• Inhibition of long noncoding RNA BLACAT1 protects anesthesia-induced neural cytotoxicity in human induced pluripotent stem cells derived neurons. (stembook.org)
  • also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS chains in neurite growth of CNS neurons in vitro from inhibition to activation. (archives-ouvertes.fr)
  • Interestingly, inhibition of these neurons paradoxically enhanced learning about neutral sensory information, regardless of prior experience, suggesting that LH GABAergic neurons normally oppose learning about irrelevant information. (nature.com)
  • Fig. 1: Inhibition of LH GABAergic neurons by infusion of a Cre-dependent AAV carrying NpHR into the LH of GAD-Cre rats. (nature.com)
  • Neural stem cells (NSCs) are multipotent cells that have the capacity for self-renewal and for differentiation into the major cell types of the nervous system, i.e. neurons, astrocytes and oligodendrocytes. (rug.nl)
  • We find that the inhibition of a specific histone deacetylase, Sirtuin 1 (SIRT1), enhances refinement of SCPN subtype molecular identity by both mES-derived cortical-like neurons and primary dissociated E12.5 mouse cortical neurons. (plos.org)
  • Together, these data indicate that SIRT1 has neuronal subtype-specific expression in the mouse cortex in vivo , and that its inhibition enhances subtype-specific differentiation of highly clinically relevant SCPN / CSN cortical neurons in vitro . (plos.org)
  • However, the most common neural point process models, the Poisson process and the gamma renewal process, do not capture interactions and correlations that are critical to modeling populations of neurons. (princeton.edu)
  • Applied to neural spike recordings from the rat hippocampus, we see that the model captures inhibitory relationships, a dichotomy of classes of neurons, and a periodic modulation by the theta rhythm known to be present in the data. (princeton.edu)
  • Motor pattern selection from a multifunctional neural network often results from direct synaptic and modulatory actions of different projection neurons onto neural network components. (jneurosci.org)
  • This inhibition does not occur within the STG, but instead results from MPN-mediated inhibition of two previously identified projection neurons within the commissural ganglia. (jneurosci.org)
  • To investigate this, UCSF graduate student Elma Frias, PhD, began to explore how the ISR and its inhibition affected neurons in the parietal cortex, a brain region involved in working memory. (eurekalert.org)
  • Neurogenesis is the process by which nervous system cells, the neurons , are produced by neural stem cells (NSCs). (wikipedia.org)
  • brain and spinal cord ) is derived from the neural tube , which contains NSCs that will later generate neurons . (wikipedia.org)
  • Neurons do not immediately form neural circuits through the growth of axons and dendrites. (wikipedia.org)
  • Instead, newborn neurons must first migrate long distances to their final destinations, maturing and finally generating neural circuitry. (wikipedia.org)
  • Both regions contain glycinergic and GABAergic neurons, and rhythmically active neurons in these regions receive appropriately coordinated phasic inhibition necessary for generation of the normal three-phase respiratory pattern. (eneuro.org)
  • The first section of the wave signifies a down state, which is an inhibition period in which the neurons in the neocortex are silent. (alchetron.com)
  • We derive a mathematical model explaining how this counterintuitive phenomenon may occur, showing that a population of independent, completely asynchronous neurons may produce narrowband oscillations if each neuron fires quasi-periodically, without requiring any intrinsic oscillatory cells or feedback inhibition. (nebraska.edu)
  • While impairments in response inhibition are central to executive dysfunction in schizophrenia, the nature and development of such impairments in children with 22q11.2DS, a group at high risk for the disorder, are not clear. (frontiersin.org)
  • Here we used a classic Go/No-Go paradigm to quantify proactive (anticipatory stopping) and reactive (actual stopping) response inhibition in 47 children with 22q11.2DS and 36 typically developing (TD) children, all ages 7-14. (frontiersin.org)
  • A cross-sectional design was used to examine age-related associations with response inhibition. (frontiersin.org)
  • When compared with TD individuals, children with 22q11.2DS demonstrated typical proactive response inhibition at all ages. (frontiersin.org)
  • By contrast, reactive response inhibition was impaired in children with 22q11.2DS relative to TD children. (frontiersin.org)
  • While older age predicted better reactive response inhibition in TD children, there was no age-related association with reactive response inhibition in children with 22q11.2DS. (frontiersin.org)
  • The results of this cross-sectional analysis suggest an impaired developmental trajectory of reactive response inhibition in some children with 22q11.2DS that might be related to atypical development of neuroanatomical systems underlying this cognitive process. (frontiersin.org)
  • An integral factor in successful cognitive control is response inhibition, which supports the suppression of a prepotent response that might be irrelevant or inappropriate in a given context. (frontiersin.org)
  • Evidence suggests that response inhibition improves throughout child development and into adulthood ( 2 - 4 ), likely due to the development of supporting neural architecture ( 5 , 6 ). (frontiersin.org)
  • Additionally, response inhibition is often impaired in individuals with developmental disabilities or psychopathology ( 7 ). (frontiersin.org)
  • Individuals with schizophrenia perform more poorly on response inhibition tasks when compared to healthy controls ( 8 , 9 ), and it is believed that aberrant response inhibition might contribute to some of the general neuropsychological impairments seen in the disorder. (frontiersin.org)
  • Response inhibition, a component of inhibitory control defined as the ability to suppress a prepotent motor response, has not been well characterized in children with 22q11.2DS. (frontiersin.org)
  • Previous lesion and neuroimaging studies have shown that the frontal lobes, especially the (right) inferior frontal gyrus and the anterior cingulate gyrus, play an important role in response inhibition. (bmj.com)
  • Cooper and colleagues, 7 for example, showed that patients with Parkinson's disease (PD) made more errors in a no-go condition than controls, thus indicating a response inhibition deficit in these patients. (bmj.com)
  • 5 Converging evidence for the involvement of the basal ganglia (especially the striatum) in response inhibition comes from animal research. (bmj.com)
  • Taken together, the findings from the reported studies provide evidence for the critical role of the basal ganglia in response inhibition. (bmj.com)
  • However, the role of the basal ganglia in response inhibition has not been studied as intensively as the involvement of the frontal lobe. (bmj.com)
  • Therefore, the present study was intended to replicate and extend the previous finding of a response inhibition deficit in patients with basal ganglia lesions. (bmj.com)
  • Dopamine transporter genotype predicts behavioural and neural measures of response inhibition. (cdc.gov)
  • Together, this suggests that the strategic deployment of proactive inhibitory motor control is implemented by upregulating the tonic inhibition of the motor system, signified by increased sensorimotor β-bursting both before and after signals to initiate a movement. (nsf.gov)
  • The neural circuit can shift from one regime to the other by a simple modulation of the synaptic strength of the inhibitory feedforward pathway present in the circuit, which, in the electrosensory circuit used as example, is known to present long-term synaptic plasticity mechanisms. (biomedcentral.com)
  • Our work illustrates how subtractive, divisive and non-monotonic gain control may be obtained in inhibitory feedforward neural circuits. (biomedcentral.com)
  • With respect to inhibitory control, impairments have been demonstrated in children with 22q11.2DS on tasks requiring interference control ( 25 ) and oculomotor inhibition ( 27 ). (frontiersin.org)
  • The stop signal task is based on a formal mathematical theory and its particular strength is that it provides a way of measuring inhibition controlling for concurrent differences in the speed and/or variability of responding on the go task which do not reflect core inhibitory control. (bmj.com)
  • The action mechanism of EOs in both periods was determined by autobiographic method evaluating the inhibitory potential on the acetylcholinesterase enzyme, indicating greater inhibition of the EO enzyme during dormancy (0.039 mg mL-1) when compared to the EO during budding (0.156 mg mL-1). (bvsalud.org)
  • The rabies virus neutralizing antibody titres were estimated by RFFIT (Rapid Fluorescent Focus Inhibition Test) on day 0, 14, 30 and 90 days. (who.int)
  • all serum was frozen and analyzed concurrently in 1989 for rabies neutralizing antibody by the rapid fluorescent focus inhibition test (4). (cdc.gov)
  • Several gain control behaviors have been found to be particularly relevant for the gating and transformation of information in neural circuits. (biomedcentral.com)
  • These experiments suggest that prior experience shapes the neural circuits recruited for future learning in a highly specific manner, reopening the neural boundaries we have drawn for learning of particular types of information from work in naïve subjects. (nature.com)
  • He suggests that these inert cells might represent ancient neural circuits that have since become obsolete. (discovermagazine.com)
  • This is hypothesized to produce long-term potentiation and possible induction of neuroplasticity within neural circuits. (psychiatrictimes.com)
  • Defining functional roles of postsynaptic inhibition in respiratory and other mammalian central pattern generation circuits is a longstanding problem. (eneuro.org)
  • Snoek, J , Adams, RP & Zemel, RS 2013, ' A determinantal point process latent variable model for inhibition in neural spiking data ', Advances in Neural Information Processing Systems . (princeton.edu)
  • The importance of serotoninergic terminals in the nucleus accumbens for latent inhibition is discussed, along with the mechanism of their interaction with the dopaminergic system during the formation of this effect. (semanticscholar.org)
  • D-Amphetamine delayed tone habituation data are consistent with electrophysiological and neurochemical data demonstrating the role of nucleus accumbens dopamine in novelty processing, and the relevance of the data to latent inhibition is discussed. (semanticscholar.org)
  • The role of dopamine in conditioning and latent inhibition: What, when, where and how? (semanticscholar.org)
  • Haloperidol potentiation of latent inhibition in rats: evidence for a critical role at conditioning rather than pre-exposure. (semanticscholar.org)
  • Latent inhibition: A neural network approach. (bvsalud.org)
  • Previously, we demonstrated a conceptual and computational plastic neural oscillator model for the mechanisms of tinnitus generation and the clinical effects of sound therapy on tinnitus. (actapress.com)
  • However, the cellular mechanisms by which ISR inhibition restored cognition remained unknown. (eurekalert.org)
  • Understanding the mechanisms by which tDCS affects the neural substrate after stroke and finding ways to optimize tDCS for each patient are key to effective rehabilitation approaches. (hindawi.com)
  • A paper published in Nature on March 31 by Matthew Panichello , a postdoctoral research associate at the Princeton Neuroscience Institute, and Timothy Buschman , an assistant professor of psychology and neuroscience at Princeton, found that attention and working memory share the same neural mechanisms. (princeton.edu)
  • In an area in the visual cortex associated with color recognition and in an area in the parietal lobe associated with visual and spatial analysis, the processes of attending to sensory input and selecting the target color from working memory involved distinct neural mechanisms. (princeton.edu)
  • Separately, both drugs reduce glutamate neural activity, albeit via different mechanisms. (dr-bob.org)
  • D. Amodio , Neural Mechanisms Underlying Prejudice Control. (routledge.com)
  • M. Inzlicht , Stigma Impairs the Neural Mechanisms Underlying Self-control. (routledge.com)
  • We discuss both behavioral and neural mechanisms underlying age-related changes in these executive control processes. (nih.gov)
  • Epigenetic modifications play a key role in regulating gene expression in the cellular differentiation of neural stem cells . (wikipedia.org)
  • Mib1 prevents Notch Cis-inhibition to defer differentiation and preserve neuroepithelial integrity during neural delamination. (ens.fr)
  • Its inhibition in human ES cells results in enhanced spontaneous differentiation. (silverchair.com)
  • She has published research articles and book chapters on the psychological, behavioral, and neural correlates of stigma and social identity threat. (routledge.com)
  • Behavioral and neural threshold data were positively correlated in the high frequency noise exposure group. (cdc.gov)
  • The results were discussed with regard to hair cell loss and implications for behavioral and neural tuning in humans. (cdc.gov)
  • Her research focuses on the behavioral and neural bases of decision-making and their perturbations in diseases states, such as addiction. (sfn.org)
  • However, recent experiments attempting to disrupt glycinergic and GABAergic postsynaptic inhibition in the pre-BötC and BötC in adult rats in vivo have questioned the critical role of synaptic inhibition in these regions, as well as the importance of the BötC, which contradicts previous physiological and pharmacological studies. (eneuro.org)
  • To further evaluate the roles of synaptic inhibition and the BötC, we bilaterally microinjected the GABA A receptor antagonist gabazine and glycinergic receptor antagonist strychnine into the pre-BötC or BötC in anesthetized adult rats in vivo and in perfused in situ brainstem-spinal cord preparations from juvenile rats. (eneuro.org)
  • Studies have reported reductions in prepulse inhibition (PPI) among adults who use marijuana chronically, although no human studies have been conducted during the critical adolescent period. (nih.gov)
  • These outcomes suggest that adolescents who are frequent marijuana users have problems maintaining prepulse inhibition, possibly due to lower quality of information processing or sustained attention, both of may contribute to continued marijuana use as well as attrition from marijuana treatment. (nih.gov)
  • T. Ito, The Neural Correlates of Social Categorization. (routledge.com)
  • While the desire to uncover the neural correlates of consciousness has taken numerous directions, self-face recognition has been a constant in attempts to isolate aspects of self-awareness. (mdpi.com)
  • The control and scaling of the input-output behavior of neural networks, or gain control, is one of the main strategies used by neural systems for the processing and gating of information. (biomedcentral.com)
  • This input-output behavior is often described by the so-called f-I curve, which shows the output firing rate as a function of the input current to the neuron or neural circuit [ 1 ]. (biomedcentral.com)
  • Point processes are popular models of neural spiking behavior as they provide astatistical distribution over temporal sequences of spikes and help to reveal the complexities underlying a series of recorded action potentials. (princeton.edu)
  • Motivation for the simulations is provided in the form of a narrative that places specific aspects of neural system behavior in the context of more general brain function. (oup.com)
  • Importantly, their work also reveals how neural representations of memories are transformed as they direct behavior. (princeton.edu)
  • Identify the advantages and disadvantages of optogenetic techniques compared to other techniques that explore the neural basis of behavior. (sfn.org)
  • After watching this presentation, you should be able to gain a general understanding on what optogenetics offers when exploring neural bases of behavior. (sfn.org)
  • BACKGROUND: Using neural stem cells (NSCs) in cell therapy and regenerative medicine is a growing knowledge. (bvsalud.org)
  • In this study, the protective role of carnosic acid and trehalose against H2O2-induced oxidative stress in autophagy induction and apoptosis inhibition in NSCs was investigated. (bvsalud.org)
  • Our results provide evidence for involvement of the basal ganglia in the inhibition of ongoing responses. (bmj.com)
  • Here, we review recent evidence, suggesting that age-related changes in inhibition, cognitive flexibility, and working memory processes underlie age-related changes in strategic variations during arithmetic problem solving. (nih.gov)
  • GEVI cell-type specific labelling and a manifold learning approach provide evidence for lateral inhibition at the population level in the mouse hippocampal CA1 area. (neurotree.org)
  • The researchers recorded neural activity in the prefrontal cortex, parietal cortex and visual cortex. (princeton.edu)
  • The prefrontal cortex is associated with a variety of executive function processes including attention, working memory, planning and inhibition. (princeton.edu)
  • A study Andarine (GTX-007) IC50 of individuals with severe unilateral ischemic lesions from the prefrontal cortex indicated that inhibition of reflexive saccades depends upon a circumscribed subregion from the human being DLPFC (Ploner et al. (bio-cavagnou.info)
  • We present here (see [ 5 ] for further details) a study of gain control in a feedforward neural circuit inspired by the electrosensory lateral-line lobe of weakly electric fish. (biomedcentral.com)
  • This is achieved partially by lateral inhibition in the retina which compensates for low/high light levels. (herts.ac.uk)
  • Sadegh C, Ebina W, Arvanites AC, Davidow LS, Rubin LL, Macklis JD (2021) Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical subcerebral/corticospinal neuron identity from mouse embryonic stem cells. (plos.org)
  • These early stem cells are called neuroepithelial cells (NEC)s, but soon take on a highly elongated radial morphology and are then known as radial glial cells (RGC)s. [2] RGCs are the primary stem cells of the mammalian CNS, and reside in the embryonic ventricular zone , which lies adjacent to the central fluid-filled cavity ( ventricular system ) of the neural tube . (wikipedia.org)
  • As embryonic development of the mammalian brain unfolds, neural progenitor and stem cells switch from proliferative divisions to differentiative divisions . (wikipedia.org)
  • The expression level at this stage is very high, up to 10-15 μ g/g of wet tissue weight 8 , which might be sufficient to modulate matrix structures 12 that typically inhibit neural plasticity and regeneration. (archives-ouvertes.fr)
  • It is written specifically for students in neuroscience, cognitive science, and related areas who want to learn about neural systems modeling but lack extensive background in mathematics and computer programming. (oup.com)
  • Tom Anastasio has created something that has been needed for a long time--a textbook that makes the relevant aspects of neural networks accessible to neuroscience students, whose mathematics preparation may be limited. (oup.com)
  • A brain's noisiness is a solid proxy for details that are more abstract, Lalwani says: "How efficient information transfer is, how well-connected the neural networks are, in general how well-functioning the underlying neural network is. (wired.com)
  • We combined two-photon calcium imaging with genetic, pharmacological, and single-cell ablation methods to examine the extent to which inhibition 'vetoes' excitation at the level of individual dendrites of direction-selective ganglion cells. (elifesciences.org)
  • Enteric ganglion cells are derived from the neural crest during embryonic development. (medscape.com)
  • 1997. Inhibition of L-aromatic amino acid decarboxylase by polychlorinated biphenyls. (cdc.gov)
  • B. Bartholow , Stereotype Activation and Control of Race Bias: Cognitive Control of Inhibition and its Impairment by Alcohol. (routledge.com)
  • Consistent with the objectives of PAR-19-289 , studies appropriate for the FOA will optimize and evaluate measures of neurophysiological and behavioral processes that may serve as surrogate markers of neural processes of clinical interest based on available knowledge of the neurobiology of mental illnesses. (nih.gov)
  • Glycogen synthase kinase 3 (GSK3) proteins (GSK3α and GSK3β) are key mediators of signaling pathways, with crucial roles in coordinating fundamental biological processes during neural development. (eneuro.org)
  • A neurosphere of neural stem cells in rat embryo spreads out into a single layer of cells. (wikipedia.org)
  • The model is extended to incorporate gain control or divisive normalization, and the modulation of neural spiking based on periodic phenomena. (princeton.edu)
  • Motor pattern selection by MPN therefore results from both a direct modulation of STG network activity and an inhibition of competing pathways. (jneurosci.org)
  • ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities. (bvsalud.org)
  • Differential routing of Mindbomb1 via centriolar satellites regulates asymmetric divisions of neural progenitors. (ens.fr)
  • Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. (cincinnatichildrens.org)
  • Because stop trials include a second, infrequent signal, the stop versus go contrast confounds inhibition with attentional and stimulus processing demands. (nsf.gov)
  • The proposed architecture effectively solves the problem of duplexed learning of inhibition and excitation by replacing recurrent inhibition between pyramidal cells in functional columns of different stimulus selectivity with a plastic disynaptic pathway. (yale.edu)
  • Recent studies indicate that the precise timing and location of excitation and inhibition (E/I) within active dendritic trees can significantly impact neuronal function. (elifesciences.org)
  • Our goal was to see if ISRIB could ameliorate the neural effects of concussion," said Michael Stryker, PhD , a co-senior author of the study and professor of physiology at UCSF. (eurekalert.org)
  • Among the signaling pathways regulated by GSK3s, the Wnt canonical pathway is the most well described, with GSK3β inhibition triggering an increase in β -catenin protein levels and its nuclear translocation to activate target gene expression ( Doble and Woodgett, 2003 ). (eneuro.org)
  • Just by learning new things and playing games that challenge your memory, it will help maintain your brain's ability to make new neural pathways and stay active and fit even as you age. (cognifit.com)
  • As you continue to play these brain training games often, your brain will stay active and actually grow more dendrites and make even more neural pathways. (cognifit.com)
  • We present an electrophysiological model of double bouquet cells (DBCs) and integrate them into an established cortical columnar microcircuit model that implements a BCPNN (Bayesian Confidence Propagation Neural Network) learning rule. (yale.edu)
  • showing that, depending on the nature of the recognition memory judgment, these cortical regions may function within a neural circuit. (jneurosci.org)
  • Hypothesis: Hughlings Jackson and presynaptic inhibition: is there a big picture? (mcmaster.ca)
  • Two tone inhibition was studied using a frequency near the unit's characteristic frequency and one that was approximately 10 to 15dB higher than threshold. (cdc.gov)
  • Two tone inhibition was affected when either tone occurred in a frequency region in which there was a loss of sensitivity. (cdc.gov)
  • 1. CNV: a neural correlate for stutter frequency and compensation strategies? (ecsf.eu)
  • Holt G, Koch C: Shunting inhibition does not have a divisive effect on firing rates. (biomedcentral.com)
  • To address this issue, we took advantage of the retinal direction-selective ganglion cell circuit, where directionally tuned inhibition is known to shape non-directional excitatory signals. (elifesciences.org)
  • Moreover a D2 antagonist reduced the DA-mediated and VTA-stimulation induced inhibition of spontaneous firing in PFC in 89% and 54% of cells respectively. (scholarpedia.org)
  • Stimulation of histone acetyltransferase or inhibition of histone deactylase may be a way to grow taller. (heightquest.com)
  • 12 About 5% of the neurones, which showed task-related activity, were specifically activated in the no-go condition, possibly reflecting a behavioural reaction consisting of the inhibition of movement. (bmj.com)
  • Extrinsic neural afferents to the ENS contain cholinergic and adrenergic fibers. (medscape.com)
  • Moreover, the degree of this burst rate difference indexed the behavioral implementation of proactive inhibition (i.e., the degree of anticipatory response slowing in the stop-signal blocks). (nsf.gov)
  • About a decade ago, scientists first showed the link between low neural signal variability and the kind of cognitive decline that accompanies healthy aging, rather than specific dementias . (wired.com)
  • We also deduce bounds on the degree of variability in neural spike-timing which will permit the emergence of such oscillations, both for action potential- and postsynaptic potential-dominated LFPs. (nebraska.edu)
  • Previous experimental studies have demonstrated the emergence of narrowband local field potential oscillations during epileptic seizures in which the underlying neural activity appears to be completely asynchronous. (nebraska.edu)
  • These results suggest that even an uncoupled network may generate collective rhythms, implying that the breakdown of inhibition and high synaptic input often observed during epileptic seizures may generate narrowband oscillations. (nebraska.edu)
  • The disruption of GSH homeotasis, as evidenced by reduced tissue GSH/GSSG ratios, likely results from cyanate-induced inhibition of glutathione reductase activity. (oregonstate.edu)
  • The results of this study suggest that cyanate neurotoxicity, and perhaps cassava-associated neurodegenerative diseases, are mediated in part by disruption of glutathione homeostasis in neural tissue. (oregonstate.edu)
  • IMSEAR at SEARO: Comparative evaluation of immunogenicity, reactogenecity and safety of purified chick embryo cell rabies vaccine and neural tissue rabies vaccine. (who.int)
  • Although tissue culture (TC) rabies vaccines (e.g., human diploid cell rabies vaccine (HDCV)) are more immunogenic and less likely to cause adverse effects than neural tissue rabies vaccine (NTV), the routine use of TC vaccine is cost-prohibitive in many developing countries. (cdc.gov)
  • Neural Computation (1998) 10 (2): 277-280. (mit.edu)
  • Accordingly, D2 agonists were more effective than D1 agonists in replicating the DA-mediated inhibition of spontaneous firing (Thierry et al, 1998). (scholarpedia.org)
  • The brain's dark matter epitomizes the tangible and highly composite byproduct of the natural evolution, trapped in inactive and invisible state by inhibition. (discovermagazine.com)
  • Pirot et al (1992) showed that the GABA antagonist bicuculline blocked the iontophoretic DA and VTA-mediated inhibition of spontaneous firing in 57% and 51% of cells respectively. (scholarpedia.org)
  • Time-invariant feed-forward inhibition of Purkinje cells in the cerebellar cortex in vivo. (ens.fr)
  • Dissociation of antibody production from disease suppression in the inhibition of allergic encephalomyelitis by myelin basic protein. (jns-journal.com)
  • However, neither SST condition-contrast (stop vs. go, successful vs. failed stop) purely operationalizes inhibition. (nsf.gov)
  • Here, we present an SST variant to address both confounds and evaluate putative neural indices of inhibition with these influences removed. (nsf.gov)
  • Accurate longitudinal evaluations of patients are important to limit serious side effects of these drugs, including osteoporosis, cataracts, and growth inhibition. (elsevier.com)
  • Thanks to continued research, experts now know that a primary cause of Parkinson's is mitochondrial dysfunction, with secondary causes being neural oxidation, neural inflammation, and alpha-synuclein aggregation all causing a toxic overload on surrounding neural cells in the substantia nigra. (wehaveparkinsons.com)
  • Lewis JE, Lindner B, Laliberte B, Groothuis S: Control of neural firing by dynamic parallel fiber feedback: implications for electrosensory reafference suppression. (biomedcentral.com)