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  • antibody
  • The removal of PSA prior to LIRD induced earlier onset of retinal cell death, an effect delayed by the coadministration of endoneuraminidase-N and the p75 NTR function-blocking antibody antiserum. (arvojournals.org)
  • The second western blot is preceded by antibody stripping to allow detection of the second molecule, and is followed by another antibody stripping to perform the protein load control by western blot of a housekeeping protein (GADPH, actin, etc). (innoget.com)
  • hippocampus
  • Existing evidence indicates that 21-days exposure of rats to restraint stress induces dendritic atrophy in pyramidal cells of the hippocampus. (hindawi.com)
  • These results demonstrate that FGL can indeed regulate neuroglial activation and reduce microglial cell density in the aged hippocampus, and support its potential use as a therapeutic agent in age-related brain disorders. (tcd.ie)
  • Expression
  • To screen for cell-surface proteins showing enhanced expression under metabolic stress, we performed a signal sequence trap in combination with a functional cloning method. (ahajournals.org)
  • We screened for cell-surface proteins showing enhanced expression using oligomycin, a mitochondorial inhibitor in H9C2 rat cardiac myoblasts. (ahajournals.org)
  • Furthermore, these finding provide the first clear evidence that life experiences can regulate the expression of polysialylated neural cell adhesion molecule in the amygdaloid complex. (open.ac.uk)
  • The results showed that untrained and trained rats exhibited similar levels of mRNA for these molecules, which supports the view that training did not influence their immediate level of expression. (epfl.ch)
  • roles
  • We studied on physiological roles of several cell adhesion proteins during development and regeneration of the nervous system. (nii.ac.jp)
  • CAMs
  • Differences in the antigenic determinants of N-CAMs from different neural tissues were detected by two independent monoclonal antibodies. (jneurosci.org)
  • These results establish that during development there are definite quantitative and qualitative differences among N- CAMs from various neural tissues. (jneurosci.org)
  • lipid
  • Later Toshio Ito [ 2 ] and Bronfenmajer [ 3 ] observed perisinusoidal cells containing lipid droplets in human livers. (springer.com)
  • role
  • Our data suggest that polysialylated neural cell adhesion molecule in these nuclei may play a prominent role in functional and structural remodeling induced by stress, being a potential mechanism for cognitive and emotional modulation. (open.ac.uk)
  • Cancer
  • Studies of human pancreatic cancer have shown that the mesenchymal cells secrete many of cytokines such as insulin-like growth factor-I (IGF-I) and fibroblast growth factor (FGF), which have an impact on disease prognosis ( Fig. ( 2 ) ). (pubmedcentralcanada.ca)
  • Growth factors that are known to induce PSC activation such as transforming growth factor-h1 (TGF-h1), platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) are secreted by pancreatic cancer cells [ 5 , 6 ]. (pubmedcentralcanada.ca)
  • Additionally, it has been shown that cancer cells can also secrete the ECM metalloproteinase inducer (EMMPRIN) [ 4 ]. (pubmedcentralcanada.ca)
  • matrix metalloproteinase 2 has been associated with the invasive phenotype of pancreatic cancer cell lines [ 7 ]. (pubmedcentralcanada.ca)
  • PSCs can also act on pancreatic cancer cells, which affect their biological behavior. (pubmedcentralcanada.ca)
  • stellate cells
  • The hepatic stellate cells (HSCs) localize at the space of Disse in the liver and have multiple functions. (springer.com)
  • The hepatic stellate cells (also referred to as Ito cell, fat-storing cell, lipocyte, perisinusoidal cell, parasinusoidal cell) are one of the key nonparenchymal components in the sinusoid compartment with multiple functions in the liver. (springer.com)
  • tissues
  • While conversion from the E to the A forms of N-CAM occurred mainly during the first 3 postnatal weeks in mice, the relative conversion rates were distinctly different in various neural tissues. (jneurosci.org)
  • Finally, in some adult neural tissues, one of the three A forms was found to be dominant. (jneurosci.org)
  • In this review we will examine the current information on human HSCs, including the methodologies for HSC isolation, primary cultures of human HSCs, human liver tissues, as well as established human HSC cell lines. (springer.com)
  • tissue
  • Tissue distribution analysis showed that Necl-1 was specifically expressed in the neural tissue. (uniprot.org)
  • These results indicate that Necl-1 is a neural-tissue-specific Ca2+-independent immunoglobulin-like cell-cell adhesion molecule which potentially has membrane-associated guanylate kinase subfamily member-binding activity and localizes at the non-junctional cell-cell contact sites. (uniprot.org)
  • Dendritic Spine
  • In addition, there appeared to be a reduction in excitatory synapses, as revealed by synaptophysin staining and apical dendritic spine density of cortical pyramidal cells. (duke.edu)
  • human
  • In this review, we focus on the current information on human HSCs isolation methods, human HSCs markers, and established human HSC cell lines. (springer.com)