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  • Encephalitis
  • Prototypic examples are anti- N-methyl-D-aspartate receptor (NMDAR) encephalitis which is induced by an immune response against the NMDAR expressed on neurons or neuromyelitis optica (NMO) in which the disease is induced by antibodies directed against aquaporin-4 expressed on astrocytes. (frontiersin.org)
  • neurons
  • They found that the response in blood and in skin was the same in 60% of cases.The researchers then generated pluripotent stem cells from fibroblasts of both a VPA responder and a non-responder, and differentiated them into GABAergic neurons (neurons that produce the amino acid GABA, the chief neurotransmitter in the mammalian nervous system). (medindia.net)
  • These specific functions modulate neuronal networks, acting both on resident (neurons, astrocytes, and microglia) as well as circulating immune system cells and the extracellular matrix. (mdpi.com)
  • multiple sclerosis
  • Researchers at UC Davis have identified previously unrecognized properties of a naturally occurring protein, finding that it enhances brain cell formation and survival and helps regenerate the protective covering around nerve cells, making it a "strong candidate" for drug development for people with diseases such as multiple sclerosis. (ucdavis.edu)
  • Multiple sclerosis is one of several disease conditions brought about by demyelination, or damage to the protective sheath around nerve cells. (ucdavis.edu)
  • endocrine
  • Paraneoplastic syndromes can also affect other organ systems including hormone (endocrine), skin (dermatologic), blood (hematologic) and joints (rheumatologic). (drugs.com)
  • disorder
  • Plasma noradrenaline (norepinephrine) is elevated in cirrhosis patients with ascites, indicating the participation of the sympathetic nervous system in the disorder. (greenmedinfo.com)
  • Decreased power of the lower limb muscles, decreased range of motion, and pain can all contribute to gait disorder due to aging and orthopedic disease. (hindawi.com)
  • Causes of gait disorder with CNS disease likewise include decreased power of the lower limb muscles and decreased range of motion, along with effects on the locomotion center. (hindawi.com)
  • drugs
  • In addition, the lack of endogenous repair mechanisms almost certainly contributes to the widespread failure of many potential therapeutic agents hitherto trialed in degenerative CNS diseases, and the consequent paucity of effective disease modifying drugs currently available. (springer.com)
  • therapy
  • Given the increased rates of these diseases, finding a suitable preventive therapy is very important," noted Morshedi, adding that the study conducted by the Iranian researchers is therefore of a great significance. (bignewsnetwork.com)
  • That makes PEDF a strong drug-therapy candidate, because it appears to encourage the regeneration of a type of brain cell called oligodendocyte and is able to repair the damage caused by demyelinative diseases, including MS. (ucdavis.edu)
  • This study will examine how HIV affects the brain and nervous system, learning, and behavior in children on highly active antiretroviral therapy (HAART). (clinicaltrials.gov)
  • Highly active antiretroviral therapy (HAART) has altered the natural history of HIV disease in children. (clinicaltrials.gov)
  • pathways
  • The application of stem cell therapeutics in CNS disease has the potential to address all three pathways and generated understandable excitement in the neuroscience community. (springer.com)
  • approaches
  • In treating disease, therapeutic approaches can employ a wide range of targets, but, broadly, these fall into either a cessation of a pathological process, an enhancement of a protective mechanism, or regeneration of damaged tissue. (springer.com)
  • people
  • For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. (greenmedinfo.com)
  • The World Health Organization has predicted that the number of people with diseases of the nervous system will grow three times over the next thirty years given the world's ageing population. (bignewsnetwork.com)
  • This fear is not completely unfounded-several studies, including a recent one by Italian researchers about the 2010-2011 vaccine-have found that getting a flu shot can indeed very slightly elevate one's risk of contracting the disease, by about one additional case per million people. (motherjones.com)
  • brain
  • MindSoothe, a natural herbal remedy, contains a selection of herbs known for their calming and supportive function in maintaining brain and nervous system health, emotional balance and overall wellbeing. (health-cares.net)
  • This is inflammation affecting a region of the brain known as the limbic system, which controls emotions, behaviors and certain memory functions. (drugs.com)
  • To explore the clinical features (neurological and psychiatric exams, neuropsychological evaluation, and neuroimaging), viral and neuroinflammatory factors, anatomic changes (brain MRI) and patterns of brain metabolites (1H-MRS) associated with HIV-related CNS disease in HIV-infected children in the HAART era. (clinicaltrials.gov)
  • Journal
  • This month's journal club covers three papers dealing with stem cells as therapeutic interventions in CNS disease. (springer.com)
  • cells
  • There are many more examples in which it has become clear that a specific adaptive immune response mediated by T or/and B cells is leading to CNS disease. (frontiersin.org)