• Studies have shown that radial glia in the SGZ express nestin and Sox2, biomarkers associated with neural stem cells, and that isolated radial glia can generate new neurons in vitro. (wikipedia.org)
  • Actively Proliferating Cells or Transit Amplifying Progenitors (Type C): express Nestin, and form clusters interspaced among chains throughout region The SVZ is a known site of neurogenesis and self-renewing neurons in the adult brain, serving as such due to the interacting cell types, extracellular molecules, and localized epigenetic regulation promoting such cellular proliferation. (wikipedia.org)
  • Generation of a NESTIN-EGFP reporter human induced pluripotent stem cell line, KSCBi005-A-1, using CRISPR/Cas9 nuclease. (bioportfolio.com)
  • Here, we introduced an EGFP reporter into the C-terminus of NESTIN in KSCBi005-A hiPSCs through homologous recombination using CRISPR/Cas9 nuclease. (bioportfolio.com)
  • Nestin-positive cells within pancreatic islets express neither the hormones insulin, glucagon, somatostatin, or pancreatic polypeptide nor the markers of vascular endothelium or neurons, such as collagen IV and galanin. (diabetesjournals.org)
  • On histological sections of untreated control kidneys, Nestin-immunoreactivity was detected in all glomeruli and in very few interstitial cells. (egms.de)
  • Seven genes encode for the heavy (NF-H), medium (NF-M) and light neurofilament (NF-L) proteins, nestin and α-internexin in nerve cells, synemin α and desmuslin/synemin β (two alternative transcripts of the DMN gene) in muscle cells, and syncoilin (also in muscle cells). (wikipedia.org)
  • After subcloning the human nestin gene into plasmid vectors, Dahlstrand et al. (wikipedia.org)
  • Putative initiation and stop codons for the human nestin gene were found at the same positions as in the rat gene, in regions where overall similarity was very high. (wikipedia.org)
  • Nestin is also expressed in non-neural stem cell populations such as pancreatic islet progenitors and hematopoietic progenitors. (esibio.com)
  • Here, we test the hypothesis, that Nestin is over-expressed in renal allografts during the development of chronic nephropathy. (egms.de)
  • In adult eye, Nestin is present in the optic nerve but also transiently expressed in the midembryonic mouse heart. (miltenyibiotec.com)
  • Nestin is of high molecular weight (240kDa) with a terminus greater than 500 residues (compared to cytokeratins and lamins with termini less than 50 residues). (wikipedia.org)
  • In summary, Nestin was strongly associated with germline BRCA1 related breast cancer, a basal-like phenotype, reduced survival, and stemness characteristics. (antibodies-online.com)