Networks transcription genetic. Medical search. Frequent questions

Transcription Factors, Gene Regulatory Networks, and Agronomic Traits. (routledge.com)
These transcription factors turn the forming tooth to become and incisor. (wikipedia.org)
Our data reveal the differential expression landscape of 493 transcription factors and 682 lncRNAs and highlight specific expression clusters operating in HSCs. (lu.se)
[ 4 ] The Hox genes, well described as the master regulators of development, encode a set of transcription factors that specify the identity of particular segments during embryogenesis. (medscape.com)
This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. (nih.gov)
Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. (nih.gov)
Although the majority of expression quantitative trait loci (eQTLs) for the gene expression traits in the two environments are shared and have similar effects, analysis of the environment-specific eQTLs reveals enrichment of binding sites for two transcription factors. (nature.com)
In addition to environmental factors, phenotypes can also respond to genetic perturbations in a plastic or homeostatic manner, which characterizes the potential of an organism to express phenotypes when genes mutate. (nature.com)
Importantly, the state of plasticity or homeostasis, with respect to either genetic or environmental variation, is not necessarily static and can be modified by both genetic and environmental factors. (nature.com)
Biochemical studies suggest that in one case this transcription factors to implement particular genetic programs. (lu.se)
In occurs through the inhibition of DNA binding of cognate cis- hematopoiesis there exist several lineage branch points with regulatory motif while in the other case DNA binding is unaffected identified key transcription factors and external signals [3-5]. (lu.se)
The regulatory code is read by proteins called transcription factors that bind to short stretches of DNA called motifs. (tum.de)
We focus on novel combinatorial codes for transcription factors as nuclear effectors of major signaling pathways, including Wnt and FGF/MEK signaling. (uibk.ac.at)
The genetic regulatory network consisting of the Oct4, Nanog, and TET transcription factors (TF's) is understood to control cell fate, specifically the transitions between somatic and pluripotent states. (aps.org)
Implementing large scale studies across different populations could substantially enhance efforts to uncover the role of genetic factors in various diseases. (cdc.gov)
New studies will need to focus on enhancers and transcription factors, as well as genetic regulatory networks, and how changes in these networks can impact health and disease. (cdc.gov)
To determine whether the extensive rewiring comes from changes in cis-regulatory modules, the upstream and downstream regulators of two conserved transcription factors, YAB2/SH1 and MYB26, will be characterized in the genetically tractable species Setaria and Brachypodium, with a combination of mutant analysis, RNA-seq, DAP-seq and bioinformatics. (usda.gov)
Additionally, scATAC-seq allows to map the binding of transcription factors (TF) and infer cell-specific regulatory networks. (uni-heidelberg.de)
B) Histone marking on the regulatory region of EC master transcription factors was switched following the order, (1) release the brake mark and then (2) enter the acceleration mark. (medicalxpress.com)
Schematic representation of the genetic regulatory network linking four transcription factors and EC differentiation. (medicalxpress.com)
Transcription factors SOX and FLI1, both important for endothelial differentiation, were induced between 12 and 24 hours. (medicalxpress.com)
Furthermore, an examination of the histone code revealed that the regulatory genomic region of the transcription factors (ETS/GATA/SOX) was found to have gradually switched from a "brake histone mark," which suppresses transcription, to an "accelerator histone mark," which activates transcription, while in the process of differentiating into the vascular endothelium. (medicalxpress.com)
It regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. (thermofisher.com)
Tzahor and his student, Itamar Harel began looking for the answer in transcription factors -- the proteins that initially control genetic activity. (scienceblogs.com)
After identifying a number of relevant transcription factors, Tzahor, Harel and their collaborators around the world spent months developing and testing knockout mice that would reveal, in detail, the functions of these regulatory proteins in the development of the heart and face progenitors. (scienceblogs.com)
Even more challenging was the creation of double-knock out embryos, missing two of the transcription factors. (scienceblogs.com)
Their ultimate finding was that the transcription factors form a network. (scienceblogs.com)
When two transcriptions factors were lacking, the network's outputs collapse, but with only one missing, others apparently stepped in to pick up some of the slack, resulting in a few "slip-ups," but more or less complete hearts and facial muscles. (scienceblogs.com)
They found that knockouts of specific transcription factors that were not previously linked to Digeorge were tied to distinctive combinations of facial muscle and cardiac defects resemble the congenital defects in babies. (scienceblogs.com)
Transcriptional control mechanisms influence these genetic networks and some success has been attained by manipulating the action of transcription factors toward a more favorable therapeutic profile. (eurekaselect.com)
A common feature of these cis-regulatory modules is the presence of multiple binding sites for multiple transcription factors. (sdbonline.org)
By using published DNA binding specificity data for five transcription factors active in the early Drosophila embryo, genomic regions containing unusually high concentrations of predicted binding sites were identified for these factors. (sdbonline.org)
The transcription factors Bicoid (Bcd), Caudal (Cad), Hunchback (Hb), Krüppel (Kr), and Knirps (Kni) act at very early stages of Drosophila development to define the anterior-posterior axis of the embryo. (sdbonline.org)
Such epigenetic rewiring processes can be artificially managed and even reversed by using a defined set of transcription factors. (ibecbarcelona.eu)
However, the identification of key transcription factors for lineage reprogramming is limited, due to the exhaustive and expensive experimental processes. (ibecbarcelona.eu)
Accumulating knowledge of genetic and epigenetic regulatory networks that are critical for defining a specific lineage provides unprecedented opportunities to model and predict pioneering factors that may drive directional lineage reprogramming to obtain the desired cell type. (ibecbarcelona.eu)
Different regulatory mechanisms can control microRNA expression at a genetic or epigenetic level as well as involve the biogenesis machinery or the recruitment of specific transcription factors. (nih.gov)
We hypothesize that a key to understanding tumorigenesis driven by these genetic alterations is identification of the transcription factors responsible for the observed oncogenic transcriptional changes. (elsevierpure.com)
We subsequently use the inferred transcriptional network to perform master regulator analyses nominating transcription factors predicted to control oncogenic transcription in specific PPGL molecular subtypes. (elsevierpure.com)
Results: A small number of master regulator transcription factors are predicted to drive the observed subtype-specific gene expression patterns in SDH loss and MAML3 translocation-positive PPGL. (elsevierpure.com)
Conclusions: The unbiased analyses presented here nominate specific transcription factors that are likely drivers of oncogenic transcription in PPGL tumors. (elsevierpure.com)
Other genes involved in rare cases of Coffin-Siris syndrome also provide instructions for making proteins that act as transcription factors. (medlineplus.gov)
Next, the importance of embryonic developmental genes such as homeobox and T-box transcription factors are highlighted in conduction system development and function. (medscape.com)
There are a myriad of mutations identified in genes encoding cardiac transcription factors, ion channels, gap junctions, energy metabolism regulators, lamins and other structural proteins. (medscape.com)

Genetic variance in expression increases at 18 °C relative to 25 °C for most genes that have a change in genetic variance. (nature.com)
Genes with higher network connectivity are under stronger stabilizing selection, suggesting that stabilizing selection on expression plays an important role in promoting network robustness. (nature.com)
We develop a computational model for the hematopoietic erythroid-myeloid lineage decision, which is determined by a genetic switch involving the genes PU.1 and GATA-1. (lu.se)
Their neural network trained on high-resolution maps of protein-DNA interactions uncovers subtle DNA sequence patterns throughout the genome, thus providing a deeper understanding of how these sequences are organized to regulate genes. (tum.de)
Stem cell treatments, such as those affecting the states of the network of pluripotency genes, are expected to play a central role in future personalized medicine. (aps.org)
In the classical view, the steady states of a dynamical system modeling the genes, mRNAs, and proteins in this network are identified with the above two types of states. (aps.org)
These domestication traits likely consisted of a few major genes controlling dramatic changes in crop physiology, as is suggested by genetic studies comparing maize to its ancestor teosinte (Doebley et al. (springer.com)
The AZ of three distantly related grass species (weedy rice, Brachypodium, and Setaria) is controlled by distinct sets of genes, suggesting rewiring of the underlying genetic network. (usda.gov)
Representative activated (red) or repressed (blue) genes by each transcription factor are shown in the box. (medicalxpress.com)
At 48 hours, after differentiation into vascular endothelium was determined, a system of transcription was established in which genes unique to vascular endothelial differentiation were induced. (medicalxpress.com)
Genes can be selectively switched on or off in different parts of the organism, and the regulation structure is a complex dynamic network itself mediated by genes and proteins. (york.ac.uk)
This trick is seen again and again: there are a few 'tool kit' genes that do their stuff, but the details of what they actually do depends on where they are expressed, and that expression is affected by the regulatory network. (york.ac.uk)
Amazingly, the tool kit genes have been preserved virtually unchanged over many million years of evolutionary history (creatures as diverse as arthropods and vertebrates have many homologous tool kit genes): what has evolved is mainly the switching network. (york.ac.uk)
Similarly to correlation network analysis, it provides ways to plot and cluster genes according to their co-expression pattern with other genes, effectively helping the study of gene interactions, becoming a new tool to identify cell-identity markers. (sns.it)
The protein produced from this gene acts as a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
A complex network of interacting genes regulates embryonic melanocyte development. (medscape.com)

As a way to demonstrate the utility of cell-free TX-TL, we illustrate the characterization of two genetic networks: an RNA transcriptional cascade and a protein regulated incoherent feed-forward loop. (biorxiv.org)
In this context, the Forkhead transcription factor, Foxo3, amplified GATA-1-mediated transcriptional activation. (nih.gov)
The lab's focus is transcriptional regulatory network inference, modeling gene expression as a function of transcription factor activities, from gene expression and measurements of chromatin state. (cincinnatichildrens.org)
Thus, we have used ATAC-seq with RNA-seq to enable de novo inference of transcriptional regulatory networks in physiological settings where sample material is limiting (e.g., intestinal immune cells in response to microbial/genetic perturbations). (cincinnatichildrens.org)
We are also developing methods to enable transcriptional regulatory network inference in very rare cell populations, as measured from single-cell RNA-seq experiments. (cincinnatichildrens.org)
B) When AHL presents and binds to transcriptional regulator, the transcription regulator binds its DNA binding site, thus to reduce the accessibility of RNA polymerase to promoter, repressing the transcription initiation. (igem.org)
Methods: We leverage publicly-available human tumor gene expression profiling experiments (N = 179) to reconstruct a PPGL tumor-specific transcriptional network. (elsevierpure.com)
Their mutagenic potential and gene regulatory effect have shaped the evolution of transcriptional networks involved in development, pluripotency, and inflammation. (lu.se)
We found that the regulation of TE transcription during brain development is essential for the establishment of long-term transcriptional repression carried to adulthood (Paper I and IV). (lu.se)

Many of the proteins expressed act in this network to control the expression of other proteins, rather than directly form building blocks of the organism's body. (york.ac.uk)
Some of these proteins activate transcription, some repress it. (york.ac.uk)
When AHL represents and binds to luxR proteins, luxR will bind to its DNA binding site, the lux box, thus to reduce the accessibility of RNA polymerases to this promoter, repressing the transcription initiation. (igem.org)

At present, the genomic and genetic information available in the public domain for this crop are scanty, which hinders an understanding of its growth and development and genetic improvement. (oregonstate.edu)
Greater availability of African genomes will improve our understanding of the role of genomic variation in genetic diseases and common complex diseases in all populations. (cdc.gov)
As he has pioneered for many years, the University of Chicago geneticist reports with new veracity, backed by over 200 references, upon a whole scale reconception of genomic phenomena in complementary terms of its dynamic, network, and communicative propensities. (naturalgenesis.net)
These molecular genetic discoveries, plus a consideration of how mobile DNA rearrangements increase the efficiency of generating functional genomic novelties, make it possible to formulate a 21st century view of interactive evolutionary processes. (naturalgenesis.net)
Transposable elements (TEs) are mobile genetic sequences that comprise around 50% of our genomic DNA. (lu.se)

Regulation of the Later Stages of Nodulation Stimulated by IPD3/CYCLOPS Transcription Factor and Cytokinin in Pea Pisum sativum L. (biologists.com)
Change in genetic variation across environments is one of the many forms of genotype by environment interaction (G×E). G×E can be interpreted equivalently either as variable genetic architecture across environments or as variable environmental plasticity across genotypes, depending on what factor is chosen as the context. (nature.com)
The key was to perform transcription factor-DNA binding experiments and computational modeling at the highest possible resolution, down to the level of individual DNA bases. (tum.de)
Dynamically and epigenetically coordinated gata/ets/sox transcription factor expression is indispensable for endothelial cell differentiation. (medicalxpress.com)
Furthermore, they found that a transcription factor group essential for blood vessel differentiation (ETS/GATA/SOX) has a previously unknown role. (medicalxpress.com)
Previously, in the region that controls the function of the transcription factor that promotes differentiation from ES cells to a specific cell type, bivalent modifications of histones such as the accelerator and brake histone marks for transcription were thought to have coexisted. (medicalxpress.com)
From endocrine-mimics that modulate nuclear receptor driven gene expression to indirectly altering homeostatic regulation of lipoprotein metabolism, transcription factor pharmacotherapy is a current reality and will increasingly contribute to the treatment of human disease. (eurekaselect.com)
Chromatin accessibility measurements by ATAC-seq, together with transcription-factor DNA-binding preferences (motifs), can be used to broadly profile potential transcription factor binding events in relatively small populations of cells. (cincinnatichildrens.org)
The maize homeobox gene knotted1 ( kn1 ) encodes an AP2/ERF transcription factor (Hake et al. (springer.com)
The synthetic biology platform is able to express transcription factor combinations that reprogram human iPSCs into highly defined and mature human cell types. (ddw-online.com)
Recently, the expansion of high-quality reference genomes and chromatin profiling techniques have opened up direct and comparative accounting of transcription factor (TF) binding locations that could modulate proximal or distal gene expression. (usda.gov)
The second strongest association was for the transcription factor IRX1 . (medscape.com)

Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in gene expression changed in a population of fully sequenced inbred Drosophila melanogaster strains when flies developed in different environments (25 °C and 18 °C). We find a substantial fraction of the transcriptome exhibited genotype by environment interaction, implicating environmentally plastic genetic architecture of gene expression. (nature.com)
To gain insight this study quantitatively investigated synaptic growth and connectivity in the Drosophila nociceptive network during larval development. (sdbonline.org)

One challenge is to infer network structure by identifying subgroups of related vertices, which in the biological domain may be inferred to have similar functions. (biomedcentral.com)
Due to the low efficiency of scRNA-seq methodologies, sensitive computational approaches are critical to accurately infer transcription profiles in a cell population. (sns.it)

More so, our results show that the epigenetic regulation of TE transcription is dynamically regulated throughout life (Paper II), upon the beginning of neuroinflammation (Paper III), and in a disease-driving polymorphic TE insertion (Paper IV). (lu.se)
My research questions have explored different aspects of transposable elements, including their transcription and epigenetic regulation. (lu.se)

In a population of genetically diverse individuals, the extent of genetic variation of a phenotype measures the overall sensitivity of individuals to mutations segregating in the population. (nature.com)
The dynamics of genetic variation (variance across different genotypes) and environmental variation (variance across different environments) may be controlled by different mechanisms. (nature.com)
This work brings together genetic epidemiology with scRNA-seq to uncover drivers of inter-individual variation in the immune system. (iscb.org)
An interesting focus is on the importance of photoperiodic flowering and dormancy in switchgrass and the relevance of these traits to N recycling and genetic variation that contributes to these dynamics. (frontiersin.org)
Collectively, these discoveries set the stage for thinking of genomes as hierarchically integrated systems capable of biologically controlled change rather than as collections of autonomous genetic units subject to individual evolution by random variation. (naturalgenesis.net)
More so, TEs are a rich source of genetic variation, which makes them an intriguing research avenue to investigate humanspecific traits, including their impact on human brain evolution and their relevance in disease. (lu.se)

However, the slow process of in vivo characterization of network function often limits the timescale of the testing step. (biorxiv.org)
High-Throughput Approaches for Characterization and Efficient Use of Plant Genetic Resources. (routledge.com)

The effects of a maize knotted1 ( kn1) gene under the control of the cauliflower mosaic virus 35S promoter on genetic transformation efficiencies of six citrus genotypes were tested. (springer.com)

To this end, our lab's major focus is reverse-engineering the underlying logic of immune cells (molecular networks that drive cellular responses) from high-dimensional molecular measurements of immune cells in action (sensing and responding to perturbations, disease conditions, etc. (cincinnatichildrens.org)

So, as new evolutionary optima have been set by environmental changes (e.g., domestication, management practices, biotic or abiotic pressures) or major shifts in genetic background, plant breeders have selected better-adapted genotypes while pursuing faster genetic gains through technological innovations and scientific breakthroughs. (springer.com)
With all six genotypes of citrus tested including Eureka lemon, a cultivar difficult to be transformed, our results demonstrate that the kn1 gene may provide an effective molecular tool to enhance genetic transformation efficiencies of various citrus varieties. (springer.com)

It is involved in the regulation of transcription. (thermofisher.com)

Upon gastrulation, the transcription of BMP4 is limited to the ventrolateral marginal zone due to inhibition from the dorsalizing side of the developing embryo. (wikipedia.org)
Satou, Y. (2020): Gata is ubiquitously required for the earliest zygotic gene transcription in the ascidian embryo. (uibk.ac.at)
p134] four critical ideas about animal development---the modularity of animal architecture, the genetic tool kit for building animals, the geography of the embryo, and the genetic switches that determine the coordinates of tool kit gene action in the embryo. (york.ac.uk)

It has been subject of many evolutionary studies within the group, due to its considerable ability to successfully occupy a wide range of environments and also because of its great genetic variability expressed by different markers. (scielo.br)
Our results indicate that the D. willistoni 17A2 strain is a candidate for hypermutability, which presents considerable cryptic genetic variability. (scielo.br)

However, practical and predictable implementations have proved challenging because of the complexity of synthesis and analysis of complex biomolecular networks. (nature.com)
Complex genetic networks control hematopoietic stem cell differentiation into progenitors that give rise to billions of erythrocytes daily. (nih.gov)
Now, an interdisciplinary team of biologists and computational researchers from the Technical University of Munich, the Stowers Institute for Medical Research and the Stanford University has shown that applying neural networks, such as those used for facial recognition, together with newly developed model interpretation techniques can be used to decipher complex instructions encoded in DNA. (tum.de)
It can be anticipated that the absence of feedback mechanisms in Boolean or Non-Boolean gene networks is definitely a major hurdle towards complex behaivor for synthetic microbial consortia. (igem.org)
This is important for the understanding of human brain evolution as well as diseases with complex networks where transposable elements may play a regulatory role. (lu.se)
The heart achieves the coordinated contraction of the atrial and ventricular chambers due to the precise timing of the cardiac conduction system (CCS), a specialized complex and heterogeneous network of cells that initiate and allow propagation of action potentials through the heart. (medscape.com)

CtBP, by contrast, suppresses canonical cluster and transposon transcription, which interferes with downstream non-canonical transcription and piRNA production. (umassmed.edu)

VDPVs are polioviruses whose genetic divergence from the parental OPV strains indicates prolonged replication or circulation ( 3 ). (cdc.gov)

CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. (thermofisher.com)
The Network consists of 12 laboratories in a 3-tiered structure: national laboratories, environmental surveillance laboratories, and intratypic differentiation laboratories. (who.int)

Identifying non-coding regions that control gene expression has become an essential aspect of understanding gene regulatory networks that can play a role in crop improvements such as crop manipulation, stress response, and plant evolution. (usda.gov)
While a full complement of open chromatin, epigenetic, and TF-binding experiments provide information for likely candidate regulatory regions, using TF-binding approaches such as ChIP-seq or DAP-seq can provide additional valuable insight and targets for reverse genetic approaches such as EMS-induced or natural SNP variant screens or CRISPR editing techniques (e.g. promoter bashing). (usda.gov)

A web-based survey on various symptoms of computer vision syndrome and the genetic understanding based on a multi-trait genome-wide association study. (nih.gov)
The life history and genome complexities exhibited by the Miscanthus species in question dictate that genome wide association studies are a necessary approach toward the genetic dissection of these traits. (frontiersin.org)
Genome System Architecture and Natural Genetic Engineering. (naturalgenesis.net)
In a contribution to the total rethinking of the nature of gene and genome, the old Mendelian version is supplanted by malleable information processing systems capable of nonrandom change guided by dynamic cellular networks. (naturalgenesis.net)
At the beginning of the 21st century, molecular cell biology has revealed a dense structure of information-processing networks that use the genome as an interactive read-write memory system rather than an organism blueprint. (naturalgenesis.net)
The natural genetic engineering functions that mediate genome restructuring are activated by multiple stimuli, in particular by events similar to those found in the DNA record: microbial infection and interspecific hybridization leading to the formation of allotetraploids. (naturalgenesis.net)

This includes the prospects of developing detailed molecular genetic and biochemical models of pathways relevant to biomass conversion efficiency. (frontiersin.org)

However, OPV use, particularly in areas with low routine vaccination coverage, is associated with the emergence of genetically divergent vaccine-derived polioviruses (VDPVs) whose genetic drift from the parental OPV strains indicates prolonged replication or circulation ( 3 ). (cdc.gov)
Genetic data analysis of polioviruses detected from sewage runoff can also show how viruses are related to each other, helping eradicators map their paths of transmission and determine the scope of the vaccination response, if appropriate. (who.int)

To determine if the disparate early regulatory networks converge on a conserved late stage set of genetic interactions, transcriptomic, enzymatic, and cell wall changes will be evaluated right before and after abscission. (usda.gov)
Network clustering is a valuable approach for summarizing the structure in large networks, for predicting unobserved interactions, and for predicting functional annotations. (biomedcentral.com)
Surprisingly, link prediction based on joint clustering of physical and genetic interactions performs worse than predictions based on individual data sets, suggesting a lack of synergy in current high-throughput data. (biomedcentral.com)

Because these approaches will rely on novel data types such as DNA sequences and high-throughput phenotyping images, Breeding 4 will call for analyses that are complementary to traditional quantitative genetic studies, being based on machine learning techniques which make efficient use of sequence and image data. (springer.com)
however, genetic linkage analyses in 2 of these families implied linkage of the piebald phenotype to KIT . (medscape.com)

Using a network reconstruction algorithm, we predict that known chloroplast gene expression regulators are differentially involved across those developmental stages. (biomedcentral.com)

These AML-iPSCs retain genetic fidelity and produce transplantable hematopoietic cells with hallmark phenotypic leukemic features. (bvsalud.org)

Registration of 252 sequenced sorghum mutants as a community reverse genetic resource. (usda.gov)

Here, I dissected inter- and intra-tumor heterogeneity in patients with different genetic aberrations representing major subgroups in AML, namely MLL fusions, IDH mutated, and FLT3-ITD rearranged AMLs. (uni-heidelberg.de)
In our lab, we are interested in studying the relationship between evolution and human disease, exploring everything from early brain development, including the evolution of the human brain itself, to the consequences of inflammatory states and different genetic disorders. (lu.se)

In summary, this work unveils a SETBP1 function that directly affects gene transcription and clarifies the mechanism operating in myeloid malignancies and in the Schinzel-Giedion syndrome caused by SETBP1 mutations. (nih.gov)

First, the indirect repression would lead to the propagation of metabolic burden and noise through networks comparing with direct repression. (igem.org)

Between 2020 and 2021, the polio programme expanded its environmental surveillance network in the Region, particularly in Afghanistan, Egypt, Somalia and Sudan. (who.int)

Cuff promotes Rhino and Deadlock localization, driving non-canonical transcription. (umassmed.edu)

To this end, this article briefly discusses numerous important processes in head and neck embryology, namely the implications of patterning in hindbrain development, the diverse roles of neural crest cells, migration of the neural crest cells into the branchial arches (particularly the hyoid arch), and the genetic control of these processes. (medscape.com)
To unravel fundamental genetic mechanisms that control cell fate choice in vivo , we study embryonic development in a simple marine invertebrate, the ascidian Ciona intestinalis , belonging to the vertebrate sister group, the tunicates. (uibk.ac.at)
We show that the first phase of plastid development begins with organelle proliferation, which extends well beyond cell proliferation, and continues with the establishment and then the build-up of the plastid genetic machinery. (biomedcentral.com)

Cell-free transcription-translation (TX-TL) systems offer a simple and fast alternative to performing these characterizations in cells. (biorxiv.org)
Here we provide an overview of a cell-free TX-TL system that utilizes the native Escherichia coli TX-TL machinery, thereby allowing a large repertoire of parts and networks to be characterized. (biorxiv.org)
We implement the controller in an Escherichia coli cell-free transcription-translation system, which allows rapid prototyping and implementation. (nature.com)
Hematopoietic stem cell lineage choices are decided by genetic networks that are turned ON/OFF in a switch-like manner. (lu.se)
This classic example of a possible dual-purpose crop can also be improved through breeding and genetic engineering of cell wall properties to further optimize biofuel production. (frontiersin.org)
This project addresses both the tempo and mode of change in the network controlling the abscission zone (AZ) in plants, a specialized cell layer that permits plants to drop seeds, fruits, petals or leaves. (usda.gov)
Molecular cell biology has uncovered sophisticated networks in all organisms. (naturalgenesis.net)
Using opti-ox, "we can edit and insert genetic information without disturbing the function of the cell," Kotter says. (ddw-online.com)
The reprogramming of human acute myeloid leukemia (AML) cells into induced pluripotent stem cell (iPSC) lines could provide new faithful genetic models of AML, but is currently hindered by low success rates and uncertainty about whether iPSC-derived cells resemble their primary counterparts. (bvsalud.org)

A central goal of synthetic biology is to engineer cellular behavior by engineering synthetic gene networks for a variety of biotechnology and medical applications. (biorxiv.org)
Such a cognitive component is absent from conventional evolutionary theory because 19th and 20th century evolutionists were not sufficiently knowledgeable about cellular response and control networks. (naturalgenesis.net)

Rhino binds to Deadlock, which recruits TRF2 to promote non-canonical transcription of these loci. (umassmed.edu)

The authors discuss yield potential, biomass quality and genetic improvement of dual-purpose food and energy cultivars and dedicated energy cultivars through plant breeding and also highlight several research needs. (frontiersin.org)

A new algorithm, Hierarchical Agglomerative Clustering (HAC), is developed for fast clustering of heterogeneous interaction networks. (biomedcentral.com)

Finally, although genotype by environment interaction in gene expression could potentially disrupt genetic networks, the co-expression networks are highly conserved across environments. (nature.com)
Here, we present data revealing the genetic network associated with ACVRL1 (the gene encoding for ALK1) expression in human cancer tissues. (lu.se)

Additionally, MAML3 translocation has recently been identified as a genetic alteration in PPGL, but is poorly understood. (elsevierpure.com)

Anatomy18

Organisms8

Chemicals and Drugs111

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes87

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Information Science12

Health Care2

Factors44

Genes16

Transcriptional9

Proteins3

Genomic5

Factor12

Drosophila2

Infer2

Epigenetic regulation2

Variation6

Characterization2

Maize1

Perturbations1

Genotypes2

Regulation1

Embryo3

Variability2

Complex6

Suppresses1

Divergence1

Differentiation2

Regions2

Genome6

Pathways1

Polioviruses2

Interactions3

Analyses2

Regulators1

Phenotypic1

Reverse genetic1

Different genetic2

Gene transcription1

Repression1

20211

Promotes1

Development3

Cell9

Cellular2

Binds1

Cultivars1

Heterogeneous1

Expression2

Alteration1