Neural crest cells neural cell adhesion molecules. Medical search. Frequent questions

Differentiation-related expression of adhesion molecules and receptors on human neuroblastoma tissues, cell lines and variants. (cellosaurus.org)
The next step in bone formation is differentiation of the cells to chondrocytes or osteoblasts. (edu.au)
In addition, their osteogenic differentiation potential was increased, and genes involved in cell adhesion, FGF-2 signalling, cell cycle, stemness, cell differentiation, and cell proliferation were upregulated, compared to that of the MSCs cultured on uncoated plates. (hindawi.com)
The differentiation of mesenchymal stem cells (MSCs) into multiple cell lineages can be exploited as an attractive strategy for cell-based therapy and regenerative medicine [ 1 ]. (hindawi.com)
The ECM provides structural and biochemical support to the cells and has various other functions including cell adhesion, cell to cell communication, and differentiation [ 17 , 18 ]. (hindawi.com)
CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. (betalifesci.com)
Our research focuses on characterising the stem and progenitor cells that build the hypothalamus and characterising the molecular networks that direct hypothalamic morphogenesis, growth and differentiation. (sheffield.ac.uk)
MiRNAs account for about half of the total RNAs of extracellular vesicles, and play important roles in biological processes such as cell proliferation and differentiation, whereas the functions of macrophage-derived apoVs remain largely unknown. (biomedcentral.com)
Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. (rndsystems.com)
Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of DArgic neurons. (rndsystems.com)
Co-differentiation and Co-maturation of Human Cardio-pulmonary Progenitors and Micro-Tissues from Human Induced Pluripotent Stem Cells. (rndsystems.com)
Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells. (rndsystems.com)
Conclusions: This study showed that an osteoblastic cell lineage may be obtained from human bone marrow derived from adherent cells, and that the presence of the rhBMP-4 seems to have an effect during the first stages of differentiation only. (bvsalud.org)

In fatal disease, LASV immunostaining was most prominent in the anterior uvea, especially in the filtration angle, ciliary body, and iris and in and around vessels in the bulbar conjunctiva and peripheral cornea, where it co-localized with an endothelial marker (platelet endothelial cell adhesion molecule). (cdc.gov)

When neural crest cells stop making N-CAM and N-cadherin, and start displaying integrin receptors, cells separate and migrate. (wikipedia.org)
Several studies have shown that sialo-glycans are critical in monitoring immune surveillance by engaging with cis and trans inhibitory Siglec receptors on immune cells. (bvsalud.org)
By recognizing common sialic acid containing glycans on glycoproteins and glycolipids as regulatory receptors for immune cell signals, Siglecs are expressed on most immune cells and play important roles in normal homeostasis and self-tolerance. (bvsalud.org)
Adhesion molecules, epithelial cell surface receptors and extracellular matrix molecules initiate condensation and set its boundaries. (edu.au)
ECM receptors thus convert both chemical and physical extracellular inputs to determine cell survival, proliferation, migration and tissue-specific gene expression. (biologists.com)
Semaphorins, a family of about 20 secreted, transmembrane and GPI-linked glycoproteins, and their cognate receptors (plexins and neuropilins) play a pivotal role in the crosstalk between cancer and stromal cells present in the tumor microenvironment. (biomedcentral.com)
Moreover, semaphorins and their cognate receptors are involved in controlling cancer stem cell phenotype, contributing to tumor progression, resistance to therapies, and metastasis initiation [ 18 ]. (biomedcentral.com)

The extracellular matrix (ECM) provides structural and biochemical support to the surrounding cells, and it has been used as a coating substrate for cell culture. (hindawi.com)
Combined omics analyses of donor VSMC secretomes and recipient neuron transcriptomes revealed that overlapping pathways of extracellular matrix receptor signaling and adhesion molecule integrin binding mediate VSMC-dependent neuronal development. (biomedcentral.com)
Cytotactin, an extracellular matrix protein of neural and non-neural tissues that mediates glia-neuron interaction. (academicinfluence.com)
Looking through my (rather dusty) volume of Betty Hay's Cell Biology of Extracellular Matrix (2nd edition, 1991), which was one of the last comprehensive books on ECM, it is startling to see how many advances have been made since then. (biologists.com)
Cells are known to bind to individual extracellular matrix glycoproteins in a complex and poorly understood way. (silverchair.com)
Functional analyses indicated that some of the genes induced by dragonfly larvae caused an increase in laminins necessary for cell adhesion in the extracellular matrix. (biomedcentral.com)

Additionally, dendritic cells (DCs) are envisioned as an important component in immunotherapies, especially in cancer research, due to their unique role as professional antigen-presenting cells (APC) and their capacity to trigger adaptive immune responses and generate immunologic memory. (bvsalud.org)
Consequently, removing sialic acid from the cell surface of human DCs induces their maturation, thus increasing the expression of MHC molecules and antigen presentation. (bvsalud.org)

Later in development, NCAM1 (CD56) expression is found on various differentiated tissues and is a major CAM mediating adhesion among neurons and between neurons and muscle. (wikipedia.org)
Normal cells that stain positively for CD56 include NK cells, activated T cells, the brain and cerebellum, and neuroendocrine tissues. (wikipedia.org)
However, MSCs need to be expanded in vitro in order to obtain sufficient cells for clinical trials since they are extremely rare in various tissues. (hindawi.com)
and standard tissues, we've got observed that NB and PCC tissues are extra similar to one another than to every other tumor en tity. (tcr-signal.com)
Through the inspection of gene expression adjustments involving NB, PCC and normal tissues along with other tumors, quite possibly the most characteristic gene expression characteristic of NB PCC is clearly associated towards the noradrenalin biosyn thesis and neural crest cell improvement. (tcr-signal.com)
The scope of the special issue is to summarize and enlarge the knowledge in signalling processes and networks in diverse cells and tissues. (mdpi.com)
The structure and structure-based modulation of ADAM17 are also described for better understanding of the various ADAM17 regulatory pathways in different cell types or tissues. (frontiersin.org)

Mesenchymal stem cells (MSCs) possess great therapeutic potential. (hindawi.com)
Unlike embryonic stem cells, adult stem cells (MSCs) have a limited lifespan and stop proliferating during in vitro culture due to replicative senescence [ 8 ]. (hindawi.com)
In tissue engineering, mesenchymal stem cells (MSCs) are common seed cells because of abundant sources, strong proliferation ability and immunomodulatory function. (biomedcentral.com)
Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells. (rndsystems.com)
Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo. (rndsystems.com)
Stem cells. (bvsalud.org)
Undifferentiated mesenchymal stem cells are pluripotent cells that can differentiate into various phenotypes and are a source of osteogenic Cells 1,2 . (bvsalud.org)
The consistent appearance of t(9;22) in pluripotent hematopoietic stem cells, apart from being the etiological factor for chronic myeloid leukemia (CML), is a clear example of what is considered a non-random chromosome aberration. (bioimagingnorthamerica.org)
In order to highlight the importance of spatial proximity, and evaluate the topological CT changes caused by t(9;22), before and after TKI treatment, we performed 3D-FISH of CT9 and CT22 in stem cells from CML patients followed by super-resolution microscopy, and image 3D reconstruction. (bioimagingnorthamerica.org)
Development: For advances in developmental biology and stem cells. (lu.se)

6 ] In the commonly used epithelial cell line MDCK, cells in a monolayer migrated directionally to the anode in an electric field (EF), whereas isolated cells displayed random migration in an EF of the same strength [ Figure 1 ]. (biomedcentral.com)

This is important because epithelial cells heal wounds via the migration of large sheets of cells with tight intercellular connections. (biomedcentral.com)
The junctions between cells maintain "supracellular" structures and result in collective polarization, intercellular force generation, decision-making and eventually, tissue organization. (biomedcentral.com)
Intercellular communication between vascular and nerve cells mediated by diffusible proteins has recently emerged as a critical intrinsic program for neural development. (biomedcentral.com)
ApoVs are rich in proteins, RNA (microRNAs, mRNAs, ncRNAs, etc.) and lipids, and are a key intercellular communication mediator that can exert different regulatory effects on recipient cells. (biomedcentral.com)
In our research, we use the zebrafish embryo to investigate how intercellular Wnt protein transport is regulated and how signals are subsequently delivered to the target cell in a living vertebrate organism. (exeter.ac.uk)

In cell adhesion, CD56 contributes to cell-cell adhesion or cell-matrix adhesion during embryonic development. (wikipedia.org)
The neural crest contributes to the craniofacial skeleton, with somites and the lateral plate mesoderm forming the axial skeleton and the limbs respectively. (edu.au)
The neural crest (NC) is an embryonic cell population that contributes to key vertebrate-specific features including the craniofacial skeleton and peripheral nervous system. (ox.ac.uk)
It has been postulated that the non-random CT's spatial organization within the cell nucleus contributes to the emergence of chromosome translocations. (bioimagingnorthamerica.org)

Removal of PSA from NCAM by the enzyme endoneuraminidase (EndoN) has been shown to abolish long-term potentiation (LTP) and long-term depression (LTD). The neural cell adhesion molecule NCAM1 appears on early embryonic cells and is important in the formation of cell collectives and their boundaries at sites of morphogenesis. (wikipedia.org)
During embryonic morphogenesis, wound repair and cancer invasion, cells often migrate collectively via tight cell-cell junctions, a process named collective migration. (biomedcentral.com)
In essential physiological processes including morphogenesis, wound healing and tissue regeneration, cells often move as a tightly or loosely associated cohesive group. (biomedcentral.com)
3 ] Lumenal epithelial cells elongate collectively within elongating ducts during branching morphogenesis in the mammary gland. (biomedcentral.com)
Normal neural development begins with appropriate neuronal morphogenesis, during which numerous highly arborized dendrites and long axons are elaborated, thus building the intricate neural circuit network [ 8 ]. (biomedcentral.com)
Here, we showed that the secretomes obtained from primary mouse cerebral vascular SMCs, a human brain SMC cell line, and a human aorta SMC cell line promote neuronal early morphogenesis, functional maturation, and survival in vitro. (biomedcentral.com)
Cell adhesion and the molecular processes of morphogenesis. (academicinfluence.com)

However, since previous studies mostly focused either on developing PNS or on adult CNS synaptic plasticity, the direct effect of vascular cell-secreted proteins on neuritogenesis in the very early stage of neuronal development is not well characterized. (biomedcentral.com)
In particular, it is unknown whether cerebral arteriolar smooth mural cell-secreted proteins act directly on neurons and accelerate neuron maturation at transcriptomic level, neuronal survival, and circuit development. (biomedcentral.com)
Along the way, the evolutionary shuffling of pre-existing and novel protein domains to form tenascins, fibronectin and other matrix proteins coincided with the emergence of neural crest, vasculature and the nervous systems that characterise chordates and advanced vertebrates. (biologists.com)
A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. (lookformedical.com)
ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. (frontiersin.org)
A Disintegrin and Metalloproteases (ADAM), originally named metalloproteinases disintegrin cystein-rich (MDC), are membrane-anchored cell surface proteins containing both disintegrin and metalloproteinase domains. (frontiersin.org)
It is estimated that as much as 10% of the cell surface proteins undergo ectodomain shedding. (frontiersin.org)
The highly conserved family of Wnt proteins represents important regulators of cell behaviour, tissue development and homeostasis by inducing responses in a concentration-dependent manner. (exeter.ac.uk)
We identified a novel way of spreading Wnt proteins in vertebrates: Wnt molecules are mobilized on specific cell protrusions known as cytonemes. (exeter.ac.uk)
These specialized signalling filopodia transmit signal proteins between communicating cells and allow a high degree of control of propagation speed, direction and concentration of the transmitted ligand. (exeter.ac.uk)
Wnt proteins regulate developmental processes, tissue regeneration and stem cell maintenance. (exeter.ac.uk)
These proteins control the dynamics of the actin cytoskeleton and thus represent key regulatory molecules that are active during cell migration ( 12 ). (spandidos-publications.com)
Objective: This study evaluated the osteogenic induction of human bone marrow cells by human recombinant bone morphogenetic protein-4 (rhBMP-4) and proteins released by Saos-2 (human osteosarcoma cell line). (bvsalud.org)
Cells derived from bone marrow can undergo osteoinduction in vitro in the absence of osteoinductive factors such as bone morphogenetic proteins. (bvsalud.org)
Examples include finding proteins indicating cardiac problems or looking for circulating tumour cells that can indicate the spread of cancer. (50webs.com)
Fluorescent proteins enable a wide range of applications where they have functioned as cell lineage tracers, reporters of gene expression, or as a measure of protein-protein interactions. (antibodiesinc.com)

Annual Review of Cell and Developmental Biology (2023) 39 (1): 145. (biologists.com)

This study provides a unique approach to treat in vitro monocyte-derived DCs with sialidase, aimed at generating DC populations with different cell surface sialic acid phenotypes and tailored maturation and co-stimulatory profiles. (bvsalud.org)
Sialic acid, a monosaccharide containing nine carbon atoms, is widely distributed in eukaryotic cells. (bvsalud.org)

One unexpected finding regarding collective cell migration is that being a "multicellular structure" enables cells to better respond to chemical and physical cues, when compared with isolated cells. (biomedcentral.com)
Recent studies discovered that cells of the same type respond differently to the same directional cues when isolated versus when acting as a cohesive group. (biomedcentral.com)
Since the realization that emotions are not exclusively human, understanding the neural circuits involved in processing emotions and other social cues has advanced rapidly through the use of experimental rodent models. (frontiersin.org)
These growing neuronal processes or neurites have an advancing growth cone that finds its appropriate target in the periphery and central nervous system (CNS), using a number of cues including cell adhesion molecules and diffusible neurotrophic factors (see Chapter 48). (pediagenosis.com)

Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing. (academicinfluence.com)

Brain metastases are cancer cells that have spread to the brain from primary tumors in other organs in the body (see the image below). (medscape.com)
Most tumors that metastasize to the brain are not chemosensitive, though small-cell lung cancer, breast cancer, and lymphoma respond to chemotherapy. (medscape.com)
Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. (betalifesci.com)
This observation will not be surprising, as the two NB and PCC are neural crest derived tumors. (tcr-signal.com)

Thus, our method allows visualization of cell-specific sialylation processes for separate classes of membrane constituents. (uni-konstanz.de)
Universal, label-free, single-molecule visualization of DNA origami nanodevices across biological samples using origamiFISH. (antibodiesinc.com)

Ciccarone V., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A. Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages. (cellosaurus.org)

These findings provide a novel paradigm by which N-cadherin regulates angiogenesis, in part, by controlling VE-cadherin expression at the cell membrane. (rupress.org)
However, whether the vascular smooth muscle cell (VSMC) secretome regulates the connectivity of neural circuits remains unknown. (biomedcentral.com)
By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node. (betalifesci.com)
The matrix is essential for early embryonic development and it regulates nearly every facet of cell behaviour. (biologists.com)
Recently, we showed that Wnt8a is transported on short, actin-based filopodia known as cytonemes to contact responding cells and activate signalling during neural plate formation in zebrafish (1).Wnt/ Ror2 signalling regulates the formation of these Wnt cytonemes (5). (exeter.ac.uk)

However, it is now clear that neural progenitor cells can be found in the adult CNS, including in humans. (pediagenosis.com)

1 ] In the zebrafish lateral line primordium, a migrating cluster of approximately two hundred cells migrate, grow, divide and differentiate simultaneously and assemble into a series of connected epithelial rosette-like mechanosensory organs. (biomedcentral.com)

NCAM has been implicated as having a role in cell-cell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory. (wikipedia.org)
For instance, the efficiency of glycosylation along neurite membranes has been characterized as cell health measure in neurotoxicology. (uni-konstanz.de)

NCAM exhibits glycoforms as it can be posttranslationally modified by the addition of polysialic acid (PSA) to the fifth Ig domain, which is thought to abrogate its homophilic binding properties and can lead to reduced cell adhesion important in cell migration and invasion. (wikipedia.org)
The first stage in bone development is migration of preskeletal cells to the correct anatomical location. (edu.au)
During such migration, cells move as coherent groups, large cell sheets, strands or tubes rather than individually. (biomedcentral.com)
In this review, we will briefly introduce the role of collective cell migration in wound healing, regeneration and cancer invasion and discuss its underlying mechanisms as well as implications for wound healing. (biomedcentral.com)
Collective cell migration is now recognized as a hallmark of tissue-remodeling events. (biomedcentral.com)
Indeed, virtually all living tissue is constructed by collective cell migration, which plays an important role in the initial symmetry-breaking and leader-follower organization of cell groups during embryonic development. (biomedcentral.com)
A cell's ECM coat provides the architectural hardware for cell positioning and migration, which is meshed together with intracellular cytoskeletal networks by myriad components of the adhesome. (biologists.com)
Transcriptome analyses identify clusters of co-regulated genes during NC specification and migration that show high conservation across vertebrates but also identify transcription factors (TFs) and cell-adhesion molecules not previously implicated in NC migration. (ox.ac.uk)
During migration in embryos, cells must alter their overall adhesiveness to the substrate to allow locomotion. (silverchair.com)
We developed isogenic cell lines, differing in only the TPM, and leveraged quantitative imaging cytometry and live cell imaging, revealing that the TPMs manifested differences in cell morphology and spatiotemporal variations in monolayer migration. (bioimagingnorthamerica.org)

Several approaches suggest that a large proportion of Sia rather incorporated in non-protein components of cell membranes than into glycoproteins. (uni-konstanz.de)
Different from neurons, most Sia was bound to protein in HepG2 hepatoma cells or in neural crest cells. (uni-konstanz.de)
Inter estingly, we found that BRG1 activated the expression of neural cell adhesion molecule and catenin/ neural plakophilin connected armadillo protein, two genes whose expression is extremely enriched in neural cells. (topoisomerasepathway.com)
Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. (betalifesci.com)
The protein acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. (betalifesci.com)
Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. (academicinfluence.com)
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. (lookformedical.com)
The RhoA activation assay was tested by loading the RhoA protein in cell lysates with either GTPγS or GDP. (cytoskeleton.com)

This is followed by chapters on integrin activation, genetics, and links with TGFβ, as well as adhesion complexes, mechanotransduction, and matrix remodelling. (biologists.com)

CADM1, together with MITF, is essential for development and survival of mast cells in vivo. (betalifesci.com)
Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment. (rndsystems.com)
To address this issue, the expression levels of Snail, RhoA and fibronectin, as well as MMP‑2, were reduced in the breast tumor cell lines MDA‑MB‑231 and MDA‑MB‑435S, and their biological responses were studied in vitro and in vivo. (spandidos-publications.com)

CD56 has been detected on other lymphoid cells, including gamma delta (γδ) Τ cells and activated CD8+ T cells, as well as on dendritic cells. (wikipedia.org)

It is important to understand whether cells acting collectively behave as a simple collection of single cells or have additional properties in terms of movement, guidance, force generation or signal transduction. (biomedcentral.com)
Therefore, the understanding of the diverse signalling molecules, signal recognition mechanisms and signal transduction pathways is fundamental for the insight into physiological and pathophysiological processes. (mdpi.com)

The down-regulation of both VE-cadherin and p120ctn was confirmed in cultured endothelial cells using small interfering RNA to knockdown N-cadherin. (rupress.org)
Cell adhesion molecules in the regulation of animal form and tissue pattern. (academicinfluence.com)
This review focuses on the structure of ADAM17, its signaling in the cardiovascular system and its participation in certain disorders involving the heart, blood vessels, and neural regulation of autonomic and cardiovascular modulation. (frontiersin.org)
An essential component for these developmental processes but also for tissue regeneration and stem cell regulation is the communication of cells by chemical signalling. (exeter.ac.uk)
The present data provide evidence that Snail promotes tumor cell motility and angiogenesis which is mainly mediated through the regulation of RhoA activity. (spandidos-publications.com)

Recombinant LASV-Josiah, based on the sequence of an isolate obtained in 1976 from the serum of a 40-year-old man hospitalized at Songo Hospital in Sebgwena, Sierra Leone ( 21 , 22 ), was rescued in BSR-T7/5 cells and passaged twice in Vero-E6 cells (GenBank accession nos. (cdc.gov)

Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. (wikipedia.org)
Homophilic binding occurs between NCAM molecules on opposing surfaces (trans-) and NCAM molecules on the same surface (cis-)1. (wikipedia.org)
Current models suggest trans- homophilic binding occurs between two NCAM molecules binding antiparallel between all five Ig domains or just IgI and IgII. (wikipedia.org)
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. (betalifesci.com)
Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule. (academicinfluence.com)

Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)

Placzek M & Briscoe J (2018) Sonic hedgehog in vertebrate neural tube development . (sheffield.ac.uk)
Due to the conserved nature of vertebrate cell behaviour, our results will be relevant to Wnt signalling during human embryonic development and could suggest novel vulnerabilities to Wnt-dependent diseases - a prerequisite for the development of novel therapeutics. (exeter.ac.uk)

Recent studies have demonstrated that in addition to the PNS, endothelial cells in the CNS produce semaphorin 3G, which directly acts on neuropilin-2/PlexinA4 in neurons to regulate synaptic structure and plasticity [ 4 ]. (biomedcentral.com)

Hence, the prevailing view is that N-cadherin's primary function in ECs is to promote heterotypic cell interactions with mural cells. (rupress.org)
CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)
Moreover, altered ECM and ECM-cell interactions lie at the root of many diseases, including cancer, diabetes, inflammatory disorders and osteoarthritis. (biologists.com)

Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. (betalifesci.com)

Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes. (academicinfluence.com)

Endothelial cells express two classic cadherins, VE-cadherin and N-cadherin. (rupress.org)
however, the function of N-cadherin in endothelial cells remains poorly understood. (rupress.org)
To investigate the role of N-cadherin in vascular development, N-cadherin was specifically deleted from endothelial cells in mice. (rupress.org)
Loss of N-cadherin in endothelial cells results in embryonic lethality at mid-gestation due to severe vascular defects. (rupress.org)
Endothelial cells in the inner layer and mural smooth muscle cells (SMCs) or mural pericytes in the outer layer constitute the major building blocks for the entire cerebral vasculature, with SMCs enveloping arteries and arterioles and pericytes covering capillaries. (biomedcentral.com)

We also show that N-cadherin is important for endothelial cell proliferation and motility. (rupress.org)
Measured in a cell proliferation assay using BaF mouse pro-B cells transfected with TrkB. (novusbio.com)

Using human dopaminergic neurons as model system, we asked here, whether it was possible to separately label diverse classes of biomolecules and to visualize them selectively on cells. (uni-konstanz.de)
Human Induced Pluripotent Stem Cell-Derived Pericytes as Scalable and Editable Source to Study Direct Lineage Reprogramming Into Induced Neurons. (antibodiesinc.com)

Moreover, BRG1 activated and repressed various cell surface and ECM interacting genes in SK MEL5 cells which have not been recognized as being BRG1 dependent in SW13 cells. (topoisomerasepathway.com)
Interestingly, BRG1 had opposite effects on MMP1 expression in SK MEL5 cells in comparison with SW13 cells So, the necessity for BRG1 in the activation of particular genes would be to a considerable extent cell context dependent. (topoisomerasepathway.com)
Activation of these neural specific genes by BRG1 may perhaps reflect the neural crest derivation of melanoma cells. (topoisomerasepathway.com)
Expression of BRG1 in melanoma cells modulated the expression of a amount of ECM relevant genes which have opposing results on melanoma invasiveness. (topoisomerasepathway.com)
Through the comparison of those seven gene lists, we've got identified 162 genes which were widespread in no less than two gene lists, as an example, CHGB, neural cell adhesion molecule 1, pla cental development factor, PNMT, vascular endothelial development factor. (tcr-signal.com)

In normal control adult mouse eyes, ETS-1 was mostly present in the nuclei of all neuroretinal layers whereas ETS-2 was mostly localized in the cytosol of the cell bodies of these layers with a smaller amount present in the nuclei. (molvis.org)

Members of the ADAM family contribute to various physiological and pathophysiological processes by modulation of molecules like growth factors or cytokines. (frontiersin.org)

Stereotactic radiosurgery is a more preferred treatment modality for radio-resistant lesions such as nonsmall cell lung cancer, renal cell carcinoma, and melanoma. (medscape.com)
Pigment Cell and Melanoma Research is a journal indexed in SJR in Biochemistry, Genetics and Molecular Biology (miscellaneous) and Oncology with an H index of 114. (countryofpapers.com)
Couldpericytic mimicryrepresent another type of melanoma cell plasticity with embryonic properties? (countryofpapers.com)
What is the impact factor of Pigment Cell and Melanoma Research? (countryofpapers.com)
Melanoma cells use distinct techniques for invasion, just about every of which may differ from the degree of dependence about the various molecular regula tors. (topoisomerasepathway.com)
In our research, each a obtain of perform and loss of perform strategy indicated that BRG1 promotes mela noma invasive means, suggesting that substantial levels of BRG1 advertise mechanisms by which melanoma cells invade that do not rely on the induction of all regarded cell surface regulators. (topoisomerasepathway.com)
Our information indicate that BRG1 activates MMP2 expression in melanoma cells by a equivalent mechanism involving co activation of SP1 mediated transcription. (topoisomerasepathway.com)
Many studies reported that some semaphorins are involved in the development of a permissive tumor niche, guiding cell-cell communication and, consequently, the development and progression, as well as the response to therapy, of different cancer histotypes, including melanoma. (biomedcentral.com)
We implemented label-free phase contrast imaging coupled with a generative neural network in combination with supervised machine learning to classify patient-derived melanoma xenografts, validate predictions regarding melanoma cell lines with unknown metastatic efficiency in mouse xenograft models, and use the network to generate in silico cell images that amplify the critical predictive cell properties. (bioimagingnorthamerica.org)

This process requires the tumor cells to penetrate the basement membrane and cross the subendothelial membrane. (medscape.com)
60% of Sia is lipid bound, and thus polysialic acid-neural cell adhesion molecule (PSA-NCAM) cannot be considered the major sialylated membrane component. (uni-konstanz.de)
P-gp belongs to a group of phosphorylated glycoproteins that function in the cell membrane as efflux pumps. (ashpublications.org)
This is associated with an epithelium and basement membrane, which interact with the preskeletal cells, causing them to undergo condensation. (edu.au)
Contrary to previous studies, we found that N-cadherin localizes to endothelial cell-cell junctions in addition to its well-known diffusive membrane expression. (rupress.org)
Although the prosaic view of cells is that they end at the plasma membrane, the cell and its pericellular matrix are actually a continuum in all complex animals. (biologists.com)

To metastasize, tumor cells have to gain access to the circulation, survive while circulating, pass through the microvasculature of the adopted organs, extravasate into the organ parenchyma, and reestablish themselves at the secondary site. (medscape.com)
In addition, it can restore the expression of co-stimulatory molecules and IL-12, resulting in DCs having a higher ability to polarize T-cells toward a Th1 phenotype and specifically activate cytotoxic T-cells to kill tumor cells. (bvsalud.org)
CADM1 may contribute to the less invasive phenotypes of lepidic growth tumor cells. (betalifesci.com)

Cell Reports (2022) 38 (2): 110234. (biologists.com)

RhoA has been implicated in the formation of stress fibers and cell adhesion in fibroblasts. (spandidos-publications.com)

During hematopoiesis, CD56 is the prototypic marker of NK cells, also present on subset of CD4+ T cells and CD8+ T cells. (wikipedia.org)
A subset of Xenopus neural crest (NC) cells respond efficiently to the chemoattractant SDF1, whereas isolated cells barely respond. (biomedcentral.com)

Edelman's Nobel Prize-winning research concerned discovery of the structure of antibody molecules. (academicinfluence.com)

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. (rndsystems.com)

Cell condensation is the process whereby populations of cells gather together and differentiate into a single cell type, be it cartilage, bone, muscle, tendon etc. (edu.au)
Tissue development is a key process for life starting from the earliest embryonic stages during which cells differentiate into later organs composing an entire body. (exeter.ac.uk)

Little is known about molecular mecha- desmosomal glycoproteins, resulting in the nisms affecting mast cell and T lympho- loss of keratinocyte cell-cell adhesion [ 1 ]. (who.int)
Overall strength of adhesion is thought to be mediated by a combinatorial mechanism, involving adhesion of a cell to a variety of binding sites on the target glycoproteins. (silverchair.com)

The skeletal system is primarily mesodermal in origin, with additional input from the neural crest. (edu.au)

Cell adhesion molecules: implications for a molecular histology. (academicinfluence.com)
Figure 4.1: Histology and illustration of compact bone tissue, highlighting cells and layers of ECM. (pressbooks.pub)

A book on such a profoundly important topic requires a clear vision of the breadth of the ECM and its roles in development, cell and tissue function and disease. (biologists.com)
Then, he moved to Stanford University for a postdoctoral fellowship on the role of transcription factor Pbx1, a leukemia proto-oncogene, on B cell development. (stanford.edu)
His work covers various topics, including B cell responses to viral infection and vaccination, human primary immunodeficiency, and biology of lymphocyte development and function and to elucidate etiology of immunological disorders. (stanford.edu)
The first signs of nervous system development occur in the third week of gestation, under the influence of secreted factors from the notochord , with the formation of a neural plate along the dorsal aspect of the embryo. (pediagenosis.com)
One important insight came from the discovery that the increased motility and invasiveness of cancer cells is reminiscent of the epithelial-mesenchymal transition (EMT) that occurs during embryonic development ( 2 ). (spandidos-publications.com)

J Cell Biol (2005) 169 (1): 29-34. (rupress.org)
J Cell Biol (1997) 138 (2): 471-480. (silverchair.com)

however, the interrelationship and functional contribution of the individual cadherins in cell adhesion and signaling is poorly understood. (rupress.org)
5 ] In isolated cells that do not interact with other cells and have unstable cell polarity, the chemoattractant SDF1 is unable to induce a distinct anterior-posterior polarity, and the cells chemotax poorly. (biomedcentral.com)

The research conducted at Sheffield uses a new method, giving the devices a catalytic coating on one side, which creates a chemical reaction when fuel molecules are added, causing the device to move automatically on a pre-determined route, using natural structures as a guide . (50webs.com)

2 ] During oogenesis in D. melanogaster , a tightly packed cluster of border cells migrates together and presents a distinct collective mechanism of polarity and guidance. (biomedcentral.com)

Anatomy61

Organisms18

Diseases8

Chemicals and Drugs97

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes44

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Differentiation13

Platelet endothel1

Receptors7

Extracellular6

Antigen2

Tissues7

Stem cells10

Epithelial cell1

Intercellular5

Contributes4

Morphogenesis7

Proteins16

Developmental Biology1

Sialic acid2

Cues4

Immunoglobulin1

Tumors4

Visualization2

Lineages1

Regulates5

Progenitor cells1

Zebrafish1

Neurite2

Migration10

Protein8

Integrin1

Vivo3

Dendritic cells1

Signal transduction2

Regulation5

Accession1

Homophilic5

Lymphocytes1

Vertebrate2

Regulate1

Interactions3

Mediates1

Membranes1

Endothelial cells5

Proliferation2

Neurons2

Genes5

Adult1

Processes1

Melanoma9

Membrane6

Tumor cells3

20221

Fibroblasts1

Subset2

Antibody1

Tissue regeneration1

Differentiate2

Glycoproteins2

Primarily1

Histology2

Development5

Biol2

Poorly2

Chemical1

Distinct1