Neural progenitors differentiation progenitor satellite cell. Medical search. Frequent questions

Here we show that human PSM cells derived in vitro-as well as those of the mouse 4 -recapitulate the oscillations of the segmentation clock. (nature.com)
Single-cell RNA sequencing reveals that mouse and human PSM cells in vitro follow a developmental trajectory similar to that of mouse PSM in vivo. (nature.com)
Fig. 1: Recapitulation of the mouse and human segmentation clocks in vitro by differentiation of pluripotent stem cells towards PSM fate. (nature.com)
Because stromal cells can modulate the functionality of myeloid cells in vitro, targeting stromal-myeloid interactions has become an attractive potential therapeutic strategy. (pklab.org)
Using biologically relevant elastic substrates to study cell function in vitro has proven beneficial, as the in vivo microenvironment usually is much softer than rigid plastic dishes. (5dok.org)

Interestingly recent data indicated that although MyoD is not indicated in quiescent satellite cells in the adult it is transiently indicated in satellite cell progenitors in the embryo suggesting that satellite cells are derived from committed embryonic precursors of myogenic lineage [4] [5]. (healthyguide.info)
The embryonic AMPs are at the origin of all adult fly muscles and, as we demonstrate here, they express repressors of myogenic differentiation and targets of the Notch pathway known to be involved in muscle cell stemness. (biologists.com)
MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation. (mdc-berlin.de)

First, we assessed the effects of BNN-20 on human induced pluripotent stem cell-derived neural progenitor cells and neurons derived from healthy and parkinsonian donors. (referencecitationanalysis.com)
On the cover: Human induced pluripotent stem cell-derived neuroepithelial-like stem cells stained for actin (green) and DNA (blue). (5dok.org)

after that period, progenitor cells produce only dissimilar mesenchymal stem cell daughters. (wikipedia.org)
From a research, medical, and business standpoint, mesenchymal stem cell (MSC)-based therapies are fascinating. (biomedcentral.com)

a reverse function mutant Talniflumate of Nkx3.2 blocks the ability of Sox9 to both inhibit myogenesis and induce chondrogenesis suggesting that Nkx3.2 is required for Sox9 to promote chondrogenic differentiation in satellite cells. (healthyguide.info)
Therefore our and analyses suggest that the balance of Pax3 Nkx3.2 and Sox9 may act as a molecular Talniflumate switch during the chondrogenic differentiation of muscle mass progenitor cells which may be important for fracture healing. (healthyguide.info)
Collectively our data suggest that the balance of Nkx3.2 Sox9 and Pax3 can act as a molecular switch during the chondrogenic differentiation of satellite cells which may play an important part in the healing process experiments were normalized to GAPDH. (healthyguide.info)

While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)
A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)

WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
Combined treatment with selumetinib and a dose of palbociclib sufficient to reinforce G1 arrest in selumetinib-sensitive cells, but not to impair proliferation of resistant cells, delays the emergence of resistant colonies, meaning that escape from G1 arrest is critical in the formation of resistant clones. (babraham.ac.uk)
Eph/ephrin signaling is a cell-to-cell communication pathway, which regulates cell migration and proliferation. (5dok.org)

Boundary cap neural crest stem cells promote survival of mutant SOD1 motor neurons. (wikipedia.org)
For example, fast dynamics in single cells or local populations recorded with multi-electrode arrays can be related to simultaneously acquired optical signals that report activity in specified subpopulations of neurons, in non-neuronal cells, or in neuromodulatory pathways. (referencecitationanalysis.com)
Enriched monolayer precursor cell cultures from micro-dissected adult mouse dentate gyrus yield functional granule cell-like neurons. (mdc-berlin.de)

He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
Firstly, loss of dGLYAT suppressed scrib depletion- or Egr overexpression-induced JNK pathway activation and invasive cell migration. (sdbonline.org)
Molecular motors lie at the heart of biological processes from DNA replication to cell migration. (nih.gov)
Our results show that we can tune cell stiffness and migration by regulating Notch activity and matrix stiffness. (5dok.org)
Control of cell migration in the development of the posterior lateral line: antagonistic interactions between the chemokine receptors CXCR4 and CXCR7/RDC1. (wanfangdata.com.cn)
Akt Activation, but not Extracellular Signal-Regulated Kinase Activation, Is Required for SDF-1{alpha}/CXCR4-Mediated Migration of Epitheloid Carcinoma Cells. (wanfangdata.com.cn)
Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury. (wanfangdata.com.cn)
Commensurate with the known truth that HuR improved the great quantity of adhesion substances VLA-4 on Th17 cells, knockout of HuR impaired splenic Th17 cell migration towards the central anxious program and abolished the condition. (globaltechbiz.com)

Satellite cells from your trunk and the limb are derived from an embryonic populace of progenitor cells in the somites transient mesodermal constructions that develop on either part of the neural tube [1]. (healthyguide.info)
In Drosophila , a population of muscle-committed stem-like cells called adult muscle precursors (AMPs) keeps an undifferentiated and quiescent state during embryonic life. (biologists.com)
A new tumor model, combining human embryonic stem cells (ESC) and tumor cells, develops abundant human vessels. (nih.gov)

Despite this, clinical responses are typically transient as tumour cells develop resistance. (babraham.ac.uk)

In contrast to adult cancers and previous NB studies, we show an increase in inflammatory monocyte cell state when contrasting normal and tumor tissue, while no differences in cytotoxicity and exhaustion score for T cells, nor in Treg activity, are observed. (pklab.org)

MSCs can be defined by their ability to adhere to tissue culture plastic, their expression of several cell surface molecular epitopes-cluster of differentiation CD73, CD90, and CD105, and others-as well as their lack of several surface markers, including CD45 [ 6 ]. (biomedcentral.com)

A progenitor cell is a biological cell that can differentiate into a specific cell type. (wikipedia.org)
Progenitor cells can only differentiate into their "target" cell type. (wikipedia.org)
Inflammatory cytokines and other factors released during infections will activate haematopoietic progenitor cells to differentiate to replenish the lost resources. (wikipedia.org)
Some of these transit amplifying neural progenitors migrate via rostral migratory stream to the olfactory bulb and differentiate further into specific types of neural cells. (wikipedia.org)
This includes bone and cartilage repair, cell types into which MSCs readily differentiate, and immune conditions such as graft versus host disease and autoimmune conditions that utilize the MSC's immune suppressive properties. (biomedcentral.com)

Fibroblast growth factor-4 and hepatocyte growth factor induce differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocytes [J].2005,(47). (wanfangdata.com.cn)

Cell damage was assessed using MTT assays, and the lactate dehydrogenase (LDH) release rate and flow cytometry were used to detect the accumulation of reactive oxygen species (ROS) and mitochondrial membrane potential respectively. (sdbonline.org)

Through gene knockout studies he has shown that these molecules act as a type of molecular "Teflon" to make cells more mobile and invasive and also facilitate chemotaxis. (ubc.ca)
Molecular cloning and structure of a pre-B-cell growth-stimulating factor. (wanfangdata.com.cn)
These changes take place on the molecular level impacting properties of specific the different parts of cell inner structure, but resulting in alterations in mechanical properties of the complete cell ultimately. (globaltechbiz.com)

His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)

Research on regenerative medicine has focused on progenitor cells, and stem cells, because their cellular senescence contributes largely to the process of aging. (wikipedia.org)
The natural aging of cells, called their cellular senescence, is one of the main contributors to aging on an organismal level. (wikipedia.org)
These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)
Upon an electrochemical switch, growth factor presentation was reversed, which initiated cellular differentiation along the neuronal lineages. (5dok.org)
Cytoskeleton, U-93631 which is a network of interconnected filaments of different types, connects the cell membrane with underlying sub-cellular components. (globaltechbiz.com)
The nucleus is the largest organelle among sub-cellular components, demonstrating solid-elastic behavior [4], and it is typically stiffer than the cell itself [5]. (globaltechbiz.com)

Our findings provide biological insights into the interplay between tumor cells and the ccRCC microenvironment. (pklab.org)
Analysis of 22 tumor samples, including multiple myeloma, gastric, breast and thyroid cancers, shows that Numbat can reconstruct the tumor copy number profile and precisely identify malignant cells in the tumor microenvironment. (pklab.org)
The response of target cells is further regulated by their microenvironment, involving the extracellular matrix, which may be modified by MSC-produced matrix metalloproteinases (MMPs) and tissue inhibitor of MMPs. (biomedcentral.com)
We hypothesize that the ESC ovarian tumor model, with human vascular cells, will provide an ideal microenvironment to support human stem cell growth. (nih.gov)
If successful, this will create a murine tumor model that nearly completely reproduces the human tumor microenvironment with human tumor stroma, vessels and tumor stem cells. (nih.gov)
We propose an opportunity to target the cancer cell/microenvironment interface instead of the Notch pathway itself in the development of cancer therapies. (5dok.org)

Bone marrow stromal cells found in the epidermis and make up 10% of progenitor cells. (wikipedia.org)
Analysis of supporting stromal cells within the tumor environment demonstrates vascular remodeling within the endothelial cells. (pklab.org)
We aimed to investigate how human liver stromal cells impact myeloid cell properties and to understand the utility of a stromal-myeloid coculture system to study these interactions in the context of cirrhosis. (pklab.org)
There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)
Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes. (wanfangdata.com.cn)
Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. (wanfangdata.com.cn)
Mesenchymal stem/stromal cells (MSC) transfected with stromal derived factor 1 (SDF-1) for therapeutic neovascularization: enhancement of cell recruitment and entrapment. (wanfangdata.com.cn)

They are valuable cells because they directly precede endothelial cells, but have characteristics of stem cells. (wikipedia.org)

Some research found that progenitor cells were mobile and that these progenitor cells could move through the body and migrate towards the tissue where they are needed. (wikipedia.org)
We provide a comprehensive immune cell landscape and characterize cell-state changes from normal tissue to NB. (pklab.org)
The levels of catalase (CAT) and glutathione (GSH) were measured in PC12 cells and Drosophila brain tissue. (sdbonline.org)
GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)

They are often classed as stem cells due to their high plasticity and potential for unlimited capacity for self-renewal. (wikipedia.org)
We used conjugated polymers to develop a novel neural stem cell culture substrate with anchored growth factors to promote cell self-renewal. (5dok.org)

Intro Satellite cells are the cells specific stem cells in the adult skeletal muscle mass. (healthyguide.info)

More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. (biomedcentral.com)
Second, we assessed if BNN-20 can boost the outcome of mouse neural progenitor cell intranigral transplantations in weaver mice, at late stages of degeneration. (referencecitationanalysis.com)
While much is known about biochemical signaling, many of the mechanisms that drive cell outcome in response to biophysical influences remain to be uncovered. (5dok.org)

Single-cell RNA sequencing (scRNA-seq) has the potential to investigate both genetic and nongenetic sources of tumor heterogeneity in a single assay. (pklab.org)
Here, we perform single-cell RNA sequencing (scRNA-seq) on 19 human NB samples coupled with multiplex immunohistochemistry, survival analysis, and comparison with normal fetal adrenal gland data. (pklab.org)

These MSC influences can range from relatively rare activities that require cell contact, such as mitochondrial transfer and cell fusion, to relatively common paracrine MSC actions through extracellular microvesicles or secreted factors. (biomedcentral.com)
Cells sense and respond to the mechanics of their substrate - be it the extracellular matrix, neighboring cells or artificial matrix in cell culture. (5dok.org)

One such alternative cell fate is the adipogenic fate as Pax7(+) satellite cells isolated from solitary myofibers used adipogenic fate in addition ARHGAP1 to muscle mass fate significance of these factors we used a mouse fracture healing model inside a genetically altered reporter mouse where muscle mass progenitors were lineage-traced. (healthyguide.info)

We found that in the descendents of muscle mass progenitors that contributed to cartilage formation Nkx3.2 and Sox9 were strongly induced while Pax3 manifestation was strongly repressed. (healthyguide.info)

However, a major unresolved question is how each cell regulates the precise number of its motile cilia during differentiation. (elifesciences.org)
This signaling pathway is a highly conserved cell-to-cell communication system that regulates cell fate in development and disease. (5dok.org)

Single-cell transcriptomic analysis of tumor cells from the primary tumors reveals a distinct transcriptional signature that is predictive of metastatic potential and patient survival. (pklab.org)
Several different cell types demonstrate a survival benefit. (pklab.org)

Interleukin-3 induces hepatocyte-specific metabolic activity in bone marrow-derived liver stem cells. (wanfangdata.com.cn)

Adult mesenchymal stem cells (MSCs) represent a subject of intense experimental and biomedical interest. (biomedcentral.com)

We have therefore investigated the role of matrix stiffness in Notch signaling in breast cancer cells. (5dok.org)

Cells constantly receive and translate physical cues into biological messages, which in turn dictate cell shape, state and function. (5dok.org)

There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
There his work focused on transcriptional control of hematopoietic stem cell maturation and cell fate. (ubc.ca)

Online interactive versions and downloadable versions of the analysed scRNA-seq datasets, as well as scRNA-seq transcript × cell count tables can be accessed at https://tinyurl.com/DiazPourquie2019 , as follows. (nature.com)

Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4. (wanfangdata.com.cn)

Research on cancer biology focuses on the impact of progenitor cells on cancer responses, and the way that these cells tie into the immune response. (wikipedia.org)
Recent studies have shown that haematopoietic progenitor cells contribute to immune responses in the body. (wikipedia.org)
Blast cells are involved in generation of B- and T-lymphocytes, which participate in immune responses. (wikipedia.org)
Understanding the complete immune cell composition of human neuroblastoma (NB) is crucial for the development of immunotherapeutics. (pklab.org)

Finally we found that in an mouse model of fracture healing where muscle mass progenitor cells were lineage-traced Nkx3.2 and Sox9 are significantly upregulated while Pax3 is significantly downregulated in the muscle mass progenitor cells that give rise to chondrocytes during fracture restoration. (healthyguide.info)

Background & aims: Myeloid cells are key regulators of cirrhosis, a major cause of mortality worldwide. (pklab.org)
Differentiation of hepatocytoid cell induced from whole-bone-marrow method isolated rat myeloid mesenchymal stem cells [J].2006,(30). (wanfangdata.com.cn)

While acknowledging progress in the other areas mentioned, this work will focus on the current debates concerning sourcing, MSC alterations of angiogenesis, cell differentiation/stimulation, and strategies to improve MSC differentiation. (biomedcentral.com)
Secondly, they can improve our understanding of the adjustments that occur during disease progression which, in turn, might uncover reasons for corresponding alterations occurring in cell mechanics [10, 11]. (globaltechbiz.com)

Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
The cell membrane is really a viscous fluid-like matter which includes several lipids, cholesterol, and inserted proteins. (globaltechbiz.com)

Hepatocytic differentiation of mesenchymal stem cells in cocultures with fetal liver cells [J].2006,(15). (wanfangdata.com.cn)

The unit can offer higher-throughput systems than typical technologies such as for example atomic drive microscopy and micropipette aspiration [5] and will be used like a comparative tool between different subpopulations of cells. (globaltechbiz.com)

Finally, our preliminary data suggest that the ESC-ovarian tumor model has human tumor vascular cells. (nih.gov)
Tumor vascular cells are critical for the growth of tumor stem cells, which reside within the vascular niche. (nih.gov)

Upon injury or when challenged with a variety of mechanical or biochemical stimuli satellite cells re-enter the cell cycle and give rise to Talniflumate differentiated myocytes which form new muscle mass materials or fuse with existing materials and contribute to muscle mass growth and restoration [1]. (healthyguide.info)

An in silico cell-to-cell interaction analysis highlights the CXCL9/CXCL10-CXCR3 axis and the CD70-CD27 axis as potential therapeutic targets. (pklab.org)
We envision that the proposed model will allow to study in silico numerous problems related to the cell biomechanics in flows. (globaltechbiz.com)

We hypothesize that ovarian cancer cells will induce human ovarian TVM expression. (nih.gov)
Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice. (wanfangdata.com.cn)
Mature human red blood cell (RBC) is perhaps among the simplest cells to model, lacking nucleus and internal cytoskeleton. (globaltechbiz.com)

He performed some of the first studies to identify transcription factors that regulate the gene expression and differentiation of eosinophils, which are known to play a major role in allergic and asthmatic responses. (ubc.ca)

The characterization or the defining principle of progenitor cells, in order to separate them from others, is based on the different cell markers rather than their morphological appearance. (wikipedia.org)

Current research on progenitor cells focuses on two different applications: regenerative medicine and cancer biology. (wikipedia.org)
The most prominent example is the changes in cell biology and morphology when it evolves from a healthy to a cancerous state [1, 3]. (globaltechbiz.com)

T cell homing to tumors detected by 3D-coordinated positron emission tomography and magnetic resonance imaging. (mdc-berlin.de)

The kind of potency they have depends on the type of their "parent" stem cell and also on their niche. (wikipedia.org)

In the beginning satellite cells were considered to Talniflumate be unipotent stem cells with the ability of generating a unique specialized phenotype the skeletal muscle mass cells. (healthyguide.info)
Plasticity of cultured mesenchymal stem cells: switch from nestin-positive to excitable neuron-like phenotype. (wanfangdata.com.cn)

Our results demonstrate that a cell-intrinsic surface area-dependent mechanism controls centriole and cilia abundance in multiciliated cells. (elifesciences.org)
Our findings demonstrate that acquisition of MEK inhibitor resistance often occurs through gene amplification and can be suppressed by impeding cell cycle entry in drug. (babraham.ac.uk)

The dynamics of RACK1 levels in isolated adult SC of mice, i.e., progressively high during differentiation and low compared to proliferating conditions, and RACK1 silencing indicated that RACK1 promotes both the formation of myotubes and the accretion of nascent myotubes. (sdbonline.org)

Because of this alternative use of MSCs, Caplan and Sorell [ 14 ] suggested a renaming of MSCs to medicinal signaling cells to suggest a new era of MSC clinical relevance due to their immunomodulatory properties. (biomedcentral.com)

dGLYAT was found to regulate Gadd45 -mediated JNK pathway activation and cell invasion. (sdbonline.org)

This study aims to understand the function and mechanism of Drosophila Glycine N-acyltransferase (GLYAT) in cell invasion. (sdbonline.org)

Anatomy70

Organisms14

Diseases6

Chemicals and Drugs75

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes53

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science5

Health Care1

Vitro5

Myogenic3

Induced pluripotent2

Mesenchymal stem2

Chondrogenic3

Cord Blood Stem Cells2

Proliferation3

Neurons3

Migration8

Embryonic3

Transient1

Monocyte1

CD731

Differentiate5

Umbilical1

Assays1

Molecular3

Hematopoietic stem2

Cellular6

Microenvironment6

Stromal7

Endothelial cells1

Tissue4

Self-renewal2

Adult skeletal muscle1

Outcome3

Single-cell RNA2

Extracellular2

Adipogenic1

Cartilage1

Regulates2

Survival2

Metabolic1

Biomedical1

Notch1

Biological1

Maturation2

ScRNA-seq1

Engraftment1

Immune4

Fracture1

Myeloid2

Alterations2

Proteins2

Fetal1

Subpopulations1

Vascular2

Stimuli1

Silico2

Human3

Transcription factors1

Characterization1

Biology2

Tumors1

Niche1

Phenotype2

Demonstrate2

Mice1

MSCs1

Pathway1

Mechanism1