from human pluripotent stem cells give rise to heterogeneous cell populations both in regard to the temporal aspects and the cellular composition. (lu.se)
  • These strat- egies provide a robust way to visualize and isolate specific cell pop- ulations of differentiated pluripotent stem cells. (lu.se)
  • 3 Embrionic stem cells (ESCs) are derived from the inner cell mass of the blastocyst and form all cell types, derived from the three germ layers, and are therefore pluripotent. (bvsalud.org)
  • Neural progenitors are precursor cells able to further differentiate into various neuronal and glial cells. (sanbio.nl)
  • In an earlier study, the Wake Forest Baptist team isolated neural precursor cells derived from skeletal muscle of adult transgenic mice (PLOS One, Feb.3, 2011). (wakehealth.edu)
  • In the current research, the team isolated neural precursor cells from in vitro adult skeletal muscle of various species including non-human primates and aging mice, and showed that these cells not only survived in the brain, but also migrated to the area of the brain where neural stem cells originate. (wakehealth.edu)
  • Recent studies have reported that taurine causes increased proliferation of neural stem/progenitor neural cells (neural precursor cells, NPCs) obtained from embryonic and adult rodent brain. (nih.gov)
  • Moreover, the Nichoid has shown ability to stimulate the expression of pluripotency genes and potentiate the therapeutic potential of neural precursor cells (NPCs) [2, 3]. (unimi.it)
  • Some neural progenitor stem cells persist in highly restricted regions in the adult vertebrate brain and continue to produce neurons throughout life. (wikipedia.org)
  • Neural stem cells are more specialized than ESCs because they only generate radial glial cells that give rise to the neurons and to glia of the central nervous system (CNS). (wikipedia.org)
  • Zhang's group, led by researcher Baoyang Hu, found that the induced cells differentiate into progenitor neural cells and further into the different kinds of functional neurons that make up the brain. (scienceblog.com)
  • When transplanted into a rat model of spinal cord injury (SCI) these neural stem cells generated mature neuronal subtypes, were able to integrate and grow axons that projected over long distances and connected with the recipient's neurons. (genengnews.com)
  • Spinal neurons around the scar cannot be restored due to the low intrinsic regenerative ability of undamaged neurons and the lack of neural stem cells in the adult spinal cord. (genengnews.com)
  • Neural stem cells are generally accepted to produce three different cell types: neurons, astrocytes and oligodendrocytes. (neurosciencenews.com)
  • Drosha degrades the messenger RNA for NFIB in the adult hippocampal stem cells and prevents the expression of this transcription factor which is necessary for the differentiation of oligodendrocytes and thus blocks their development and therefore biases differentiation towards neurons. (neurosciencenews.com)
  • Magenta: the hippocampal stem cells generate newborn neurons. (neurosciencenews.com)
  • This is consistent with a negative-feedback loop, in which newly generated neurons modulate cell division of SVZ stem cells. (jneurosci.org)
  • Virtually all of the neurons and glia that populate the mature brain arise from neural precursors (NPs) that reside immediately adjacent to the lateral ventricles. (karger.com)
  • It also increased the number of neurons produced by the stem cells, prompting increased neurogenesis of cells in culture. (wisc.edu)
  • And given the fact that adult humans have neural stem cells that continue to make new neurons in some parts of the brain, there is a possibility that DHEA could play a role in moderating the genesis of new brain cells. (wisc.edu)
  • The cells then differentiated into neural tissue cells, such as oligodendrocytes and early neurons, and migrated to spinal cord injury sites. (uci.edu)
  • In addition, the Wake Forest Baptist team is now conducting research to determine if these neural-like cells also have the capability to become functioning neurons in the central nervous system. (wakehealth.edu)
  • Human embryonic stem cells (hESCs) and their derived products offer great promise for targeted therapies and drug screening, however, the hESC differentiation process of mature neurons is a lengthy process. (northumbria.ac.uk)
  • Summary Mammalian neural stem/progenitor cells (NSPCs) sequentially generate neurons and glia during CNS development. (prinsesmaximacentrum.nl)
  • The goal of our research is to develop stem cell-based therapies to replace lost neurons as a treatment for brain diseases. (lu.se)
  • We aim to develop novel, lasting therapies for neurodegenerative diseases through the replacement of lost neurons in the brain with new neurons generated from stem cells. (lu.se)
  • Stem Derived Dopamine Neurons: Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson's Disease? (lu.se)
  • Quiescent stem cells are Type B that are able to remain in the quiescent state due to the renewable tissue provided by the specific niches composed of blood vessels, astrocytes, microglia, ependymal cells, and extracellular matrix present within the brain. (wikipedia.org)
  • Using a WNT-activating gradient, we generated a neural tissue exhibiting progressive caudalization from forebrain to midbrain to hindbrain, including formation of isthmic organizer characteristics. (nature.com)
  • Fig. 2: Neural patterning along the rostro-caudal axis in day 14 MiSTR tissue. (nature.com)
  • Here we derived NCSCs from human iPSCs and embryonic stem cells (ESCs), and investigated the potential of NCSCs for neural tissue engineering. (ca.gov)
  • This study demonstrates that iPSC-derived multipotent NCSCs can be directly used for tissue engineering and that the approach that combines stem cells and scaffolds has tremendous potential for regenerative medicine applications. (ca.gov)
  • The researchers reported on their developments in Advanced Science , in a paper titled, " Transplanting Human Neural Stem Cells with ≈50% Reduction of SOX9 Gene Dosage Promotes Tissue Repair and Functional Recovery from Severe Spinal Cord Injury ," in which they concluded, "Our findings represent a new paradigm in generating genetically modified hNSCs for the treatment of SCI. (genengnews.com)
  • Understanding the role of tissue-specific decellularized spinal cord matrix hydrogel for neural stem/progenitor cell microenvironment reconstruction and spinal cord injury. (physiciansweekly.com)
  • Decellularized tissue matrices (DTMs) have shown their unique and beneficial characteristics in promoting neural tissue regeneration, especially those derived from the nervous system. (physiciansweekly.com)
  • The tissue-specificity of DSCM-gel was evaluated both in vitro, using neural stem/progenitor cell (NSPC) culture, and in vivo, using various materials and biological analyses, including transcriptome and proteomics. (physiciansweekly.com)
  • Engineering Neural Tissue from Stem Cells covers the basic knowledge needed to understand the nervous system and how existing cells can be used to create neural tissue. (elsevier.com)
  • This book presents a broad range of topics related to the design requirements for engineering neural tissue from stem cells. (elsevier.com)
  • In addition, the book explores the role of the extracellular matrix and vasculature/immune system and biomaterials, including their suitability for neural tissue engineering applications. (elsevier.com)
  • 1. The need for engineering neural tissue using stem cells2. (elsevier.com)
  • Design considerations when engineering neural tissue from stem cells5. (elsevier.com)
  • Natural biomaterials for engineering neural tissue from stem cells6. (elsevier.com)
  • Synthetic biomaterials for engineering neural tissue from stem cells7. (elsevier.com)
  • Dr. Willerth is the author of Engineering Neural Tissue from Stem Cells, published by Elsevier Academic Press in 2016. (elsevier.com)
  • Analyses of miRNA expression profiles have demonstrated tissue- and stage-specific miRNAs including the let-7 family, miR-124, and miR-9, which regulate the differentiation of embryonic stem cells and/or neurogenesis. (elsevierpure.com)
  • Scientists at Wake Forest Baptist Medical Center have taken the first steps to create neural-like stem cells from muscle tissue in animals. (wakehealth.edu)
  • Skeletal muscle tissue, which makes up 50 percent of the body, is easily accessible and biopsies of muscle are relatively harmless to the donor, so we think it may be an alternative source of neural-like cells that potentially could be used to treat brain or spinal cord injury, neurodegenerative disorders, brain tumors and other diseases, although more studies are needed. (wakehealth.edu)
  • Neural tissue is flexible and susceptible to compression. (msdmanuals.com)
  • To model complex human brain diseases in the dish using stem cell-derived brain tissue models. (lu.se)
  • Due to the ability to self-renew and to differentiate into cells that are found throughout the body, there is a great interest in using stem cells for the regeneration of injured tissues as well as to develop tissue-engineered implants and bio-hybrid organs, in order to restore tissue function. (bvsalud.org)
  • Previous work in the embryonic rodent brain suggested that the preferential inheritance of the pre-existing (older) centrosome to the self-renewed progenitor cell is required to maintain stem cell properties, ensuring proper neurogenesis. (elifesciences.org)
  • We observed that the co- transfection of NS4A and NS4B altered the neural stem cell fate by arresting proliferation and inducing premature neurogenesis . (bvsalud.org)
  • It is essential to have sensitive and reproducible methods of either quantifying or isolating these stem cells and progenitors to understand their intrinsic properties and how extrinsic signals regulate their development. (karger.com)
  • However, stem cells are difficult to distinguish from multipotential progenitors, which may look and act like them. (karger.com)
  • Here we define a 4-color flow cytometry panel using CD133, LeX, CD140a, NG2 to define a neural stem cell (NSC) as well as 4 classes of multipotential progenitors and 3 classes of bipotential progenitors, several of which have not been described previously. (karger.com)
  • In an effort to develop cell therapy-based strategies for progressive MS, we investigated the pre-clinical efficacy of bone marrow mesenchymal stem cell-derived neural progenitors (MSC-NPs) as an autologous source of stem cells. (listlabs.com)
  • Although developmental myelination and axonal coverage by endogenous oligodendrocytes was extensive, as assessed using electron microscopy (n = 3 at each of four end points) and immunostaining (n = 3 at each of four end points), wild-type neural precursors, transplanted into the brains of the newborn mutants, were able to effectively compete and replace the defective myelin (n = 2 at each of four end points). (gla.ac.uk)
  • The differentiation of iPSCs and the expansion of derived NCSCs varied in different cell lines, but all NCSC lines were capable of differentiating into mesodermal and ectodermal lineages, including neural cells. (ca.gov)
  • This approach alters the grafts' response in the injury environment and confers enhanced neuronal differentiation capacity, survival, and integration, as well as reduced glial scar formation to provide a more effective stem cell therapy for severe traumatic SCI. (genengnews.com)
  • The repair of spinal cord injury (SCI) highly relies on microenvironment remodeling and facilitating the recruitment and neuronal differentiation of endogenous stem/progenitor cells. (physiciansweekly.com)
  • Neural Progenitor Cells Derived from XCL-1 DCXp-GFP are a neuronal lineage reporter cell line that can be used in neuronal differentiation and drug screening. (atcc.org)
  • In this study, VGF (non-acronymic) was found regulated by NPAS3 in neuronal stem cells. (frontiersin.org)
  • To download a certificate of analysis for Neural Progenitor Cells Derived from XCL-1 DCXp-GFP ( ACS-5005 ), enter the lot number exactly as it appears on your product label or packing slip. (atcc.org)
  • The certificate of analysis for that lot of Neural Progenitor Cells Derived from XCL-1 DCXp-GFP ( ACS-5005 ) is not currently available online. (atcc.org)
  • These data demonstrate the potential of neural stem cell therapies to restore normal myelination and protect axons in patients with PLP1 gene duplication mutation and further, provide proof of principle for the benefits of stem cell transplantation for other fatal leukodystrophies with 'normal' developmental myelination. (gla.ac.uk)
  • During human forebrain development, neural progenitor cells (NPCs) in the ventricular zone (VZ) undergo asymmetric cell divisions to produce a self-renewed progenitor cell, maintaining the potential to go through additional rounds of cell divisions, and differentiating daughter cells, populating the developing cortex. (elifesciences.org)
  • Using a novel, recombination-induced tag exchange-based genetic tool to birthdate and track the segregation of centrosomes over multiple cell divisions in human embryonic stem cell-derived regionalised forebrain organoids, we show the preferential inheritance of the older mother centrosome towards self-renewed NPCs. (elifesciences.org)
  • During human brain development, neural progenitor cells (NPCs) undergo two modes of cell division. (elifesciences.org)
  • Such stem cell therapies have the potential to repair the damaged brain, making patients independent of daily medications with severe side effects. (lu.se)
  • Through our work on developing novel stem cell therapies for brain diseases, we contribute to the main goal of MultiPark on establishing novel therapeutic approaches for developing more effective symptomatic, new disease-modifying, and/or plasticity-enhancing treatments. (lu.se)
  • Conclusion: stem cells from dental origin are an interesting alternative for research and application in regenerative therapies in Dentistry. (bvsalud.org)
  • Svendsen and Suzuki carried out the experiments by growing human fetal neural stem cells in culture. (wisc.edu)
  • In this study, we explored the role of ZIKV non-structural protein NS4A and NS4B in ZIKV pathogenesis in a well-characterized primary culture of human fetal neural stem cells (fNSCs). (bvsalud.org)
  • Neural crest stem cells (NCSCs) are multipotent and represent a valuable system to investigate iPSC differentiation and therapeutic potential. (ca.gov)
  • Neural induction and directed neural differentiation. (unipi.it)
  • In the adult mammalian brain, the subgranular zone in the hippocampal dentate gyrus, the subventricular zone around the lateral ventricles, and the hypothalamus (precisely in the dorsal α1, α2 region and the "hypothalamic proliferative region", located in the adjacent median eminence) have been reported to contain neural stem cells. (wikipedia.org)
  • Mammalian neural stem cells. (bvsalud.org)
  • Finally, NPAS3 was found to influence proliferation of neural cells through VGF. (frontiersin.org)
  • Scientists in the burgeoning field of regenerative medicine are pinning their hopes on induced stem cells because they offer advantages over embryonic stem cells, not the least of which is the fact that they do not need to be derived from early-stage human embryos. (scienceblog.com)
  • Here, we model early human neural tube development using human embryonic stem cells cultured in a microfluidic device. (nature.com)
  • Researchers at the University of Hong Kong (HKUMed) LKS Faculty of Medicine, and at City University of Hong Kong (CityU) have generated human neural stem cells (hNSCs) that exhibit what they claim is "powerful therapeutic potential" for the treatment of spinal cord injury. (genengnews.com)
  • A research team from HKUMed has generated human neural stem cells with powerful therapeutic potential for the treatment of spinal cord injury that paves the way for new therapeutic opportunities. (genengnews.com)
  • The Studer laboratory investigates human stem cells as tools to understand normal and pathological development in the nervous system and to develop cell-based strategies for regenerative medicine. (uctv.tv)
  • The comprehensive miRNA profiling presented here reveals novel sets of miRNAs differentially expressed during human neural cell fate determination in vitro. (muni.cz)
  • Human neural stem cells, exposed in a lab dish to the steroid DHEA, exhibit a remarkable uptick in growth rates, suggesting that the hormone may play a role in helping the brain produce new cells, according to a new study published this week in the online editions of the Proceedings of the National Academy of Sciences (PNAS). (wisc.edu)
  • The new work, conducted by a team of scientists at UW-Madison, provides some of the first direct evidence of the biological effects of DHEA on the human nervous system, according to Clive Svendsen, the study's senior author and an authority on brain stem cells at the Waisman Center . (wisc.edu)
  • This is the first real evidence of DHEA's effects on human neural cells. (wisc.edu)
  • Human neural stem cells restore motor function in mice with chronic spinal cord injury. (uci.edu)
  • A UC Irvine study is the first to demonstrate that human neural stem cells can restore mobility in cases of chronic spinal cord injury, suggesting the prospect of treating a much broader population of patients. (uci.edu)
  • The Anderson-Cummings team transplanted human neural stem cells into mice 30 days after a spinal cord injury caused hind-limb paralysis. (uci.edu)
  • Human neural stem cells are a novel therapeutic approach that holds much promise for spinal cord injury," said Anderson, associate professor of physical medicine & rehabilitation and anatomy & neurobiology at UCI. (uci.edu)
  • This latest study provides additional evidence that human neural stem cells may be a viable treatment approach for them. (uci.edu)
  • The research is the latest in a series of collaborative studies conducted since 2002 with StemCells Inc. that have focused on the use of StemCells' human neural stem cells in spinal cord injury and resulted in multiple co-authored publications. (uci.edu)
  • Statement of significance: Human embryonic stem cells (hESC) are used for investigating the complex mechanisms involved in the development of specialized biological cells and organs. (northumbria.ac.uk)
  • Biologists have shown for the first time in the laboratory that they can convert some adult human neural stem cells to brain cells that can produce dopamine, the brain chemical missing in Parkinson's disease. (scienceblog.com)
  • Johan Jakobsson, a professor at Lund University and research group leader at Lund Stem Cell Center, explains, "LINE-1 retrotransposons are a rich source of genetic sequences that we suspect have shaped the evolution of the human brain, and we now have the tools to explore their role in brain development. (lu.se)
  • 2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
  • In the Kirkeby lab, we further apply advanced human stem cells models and single-cell RNA sequencing to understand how the hundreds of human neural subtypes of cells are formed during embryo development. (lu.se)
  • To study human brain development using stem cell models. (lu.se)
  • We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells. (lu.se)
  • Here we describe how this system can be used for human embry- onic stem cells. (lu.se)
  • 8,9 Because dental stem cells (DSCs) are easy to obtain and present a great potential of differentiation, there has been a growing interest in their use in regenerative medicine for treatment of various human diseases. (bvsalud.org)
  • In human postnatal dental tissues, five main sources of DSCs have been identified: dental pulp stem cells (DPSCs), 11 stem cells from human exfoliated deciduous teeth (SHEDs), 12 periodontal ligament stem cells (PDLSCs), 13 dental follicle stem cells (DFSCs) 14 and stem cells from apical papilla (SCAPs). (bvsalud.org)
  • Stem cells are characterized by their capacity to differentiate into multiple cell types. (wikipedia.org)
  • Stem cells are undifferentiated cells that have the potential to differentiate into many cell types. (neurosciencenews.com)
  • Stem cells rely on extracellular signals produced by the niche, which dictate their ability to self-renew, expand and differentiate. (karger.com)
  • After thawing and plating, neural stem cells finally differentiate to obtain mature electrophysiological properties, and form a functional synaptic network within 40 to 50 days. (creative-biolabs.com)
  • Stem cells (SCs) are undifferentiated cells with self-renewal ability and capacity to differentiate into specialized cell types. (bvsalud.org)
  • Previous breakthrough stem cell studies have focused on the acute, or early, phase of spinal cord injury, a period of up to a few weeks after the initial trauma when drug treatments can lead to some functional recovery. (uci.edu)
  • The UCI study, led by Aileen Anderson and Brian Cummings of the Sue and Bill Gross Stem Cell Research Center, is significant because the therapy can restore mobility during the later chronic phase, the period after spinal cord injury in which inflammation has stabilized and recovery has reached a plateau. (uci.edu)
  • Reversing brain degeneration and trauma lesions will depend on cell therapy, but we can't harvest neural stem cells from the brain or spinal cord without harming the donor," said Osvaldo Delbono, M.D., Ph.D., professor of internal medicine at Wake Forest Baptist and lead author of the studies. (wakehealth.edu)
  • impaired epiphyseal bone growth, resulting in shortened, malformed bones) sometimes causes the foramen magnum to narrow or fuse with the atlas and thus may compress the spinal cord or brain stem. (msdmanuals.com)
  • Dr. Xinyu Zhao of the Waisman Center and Department of Neuroscience at University of Wisconsin-Madison joins us in this seminar to present Interrogate the Functions of FMRP in Brain Development Using Stem Cells. (fraxa.org)
  • Differences in the size of the central nervous system are among the most important distinctions between the species and thus mutations in the genes that regulate the size of the neural stem cell compartment are among the most important drivers of vertebrate evolution. (wikipedia.org)
  • Because FOX proteins regulate neural stem cell homeostasis, FOX proteins have been used to protect neural stem cells by inhibiting Wnt signaling. (wikipedia.org)
  • Summary: A new study reports hippocampal neural stem cells regulate their own cell fate via the protein Drosha. (neurosciencenews.com)
  • A research group at the University of Basel now describes for the first time a mechanism by which hippocampal neural stem cells regulate their own cell fate via the protein Drosha. (neurosciencenews.com)
  • Identification of VENT - ventrally emigrating neural tube - cells within the stomach and small intestine is another piece in Dr. Sohal's effort to fully define and describe the cells that he first found migrating out from the neural tube of a chick embryo. (scienceblog.com)
  • Our main model organism is the chick embryo , ideal for functional and translational studies on neural crest development. (lu.se)
  • Primary antibodies are available for the characterization of neural stem cells, neural progenitor cells and their progeny. (stemcell.com)
  • It's the only steroid we tested that had such a direct effect on stem cell growth and new neuron formation," according to Suzuki. (wisc.edu)
  • Moreover, the immunostaining confirmed that more mature neuron marker Tuj1-positive cells, while less stem cell marker Sox2-positive cells, are presented in the SAW dose groups. (northumbria.ac.uk)
  • Neural differentiation of the hESCs is greatly accelerated after application of the acoustic stimulations. (northumbria.ac.uk)
  • RePub, Erasmus University Repository: The pyriproxyfen metabolite, 4 '-OH-PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection. (eur.nl)
  • Researchers from the Department of Biomedicine at the University of Basel have now found that the fate of adult hippocampal stem cells is not only controlled by their local niche, but also by a cell-intrinsic mechanism. (neurosciencenews.com)
  • If Dr. Sohal's studies are on target, he's found the first source of new cells identified in the embryo since 1868 and what might be the precursor for adult stem cells. (scienceblog.com)
  • This has enabled her to combine her interests in neurodevelopment and brain plasticity with the study of neural stem cell biology and regeneration. (brainresearchuk.org.uk)
  • Working in the Bayin lab has given Giada the opportunity to combine her interest in neurodevelopment and brain plasticity with the study of stem cell biology to identify opportunities to stimulate the regeneration of the adult brain. (brainresearchuk.org.uk)
  • To date, it has been assumed that the differentiation of stem cells depends on the environment they are embedded in. (neurosciencenews.com)
  • The involvement of microRNAs (miRNAs) in orchestrating self-renewal and differentiation of stem cells has been revealed in a number of recent studies. (muni.cz)
  • Single-cell transcriptomics revealed that rostro-caudal organization was already established at 24 h of differentiation, and that the first markers of a neural-specific transcription program emerged in the rostral cells at 48 h. (nature.com)
  • The neural progenitor cell markers, including Pax6, Sox1, Sox2, Sox10 and Nkx2-1, are less expressed in the SAW dose groups compared with the control group by the qPCR. (northumbria.ac.uk)
  • Epidermal growth factor (EGF) and fibroblast growth factor (FGF) are mitogens that promote neural progenitor and stem cell growth in vitro, though other factors synthesized by the neural progenitor and stem cell populations are also required for optimal growth. (wikipedia.org)
  • The transcriptomic hallmarks of rostro-caudal organization recapitulated gene expression patterns of the early rostro-caudal neural plate in mouse embryos. (nature.com)
  • However, the cell types that somatic stem cells produce are usually restricted to those of the organ in which they sit. (neurosciencenews.com)
  • 2012). Therefore , making stably expandable iNSCs from somatic cells represents the most feasible way of obtaining autologous brain stem cells for downstream clinical applications ( Wörsdörfer et al. (nbscience.com)
  • Okano, Shimazaki, and colleagues identified a microRNA, miR-153, as an inhibitor of gliogenesis in early neurogenic neural stem/progenitor cells (NSPCs). (prinsesmaximacentrum.nl)
  • Furthermore, in vivo assessments confirmed that DSCM-gel provides a suitable microenvironment for endogenous stem/progenitor cell recruitment and axonal regeneration for bridging the lesion site after a completely transected SCI. (physiciansweekly.com)
  • If there is an interdependence between the vascular and neural environments, differences in the vascular microenvironment could have an impact on neural development and adult neural stability and repair. (csbsju.edu)
  • 11. Advanced 3D neural systems: retina and brain organoids. (unipi.it)