• These materials could be useful for covering electrodes used for treating movement disorders like Parkinson's because they are well accepted by tissue, while the implants being used today become less effective over time because of scar tissue. (phys.org)
  • Doctors don't know what causes MS, just that it occurs when the protective insulation, called myelin, that coats nerve fibers is gradually destroyed, leaving behind tough scar tissue. (dailyherald.com)
  • The researchers discovered that annexin A2 links with another protein called vascular endothelial cadherin (VEC) and two enzymes, endothelial-specific protein tyrosine phosphatase and Src homology phosphatase-2, that help remove the phosphates and keep the gates closed. (healthcanal.com)
  • For that, we investigated the changes of CaM, CaMKII, protein kinase C (PKC) and polymerization ratios (PRs) of NF-L, NF-M and NF-H in cerebral cortex (CC, including total cortex and some gray), spinal cord (SC) and sciatic nerve (SN) of rats treated with HD at a dosage of 1.75 or 3.50 mmol/kg for 8 weeks (five times per week). (eurekamag.com)
  • An experiment conducted on rats demonstrates that a course of therapy combining the stimulation of nerve fiber growth with drugs and motor training can be successful. (medicalxpress.com)
  • On the one hand, the treatment of rats after a stroke involves specific immune therapy, where so-called Nogo proteins are blocked with antibodies. (medicalxpress.com)
  • All the rats received antibody treatment first to boost nerve-fiber growth and - either at the same time or only afterwards - motor training. (medicalxpress.com)
  • An example would include, for example, the generation of myelin which insulates and protects nerves. (wikipedia.org)
  • Prion protein triggers are an important factor in the signals that ensure myelin maintenance and are distinct from those that direct myelination. (wikipedia.org)
  • The result indicated that neuronal expression and regulated proteolysis of prion protein are essential for myelin maintenance. (wikipedia.org)
  • In addition to relatively fast inhibition by ionotropic receptors, GABA can modulate many signal transduction pathways by activating metabotropic G protein coupled GABA B receptors that play critical roles in long-term modulation of synaptic transmission ( Bowery 1993 ). (physiology.org)
  • The fusion protein contained most of the preS sequences, including the hepatocyte receptor, and part of the S sequence including the 'a' determinant, and was expressed from multiple genomic copies (MIRY) using the constitutive PCK promoter. (tudelft.nl)
  • Erythropoietin (EPO) is a renal cytokine that is primarily involved in hematopoiesis while also playing a role in non-hematopoietic tissues expressing the EPO-receptor (EPOR). (frontiersin.org)
  • This allows the DES to attach itself to a mutated receptor and signal tissue growth during training. (burrillandco.com)
  • The noggin protein regulates the activity of certain BMPs by attaching to them and blocking them from binding to the receptor, which leads to a decrease in BMP signaling. (medlineplus.gov)
  • The cellular events associated with sympathetic activation of BAT thermogenesis are the binding of norepinephrine (NE) released from sympathetic nerve terminal to β-adrenergic receptor, the activation of adenylate cyclase, and increased hydrolysis of triglyceride. (diabetesjournals.org)
  • Neuronal apoptosis inhibitory protein (NAIP) belongs to the family of proteins called the inhibiter of apoptosis family (IAP), these proteins are one of the key regulators of apoptosis. (wikipedia.org)
  • The semaphorins are a family of proteins that are involved in signaling. (cancerindex.org)
  • These homologous endopeptidases belong to the large family of proteins called caspases (cysteine-dependent aspartate-specific protease). (hindawi.com)
  • Blocking this increase prevents nerve injury-induced methylation of the voltage-dependent potassium (Kv) channel subunit Kcna2 promoter region and rescues Kcna2 expression in the injured DRG and attenuates neuropathic pain. (nature.com)
  • These are typically calcium-binding proteins. (wikipedia.org)
  • The interaction between NAIP and hippocalcin, a neuronal calcium-sensor protein, has been observed to take place in the zinc-binding region along with other specific amino acids. (wikipedia.org)
  • Hippocalcin is a neuronal calcium-sensor protein which has two to three regions that can bind with calcium ions. (wikipedia.org)
  • Neurogranin (NG) is a brain-specific protein kinase C substrate involved in the regulation of calcium signaling and neuronal plasticity. (nih.gov)
  • Calcium-dependent mechanisms, particularly those mediated by Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII), have been implicated in neurotoxicant-induced neuropathy. (eurekamag.com)
  • Tissue sections on slides were analyzed for the presence of calcium salts using von Kossa staining. (cdc.gov)
  • In contrast, an 80-kDa protein is the primary substrate for calcium/phospholipid-dependent protein kinase , and its phosphorylation is inhibited by agents that elevate cyclic AMP levels and thereby activate cyclic AMP-dependent protein kinase . (curehunter.com)
  • Swine rations are generally based on a ground cereal grain as a carbohydrate source, soybean meal as a protein source, minerals like calcium and phosphorus are added, and vitamins. (wikipedia.org)
  • In addition to being an excellent fiber source (mostly insoluble, which creates bulk for stool), chia is a rich plant-based source of Omega-3 fatty acids, consists of about 20 percent protein, and contains high levels of antioxidants, calcium, magnesium and iron. (chicagotribune.com)
  • Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant inherited disorders, and carriers are at greatly increased risk of developing malignant peripheral nerve sheath tumours (MPNST). (uio.no)
  • Neurofibrillary tangles are another hallmark characteristic of the brain tissue associated with Alzheimer's disease. (news-medical.net)
  • Both are thought to interfere with the nervous messages within the brain tissue. (news-medical.net)
  • As Creutzfeldt-Jakob disease progresses, vacuolization increases and brain tissue becomes spongy. (sciencephoto.com)
  • Once in the brain tissue, there was a higher risk of developing brain or nerve diseases, such as Alzheimer's, Parkinson's or multiple sclerosis. (theregister.co.uk)
  • Viruses and bacteria can damage nerve tissue, usually sensory fibres, leading to a painful neuropathy. (amazonaws.com)
  • Multiplanar movement patterns challenge the tissue to control a load (e.g., a limb and the weight it's lifting) as it moves through space, which signals more information into the afferent (sensory) nerves. (acefitness.org)
  • For individuals with Alzheimer's disease, there is a larger number of phosphate molecules bound to the tau protein than normal, known as hyperphosphorylation. (news-medical.net)
  • Due to their central role in the regulation of apoptosis, the antiapoptotic BCL2-proteins are highly promising targets for the development of novel anticancer treatments. (hindawi.com)
  • Analysis of the levels of these proteins might be clinically useful in predicting responses to taxanes, but none have proven to be specific targets for increasing the efficacy of taxane-based therapy in breast cancer. (aacrjournals.org)
  • The cancer drug targets a protein that normally restricts nerve growth. (fbresearch.org)